The effects of electric current applied to skin: A review for transdermal drug delivery

Advanced Drug Delivery Reviews

Volumn 18, Issue 3, 1996, Pages 395-425

  Prausnitz, Mark R ^a  

^a Georgia Institute of Technology   (United States)

Author keywords

Electrical safety; Electroporation; High voltage medical device; Iontophoresis; Muscle stimulation; Nerve stimulation; Pain; Skin electrical properties; Skin irritation

Indexed keywords

DRUG INFUSION; DRUG INTERACTIONS; ELECTRIC CURRENTS; ELECTRIC PROPERTIES; ELECTROPHYSIOLOGY; FUNCTIONAL ELECTRIC STIMULATION; FUNCTIONAL NEURAL STIMULATION; MUSCLE; SENSORY PERCEPTION; SKIN;

ELECTROPORATION; IONTOPHORESIS; TRANSDERMAL DRUG DELIVERY;

CONTROLLED DRUG DELIVERY;

BURN; DRUG ADMINISTRATION; ELECTRIC CURRENT; ELECTROPORATION; HEART; HUMAN; IONTOPHORESIS; MUSCLE EXCITATION; NERVE STIMULATION; PAIN; PRIORITY JOURNAL; REVIEW; SENSATION; SKIN; SKIN IRRITATION; TISSUE INJURY; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030574682     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(95)00081-H     Document Type: Review

References (351)

1. Geddes, L.A. (1984) A short history of the electrical stimulation of excitable tissue including electrotherapeutic applications. Physiologist 27 (Suppl.), S1-S47.
2. Licht, S.H. (1971) History of electrodiagnosis. In: S.H. Licht (Ed.). Electrodiagnosis and Electromyography. Waverly Press/E. Licht, Baltimore, MD/New Haven CT, pp. 1-23.
3. McNeal, D.R. (1977) 2000 years of electrical stimulation. In: T.F. Hambrecht and J.B. Reswick (Eds), Functional Electrical Stimulation, Marcel Dekker, New York, pp. 3-35.
4. Webster, J.G. (Ed.) (1988) Encyclopedia of Medical Devices and Instrumentation. Wiley & Sons, New York.
5. Geddes, L.A. and Baker, L.E. (1989) Principles of Applied Biomedical Instrumentation. Wiley & Sons, New York.
6. Nelson, R.M. and Currier, D.P. (Eds) (1991) Clinical Electrotherapy, Appleton & Lange, Norwalk, CT.
7. Reilly, J.P. (1992) Electrical Stimulation and Electropathology, Cambridge University Press, New York.
8. Leduc, S. (1908) Electric Ions and Their Use in Medicine, Rebman, London.
9. Harris, R. (1967) Iontophoresis. In: S.H. Licht (Ed.), Therapeutic Electricity and Ultraviolet Radiation, Waverly Press, Baltimore, pp. 156-178.
10. Stillwell, G.K. (1971) Electrical stimulation and iontophoresis. In: F.H. Krussen, F.J. Kottke and P.M. Ellwood (Eds). Handbook of Physical Medicine and Rehabilitation, Saunders, Philadelphia, ch. 14.
11. Gangarosa, L.P. (1983) Iontophoresis in Dental Practice, Quintessence Publishing, Chicago.
12. Sloan, J.B. and Soltani, K. (1986) Iontophoresis in dermatology. J. Am. Acad. Dermatol. 15, 671-684.
13. Tyle, P. (1986) Iontophoretic devices for drug delivery. Pharm. Res. 3, 318-326.
14. Chien, Y.W., Siddiqui, O., Sun, Y., Shi, W.M. and Liu, J.C. (1987) Transdermal iontophoretic delivery of therapeutic peptides/proteins. Ann. NY Acad. Sci. 507, 32-51.
15. Banga, A.K. and Chien, Y.W. (1988) Iontophoretic delivery of drugs: fundamentals, developments and biomedical applications. J. Control. Release 7, 1-24.
16. Tyle, P. and Kari, B. (1988) Iontophoretic devices. In: P. Tyle (Ed.). Drug Delivery Devices. Fundamentals and Applications, Marcel Dekker, New York, pp. 421-454.
17. Burnette, R.R. (1989) Iontophoresis. In: J. Hadgraft and R.H. Guy (Eds), Transdermal Drug Delivery. Developmental Issues and Research Initiatives, Marcel Dekker, New York, pp. 247-291.
18. Chien, Y.W. and Banga, A.K. (1989) Iontophoretic (transdermal) delivery of drugs: overview of historical development. J. Pharm. Sci. 78, 353-354.
19. Chien, Y.W., Siddiqui, O., Shi, W., Lelawongs, P. and Liu, J. (1989) Direct current iontophoretic transdermal delivery of peptide and protein drugs. J. Pharm. Sci. 78, 376-383.
20. Singh, J. and Roberts, M.S. (1989) Transdermal delivery of drugs by iontophoresis: a review. Drug Design and Delivery 4, 1-12.
21. Chien, Y.W., Lelawongs, P., Siddiqui, O., Sun, Y. and Shi, W.M. (1990) Facilitated transdermal delivery of therapeutic peptides and proteins by iontophoretic delivery devices. J. Control. Release 13, 263-278.
22. Cummings, J. (1991) Iontophoresis. In: R.M. Nelson and D.P. Currier (Eds). Clinical Electrotherapy, Appleton & Lange, Norwalk, CT, pp. 317-330.
23. Lattin, G.A., Padmanabhan, R.V. and Phipps, J.B. (1991) Electronic control of iontophoretic drug delivery. Ann. NY Acad. Sci. USA 618, 450-464.
24. Cullander, C. (1992) What are the pathways of iontophoretic current flow through mammalian skin? Adv. Drug Deliv. Rev. 9, 119-135.
25. Cullander, C. and Guy, R.H. (1992) Transdermal delivery of peptides and proteins. Adv. Drug Deliv. Rev. 8, 291-329.
26. Kasting, G.B. (1992) Theoretical models for iontophoretic delivery. Adv. Drug Deliv. Rev. 9, 177-199.
27. Ledger, P.W. (1992) Skin biological issues in electrically enhanced transdermal delivery. Adv. Drug Deliv. Rev. 9, 289-307.
28. Phipps, J.B. and Gyory, J.R. (1992) Transdermal ion migration. Adv. Drug Deliv. Rev. 9, 137-176.
29. Pikal, M.J. (1992) The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 9, 201-237.
30. Sage, B.H. and Riviere, J.E. (1992) Model systems in iontophoresis - transport efficacy. Adv. Drug Deliv. Rev. 9, 265-289.
31. Yoshida, N.H. and Roberts, M.S. (1992) Structure-transport relationships in transdermal iontophoresis. Adv. Drug Deliv. Rev. 9, 239-264.
32. Prausnitz, M.R., Bose, V.G., Langer, R. and Weaver, J.C. (1995) Electroporation. In: E.W. Smith and H.I. Maibach (Eds), Percutaneous Penetration Enhancers, CRC Press, Boca Raton, FL, pp. 393-405.
33. Sage, B.H. (1995) Iontophoresis. In: E.W. Smith and H.I. Maibach (Eds), Percutaneous Penetration Enhancers. CRC Press, Boca Raton, FL, pp. 251-268.
34. Berner, B. and Dinh, S.M. (Eds) (in press) Electronically Controlled Drug Delivery, CRC Press, Boca Raton, FL.
35. Amsden, B.G. and Goosen, M.F.A. (in press) Transdermal delivery of peptide and protein drugs: an overview. AIChE J.
36. Okabe, K., Yamaguchi, H. and Kawai, Y. (1986) New iontophoretic transdermal administration of the beta-blocker metoprolol. J. Control. Release 4, 79-85.
37. Duvanel, T., Harms, M. and Saurat, J. (1988) New technique to perform local anesthesia: pulsed iontophoresis. Dermatologica 177, 30.
38. Liu, L.C., Sun, Y., Siddiqui, O., Chien, Y.W., Shi, W.M. and Li, J. (1988) Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin. Int. J. Pharm. 44, 197-204.
39. Bagniefski, T. and Burnette, R.R. (1990) A comparison of pulsed and continuous current iontophoresis. J. Control. Release 11, 113-122.
40. Koizumi, T., Kakemi, M., Katayama, K., Inada, H., Sudeji, K. and Kawasaki, M. (1990) Transfer of diclofenac sodium across excised guinea pig skin on high-frequency pulse iontophoresis I. Equivalent circuit model. Chem. Pharm. Bull. 38, 1019-1021.
41. Koizumi, T., Kakemi, M., Katayama, K., Inada, H., Sudeji, K. and Kawasaki, M. (1990) Transfer of diclofenac sodium across excised guinea pig skin on high-frequency pulse iontophoresis II. Factors affecting steady-state transport rate. Chem. Pharm. Bull. 38, 1022-1023.
42. Wearley, L.L., Tojo, K. and Chien, Y.W. (1990) A numerical approach to study the effect of binding on the iontophoretic transport of a series of amino acids. J. Pharm. Sci. 79, 992-998.
43. Mc Nichols, L.A. and Lattin, G.A. (1991) Method and apparatus for pulsed iontophoretic drug delivery. US Patent No. 5,047,007
44. Pikal, M.J. and Shah, S. (1991) Study of the mechanisms of flux enhancement through hairless mouse skin by pulsed dc iontophoresis. Pharm. Res. 8, 365-369.
45. Powell, K.T., Morgenthaler, A.W. and Weaver, J.C. (1989) Tissue electroporation: observation of reversible electrical breakdown in viable frog skin. Biophys. J. 56, 1163-1171.
46. Sims, S.M., Higuchi, W.I. and Srinivasan, V. (1991) Skin alteration and convective solvent flow effects during iontophoresis: I. Neutral solute transport across human skin. Int. J. Pharm 69, 109-121.
47. Keister, J.C. and Kasting, G.B. (1992) A kinetic model for ion transport across skin. J. Membrane Sci. 71, 257-271.
48. Prausnitz, M.R., Bose, V.G., Langer, R. and Weaver, J.C. (1992) Transdermal drug delivery by electroporation. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 19, 232-233.
49. Prausnitz, M.R., Bose, V.G., Langer, R. and Weaver, J.C. (1993) Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. USA 90, 10504-10508.
50. Prausnitz, M.R., Bose, V.G., Langer, R.S. and Weaver, J.C. (1993) Transtissue molecular transport due to electroporation of skin. In: M. Blank (Ed.), Electricity and Magnetism in Biology and Medicine, San Francisco Press, San Francisco, pp. 122-124.
51. Scott, E.R., Laplaza, A.I., White, H.S. and Phipps, J.B. (1993) Transport of ionic species in skin: contribution of pores to the overall skin conductance. Pharm. Res. 10, 1699-1709.
52. Tamada, J., Sharifi, J., Bommannan, D.B., Leung, L., Azimi, N., Abraham, W. and Potts, R. (1993) Effect of electroporation on the iontophoretic delivery of peptides in vitro. Pharm. Res. 10, S-257.
53. Bommannan, D., Tamada, J., Leung, L. and Potts, R.O. (1994) Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro. Pharm. Res. 11, 1809-1814.
54. Bose, V.G. (1994) Electrical Characterization of Electroporation of Human Stratum Corneum, MS Thesis, Massachusetts Institute of Technology, Cambridge, MA.
55. Inada, H., Ghanem, A.-H. and Higuchi, W.I. (1994) Studies on the effects of applied voltage and duration on human epidermal membrane alteration/recovery and the resultant effects upon iontophoresis. Pharm. Res. 11, 687-697.
56. Prausnitz, M.R., Pliquett, U., Langer, R. and Weaver, J.C. (1994) Rapid temporal control of transdermal drug delivery by electroporation. Pharm. Res. 11, 1834-1837.
57. Vanbever, R., Lecouturier, N. and Préat, V. (1994) Transdermal delivery of metoprolol by electroporation. Pharm. Res. 11, 1657-1662.
58. Chizmadzhev, Y.A., Zarnytsin, V.G., Weaver, J.C. and Potts, R.O. (1995) Mechanism of electroinduced ionic species transport through a multilamellar lipid system. Biophys. J. 68, 749-765.
59. Edwards, D.A., Prausnitz, M.R., Langer, R. and Weaver, J.C. (1995) Analysis of enhanced transdermal transport by skin electroporation. J. Control. Release 34, 211-221.
60. Prausnitz, M.R., Electroporation. In: B. Berner and S.M. Dinh (Eds), Electronically Controlled Drug Delivery, CRC Press, Boca Raton, FL, in press.
61. Pliquett, U. and Weaver, J.C., Transport of a charged molecule across the human epidermis due to electroporation. J. Control. Release, submitted.
62. Pliquett, U. and Weaver, J.C., Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties. Bioelectrochem. Bioenerget., submitted.
63. Pliquett, U., Zewart, T.E., Chen, T., Langer, R. and Weaver, J.C., Imaging of fluorescent molecule and small ion transport through human stratum corneum during high voltage pulsing: localized transport regions are involved. Biophys. Chem., submitted.
64. Pliquett, U., Langer, R. and Weaver, J.C., The change in the passive electrical properties of human stratum corneum due to electroporation. Biochim. Biophys. Acta, submitted.
65. Prausnitz, M.R., Lee, C.S., Liu, C.H., Pang, J.C., Singh, T.-P., Langer, R. and Weaver, J.C., Transdermal transport efficiency during skin electroporation and iontophoresis. J. Control. Release, submitted.
66. Prausnitz, M.R., Seddick, D.S., Kon, A.A., Bose, V.G., Frankenburg, S., Klaus, S.N., Langer, R. and Weaver, J.C. (1993) Methods for in vivo tissue electroporation using surface electrodes. Drug Delivery 1, 125-131.
67. Tregear, R.T. (1966) Physical Functions of Skin, Academic Press, New York.
68. Ackmann, J.J. and Seitz, M.A. (1984) Methods of complex impedance measurements in biologic tissue. Crit. Rev. Biomed. Eng. 2, 281-311.
69. Horton, J.W. and Ravenswaay, A.C.V. (1935) Electrical impedance of the human body. J. Franklin Inst. 220, 557-572.
70. Rosendal, T. (1945) Concluding studies on the conducting properties of human skin to alternating current. Acta Physiol. Scan. 9, 39-49.
71. Tregear, R.T. (1965) Interpretation of skin impedance measurement. Nature 205, 600-601.
72. Burton, C.E., David, R.M., Portnoy, W.M. and Akers, L.A. (1974) The application of Bode analysis to skin impedance. Psychophysiology 11, 517-525.
73. Yamamoto, T. and Yamamoto, Y. (1976) Electrical properties of the epidermal stratum corneum. Med. Biol. Eng. 151-158.
74. Clar, E.J., Cambral, M. and Sturelle, C. (1982) Study of skin horny layer hydration and restoration by impedance measurement. Cosmet. Toiletries 97, 33-40.
75. Leveque, J.L. and Rigal, J.D. (1983) Impedance methods for studying skin moisturization. J. Soc. Cosmet. Chem. 34, 419-428.
76. Biegelmeier, G. (1985) New experiments with regard to basic safety measures for electrical equipment and installations. In: J.E. Bridges (Ed.), Electrical Shock Safety Criteria, Pergamon Press, New York.
77. Yamamoto, Y. and Yamamoto, T. (1987) Measurement of electrical bio-impedance and its applications. Med. Progress Tech. 12, 171-183.
78. Rosell, J., Colominas, J., Riu, P., Pallas-Areny, R. and Webster, J.G. (1988) Skin impedance from 1 Hz to 1 MHz. IEEE Trans. Biomed. Eng. 35, 649-651.
79. DeNuzzio, J.D. and Berner, B. (1990) Electrochemical and iontophoretic studies of human skin. J. Control. Release 11, 105-112.
80. Oh, S.Y., Leung, L., Bommannan, D., Guy, R.H. and Potts, R.O. (1993) Effect of current, ionic strength and temperature on the electrical properties of skin. J. Control. Release 27, 115-125.
81. Gougerot, L. (1948) Des schémas électriques d'impédance équivalents a la peau humaine. J. Radiol. Electrol. 29, 479-486.
82. Gerstner, H. and Gerbstädt, H. (1949) Der Wechselstromwiderstand der menschlichen haut. Ptlügers Arch. 252, 111-122.
83. Clar, E.J., Her, C.P. and Sturelle, C.G. (1975) Skin impedance and moisturization. J. Soc. Cosmet. Chem. 26, 337-353.
84. Van Boxtel, A. (1977) Skin resistance during square-wave electrical pulses of 1 to 10 mA. Med. Biol. Eng. Comput. 15, 679-687.
85. Lykken, D.T. (1959) Properties of electrodes used in electrodermal measurement. J. Comp. Physiol. Psychol. 52, 629-634.
86. Lykken, D.T. and Venables, P.H. (1971) Direct measurement of skin conductance: a proposal for standardization. Psychophysiology 8, 656-672.
87. Saunders, F.A. (1974) Electrocutaneous displays. In: F.A. Geldard (Ed.), Conference on Cutaneous Communication Systems and Devices, Psychonomic Society, Austin, TX, pp. 20-26.
88. Mueller, E.E., Loeffel, R. and Mead, S. (1953) Skin impedance in relation to pain threshold testing by electrical means. J. Appl. Physiol. 5, 746-752.
89. Stephens, W.G.S. (1963) The current-voltage relationship in human skin. Med. Electron. Biol. Eng. 1, 389-399.
90. Edelberg, R. (1972) Electrical activity of the skin. Its measurement and uses in psychophysiology. In: N.S. Greenfield and R.A. Sternbach (Eds), Handbook of Psychophysiology, Holt, Rinehart, and Winston, New York, pp. 367-418.
91. Grimnes, S. (1983) Skin impedance and electro-osmosis in the human epidermis. Med. Biol. Eng. Comput. 21, 739-749.
92. Rosendal, T. (1944) Further studies on the conducting properties of human skin to direct and alternating current. Acta Physiol. Scand. 8, 183-202.
93. Campbell, S.D., Kranino, K.K., Schibli, E.G. and Momii, S.T. (1977) Hydration characteristics and electrical resistivity of stratum corneum using a noninvasive four-point microelectrode method. J. Invest. Dermatol. 89, 290-296.
94. Tagami, H., Ohi, M., Iwatsuki, K., Kanamaru, Y., Yamada, M. and Ichijo, B. (1980) Evaluation of the skin surface hydration in vivo by electrical measurement. J. Invest. Dermatol. 75, 500-507.
95. Allenby, A.C., Fletcher, J., Schock, C. and Tees, T.F.S. (1969) The effect of heat, pH and organic solvents on the electrical impedance and permeability of excised human skin. Br. J. Dermatol. 81, 31-39.
96. Serban, G.P., Henry, S.M., Cotty, V.F. and Marcus, A.D. (1981) In vivo evaluation of skin lotions by electrical capacitance: I. The effect of several lotions on the progression of damage and healing after repeated insult with sodium lauryl sulfate. J. Soc. Cosmet. Chem. 32, 407-419.
97. Bronaugh, R.L. and Maibach, H.I. (Eds) (1989) Percutaneous Absorption, Mechanisms - Methodology -Drug Delivery, Marcel Dekker, New York.
98. Walters, K.A. (1989) Penetration enhancers and their use in transdermal therapeutic systems. In: J. Hadgraft and R.H. Guy (Eds), Transdermal Drug Delivery. Developmental Issues and Research Initiatives, Marcel Dekker, New York, pp. 197-246.
99. Hsieh, D.S. (Ed.) (1994) Drug Permeation Enhancement, Marcel Dekker, New York.
100. Lawler, J.C., Davis, M.J. and Griffith, E.C. (1960) Electrical characteristics of the skin. The impedance of the surface sheath and deep tissues. J. Invest. Dermatol. 34, 301-308.
101. Schweizerischer Elektrotechnischer Verein (1929) Beitrag zur Kenntnis der Vorgänge beim Stromdurchgang durch den menschlichen Körper. Elektrizitätswerke des Kantons Zürich., Bull. Schweiz. Elektrotechn. Ver. 13, 428-441.
102. Offner, F. (1942) Electrical properties of tissues in shock therapy. Proc. Soc. Exp. Biol. Med. 49, 571-576.
103. Rosendal, T. (1943) Studies on the conducting properties of the human skin to direct current. Acta Physiol. Scand. 5, 130-151.
104. Gougerot, L. and Bulliard, J. (1950) Non-linéarité des caractéristiques électriques de la peau en courant sinudoidal de basse fréquence pour des intensités suffisamment fortes. C. R. Soc. Biol. 144, 768-770.
105. Grings, W.W. (1953) Methodological considerations underlying electrodermal measurement. J. Psychol. 35, 271-282.
106. Edelberg, R., Greiner, T. and Burch, N.R. (1960) Some membrane properties of the effector in the galvanic skin response. J. Appl. Physiol 15, 691-696.
107. Davis, D.R. and Kennard, D.W. (1962) Influence of electric current on the skin. Nature 193, 1186-1187.
108. Kryspin, J. (1965) The phoreographical determination of the electrical properties of human skin. J. Invest. Dermatol. 44, 227-229.
109. Wilcott, R.C. and Hammond, L.J. (1965) On the constant-current error in skin resistance measurement. Psychophysiology 2, 39-41.
110. Venables, P.H. and Martin, I. (1967) Skin resistance and skin potential. In: P.H. Venables and I. Martin (Eds). A Manual of Psychophysiological Methods, North-Holland Publishing Co., Amsterdam, pp. 53-102.
111. Lane, J.F. (1970) Electrical impedances of superficial limb tissues: epidermis, dermis, and muscle sheath. Ann. NY Acad. Sci. 170, 812-825.
112. Yamamoto, T. and Yamamoto, Y. (1981) Non-linear electrical properties of skin in the low frequency range. Med. Biol. Eng. Comput. 19, 302-310.
113. Grimnes, S. (1983) Dielectric breakdown of human skin in vivo. Med. Biol. Eng. Comput. 21, 379-381.
114. + permeability of excised nude mouse skin. J. Pharm. Sci. 77, 492-497.
115. Burnette, R.R. and Ongpipattanakul, B. (1988) Characterization of the pore transport properties and tissue alteration of excised human skin during iontophoresis. J. Pharm. Sci. 77, 132-137.
116. Srinivasan, V., Higuchi, W.I. and Su, M.-H. (1989) Baseline studies with the four-electrode system: the etlect of skin permeability increase and water transport on the flux of a model uncharged solute during iontophoresis. J. Control. Release 10, 157-165.
117. Kasting, G.B. and Bowman, L.A. (1990) DC electrical properties of frozen. excised human skin. Pharm. Res. 7, 134-143.
118. Pikal, M.J. and Shah, S. (1990) Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electroosmotic flow and permeability change in transport of low and high molecular weight solutes. Pharm. Res. 7, 222-229.
119. Sims, S.M., Higuchi, W.I. and Srinivasan, V. (1992) Skin alteration and convective solvent flow effects during iontophoresis II. Monovalent anion and cation transport across human skin. Pharm. Res. 9, 1402-1409.
120. Dinh, S.M., Luo, C.-W. and Berner, B. (1993) Upper and lower limits of human skin electrical resistance in iontophoresis. AIChE J. 39, 2011-2018.
121. Edelberg, R. (1967) Electrical properties of the skin. In: C.C. Brown (Ed.), Methods in Psychophysiology, Williams & Wilkins, Baltimore.
122. Hardt, D.E. (1974) Parameters of Electrocutaneous Stimulation. MASc Thesis, Massachusetts Institute of Technology, Cambridge, MA.
123. Kouwenhoven, W.B., Knickerbocker, G.G., Chesnut, R.W., Milnor, W.R. and Sass, D.J. (1959) A-C shocks of varying parameters affecting the heart. AIEE Trans. 78, 163-169.
124. Kugelberg, J. (1972) The interelectrode electrical resistance at defibrillation. Scand. J. Thor. Cardiovasc. Surg. 6, 274-277.
125. Connell, P.N., Ewy, G.A., Dahl, C.F. and Ewy, M.D. (1973) Transthoracic impedance to defibrillator discharge. Effect of electrode size and electrode-chest wall interface. J. Electrocardiol. 6, 313-317.
126. Geddes, L.A., Tacker, W.A., Cabler, P. and Gothard, R. (1974) Electrode-subject impedance during transthoracic ventricular defibrillation. Med. Instrum. 8, 127-128.
127. Geddes, L.A., Tacker, W.A., Cabler, P., Chapman, R., Rivera, R. and Kidder, H. (1975) The decrease in transthoracic impedance during successive ventricular defibrillation trials. Med. Instrum. 9, 179-180.
128. Dahl, C.F., Ewy, G.A., Ewy, M.D. and Thomas, E.D. (1976) Transthoracic impedance to direct current discharge: effect of repeated countershocks. Med. Instrum. 10, 151-154.
129. Chambers, W., Miles, R. and Stratbucker, R. (1977) Human chest resistance during successive counter-shocks. Circulation 55 (Suppl III), 183.
130. Ewy, G.A. (1977) Effectiveness of direct current defibrillation: role of paddle electrode size: II, Am. Heart J. 93, 674-675.
131. Machin, J.W. (1978) Thoracic impedance of human subjects. Med. Biol. Eng. Comput. 16, 169-178.
132. Tacker, W.A. and Geddes, E.A. (1980) Electrical Defibrillation, CRC Press, Boca Raton, FL.
133. Srinivasan, V., Higuchi, W.I., Sims, S.M., Ghanem, A.H. and Behl, C.R. (1989) Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery. J. Pharm. Sci. 78, 370-375.
134. Green, P., Shroot, B., Bernerd, R., Pilgrim, W.R. and Guy, R.H. (1992) In vitro and in vivo iontophoresis of a tripeptide across nude rat skin. J. Control. Release 20, 209-218.
135. Neumann, E., Sowers, A.E. and Jordan, C.A. (1989) Electroporation and Electrofusion in Cell Biology, Plenum Press, New York.
136. Tsong, T.Y. (1991) Electroporation of cell membranes. Biophys. J. 60, 297-306.
137. Chang, D.C., Chassy, B.M., Saunders, J.A. and Sowers, A.E. (Eds) (1992) Guide to Electroporation and Electrofusion, Academic Press, New York.
138. Orlowski, S. and Mir, L.M. (1993) Cell electropermeabilization: a new tool for biochemical and pharmacological studies. Biochim. Biophys. Acta 1154, 51-63.
139. Weaver, J.C. (1993) Electroporation: a general phenomenon for manipulating cells and tissues. J. Cell. Biochem. 51, 426-435.
140. 2. Bioelectrochem. Bioenerget. 9, 149-155.
141. Sowers, A.E. and Lieber, M.R. (1986) Electropore diameters, lifetimes, numbers, and locations in individual erythrocyte ghosts. FEBS Lett. 205, 179-184.
142. Rosemberg, Y. and Korenstein, R. (1990) Electroporation of the photosynthetic membrane: a study by intrinsic and external optical probes. Biophys. J. 58, 823-832.
143. Kinosita, K., Jr., Hibino, M., Itoh, H., Shigemori, M., Hirano, K., Kirino, Y. and Hayakawa, T. (1992) Events of membrane electroporation visualized on a time scale from microsecond to seconds. In: D.C. Chang, B.M. Chassy, J.A. Saunders and A.E. Sowers (Eds), Guide to Electroporation and Electrofusion, Academic Press, New York, pp. 29-46.
144. Kwee, S., Nielsen, H.V. and Celis, J.E. (1990) Electropermeabilization of human cultured cells grown in monolayers. Bioelectrochem. Bioenerget. 23, 65-80.
145. Belehradek, J., Orlowski, S., Ramirez, L.H., Pron, G., Poddevin, B. and Mir, L.M. (1994) Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. Biochim. Biophys. Acta 1190, 155-163.
146. Dev, S.B. and Hofmann, G.A. (1994) Electrochemotherapy - a novel method of cancer treatment. Cancer Treat. Rev. 20, 105-115.
147. Bockris, J.O. and Reddy, A.K.N. (1970) Modern Electrochemistry, Plenum Press, New York.
148. Gibson, R.H. (1968) Electrical stimulation of pain and touch. In: D.R. Kenshalo (Ed.), The Skin Senses, Charles C. Thomas, Springfield, IL, pp. 223-261.
149. Mason, J.L. and Mackay, N.A.M. (1976) Pain sensations associated with electrocutaneous stimulation. IEEE Trans. Biomed. Eng. BME-23, 405-409.
150. Pfeiffer, E.A. (1968) Electrical stimulation of sensory nerves with skin electrodes for research, diagnosis, communication and behavioral conditioning: a survey. Med. Biol. Eng. 6, 637-651.
151. Szeto, A.Y.J. and Saunders, F.A. (1982) Electrocutaneous stimulation for sensory communication in rehabilitation engineering. IEEE Trans. Biomed. Eng. BME-29, 300-308.
152. Kaczmarek, K.A., Webster, J.G., Bach-y-Rita, P. and Tompkins, W.J. (1991) Electrotactile and vibrotactile displays for sensory substitution systems. IEEE Trans. Biomed. Eng. 38, 1-16.
153. Weiss, G. (1901) Sur la possibilité de rendre comparables entre eux les appareils servant a l'excitation électrique. Arch. Ital. Biol. 35, 413-446.
154. Lapicque, L. (1909) Definition experimental de excitabilite. C.R. Soc. Biol. 67, 280-283.
155. Blair, H.A. (1932) On the intensity-time relations for stimulation by electric currents. I. J. Gen. Physiol. 15, 709-729.
156. Blair, H.A. (1932) On the intensity-time relations for stimulation by electric currents, II. J. Gen. Physiol. 15, 731-755.
157. Plonsey, R. and Fleming, D.G. (1969) Bioelectric Phenomena, McGraw Hill, New York.
158. Bütikofer, R. and Lawrence, P.D. (1978) Electrocutaneous nerve stimulation - I: Model and experiment. IEEE Trans. Biomed. Eng. BME-25, 526-531.
159. Pearce, J.A., Bourland, J.D., Neilsen, W., Geddes, L.A. and Voelz, M. (1982) Myocardial stimulation with ultrashort duration current pulses. PACE 5, 52-58.
160. Geddes, L.A. and Bourland, J.D. (1985) Tissue stimulation: theoretical considerations and practical applications. Med. Biol. Eng. Comput. 23, 131-137.
161. Ayers, G.M., Aronson, S.W. and Geddes, L.A. (1986) Comparison of the ability of the Lapicque and exponential strength-duration curves to fit experimentally obtained perception threshold data. Aust. Phys. Eng. Sci. Med. 9, 111-116.
162. Rattay, F. (1988) Modeling the excitation of fibers under surface electrodes. IEEE Trans. Biomed. Eng. 35, 199-202.
163. Shepherd, G.M. (1988) Neurobiology, Oxford University Press, New York.
164. Lapicque, L.E. (1926) L'excitabilite en Fonction du Temps, Les Presses Univ. de France. Paris.
165. Adrian, E.D. (1919) The response of human sensory nerves to currents of short duration. J. Physiol. 53, 70-85.
166. Conrad, A.G., Haggard, H.W. and Teare, B.R. (1936) Electrical studies of living tissue. Electr. Eng. 55, 768-772.
167. Hahn, J.F. (1958) Cutaneous vibratory thresholds for square-wave electrical pulses. Science 127, 879-880.
168. Notermans, S.L.H. (1966) Measurement of the pain threshold determined by electrical stimulation and its clinical application. Part I. Method and factors possibly influencing the pain threshold. Neurology 16, 1071-1086.
169. Rollman, G.B. (1973) Electrocutaneous stimulation. In: F.A. Geldard (Ed.), Conference on Cutaneous Communication Systems and Devices, Psychonomic Society, Austin, TX, pp. 38-51.
170. Girvin, J.P., Marks, L.E., Antunes, J.L., Quest, D.O., O'Keefe, M.D., Ning, P. and Dobelle, W.H. (1982) Electrocutaneous stimulation. I. The effects of stimulus parameters on absolute threshold. Percept. Psychophys. 32, 524-528.
171. Li, C.-L. and Bak, A. (1976) Excitability characteristics of the A-and C-fibers in a peripheral nerve. Exp. Neurol. 50, 67-79.
172. Larkin, W.D. and Reilly, J.P. (1984) Strength/duration relationships for electrocutaneous sensitivity: stimulation by capacitive discharges. Percept. Psychophys. 36, 68-78.
173. Dalziel, C.F. and Mansfield, T.H. (1950) Effect of frequency on perception currents. AIEE Trans., part 2 69, 1162-1168.
174. Schwarz, F. (1944) On the stimulation of sensory nerves in man by AC-currents above the audio range. Pflügers Arch. 247, 405-440.
175. Solomonow, M. and Preziosi, M. (1982) Electrotactile sensation and pain thresholds and ranges as a function of body site, laterality and sex. In: IEEE Frontiers of Engineering in Health Care Conference. IEEE Engineering in Medicine and Biology Society, New York, pp. 329-331.
176. Ellahir, K. (1965) The stimulating effect of rectangular electric alternating impulses on the sensitivity of the skin in man. Gildemeister-effect (German), Acta Biol. Med. German. 15, 597-607.
177. Alles, D.S. (1970) Information transmission by phantom sensations. IEEE Trans. Man-Mach. Syst. MMS-11, 85-91.
178. Lewis, E.A., Sheredos, C.R., Sowell, T.T. and Houston, V.L. (1975) Clinical application study of externally powered upper-limb prosthetics systems: the VA elbow, the VA hand, and the VA/NU myoelectric hand systems. Bull. Prosthet. Res. 10-24, 51-136.
179. Szeto, A.Y.J. (1985) Relationship between pulse rate and pulse width for a constant-intensity level of electrocutaneous stimulation. Ann. Biomed. Eng. 13, 373-383.
180. Gibson, R.H. (1963) Requirements for the use of electrical stimulation of the skin. Proc. Int. Congr. Technol. Blindness 2, 183-207.
181. Geddes, L.A., Baker, L.E., Moore, A.G. and Coulter, T.W. (1969) Hazards in the use of low frequencies for the measurement of physiological events by impedance. Med. Biol. Eng. 7, 289-296.
182. Keesey, J.C. and Letcher, F.S. (1970) Human thresholds of electric shock at power transmission frequencies. Arch. Environ. Health 21, 547-552.
183. Geddes, L.A. and Baker, L.E. (1971) Response to the passage of electric current through the body. J. Assoc. Adv. Med. Instrum. 5, 13-18.
184. Katims, J.J., Naviasky, E.H., Rendell, M.S., Ng, L.K.Y. and Bleecker, M.L. (1987) Constant current sine wave transcutaneous nerve stimulation for the evaluation of peripheral neuropathy. Arch Phys Med Rehabil 68, 210-213.
185. Dalziel, C.F. and Lagen, J.B. (1941) Effects of electric current on man. Electr. Eng. 60, 63-66.
186. Tuckett, R.P. (1982) Itch evoked by electrical stimulation of the skin. J. Invest. Dermatol. 79, 368-373.
187. Garnsworthy, R.K., Gully, R.L., Kenins, P. and Westerman, R.A. (1988) Transcutaneous electrical stimulation and the sensation of prickle. J. Neurophysiol. 59, 1116-1127.
188. Gilmer, B. (1937) The sensitivity of the fingers to alternating electrical current. Am. J. Psychol. 49, 444-449.
189. Vallbo, Å.B. and Johansson, R.S. (1984) Properties of cutaneous mechanoreceptors in the human hand related to touch sensation. Human Neurobiol. 3, 3-14.
190. Phillips, J.R. and Johnson, K.O. (1985) Neural mechanisms of scanned and stationary touch. J. Acoust. Soc. Am. 77, 220-224.
191. Abramson, H.A. (1941) Skin reactions. X. Preseasonal treatment of hay fever by electrophoresis of ragweed pollen extracts into the skin: preliminary report. J. Allergy 12, 169-175.
192. Zlotogorski, A. (1987) Iontophoresis in dermatology. J. Am. Acad. Dermatol. 17, 690.
193. Sanderson, J.E., De Riel, S. and Dixon, R. (1989) Iontophoretic delivery of nonpeptide drugs: formulation optimization for maximum skin permeability. J. Pharm. Sci. 78, 361-364.
194. Koning, G., Schneider, H., Reneman, R.S. and Hoelen, A.J. (1972) An electrode system with rounded edges for direct ventricular defibrillation. Med. Biol. Eng. 10, 201-206.
195. Caruso, P.M., Pearce, J.A. and DeWitt, D.P. (1979) Temperature and current density distributions at electrosurgical dispersive electrode sites. In: L.E. Ostrander (Ed.), Proceedings of the Seventh New England (Northeast) Bioengineering Conference, IEEE, New York, pp. 373-376.
196. Overmeyer, K.M., Pearce, J.A. and DeWitt, D.P. (1979) Measurements of temperature distributions at electrosurgical dispersive electrode sites. J. Biomech. Eng. 101, 66-72.
197. Wiley, J.D. and Webster, J.G. (1982) Analysis and control of the current distribution under circular dispersive electrodes. IEEE Trans. Biomed. Eng. BME-29, 381-385.
198. Saunders, F.A. (1973) An electrotactile sound detector for the deaf. IEEE Trans. Audio Electroacoust. AU-21, 285-287.
199. Grimnes, S. (1984) Pathways of ionic flow through human skin in vivo. Acta Derm. Venereol. (Stockh) 64, 93-98.
200. Cullander, C. and Guy, R.H. (1991) Sites of iontophoretic current flow into the skin: identification and characterization with the vibrating probe electrode. J. Invest. Dermatol. 97, 55-64.
201. Potts, R.O., Guy, R.H. and Francoeur, M.L. (1992) Routes of ionic permeability through mammalian skin. Solid State Ionics 53-56, 165-169.
202. Scott, E.R., White, H.S. and Phipps, J.B. (1992) Direct imaging of ionic pathways in stratum corneum using scanning electrochemical microscopy. Solid State Ionics 53-56, 176-183.
203. Lin, C. (1984) Electrodes for Sensory Substitution, MS Thesis, University of Wisconsin, Madison, WI.
204. Scharf, B., Hyvärinen, J. and Poranen, A. (1973) Electrical stimulation of human hair follicles via microelectrodes. Percept. Psychophys. 14, 273-276.
205. Solomonow, M., Lyman, J. and Freedy, A. (1977) Electrotactile two-point discrimination as a function of frequency, body site, laterality, and stimulation codes. Ann. Biomed. Eng. 5, 47-60.
206. Crook, M.N. (1932) The sensory aspects of electrical stimulation. J. Genet. Psychol. 6-7, 49-67.
207. Békésy, G. (1959) Synchronism of neural discharges and their demultiplication in pitch perception on the skin and in hearing. J. Acoust. Soc. Am. 31, 338-349.
208. Szeto, A.Y.J. and Lyman, J. (1977) Comparison of codes for sensory feedback using electrocutaneous tracking. Ann. Biomed. Eng. 5, 367-383.
209. Szeto, A.Y.J. (1980) Comparison of electrocutaneous code pairs for sensory communications. In: V.C. Mow (Ed.), 1980 advances in bioengineering, ASME, New York, pp. 73-76.
210. Dalziel, C.F. and Massoglia, F.P. (1956) Let-go currents and voltages. AIEE Trans 75, 49-56.
211. Dalziel, C.F., Ogden, E. and Abbott, C.E. (1943) Effect of frequency on let-go currents. Trans. Electr. Eng. 62, 745-750.
212. Plutchik, R. and Bender H. (1966) Electrocutaneous pain thresholds in humans to low frequency square-wave pulses. J. Psychol. 62, 151-154.
213. Green, R.T. (1962) The absolute threshold of electric shock. Br. J. Psychol. 53, 107-115.
214. Hawkes, G.R. (1962) Effect of skin temperature on absolute threshold for electrical current. J. Appl. Physiol. 17, 110-112.
215. Kahn, J. (1977) Acetic acid iontophoresis for calcium deposits. Phys. Ther. 57, 658-659.
216. Hölzle, E. and Alberti, N. (1987) Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis - the usefulness of home therapy. Dermatologica 175, 126-135.
217. Bourland, J.D., Tacker, W.A., Geddes, L.A. and Chafee, V. (1978) Comparative efficacy of damped sine wave and square wave current for transchest ventricular defibrillation in animals. Med. Instrum. 12, 42-45.
218. Bourland, J.D., Tacker, W.A. and Geddes, L.A. (1978) Strength-duration curves for trapezoidal waveforms of various tilts for transchest defibrillation in animals. Med. Instrum. 12, 38-41.
219. Wessale, J.L., Geddes, L.A., Ayers, G.M. and Foster, K.S. (1992) Comparison of rectangular and exponential current pulses for evoking sensation. Ann. Biomed. Eng. 20, 237-244.
220. Dalziel, C.F. (1943) Effect of wave form on let-go currents. Electr. Eng. 62, 739-744.
221. Sternbach, R.A. and Tursky, B. (1965) Ethnic differences among housewives in psychophysical and skin potential responses to electric shock. Psychophysiology 1, 241-246.
222. Anderson, A.B. and Munson, W.A. (1951) Electrical excitation of nerves in the skin at audiofrequencies. J. Acoust. Soc. Am. 23, 155-159.
223. Stevens, S.S. (1961) The psychophysics of sensory function. In: W.A. Rosenblith (Ed.). Sensory Communication, Massachusetts Institute of Technology, Cambridge, MA, pp. 1-33.
224. Stumbach, R.A. and Tursky, B. (1964) On the psychophysical power function in electric shock. Psychol. Sci. 1, 217-218.
225. Ekman, G., Frankenhaeuser, M., Levander, S. and Mellis, I. (1964) Scales of unpleasantness of electrical stimulation. Scand. J. Psychol. 5, 257-261.
226. Ekman, G., Frankenhaeuser, M., Levander, S. and Mellis, I. (1966) The influence of intensity and duration of electrical stimulation on subjective variables. Scand. J. Psychol. 7, 58-64.
227. Cross, D.V., Tursky, B. and Lodge, M. (1975) The role of regression and range effects in determination of the power function for electric shock. Percept. Psychophys. 18, 9-14.
228. Bromm, B. and Treede, R.-D. (1980) Withdrawal reflex, skin resistance reaction and pain ratings due to electrical stimuli in man. Pain 9, 339-354.
229. Geddes, L.A., Babbs, C.F., Voorhees, W.D., Foster, K.S. and Aronson, A. (1985) Choice of the optimum pulse duration for precordial cardiac pacing: a theoretical study. PACE 8, 862-869.
230. Forbes, T.W. and Bernstein, A.L. (1935) The standardization of sixty-cycle electric shock for practical use in psychological experimentation. J. Gen. Psychol. 12/13, 436-441.
231. Hill, H.E., Flanary, H.G., Kornetsky, C.H. and Wikler, A. (1952) Relationship of electrically induced pain to the amperage and the wattage of shock stimuli. J. Clin. Invest. 31, 464-472.
232. Benton, L.A., Baker, L.L., Bowman, B.R. and Waters, R.L. (1981) Functional Electrical Stimulation - A Practical Clinical Guide, Rancho Los Amigos Rehabilitation Engineering Center, Downey, CA.
233. Peckham, P.H. (1988) Functional electrical stimulation. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation, Wiley & Sons, New York, pp. 1331-1352.
234. Solomonow, M. (1984) External control of the neuromuscular system. IEEE Trans. Biomed. Eng. BME-31, 752-763.
235. Moritz, A.R. and Henriques, F.C. (1947) Studies of thermal injury. II. The relative importance of time and surface temperature in the causation of cutaneous burns. Am. J. Pathol. 23, 695-720.
236. Pearce, J.A., Geddes, E.A., Van Vleet, J.F., Foster, K. and Allen, J. (1983) Skin burns from electrosurgical current. Mod. Instrum. 17, 225-231.
237. AAMI (1986) American National Standard for Electrosurgical Devices (ANSI/AAMI HF18-1986), Association for the Advancement of Medical Instrumentation. Arlington, VA.
238. De Rosa, J.F. and Gadsby, P.D. (1979) Radio-frequency heating under ECG electrodes. Med. Instrum. 13, 273-276.
239. Weast, R.C. (Ed.) (1985) CRC Handbook of Chemistry and Physics, CRC Press, Boca Raton, FL.
240. Schimmel, H. and Vaughan, H.G. (1971) Design of a prosthetic system. In: T.D. Sterling, A.E. Bering, S.V. Pollack and H.G. Vaughan (Eds), Visual Prosthesis, the Interdisciplinary Dialogue, Academic Press, New York, pp. 215-240.
241. Ruggeri, R.T. and Beck, T.R. (1985) Calculations of temperature rise produced in body tissue by a spherical electrode. Ann. Biomed. Eng. 13, 177-194.
242. Schwarz, V., Sutcliffe, C.H. and Style, P.P. (1968) Some hazards of the sweat test. Arch. Dis. Childh. 43, 695-701.
243. Tapper, R. (1980) Iontophoretic burn-protection method. US Patent No. 4,211,222.
244. Jacobsen, S.C. and Luntz, R.D. (1983) Ion mobility limiting iontophoretic bioelectrode. US Patent No. 4,416,274.
245. Warwick, W.J., Huang, N.N., Waring, W.W., Cherian, A.G., Brown, I., Stejskal-Lorenz, E., Yeung, W.H., Duhon, G., Hill, J.G. and Strominger, D. (1986) Evaluation of a cystic fibrosis screening system incorporating a miniature sweat stimulator and disposable chloride sensor. Clin. Chem. 32, 850-853.
246. AAMI (1989) American National Standard for Cardiac Defibrillator Devices (ANSI/AAMI DF2-1989), Association for the Advancement of Medical Instrumentation. Arlington, VA.
247. AAMI (1985) American National Standard for Salt-Current Limits for Electromedical Apparatus (ANSI/ AAMI ES1-1985), Association for the Advancement of Medical Instrumentation, Arlington, VA.
248. Roy, O.Z. (1980) Summary of cardiac fibrillation thresholds for 60 Hz currents and voltages applied directly to the heart. Med. Biol. Eng. Comput. 18, 657-659.
249. Geddes, L.A., Cabler, P., Moore, A.C., Rosborough, J. and Tacker, W.A. (1973) Threshold 60-Hz current required for ventricular fibrillation in subjects of various body weights. IEEE Trans. Biomed. Eng. BME-20, 465-468.
250. Roy, O.Z., Park, G.C. and Scott, J.R. (1977) Intracardiac catheter fibrillation thresholds as a function of the duration of 60 Hz current and electrode area. IEEE Trans. Biomed. Eng. BME-24, 430-435.
251. Geddes, L.A., Voorhees, W.D., Babbs, C.F., Sisken, R. and DeFord, J. (1984) Precordial pacing windows. PACE 7, 806-812.
252. Zoll, P.M. and Linenthal, A.J. (1964) External electric stimulation of the heart. Ann. NY Acad. Sci. 111, 932-937.
253. AAMI (1985) American National Standard for Transcutaneous Electrical Nerve Stimulators (ANSI/AAMI NS4-1985). Association tor the Advancement of Medical Instrumentation, Arlington, VA.
254. UL (1986) American National Standard for Leakage-Current for Appliances (ANSI C101.1-1986), Underwriters Laboratories, Northbrook, IL.
255. Molitor, H. and Fernandez, L. (1939) Studies on Iontophoresis. I. Experimental studies on the causes and prevention of iontophorelic burns. Am. J. Med. Sci. 198, 778-785.
256. Jarvis, C.W. and Voita, D.A. (1971) Low voltage skin burns. Pediatrics 48, 831-832.
257. Newton, R.A. and Karselis, T.C. (1983) Skin pH following high voltage pulsed galvanic stimulation. Phys. Ther. 63, 1593-1596.
258. Phipps, J.B. and Untereker, D.F. (1988) Iontophoretic apparatus and methods of producing same. US Patent No. 4,744,787.
259. Brummer, S.B., Robblee, L.S. and Hambrecht, F.T. (1983) Criteria for selecting electrodes for electrical stimulation: theoretical and practical considerations. Ann. NY Acad. Sci. 405, 159-171.
260. Lilly, J.C. (1961) Injury and excitation by electric currents: the balanced pulse-pair waveform. In: D.E. Sheer (Ed.), Electrical Stimulation of the Brain, Texas University Press. Dallas, TX, pp. 60-64.
261. Saunders, F.A. and Saunders, V.F. (1974) Intradermal recording during electrocutaneous stimulation. Fed. Proc. 33, 312.
262. Saunders, F.A. (1983) Information transmission across the skin: high-resolution tactile sensory aids for the deaf and the blind. Int. J. Neuroscience 19, 21-28.
263. Sanderson, J.E., Caldwell, R.W., Hsiao, J., Dixon, R. and Tuttle, R.R. (1987) Noninvasive delivery of a novel inotropic catecholamine: iontophoretic versus intravenous infusion in dogs. J. Pharm. Sci 76, 215-218.
264. Sanderson, J.E. and Deriel, S.R. (1988) Method and apparatus for iontophoretic drug delivery. US Patent No. 4,722,726.
265. Gangarosa, L.P. (1989) pH and inflammatory changes with electrolytes used for return electrodes in iontophoresis,. Southeastern Pharmacology Society Program Presentation and Abstracts 11.
266. Tapper, R. (1981) Method for iontophoretic treatment. US Patent No. 4,301,794.
267. Sasaki, M. (1988) Iontophoresis device. US Patent No. 4,764,164.
268. Fisher, A.A. (1978) Dermatitis associated with transcutaneous electrical nerve stimulation. Cutis 21, 24-47.
269. [269| Arvidsson, S.B., Ekroth, R.H., Hansby, A.M.C., Lindholm, A.H. and William-Olsson, O. (1984) Painless venipuncture. A clinical trial of iontophoresis of lidocaine for venipuncture in blood donors. Acta Anaesthesiol. Scand. 28, 209-210.
270. Myyra, R., Dalpra, M. and Globerson, J. (1988) Electrical erythema? Anesthesiology 69, 440.
271. Meyer, B.R., Kreis, W., Eschbach, J., O'Mara, V. Rosen, S. and Sihalis, D. (1990) Transdermal versus subcutaneous leuprolide: a comparison of acute pharmacodynamic effect. Clin. Pharmacol. Ther. 48, 340-345.
272. Westerman, R.A., Low, A., Pratt, A., Hutchinson, J.S., Szolcsanyi, J., Magerl, W., Handwercker, H.O. and Kozak, W.M. (1987) Electrically evoked skin vasodilatation: a quantitative test of nociceptor function in man. Clin. Exp. Neurol. 23, 81-89.
273. Nannmark, U., Buch, F. and Albrektsson, T. (1985) Vascular reactions during electrical stimulation. Acta Orthop. Scand. 56, 52-56.
274. Blamey, P.J. and Clark, G.M. (1987) Psychophysical studies relevant to the design of a digital electrotactile speech processor. J. Acoust. Soc. Am. 82, 116-125.
275. Cowan, R.S.C., Blamey, P.J., Alcántara, J.I., Blomberg, P.A., Hopkins, I.J., Whitford, L.A. and Clark, G.M. (1992) Safety studies with the University of Melbourne multichannel electrotactile speech processor. J. Rehabil. Res. Dev. 29, 35-52.
276. Boone, D.C. (1969) Hyaluronidase iontophoresis. Phys. Ther. 49, 139-145.
277. Cho, Y.B. and Kitamura, K. (1988) Short-term effects of iontophoresis on the structure of the guinea pig tympanic membrane. Acta Otolaryngol. (Stockh.) 106, 161-170.
278. Monteiro-Riviere, N.A. (1990) Altered epidermal morphology secondary to lidocaine iontophoresis: in vivo and in vitro studies in porcine skin. Fundam. Appl. Toxicol. 15, 174-185.
279. Monteiro-Riviere, N.A., Inman, A.O. and Riviere, J.E. (1994) Identification of the pathway of iontophoretic drug delivery: light and ultrastructural studies using mercuric chloride in pigs. Pharm. Res. 11, 251-256.
280. Kanerva, L. (1990) Electron microscopy of the effects of dithranol on healthy and on psoriatic skin. Am. J. Dermatopath. 12, 51-62.
281. Zugerman, C. (1982) Dermatitis from transcutaneous electric nerve stimulation. J. Am. Acad. Dermatol. 6, 936-939.
282. Ronnen, M., Suster, S., Kahana, M. and Schewach-Millet, M. (1986) Contact dermatitis due to karaya gum and induced by the application of electrodes. Int. J. Dermatol. 25, 189-190.
283. Dick, J.B., Northridge, D.B. and Lawson, A.A. (1987) Skin reactions to long-term transdermal clonidine. Lancet 1, 516.
284. Lynch, D.H., Roberts, L.K. and Daynes, R.A. (1987) Skin immunology: the Achilles heel to transdermal drug delivery. J. Control. Release 6, 39-50.
285. Kurihara-Bergstrom, T., Good, W.R., Feisullin, S. and Signor, C. (1991) Skin compatibility of transdermal drug delivery systems. J. Control. Release 15, 271-278.
286. Vermeer, B.J. (1991) Skin irritation and sensitization. J. Control. Release 15, 261-266.
287. Watson, J. (1988) Electrical treatment of bone ununited fracture. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation, Wiley & Sons, New York, pp. 512-525.
288. Brown, W.J., Babb, T.L., Soper, H.V., Lieb, J.P., Ottino, C.A. and Crandall, P.H. (1977) Tissue reactions to long-term electrical stimulation of the cerebellum in monkeys. J. Neurosurg. 47, 366-379.
289. Dauth, G.W., Defendini, R., Gilman, S., Tennyson, V.M. and Kremzner, L. (1977) Long-term surface stimulation of the cerebellum in the monkey I. Light microscopic, electrophysiologic, and clinical observations. Surg. Neurol. 7, 377-384.
290. Tennyson, V.M., Kremzner, L.T., Dauth, G.W., Defendini, R. and Gilman, S. (1977) Long-term surface stimulation of the cerebellum in the monkey II. Electron microscopic and biochemical observations. Surg. Neurol. 8, 17-29.
291. Glenn, W.W.L. (1978) Diaphragm pacing: present status. PACE 1, 357-370.
292. Hambrecht, F.T. (1979) Neural prostheses. Annu. Rev. Biophys. Bioeng. 8, 239-267.
293. Babb, T.L., Mariani, E., Seidner, K.A., Mutafyan, G., Halgren, E., Wilson, C.L. and Crandall, P.H. (1980) A circuit for safe diagnostic electrical stimulation of the human brain. Neurol. Res. 2, 181-197.
294. Walsh, S.M. and Leake-Jones, P.A. (1982) Chronic electrical stimulation of auditory nerve in cat: physiological and histological results. Hearing Res. 7, 281-304.
295. Shepherd, R.K., Clark, G.M. and Black, R.C. (1983) Chronic electrical stimulation of the auditory nerve in cats. Acta Otolaryngol. (Stockh.), Suppl. 399, 19-31.
296. Yuen, T.G.H., Agnew, W.F. and Bullara, L.A. (1984) Histopathological evaluation of dog sacral nerve after chronic electrical stimulation. Neurosurgery 14, 449-455.
297. Seligman, L. (1988) Physiological stimulators. In: J.G. Webster (Ed.). Encyclopedia of Medical Devices and Instrumentation, Wiley & Sons, New York, pp. 2704-2715.
298. Szeto, A.Y.J. and Mao, L. (1981) Dermal response to extended electrocutaneous stimulation. In: Proceedings of the 34th Annual Conference on Engineering in Medicine and Biology, Alliance for Engineering in Medicine and Biology, Washington, DC, p. 305.
299. Teyssandier, M.-J., Briffod, P. and Ziegler, G. (1977) Intéret de la diélectrolyse de kétoprofène en rhumatologie et en petite traumatologie. Sci. Méd 8, 157-162.
300. Aaron, C. and Quesnel, M.J. (1978) Celestene use by ionization for rheumatology diseases treatment (French). Semin. Hop. (Paris) 54, 1091-1094.
301. Leduc, S. (1900) Introduction of medicinal substances into the depth of tissues by electric current. Ann. d'Electrobiol. 3, 545-560.
302. Ramsden, R.T., Gibson, W.P. and Moffat, D.A. (1977) Anesthesia of the tympanic membrane using iontophoresis. J. Laryngol. Otol. 91, 779-785.
303. Sela, M., Peled, I., Zagher, A. and Taicher, S. (1985) Maxillofacial prosthetics and iontophoresis in management of burned ears. J. Prosthet. Dent. 53, 226-227.
304. Barza, M., Peckman, C. and Baum, J. (1986) Transscleral iontophoresis of cefazolin, ticarcillin, and gentamicin in the rabbit. Ophthalmology 93, 133-139.
305. Brough, K.M., Anderson, D.M., Love, J. and Overman, P.R. (1985) The effectiveness of iontophoresis in reducing dentin hypersensitivity. J. Am. Dent. Assoc. 111, 761-765.
306. James, M.P., Graham, R.M. and English, J. (1986) Percutaneous iontophoresis of prednisolone - a pharmacokinetic study. Clin. Exp. Dermatol. 11, 54-61.
307. Denning, C.R., Huang, N.N., Cuasa, L.R., Shwachman, H., Tocci, P., Warwick, W.J. and Gibson, L.E. (1980) Cooperative study comparing three methods of performing sweat tests to diagnose cystic fibrosis. Pediatrics 66, 752-757.
308. Peterson, J.L., Read, S.I. and Rodman, O.G. (1982) A new device in the treatment of hyperhidrosis by iontophoresis. Cutis 29, 82-89.
309. + is critical for inhibition of palmar sweating by iontophoresis in water. J. Appl. Physiol. 75, 2258-2264.
310. Cornwall, M.W. (1981) Zinc iontophoresis to treat ischemic skin ulcers. Phys. Ther. 61, 359-360.
311. Harris, P.R. (1982) Iontophoresis: clinical research in musculoskelelal inflammatory conditions. J. Orthopaed. Sports Phys. Ther. 4, 109-112.
312. Winquist, R.A. and Stamm, S.J. (1970) Arterialized capillary sampling using histamine iontophoresis. J. Pediatr. 76, 455-458.
313. Mclzack, R. and Wall, P.D. (1965) Pain mechanisms: a new theory. Science 150, 971-979.
314. Szeto, A.Y.J. (1988) Pain relief using transcutaneous electrical nerve stimulation (TENS). In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation. Wiley & Sons, New York, pp. 2203-2220.
315. Witters, D.M., Lapp, A.K. and Hinckley, S.M. (1991) A descriptive study of transcutaneous electrical nerve stimulation devices and their electrical output characteristics. J. Clin. Electrophysiol. 3, 9-16.
316. Axelgaard, J. and Brown, J.C. (1983) Lateral electrical surface stimulation for the treatment of progressive idiopathic scoliosis. Spine 8, 242-260.
317. Tachdjian, M.O. (1990) Pediatric Orthopedics, W. B. Saunders. Philadelphia.
318. De Luca, C.J. (1988) Electromyography. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation, Wiley & Sons, New York, pp. 1111-1120.
319. Eberstein, A. (1988) Electroneurography: nerve conduction studies. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation, Wiley & Sons, New York, pp. 1120-1126.
320. Johnson, E.W. (Ed.) (1988) Practical electromyography. Williams & Wilkins, Baltimore.
321. Beleiter, H. (Ed.) (1979) Evoked Brain Potentials and Behavior, Plenum Press, New York.
322. Cadwell Laboratories (1989) The Very Basics in Evoked Potentials Testing, Cadwell Laboratories, Kennewick, WA.
323. Blank, M. (Ed.) (1993) Electricity and Magnetism in Biology and Medicine, San Francisco Press, San Francisco.
324. Geldard, F.A. (Ed.) (1974) Conference on Cutaneous Communication Systems and Devices, Psychonomic Society. Austin, TX.
325. Weisenberger, J.M., Broadstone, S.M. and Saunders, F.A. (1989) Evaluation of two multichannel tactile aids for the hearing impaired. J. Acoust. Soc. Am. 86, 1764-1775.
326. Sances, A. and Larson, S.J. (1975) Electroanesthesia. Biomedical and Biophysical Studies, Academic Press. New York.
327. Stanley, T.H. and Limoge, A. (1988) Systemic Electroanalgesia. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation, Wiley & Sons, New York, pp. 997-1002.
328. Maletzky, B.M. (1988) Electroconvulsive therapy. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation. Wiley & Sons, New York, pp. 1072-1084.
329. Abrams, R. (1992) Electroconvulsive Therapy, Oxford University Press, New York.
330. Trigano, J.A. and Birkui, P.J. (1993) Noninvasive transcutaneous cardiac pacing: current devices and related products. In: P.J. Birkui, J.A. Trigano and P.M. Zoll (Eds), Noninvasive Transcutaneous Cardiac Pacing, Futura Publishing, Mount Kisco, NY, pp. 205-218.
331. Zoll, P.M. (1990) Noninvasive temporary cardiac pacing. In: C.E. Bartecchi and D.E. Mann (Eds), Temporary Cardiac Pacing, Precept Press, Chicago, pp. 124-136.
332. Tucker, W.A. (1988) Electrical defibrillators. In: J.G. Webster (Ed.), Encyclopedia of Medical Devices and Instrumentation. Wiley & Sons, New York, pp. 939-944.
333. Huang, L.G., Brush, L.C., Nighswonger, G. and Pacela, A.F. (1993) The Guide to Biomedical Standards, Quest Publishing, Brea, CA.
334. IEC (1984) Effect of Current Passing Through the Human Body. Part 1: General Aspects (IEC 479-1), International Electrotechnical Commission, Geneva, Switzerland.
335. IEC (1987) Effect of Current Passing Through the Human Body, Part 2: Special Aspects (IEC 479-2), International Electrotechnical Commission, Geneva, Switzerland.
336. IEC (1988) Medical Electrical Equipment Part 1: General Requirements for Safety (IEC 601-1). International Electrotechnical Commission, Geneva, Switzerland.
337. ANSI (1987) Procedures for the Development and Coordination of American National Standards, American National Standards Institute, New York.
338. ANSI (1990) National Electrical Safety Code (ANSI C2-1990), American National Standards Institute, New York.
339. UL (1992) Method of Development. Revision and Implementation of UL Standards for Safety (Form #200-46). Underwriters Laboratories, Chicago. IL.
340. Glover, T.J. (1994) Pocket Ref. Sequoia Publishing, Littleton, CO.
341. Jackson, T.A. and Riess, B.F. (1934) Electric shock with different size electrodes. J. Gen. Psychol. 45, 262-266.
342. Carter, H.A. and Coulter, J.S. (1942) Threshold of stimulation of alternating currents. Arch. Phys. Ther. 23, 207-213.
343. Tursky, B. and Watson, P.D. (1964) Controlled physical and subjective intensities of electric shock. Psychophysiology 1, 151-162.
344. Frankenhaeuser, M., Mellis, I. and Froeberg, J. (1967) Effect of electrical stimulation on sensation threshold. Percept. Motor Skills 24, 271-275.
345. Nethken, R.P. and Bulot, M.A. (1967) Threshold of electrical signals on the upper arm. In: 1967 Proceedings, IEEE Region III Convention, IEEE, New York, pp. 81-83.
346. Higgins, J.D., Tursky, B. and Schwartz, G.E. (1971) Shock-elicited pain and its reduction by concurrent tactile stimulation. Science 172, 866-867.
347. Westerman, R.A., Margerl, W., Handwerker, H.O. and Szolcsányi, J. (1985) Itch sensation evoked by percutaneous microiontophoresis of histamine on human hairy skin. Proc. Aust. Physiol. Pharmacol. Soc. 16, 79.
348. Kellogg, D.L., Johnson, J.M. and Kosiba, W.A. (1989) Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am. J. Physiol. 257, H1599-H1606.
349. Rafferty, E.B., Green, H.L. and Gregory, I.C. (1975) Disturbances of heart rhythm produced by 50 Hz leakage currents in dogs. Cardiovasc. Res. 9, 256-262.
350. Rafferty, E.B., Green, H.L. and Yacoub, M.H. (1975) Disturbances of heart rhythm produced by 50 Hz leakage currents in human subjects. Cardiovasc. Res. 9, 263-265.
351. Lykken, D.T. (1970) Square-wave analysis of skin impedance. Psychophysiology 7, 262-275.