Pharmacology of therapeutic oligonucleotides

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 239-243

  Diasio, Robert B ^a   Zhang, Ruiwen ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

BLOOD TOXICITY; CLINICAL TRIAL; CONFERENCE PAPER; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STABILITY; DRUG TARGETING; GENE REPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRADERMAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER TOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPLENOMEGALY; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030796757     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.239     Document Type: Conference Paper

References (6)

1. AGRAWAL, S. (1996). Antisense oligonucleotides: Towards clinical trial. Trends Biotechnol. 14, 375-387.
2. AGRAWAL, S., and IYER, R.P. (1995). Modified oligonucleotides as therapeutic and diagnostic agents. Curr. Opin. Biotechnol. 6, 112-119.
3. AGRAWAL, S., JIANG, Z., ZHAO, Q., SHAW, D., CAI, Q., ROSKEY, A., CHANNAVAJJALA, L., SAXINGER, C., and ZHANG, R. (1997). Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 94, 2620-2625.
4. AGRAWAL, S., and TANG, J.Y. (1992). GEM 91 - An antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS. Antisense Res. Dev. 2, 261-266.
5. AGRAWAL, S., TEMSAMANI, J., GALBRAITH, W., and TANG, J. (1995a). Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28, 7-16.
6. AGRAWAL, S., TEMSAMANI, J., and TANG, J.Y. (1991). Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA 88, 7595-7599.