메뉴 건너뛰기




Volumn 292, Issue 3, 1998, Pages 435-445

Predicting response to cancer chemotherapy: The role of p53

Author keywords

Apoptosis; Cell cycle; Chemotherapy; Differentiation; p53

Indexed keywords

FAS ANTIGEN; FAS LIGAND; PROTEIN P21; PROTEIN P53;

EID: 0031869758     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410051072     Document Type: Review
Times cited : (225)

References (75)
  • 2
    • 0030023846 scopus 로고    scopus 로고
    • Cleavage of retinoblastoma protein during apoptosis: An interleukin 1β-converting enzyme-like protease as candidate
    • An B, Dou QP (1996) Cleavage of retinoblastoma protein during apoptosis: an interleukin 1β-converting enzyme-like protease as candidate. Cancer Res 56:438-442
    • (1996) Cancer Res , vol.56 , pp. 438-442
    • An, B.1    Dou, Q.P.2
  • 3
    • 0028875410 scopus 로고
    • Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
    • Bergh J, Norberg T, Sjögren S, Lindgren A, Holmberg L (1995) Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med 1: 1029-1034
    • (1995) Nat Med , vol.1 , pp. 1029-1034
    • Bergh, J.1    Norberg, T.2    Sjögren, S.3    Lindgren, A.4    Holmberg, L.5
  • 4
    • 0028319289 scopus 로고
    • Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development
    • Biard DSF, Martin M, Rhun Y, Duthu A, Lefaix JL, May E, May P (1994) Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development. Cancer Res 54:3361-3364
    • (1994) Cancer Res , vol.54 , pp. 3361-3364
    • Biard, D.S.F.1    Martin, M.2    Rhun, Y.3    Duthu, A.4    Lefaix, J.L.5    May, E.6    May, P.7
  • 5
    • 0030778862 scopus 로고    scopus 로고
    • Amplification and overexpression of MDM2 in primary (de novo) glioblastomas
    • Biernat W, Kleihues P, Yonekawa Y, Ohgaki H (1997) Amplification and overexpression of MDM2 in primary (de novo) glioblastomas. J Neuropathol Exp Neurol 56:180-185
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 180-185
    • Biernat, W.1    Kleihues, P.2    Yonekawa, Y.3    Ohgaki, H.4
  • 6
    • 0029832231 scopus 로고    scopus 로고
    • In vitro evaluation of a p53-expressing adenovirus as an anticancer drug
    • Blagosklonny MV, El-Deiry WS (1996) In vitro evaluation of a p53-expressing adenovirus as an anticancer drug. Int J Cancer 67:386-392
    • (1996) Int J Cancer , vol.67 , pp. 386-392
    • Blagosklonny, M.V.1    El-Deiry, W.S.2
  • 7
    • 0027331811 scopus 로고
    • p53 accumulation in ovarian carcinomas and its prognostic implications
    • Bosari S, Viale G, Radaeli U, Bossi P, Bonoldi E, Coggi G (1993) p53 accumulation in ovarian carcinomas and its prognostic implications. Hum Pathol 24:1175-1179
    • (1993) Hum Pathol , vol.24 , pp. 1175-1179
    • Bosari, S.1    Viale, G.2    Radaeli, U.3    Bossi, P.4    Bonoldi, E.5    Coggi, G.6
  • 8
    • 0027176479 scopus 로고
    • p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines
    • Brachman DG, Beckett M, Graves D, Haraf D, Yokes E, Weichselbaum RR (1993) p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Res 53:3667-3669
    • (1993) Cancer Res , vol.53 , pp. 3667-3669
    • Brachman, D.G.1    Beckett, M.2    Graves, D.3    Haraf, D.4    Yokes, E.5    Weichselbaum, R.R.6
  • 9
    • 0030232710 scopus 로고    scopus 로고
    • The p53 gene as a modifier of intrinsic radiosensitivity: Implications for radiotherapy
    • Bristow RG, Benchimol S, Hill RP (1996) The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiother Oncol 40:197-223
    • (1996) Radiother Oncol , vol.40 , pp. 197-223
    • Bristow, R.G.1    Benchimol, S.2    Hill, R.P.3
  • 11
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A, Karin M (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370:220-223
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 12
    • 0029929672 scopus 로고    scopus 로고
    • Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high bax:bcl-2 ratio
    • Chresta CM, Masters JRW, Hickman JA (1996) Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high bax:bcl-2 ratio. Cancer Res 56:1834-1841
    • (1996) Cancer Res , vol.56 , pp. 1834-1841
    • Chresta, C.M.1    Masters, J.R.W.2    Hickman, J.A.3
  • 14
    • 0031008749 scopus 로고    scopus 로고
    • p53, mutation frequency and apoptosis in the murine small intestine
    • Clarke AR, Howard LA, Harrison DJ, Winton DJ (1997) p53, mutation frequency and apoptosis in the murine small intestine. Oncogene 14:2015-2018
    • (1997) Oncogene , vol.14 , pp. 2015-2018
    • Clarke, A.R.1    Howard, L.A.2    Harrison, D.J.3    Winton, D.J.4
  • 19
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen C, Herr I, Krammer PH, Debatin KM (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med 2:574-577
    • (1996) Nat Med , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.M.4
  • 20
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
    • Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB, Roth JA (1994) Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 54:2287-2291
    • (1994) Cancer Res , vol.54 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3    Zhang, W.W.4    Owen-Schaub, L.B.5    Roth, J.A.6
  • 21
    • 0031014097 scopus 로고    scopus 로고
    • Identification of p53 genetic suppressor elements which confer resistance to cisplatin
    • Gallagher WM, Cairney M, Schott B, Rominson IB, Brown R (1997) Identification of p53 genetic suppressor elements which confer resistance to cisplatin. Oncogene 14:185-193
    • (1997) Oncogene , vol.14 , pp. 185-193
    • Gallagher, W.M.1    Cairney, M.2    Schott, B.3    Rominson, I.B.4    Brown, R.5
  • 22
    • 0029904706 scopus 로고    scopus 로고
    • Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity
    • Gallardo D, Drazan KE, McBride WH (1996) Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity. Cancer Res 56:4891-4893
    • (1996) Cancer Res , vol.56 , pp. 4891-4893
    • Gallardo, D.1    Drazan, K.E.2    McBride, W.H.3
  • 23
    • 0029555339 scopus 로고
    • Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53
    • Gjerset R, Turia ST, Sobol RE, Scalise JJ, Mercola D, Collins H, Hopkins PJ (1995) Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53. Mol Carcinog 14:275-285
    • (1995) Mol Carcinog , vol.14 , pp. 275-285
    • Gjerset, R.1    Turia, S.T.2    Sobol, R.E.3    Scalise, J.J.4    Mercola, D.5    Collins, H.6    Hopkins, P.J.7
  • 24
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 26
    • 0031034762 scopus 로고    scopus 로고
    • p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in Rat-1 fibroblasts constitutively expressing c-myc
    • Han JW, Dionne CA, Kedersha NL, Goldmacher VS (1997) p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in Rat-1 fibroblasts constitutively expressing c-myc. Cancer Res 57:176-182
    • (1997) Cancer Res , vol.57 , pp. 176-182
    • Han, J.W.1    Dionne, C.A.2    Kedersha, N.L.3    Goldmacher, V.S.4
  • 27
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by transactivation deficient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden HK, Oren M (1995) Induction of apoptosis in HeLa cells by transactivation deficient p53. Genes Dev 9:2170-2183
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, H.K.4    Oren, M.5
  • 28
    • 0030021996 scopus 로고    scopus 로고
    • Inactivation of p53 enhances sensitivity to multiple chemotherapeutic drugs
    • Hawkins DS, Demers GW, Galloway DA (1996) Inactivation of p53 enhances sensitivity to multiple chemotherapeutic drugs. Cancer Res 56:892-898
    • (1996) Cancer Res , vol.56 , pp. 892-898
    • Hawkins, D.S.1    Demers, G.W.2    Galloway, D.A.3
  • 29
    • 0029824596 scopus 로고    scopus 로고
    • Strange bedfellows in even stranger places: The role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53
    • Hawley RS, Friend SH (1996) Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53. Genes Dev 10:2383-2388
    • (1996) Genes Dev , vol.10 , pp. 2383-2388
    • Hawley, R.S.1    Friend, S.H.2
  • 31
    • 0030974567 scopus 로고    scopus 로고
    • Inability to induce the alteration of tumorigenicity and chemosensitivity of p53-null human pancreatic carcinoma cells after the transduction of wild-type p53 gene
    • Kimuru M, Tagawa M, Takenaga K, Yamaguchi T, Saisho H, Nakagawara A, Sakiyama S (1997) Inability to induce the alteration of tumorigenicity and chemosensitivity of p53-null human pancreatic carcinoma cells after the transduction of wild-type p53 gene. Anticancer Res 17:879-884
    • (1997) Anticancer Res , vol.17 , pp. 879-884
    • Kimuru, M.1    Tagawa, M.2    Takenaga, K.3    Yamaguchi, T.4    Saisho, H.5    Nakagawara, A.6    Sakiyama, S.7
  • 33
    • 0029112238 scopus 로고
    • Viability of wild type p53-containing and p53-deficient tumor cells following anticancer treatment: The use of human papillomavirus E6 to target p53
    • Labrecque S, Matlashewski GJ (1995) Viability of wild type p53-containing and p53-deficient tumor cells following anticancer treatment: the use of human papillomavirus E6 to target p53. Oncogene 11:387-392
    • (1995) Oncogene , vol.11 , pp. 387-392
    • Labrecque, S.1    Matlashewski, G.J.2
  • 34
    • 0027285380 scopus 로고
    • p53 mutations increase resistance to ionizing radiation
    • Lee JM, Bernstein A (1993) p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci USA 90:5742-5746
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5742-5746
    • Lee, J.M.1    Bernstein, A.2
  • 35
    • 0029038135 scopus 로고
    • Apoptosis, cancer and the p53 tumour suppressor gene
    • Lee JM, Bernstein A (1995) Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metastasis Rev 14:149-161
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 149-161
    • Lee, J.M.1    Bernstein, A.2
  • 36
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 85:323-331
    • (1997) Cell , vol.85 , pp. 323-331
    • Levine, A.J.1
  • 37
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE (1993a) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 38
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993b) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 40
    • 0028999374 scopus 로고
    • p53 protein overexpression and chemosensitivity in breast cancer
    • Makris A, Powels TJ, Dowsett M, Allred C (1995) p53 protein overexpression and chemosensitivity in breast cancer. Lancet 345:1181-1182
    • (1995) Lancet , vol.345 , pp. 1181-1182
    • Makris, A.1    Powels, T.J.2    Dowsett, M.3    Allred, C.4
  • 41
    • 0028861937 scopus 로고
    • p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs
    • Malcomson RDG, Oren M, Wyllie AH, Harrison DJ (1995) p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs. Br J Cancer 72:952-957
    • (1995) Br J Cancer , vol.72 , pp. 952-957
    • Malcomson, R.D.G.1    Oren, M.2    Wyllie, A.H.3    Harrison, D.J.4
  • 43
    • 0027931008 scopus 로고
    • Cell cycle arrests and radiosensitivity of human tumor cell lines: Dependence on wild-type p53 for radiosensitivity
    • McIlwrath AJ, Vasey PA, Ross GM, Brown R (1994) Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res 54:3718-3722
    • (1994) Cancer Res , vol.54 , pp. 3718-3722
    • McIlwrath, A.J.1    Vasey, P.A.2    Ross, G.M.3    Brown, R.4
  • 44
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous apoptosis and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP, Hall PA (1994) The role of p53 in spontaneous apoptosis and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 54:614-617
    • (1994) Cancer Res , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 45
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalowitz D, Halevy O, Oren M (1990) Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62:671-680
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalowitz, D.1    Halevy, O.2    Oren, M.3
  • 46
    • 0030910037 scopus 로고    scopus 로고
    • p53 and ATM: Cell cycle, cell death, and cancer
    • Morgan SE, Kastan MB (1997) p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res 1-25
    • (1997) Adv Cancer Res , pp. 1-25
    • Morgan, S.E.1    Kastan, M.B.2
  • 47
    • 0030485536 scopus 로고    scopus 로고
    • The dual role of mutant p53 protein in chemosensitivity of human cancers
    • Müller H, Eppenberger U (1996) The dual role of mutant p53 protein in chemosensitivity of human cancers. Anticancer Res 16:3845-3848
    • (1996) Anticancer Res , vol.16 , pp. 3845-3848
    • Müller, H.1    Eppenberger, U.2
  • 48
    • 0040419494 scopus 로고    scopus 로고
    • Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/ Fas) receptor/ligand system and involves activation of wild-type p53
    • Müller M, Strand S, Hug H, Heinemann EM, Walczak H, Hofmann WJ, Stremmel W, Krammer PH, Galle PR (1997) Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/ Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest 99:403-413
    • (1997) J Clin Invest , vol.99 , pp. 403-413
    • Müller, M.1    Strand, S.2    Hug, H.3    Heinemann, E.M.4    Walczak, H.5    Hofmann, W.J.6    Stremmel, W.7    Krammer, P.H.8    Galle, P.R.9
  • 49
    • 0029835487 scopus 로고    scopus 로고
    • Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer
    • Nguyen DM, Spitz FR, Yen N, Cristiano RJ, Roth JA (1996) Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J Thorac Cardiovasc Surg 112:1372-1377
    • (1996) J Thorac Cardiovasc Surg , vol.112 , pp. 1372-1377
    • Nguyen, D.M.1    Spitz, F.R.2    Yen, N.3    Cristiano, R.J.4    Roth, J.A.5
  • 54
  • 57
  • 58
    • 7144256289 scopus 로고    scopus 로고
    • Taxol-mediated augmentation of CD95 ligand-induced apoptosis of human malignant glioma cells is independent of p53 induction and G2/M cell cycle arrest
    • in press
    • Roth W, Wagenknecht B, Grimmel C, Dichgans J, Weller M (1997b) Taxol-mediated augmentation of CD95 ligand-induced apoptosis of human malignant glioma cells is independent of p53 induction and G2/M cell cycle arrest. Br J Cancer (in press)
    • (1997) Br J Cancer
    • Roth, W.1    Wagenknecht, B.2    Grimmel, C.3    Dichgans, J.4    Weller, M.5
  • 59
    • 0028840535 scopus 로고
    • Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer
    • Rusch V, Klimstra D, Venkatraman E, Oliver J, Martini N, Gralla R, Kris M, Dmitrovsky E (1995) Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res 55:5038-5042
    • (1995) Cancer Res , vol.55 , pp. 5038-5042
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3    Oliver, J.4    Martini, N.5    Gralla, R.6    Kris, M.7    Dmitrovsky, E.8
  • 61
    • 0031029576 scopus 로고    scopus 로고
    • Expression of wild-type p53 increases etoposide cytotoxicity in M1 myeloid leukemia cells by facilitated GT to M transition: Implications for gene therapy
    • Skladanowski A, Larsen AK (1997) Expression of wild-type p53 increases etoposide cytotoxicity in M1 myeloid leukemia cells by facilitated GT to M transition: implications for gene therapy. Cancer Res 57:818-823
    • (1997) Cancer Res , vol.57 , pp. 818-823
    • Skladanowski, A.1    Larsen, A.K.2
  • 62
    • 0027893001 scopus 로고
    • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNa damage
    • Slichenmyer WJ, Nelson WG, Slebos RJ, Kastan MB (1993) Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res 53:4164-4168
    • (1993) Cancer Res , vol.53 , pp. 4164-4168
    • Slichenmyer, W.J.1    Nelson, W.G.2    Slebos, R.J.3    Kastan, M.B.4
  • 65
    • 0029054581 scopus 로고
    • Abrogation of p53 function by transfection of HPV 16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation
    • Tsang NM, Nagasawa H, Li C, Little JB (1995) Abrogation of p53 function by transfection of HPV 16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. Oncogene 10:2403-2408
    • (1995) Oncogene , vol.10 , pp. 2403-2408
    • Tsang, N.M.1    Nagasawa, H.2    Li, C.3    Little, J.B.4
  • 66
    • 0030465009 scopus 로고    scopus 로고
    • Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance
    • Vasey PA, Jones NA, Jenkins S, Dive C, Brown R (1996) Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance. Mol Pharmacol 50:1536-1540
    • (1996) Mol Pharmacol , vol.50 , pp. 1536-1540
    • Vasey, P.A.1    Jones, N.A.2    Jenkins, S.3    Dive, C.4    Brown, R.5
  • 67
    • 0028916558 scopus 로고
    • Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF/CIP1 genes
    • Vikhanskaya F, D'Incalci M, Broggini M (1995) Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF/CIP1 genes. Int J Cancer 61:397-401
    • (1995) Int J Cancer , vol.61 , pp. 397-401
    • Vikhanskaya, F.1    D'Incalci, M.2    Broggini, M.3
  • 71
    • 0030442972 scopus 로고    scopus 로고
    • TP53 tumour suppressor gene: Clues to molecular carcinogenesis and cancer therapy
    • Wang XW, Harris CC (1996) TP53 tumour suppressor gene: clues to molecular carcinogenesis and cancer therapy. Cancer Surv 28:169-196
    • (1996) Cancer Surv , vol.28 , pp. 169-196
    • Wang, X.W.1    Harris, C.C.2
  • 73
    • 0031018994 scopus 로고    scopus 로고
    • Relationship of p53, bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas
    • Wilson WH, Teruya-Feldstein J, Fest T, Harris C, Steinberg SM, Jaffe ES, Raffeid M (1997) Relationship of p53, bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas. Blood 89:601-609
    • (1997) Blood , vol.89 , pp. 601-609
    • Wilson, W.H.1    Teruya-Feldstein, J.2    Fest, T.3    Harris, C.4    Steinberg, S.M.5    Jaffe, E.S.6    Raffeid, M.7
  • 74
    • 7144229412 scopus 로고    scopus 로고
    • Synergistic activity of CD95 ligand and teniposide (VM26) does not involve enhanced formation of cleavable DNA complexes or changes in CD95/CD95 ligand expression
    • in press
    • Winter S, Roth W, Dichgans J, Weller M (1997) Synergistic activity of CD95 ligand and teniposide (VM26) does not involve enhanced formation of cleavable DNA complexes or changes in CD95/CD95 ligand expression. Eur J Pharmacol (in press)
    • (1997) Eur J Pharmacol
    • Winter, S.1    Roth, W.2    Dichgans, J.3    Weller, M.4
  • 75
    • 0030094571 scopus 로고    scopus 로고
    • p53 and chemosensitivity
    • Wu GS, El-Deiry WS (1996) p53 and chemosensitivity. Nat Med 2:255-256
    • (1996) Nat Med , vol.2 , pp. 255-256
    • Wu, G.S.1    El-Deiry, W.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.