Needle-free, non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatitis B virus

Vaccine

Volumn 18, Issue 5-6, 1999, Pages 517-523

  Misra, Amit ^a   Ganga, Srinivasan ^a   Upadhyay, Pramod ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXOID; HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTROPORATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; INTRADERMAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPH NODE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TECHNIQUE; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS; CELL DIVISION; DIPHTHERIA TOXOID; ELECTROPORATION; HEPATITIS B VACCINES; IMMUNIZATION; IMMUNOGLOBULIN G; LYMPH NODES; MALE; MICE; MICE, INBRED C3H; TH1 CELLS; TH2 CELLS;

EID: 0032873475     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00212-1     Document Type: Article

References (17)

1. Bos J.D. The skin as an organ of immunity. Clin. Exp. Immunol. 107:(Suppl. 1):1997;3-5.
2. Watts C. Inside the gearbox of the dendritic cell. Nature. 388:1997;724-725.
3. Austyn J.M. Prospects for immunotherapy using dendritic cells. Immunology. 92:(Suppl. 1):1998;15-51.
4. Wang L.F., Lin J.Y., Hsieh K.H., Lin R.H. Epicutaneous exposure of protein antigen induces a predominant Th-2-like response with high IgE production in mice. J. Immunol. 156:1996;4079-4082.
5. Glenn G.M., Rao M., Matyas G.R., Alving C.R. Skin immunization made possible by cholera toxin. Nature. 391:1998;851.
6. Misra A, Rafi K, Khar RK. Iontophoretic in vivo release of Diphtheria toxoid through skin. 46th Indian Pharmaceutical Congress, Chandigarh, 1994:A-08.
7. Abbas A.K., Murphy M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
8. Rattis F.M., Peguet-Navarro J., Staquet M.J., Dezutter-Dambuyant C., Courtellemont P., Redziniak G., Schmitt D. Expression and function of B7-1 (CD80) and B7-2 (CD86) on human epidermal Langerhans cells. Eur. J. Immunol. 26:1996;449-453.
9. Caux C., Liu Y.J., Banchereau D. Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol. Today. 16:1995;2-4.
10. Prausnitz M.R. The effects of electric current applied to skin: A review for transdermal drug delivery. Adv. Drug Deliv. Revs. 18:1996;395-425.
11. Mishra A., Rao K.V.S., Durgapal H., Manivel V., Panda S.K. Human T-helper cell responses to a synthetic peptide derived from the hepatitis B surface antigen. Immunology. 79:1993;362-367.
12. Chuang Y.H., Chiang B.L., Chou C.C., Hsieh K.H. Different kinds of antigen presenting cells exert different effects on T-helper cells development. Int. Arch. Allerg. Immunol. 111:1996;366-371.
13. Miller M.J., Wrightsmann R.A., Manning J.E. Trypanosoma cruzi: protective immunity in mice immunized with paraflagellar rod proteins is associated with a T-helper type 1 response. Exp. Parasitol. 84:1996;156-167.
14. Kang K., Kubin M., Cooper K.D., Lessin S.R., Trinchieri G., Rook A.H. IL-12 synthesis by human Langerhans cells. J. Immunol. 156:1996;1402-1407.
15. Staats H.F., McGhee J.R. Application of basic principles of mucosal immunity to vaccine development. Kiyono H., Ogra P.L., McGhee J.R. Mucosal vaccines. 1996;18-27 Academic Press, San Diego.
16. Ibrahim M.A., Chain B.M., Katz D.R. The injured cell: the role of the dendritic cell system as a sentinel receptor pathway. Immunol. Today. 16:1995;181-186.
17. Cella M., Engering A., Pinet V., Pieters J., Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 388:1997;782-787.