Topical prostaglandin E1 SEPA gel for the treatment of erectile dysfunction

Journal of Urology

Volumn 162, Issue 3 I, 1999, Pages 726-730

  McVary, Kevin T ^a   Polepalle, Sapan ^c   Riggi, Stephen ^a   Pelham, Russell W ^a,b  

^a MacroChem Corporation   (United States)

^b Braintree Laboratories Inc   (United States)

^c NONE

Author keywords

Alprostadil; Gels; Impotence; Penile erection

Indexed keywords

2 NONYL 1,3 DIOXOLANE; PLACEBO; PROSTAGLANDIN E1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUDITORY STIMULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG MIXTURE; DRUG PENETRATION; DRUG SAFETY; ERECTILE DYSFUNCTION; GEL; HUMAN; INTRACAVERNOUS DRUG ADMINISTRATION; MALE; PENIS ERECTION; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; SKIN IRRITATION; TACTILE STIMULATION; TOPICAL DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION; TREATMENT OUTCOME; VISUAL STIMULATION;

EID: 0032852624     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-199909010-00025     Document Type: Article

References (21)

1. Kim, E. D., El-Rashidy, R. and McVary, K. T.: Papaverine topical gel for treatment of erectile dysfunction. J. Urol., 153: 361, 1995.
2. Kim, E. D. and McVary, K. T.: Topical prostaglandin-E1 for the treatment of erectile dysfunction. J. Urol., 153: 1828, 1995.
3. Pelham, R. and Samour, C.: SEPA-009-safety and efficacy studies of a broad spectrum transdermal enhancer. Proc. Intern. Symp. Control. Rel. Bioact. Mat., 22: 694, 1995.
4. Wincze, J. P., Bansal, S., Malhotra, C., Balko, A., Susset, J. G. and Malamud, M.: A comparison of nocturnal penile tumescence and penile response to erotic stimulation during waking states in comprehensively diagnosed groups of males experiencing erectile difficulties. Arch. Sex. Behav., 17: 333, 1988.
5. Donatucci, C. F. and Lue, T. F.: The combined intracavernous injection and stimulation test: diagnostic accuracy. J. Urol., 148: 61, 1992.
6. NIH Consensus Development Panel on Impotence: NIH Consensus Conference. Impotence. J.A.M.A., 270: 83, 1993.
7. O'Leary, M. C., Fowler, F. J., Lenderking, W. R., Barber, B., Sagnier, P. P., Guess, H. A. and Barry, M. J.: A Brief Male Sexual Function Inventory for Urology. Urology, 46: 697, 1995.
8. Padma-Nathan, H., Hellstrom, W. J., Kaiser, F. E., Labasky, R. F., Lue, T. F., Nolten, W. E., Norwood, P. C., Peterson, C. A., Shabsigh, R., Tam, P. Y. and the Medicated Urethral System for Erection (MUSE) Study Group: Treatment of men with erectile dysfunction with transurethral alprostadil. New Engl. J. Med. 336: 1, 1997.
9. Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., Wicker, P. A. and the Sildenafil Study Group: Oral sildenafil in the treatment of erectile dysfunction. New Engl. J. Med. 338: 1397, 1998.
10. Moltz, H.: E-series prostaglandins and arginine vasopressin in the modulation of male sexual behavior. Neurosci. Biobehav. Rev., 14: 109, 1990.
11. Vasko, M. R.: Prostaglandin-induced neuropeptide release from spinal cord. Prog. Brain Res., 104: 367, 1995.
12. Mudd, J. W.: Impotence responsive to glyceryl trinitrate. Amer. J. Psych., 134: 922, 1977.
13. Owen, J. A., Saunders, F., Harris, C., Fenemore, J., Reid, K., Surridge, D., Condra, M. and Morales, A.: Topical nitroglycerin: a potential treatment for impotence. J. Urol., 141: 546, 1989.
14. Nunez, B. D. and Anderson, D. C.: Nitroglycerin ointment in the treatment of impotence. J. Urol., 150: 1241, 1993.
15. Wolfson, B., Pickett, S., Scott, N. E., DeKernion, J. B. and Rajfer, J.: Intraurethral prostaglandin E-2 cream: a possible alternative treatment for erectile dysfunction. Urology, 42: 73, 1993.
16. Maibach, H. I., Feldman, R. J., Milby, T. H. and Serat, W. F.: Regional variation in percutaneous penetration in man. Pesticides. Arch. Environ. Health, 23: 208, 1971.
17. Cavallini, G.: Minoxidil versus nitroglycerin: a prospective double-blind controlled trial in transcutaneous erection facilitation for organic impotence. J. Urol., 146: 50, 1991.
18. Clark, R. V., Murray, F. T., Hirshkowitz, M., Ferry, J., Lin, T., Murphy, T. C. and Francom, S. F.: Treatment of erectile dysfunction in men with diabetes mellitus using a penetration-enhanced topical minoxidil solution. J. Androl., suppl., 14: 55, 1999.
19. McCall, J. M., Aiken, J. W., Chidester, C. G., DuCharme, D. W. and Wendung, M. G.: Pyrimidine and triazine 3-oxide sulfates: a new family of vasodilators. J. Med. Chem., 26: 1791, 1983.
20. Samour, C. M., Donaruma, L. G., Daskalakis, S., Fulton, B. S., Marty, J. P., Dervault, A. M., Chanez, J. F. and Doucet, O.: SEPAs, a new class of percutaneous absorption enhancers. Proc. Intern. Symp. Control. Rel. Bioact. Mat., 16: 183, 1989.
21. Morganti, F., Bramanti, E., Solaro, R., Nannipieni, E., Narducci, P., Krauser, S. F., Samour, C. M., Benedetti, E. and Chiellini, E.: Thermal and spectroscopic characterization of interactions between 2-nonyl-1,3-dioxolane and stratum corneum components. J. Bioactive Compatible Polymers, 14: 162, 1999.