Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation

International Journal of Radiation Oncology Biology Physics

Volumn 48, Issue 5, 2000, Pages 1507-1512

  Colletier, Philip J ^a   Ashoori, Faramarz ^b   Cowen, Didier ^b   Meyn, Raymond E ^b   Tofilon, Philip ^b   Meistrich, Marvin E ^b   Pollack, Alan ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c NONE   (United States)

Author keywords

Apoptosis; Gene therapy; p53; Prostate cancer; Radiotherapy

Indexed keywords

BETA GALACTOSIDASE; COMPLEMENTARY DNA; GENE PRODUCT; PROTEIN P53;

ADENOVIRUS 5; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; EXPRESSION VECTOR; GAMMA IRRADIATION; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; PROSTATE CANCER; RADIOSENSITIZATION; REPORTER GENE; TRANSGENE; VIRUS RECOMBINANT;

ADENOVIRIDAE; APOPTOSIS; BETA-GALACTOSIDASE; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, REPORTER; GENETIC VECTORS; HUMANS; MALE; PROSTATIC NEOPLASMS; RADIATION TOLERANCE; RADIOBIOLOGY; TRANSFECTION; TRANSGENES; TUMOR CELLS, CULTURED;

EID: 0034566035     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01409-7     Document Type: Article

References (31)

1. Radiation-induced apoptosis; Relevance to radiotherapy
2. Supra-additive apoptotic response of R3327-G rat prostate tumors to androgen ablation, and radiation
3. The early supra-additive apoptotic response of R3327-G prostate tumors to androgen ablation plus radiation is not sustained with multiple fractions
4. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer
5. Detection of the apoptosis suppressing oncoprotein bcl-2 in hormone refractory human prostate cancers
6. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6
7. Participation of p53 protein in the cellular response to DNA damage
8. Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells
9. Radiation-induced apoptosis of human prostate cancer cells is independent of mutant p53 overexpression
10. Recombinant adenovirus vector expressing wild-type p53 is a potent inhibitor of prostate cancer cell proliferation
11. Adenovirus-mediated wild-type p53 expression induces apoptosis, and suppresses tumorigenesis of prostatic tumor cells
12. Safety evaluation of Ad5/CMV-p53 In Vitro In Vivo
13. Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation
14. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleoidyl transferase and nick translation assays
15. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques
16. Management of unfavorable locoregional prostate carcinoma with radiation and androgen ablation
17. Conventional external-beam radiation therapy alone or with androgen ablation for clinical stage III (T3, NX/NO, MO) adenocarcinoma of the prostate
18. Radical prostatectomy for high grade disease; A reevaluation
19. Can radical prostatectomy alter the progression of poorly differentiated prostate cancer?
20. Prostate cancer and radiation therapy-the message conveyed by serum prostate-specific antigen
21. Phase III trial of androgen suppression using goserelin in unfavorable-prognosis carcinoma of the prostate treated with definitive radiotherapy. Report of the Radiation Therapy Oncology Group protocol 85-31
22. Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin
23. p53 mediated sensitization of squamous cell carcinoma of the head, and neck radiotherapy
24. The effects of ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma
25. Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity
26. Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene
27. Combined radiation and p53 gene therapy of malignant glioma cells
28. Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer
29. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
30. Current challenges of gene therapy for prostate cancer