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Volumn 35, Issue 7, 1999, Pages 1083-1088

Expression of p53 and mdm2 mRNA and protein in colorectal carcinomas

Author keywords

Colorectal carcinomas; Distant metastases; Lymph node metastases; mdm2 oncogene; MRNA level protein level; TP53 tumour suppressor gene

Indexed keywords

MESSENGER RNA; PROTEIN MDM2; PROTEIN P53;

EID: 0033165975     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(99)00058-1     Document Type: Article
Times cited : (16)

References (33)
  • 1
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumourigenesis
    • Fearon E.R., Vogelstein B. A genetic model for colorectal tumourigenesis. Cell. 61:1990;759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 2
    • 0027109075 scopus 로고
    • P53, guardian of the genome
    • Lane D.P. P53, guardian of the genome. Nature. 358:1992;15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 3
    • 0027498314 scopus 로고
    • The mdm2-oncogene can overcome wild-type p53 suppression of transformed cell growth
    • Finlay C.A. The mdm2-oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol. 13:1993;301-306.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 301-306
    • Finlay, C.A.1
  • 4
    • 0026649648 scopus 로고
    • The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J., Zambetti P., Olsen D.C., George D., Levine A.J. The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 69:1992;1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, P.2    Olsen, D.C.3    George, D.4    Levine, A.J.5
  • 5
    • 0027369667 scopus 로고
    • Tumorigenesis associated with the p53 tumour suppressor gene
    • Chang F., Syrjänen S., Tervahauta A., Syrjänen K. Tumorigenesis associated with the p53 tumour suppressor gene. Br. J. Cancer. 68:1993;653-661.
    • (1993) Br. J. Cancer , vol.68 , pp. 653-661
    • Chang, F.1    Syrjänen, S.2    Tervahauta, A.3    Syrjänen, K.4
  • 6
    • 0023339504 scopus 로고
    • Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
    • Cahilly-Snyder L., Yang-Feng T., Francke U., George D.L. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somatic. Cell. Mol. Genet. 13:1987;235-244.
    • (1987) Somatic. Cell. Mol. Genet. , vol.13 , pp. 235-244
    • Cahilly-Snyder, L.1    Yang-Feng, T.2    Francke, U.3    George, D.L.4
  • 7
    • 0029829291 scopus 로고    scopus 로고
    • A molecular and immunohistochemical study of the mdm2 protein isoforms and p53 gene product in bronchogenic carcinoma
    • Gorgoulis V.G., Zoumpourlis V., Rassidakis G.Z.et al. A molecular and immunohistochemical study of the mdm2 protein isoforms and p53 gene product in bronchogenic carcinoma. J. Pathol. 180:1996;129-137.
    • (1996) J. Pathol. , vol.180 , pp. 129-137
    • Gorgoulis, V.G.1    Zoumpourlis, V.2    Rassidakis, G.Z.3
  • 8
    • 0028049474 scopus 로고
    • Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
    • Barak Y., Gottlieb E., Juven-Gershon T., Oren M. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 8:1994;1739-1749.
    • (1994) Genes Dev. , vol.8 , pp. 1739-1749
    • Barak, Y.1    Gottlieb, E.2    Juven-Gershon, T.3    Oren, M.4
  • 9
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen J., Marechal V., Levine A.J. Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol. 13:1993;4107-4114.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 10
    • 0030812191 scopus 로고    scopus 로고
    • P53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1
    • Giannikaki E., Kouvidou C., Tzardi M.et al. p53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1. Anticancer Res. 17:1997;2123-2127.
    • (1997) Anticancer Res. , vol.17 , pp. 2123-2127
    • Giannikaki, E.1    Kouvidou, C.2    Tzardi, M.3
  • 11
    • 0030825813 scopus 로고    scopus 로고
    • P53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley C.A., Lane D.P. p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene. 15:1997;1179-1189.
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 12
    • 0030877712 scopus 로고    scopus 로고
    • Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas
    • Valassiadou K.E., Stefanaki K., Tzardi M.et al. Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas. Anticancer Res. 17:1997;2571-2576.
    • (1997) Anticancer Res. , vol.17 , pp. 2571-2576
    • Valassiadou, K.E.1    Stefanaki, K.2    Tzardi, M.3
  • 13
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu X., Bayle J.H., Olson D., Levine A.J. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7:1993;1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 14
    • 0028952962 scopus 로고
    • Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: Prognostic significance
    • Öfner D., Maier H., Riedmann B.et al. Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: prognostic significance. J. Clin. Pathol.: Mol. Pathol. 48:1995;M12-M16.
    • (1995) J. Clin. Pathol.: Mol. Pathol. , vol.48
    • Öfner, D.1    Maier, H.2    Riedmann, B.3
  • 17
    • 0028983308 scopus 로고
    • Mdm2 gene alterations and mdm2 protein expression in breast carcinomas
    • Marchetti A., Buttitta F., Girlando S.et al. Mdm2 gene alterations and mdm2 protein expression in breast carcinomas. J. Pathol. 175:1995;31-38.
    • (1995) J. Pathol. , vol.175 , pp. 31-38
    • Marchetti, A.1    Buttitta, F.2    Girlando, S.3
  • 18
    • 0031045324 scopus 로고    scopus 로고
    • Overexpression of p53 mRNA in colorectal cancer and its relationship to p53 gene mutation
    • El-Mahdani N., Vaillant J.C., Guiguet M.et al. Overexpression of p53 mRNA in colorectal cancer and its relationship to p53 gene mutation. Br. J. Cancer. 75:1997;528-536.
    • (1997) Br. J. Cancer , vol.75 , pp. 528-536
    • El-Mahdani, N.1    Vaillant, J.C.2    Guiguet, M.3
  • 19
    • 0029766553 scopus 로고    scopus 로고
    • Translational regulation of human p53 gene expression
    • Fu L., Minden M.D., Benchimol S. Translational regulation of human p53 gene expression. EMBO J. 15:1996;4392-4401.
    • (1996) EMBO J. , vol.15 , pp. 4392-4401
    • Fu, L.1    Minden, M.D.2    Benchimol, S.3
  • 20
    • 0028942692 scopus 로고
    • Immunohistochemical analysis of p53 in colorectal cancer regarding clinicopathological correlation and prognostic significance
    • Tomoda H., Kakeji Y. Immunohistochemical analysis of p53 in colorectal cancer regarding clinicopathological correlation and prognostic significance. J. Surg. Oncol. 58:1995;125-128.
    • (1995) J. Surg. Oncol. , vol.58 , pp. 125-128
    • Tomoda, H.1    Kakeji, Y.2
  • 21
    • 0028990168 scopus 로고
    • P53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers
    • Costa A., Marasca R., Valentinis B.et al. p53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers. J. Pathol. 176:1995;45-53.
    • (1995) J. Pathol. , vol.176 , pp. 45-53
    • Costa, A.1    Marasca, R.2    Valentinis, B.3
  • 22
  • 23
    • 0028071555 scopus 로고
    • Mutations in the p53 tumour suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54:1994;4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 24
    • 0029666236 scopus 로고    scopus 로고
    • Immunohistochemical p53 staining is of limited value in the staging and prognostic prediction of colorectal cancer
    • Kressner U., Lindmark G., Gerdin B., Pahlman L., Glimelius B. Immunohistochemical p53 staining is of limited value in the staging and prognostic prediction of colorectal cancer. Anticancer Res. 16:1996;951-958.
    • (1996) Anticancer Res. , vol.16 , pp. 951-958
    • Kressner, U.1    Lindmark, G.2    Gerdin, B.3    Pahlman, L.4    Glimelius, B.5
  • 26
    • 0028903782 scopus 로고
    • Association of p53 gene and protein alterations with metastasis in colorectal carcinomas
    • Bertorelle R., Esposito G., Del Mistro A.et al. Association of p53 gene and protein alterations with metastasis in colorectal carcinomas. Am. J. Surg. Pathol. 19:1995;463-471.
    • (1995) Am. J. Surg. Pathol. , vol.19 , pp. 463-471
    • Bertorelle, R.1    Esposito, G.2    Del Mistro, A.3
  • 27
    • 0027170898 scopus 로고
    • P53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance
    • Yamaguchi A., Nakagawara G., Kurosaka Y., Nishimura G., Yonemura Y., Miyazaki I. P53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance. Br. J. Cancer. 68:1993;399-402.
    • (1993) Br. J. Cancer , vol.68 , pp. 399-402
    • Yamaguchi, A.1    Nakagawara, G.2    Kurosaka, Y.3    Nishimura, G.4    Yonemura, Y.5    Miyazaki, I.6
  • 28
    • 0030443917 scopus 로고    scopus 로고
    • DNA amplifications at 30q13 and mdm2 define distinct subsets of evolved breast and ovarian tumours
    • Courjal F., Cuny M., Rodriguez C.et al. DNA amplifications at 30q13 and mdm2 define distinct subsets of evolved breast and ovarian tumours. Br. J. Cancer. 74:1996;1984-1989.
    • (1996) Br. J. Cancer , vol.74 , pp. 1984-1989
    • Courjal, F.1    Cuny, M.2    Rodriguez, C.3
  • 29
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G., Liu L., Ichimura K., Schmidt E.E., Collins V.P. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53:1993;2736-2739.
    • (1993) Cancer Res. , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 30
    • 0028167551 scopus 로고
    • Detection of MDM2-proto-oncogene in paraffin embedded human bronchial epithelium
    • Wiethege T., Voss B., Müller K.M. Detection of MDM2-proto-oncogene in paraffin embedded human bronchial epithelium. J. Cancer Res. Clin. Oncol. 120:1994;252-255.
    • (1994) J. Cancer Res. Clin. Oncol. , vol.120 , pp. 252-255
    • Wiethege, T.1    Voss, B.2    Müller, K.M.3
  • 31
    • 0028670937 scopus 로고
    • Selective compartmentalization of different mdm2 proteins within the nucleus
    • Maxwell S.A. Selective compartmentalization of different mdm2 proteins within the nucleus. Anticancer Res. 14:1994;2541-2548.
    • (1994) Anticancer Res. , vol.14 , pp. 2541-2548
    • Maxwell, S.A.1
  • 33
    • 0028334197 scopus 로고
    • Abnormalities of the p53 MDM2 and DCC genes in human leiomyosarcomas
    • Patterson H., Gill S., Fisher C.et al. Abnormalities of the p53 MDM2 and DCC genes in human leiomyosarcomas. Br. J. Cancer. 69:1994;1052-1058.
    • (1994) Br. J. Cancer , vol.69 , pp. 1052-1058
    • Patterson, H.1    Gill, S.2    Fisher, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.