Dependence of skin permeability on contact area

Pharmaceutical Research

Volumn 20, Issue 2, 2003, Pages 257-263

  Karande, Pankaj ^a   Mitragotri, Samir ^a  

^a University of California   (United States)

Author keywords

Array; Gradient; Hydration; Strain; Stress; Transdermal

Indexed keywords

BUFFER; DODECYL SULFATE SODIUM; MANNITOL; OLEIC ACID; PHOSPHATE; SODIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONTACT EXAMINATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG TRANSPORT; EXPERIMENTAL TEST; GEL; HYDROPHILICITY; LIQUID; MEASUREMENT; MEDICAL ASSESSMENT; MODEL; NONHUMAN; PRIORITY JOURNAL; RESERVOIR; SKIN PERMEABILITY; SKINFOLD THICKNESS; SOLUTE;

ADMINISTRATION, CUTANEOUS; ANIMALS; DIFFUSION CHAMBERS, CULTURE; DRUG DELIVERY SYSTEMS; PERMEABILITY; SKIN ABSORPTION; SWINE;

EID: 0037331778     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022231406277     Document Type: Article

References (20)

1. A. Bouwstra. The skin, a well organized membrane. Coll. Surf. A. 123-124:403-413 (1997).
2. S. Mitragotri. Synergistic effect of enhancers for transdermal drug delivery. Pharm. Res. 17:1354-1359 (2000).
3. S. Mitragotri, D. Blankschtein, and R. Langer. Ultrasound-Mediated Transdermal Protein Delivery. Science 269:850-853 (1995).
4. A. V. Badkar and A. K. Banga. Electrically enhanced transdermal delivery of a macromolecule. J. Pharm. Pharmacol. 54:907-912 (2002).
5. C. B. Finnin and M. T. Morgan. Transdermal penetration enhancers: Applications, limitations and potential. J. Pharm. Sci. 88:955-958 (1999).
6. Y. S. Papir, K. Hsu, and R. H. Wildnauer. The mechanical properties of stratum corneum. I. The effect of water and ambient temperature on the tensile properties of newborn rat stratum corneum. Biochim. Biophys. Acta 399:170-180 (1975).
7. L. Norlen, A. Emilson, and B. Forsllnd. Stratum corneum swelling. Biophysical and computer assisted quantitative assessments. Arch. Dermatol. Res. 289:506-513 (1997).
8. B. Van Duzee. The influence of water content, chemical treatment and ambient temperature on rheological properties of skin. J. Invest. Dermatol. 71:140-144 (1978).
9. G. B. James, B. Jemec, B. I. Jemec, and J. Serup. The effect of superficial hydration on mechanical properties of skin in vivo: implications for plastic surgery. Plast. Reconstr. Surg. 85:100-103 (1990).
10. A. Alonso, N. Meirelles, V. Yushmanov, and M. Tabak. Water increases the fluidity of intercellular membranes of stratum corneum: Correlation with water permeability, elastic and electrical resistance properties. J. Invest. Dermatol. 106:1058-1063 (1996).
11. 1H-NMR. J. Invest. Dermatol. 93:160-164 (1989).
12. L. Pedersen and G. Jemec. Plasticising effect of water and glycerin on human skin in vivo. J. Dermatol. Sci. 19:48-52 (1999).
13. I. H. Blank. Further observations on factors which influence the water content of the stratum corneum. J. Invest. Dermatol. 21:259-271 (1953).
14. E. Sparr and H. Wennerstrom. Responding phospholipid membranes-interplay between hydration and permeability. Biophys. J. 81:1014-1028 (2001).
15. D. A. Van Hal, E. Jeremiasse, H. E. Junginger, F. Spies, and A. Bouwstra. Structure of Fully Hydrated Human Stratum Corneum - a freeze fracture electron microscopy study. J. Invest. Dermatol. 106:89-95 (1996).
16. M. Buchanan, J. Arrault, and M. Cates. Swelling and dissolution Lamellar phases: role of bilayer organization. Langmuir 14:7371-7377 (1998).
17. S. Diridollou, F. Patat, F. Gens, L. Vaillant, D. Black, J. Lagarde, Y. Gall, and M. Berson. In vivo model of the mechanical properties of the human skin under suction. Skin Res. Technol. 6:214-221 (2000).
18. M. Walser. Role of edge damage in sodium permeability of toad bladder and a means of avoiding it. Am. J. Phys. 219:252-255 (1970).
19. S. Helman and D. A. Miller. Edge damage effect on electrical measurements of frog skin. Am. J. Phys. 225:972-977 (1973).
20. S. Helman and D. A. Miller. Edge damage effect on measurement of urea and sodium flux in frog skin. Am. J. Phys. 226:1198-1203 (1974).