Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule

Bioelectrochemistry and Bioenergetics

Volumn 49, Issue 1, 1999, Pages 11-20

  Zewert, Thomas E ^a   Pliquett, Uwe F ^a   Vanbever, Rita ^a   Langer, Robert ^a,b   Weaver, James C ^a  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology   (United States)

Author keywords

Microconduit; Protein delivery; Skin electroporation; Transdermal drug delivery

Indexed keywords

ANTIBODY; SODIUM THIOSULFATE;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRIC CONDUCTIVITY; ELECTROPORATION; HUMAN; HUMAN TISSUE; MACROMOLECULE; SKIN PERMEABILITY; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

ELECTROPORATION; HUMANS; LIPID BILAYERS; PHARMACOKINETICS; SKIN; SKIN ABSORPTION;

EID: 0032733727     PISSN: 03024598     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0302-4598(99)00056-2     Document Type: Article

References (53)

1. L.A. Goldsmith (Ed.), Physiology, Biochemistry and Molecular Biology of the Skin, 2nd edn., Oxford University Press, New York, 1991.
2. Michaels A.S., Chandrasekaran S.K., Shaw J.E. Drug permeation through human skin: theory and in vitro experimental measurements. AIChE J. 21:1975;985-996.
3. Langer R. Drug delivery and targeting. Nature. 392:1998;S5-S10.
4. H. Schaefer, T.E. Redelmeier. Skin Barrier: Principles of Percutaneous Absorption. Karger, Basel, 1996.
5. J.C. Weaver, Y.A. Chizmadzhev. Electroporation, in: C. Polk, E. Postow (Eds.), CRC Handbook of Biological Effects of Electromagnetic Fields, 2nd edn., CRC Press, Boca Raton, 1996, pp. 247-274.
6. Weaver J.C., Chizmadzhev Y.A. Theory of electroporation: a review. Bioelectrochem. Bioenerget. 41:1996;135-160.
7. Prausnitz M.R., Bose V.G., Langer R., Weaver J.C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. 90:1993;10504-10508.
8. Zewert T.E., Pliquett U.F., Langer R., Weaver J.C. Transport of DNA antisense oligonucleotides across human skin by electroporation. Biochem. Biophys. Res. Commun. 212:1995;286-292.
9. Pliquett U.F., Zewert T.E., Chen T., Langer R., Weaver J.C. Imaging of fluorescent molecule and small ion transport through human stratum corneum during high-voltage pulsing: localized transport regions are involved. J. Biophys. Chem. 58:1996;185-204.
10. Prausnitz M.R., Gimm J.A., Guy R.H., Langer R., Weaver J.C., Cullander C. Imaging regions of transport across human stratum corneum during high voltage and low voltage exposures. J. Pharm. Sci. 85:1996;1363-1370.
11. Chen T., Langer R., Weaver J.C. Skin electroporation causes molecular transport across the stratum corneum through local transport regions. J. Invest. Dermatol. Symp. Proc. 3:1998;159-165.
12. Prausnitz M.R., Edelman E.R., Gimm J.A., Langer R., Weaver J.C. Transdermal delivery of heparin by skin electroporation. Bio/Technology. 13:1995;1205-1208.
13. Graziadei L., Burfeind P., Bar-Sagi D. Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake. Anal. Biochem. 194:1991;198-203.
14. Berglund D.L., Starkey J.R. Introduction of antibody into viable cells using electroporation. Cytometry. 12:1991;64-67.
15. Lukas J., Bartek J., Strauss M. Efficient transfer of antibodies into mammalian cells by electroporation. J. Immunol. Methods. 170:1994;255-259.
16. Zimmermann U., Scheurich P., Pilwat G., Benz R. Cells with manipulated functions: new perspectives for cell biology, medicine and technology. Angew. Chem., Int. Ed. Engl. 20:1981;325-344.
17. Hejna J.A., Johnstone P.L., Kohler S.L., Bruun D.A., Reifsteck C.A., Olson S.B., Moses R.E. Functional complementation by electroporation of human BACs into mammalian fibroblast cells. Nucleic Acids Res. 26:1998;1124-1125.
18. U. Reichert, A. Michels, R. Schmidt, The cornified envelope: a key structure of terminally differentiating keratinocytes, The Keratinocytes, Academic Press, New York, 1993, pp. 107-150.
19. P.M. Steinert, I.M. Freedberg. Molecular and cell biology of the keratins, Physiology, Biochemistry and Molecular Biology of the Skin, Oxford University Press, Oxford, 1991, pp. 113-147.
20. R.D.B. Fraser, T.P. MacRae, G.E. Rogers. Keratins: Their Composition, Structure and Biosynthesis. Charles C. Thomas, Springfield, 1972.
21. H. Schaefer, T.E. Redelmeier. Skin Barrier: Principles of Percutaneous Absorption, Karger, Basel, 1996. p. 52.
22. Baskin S.I., Horowitz A.M., Neally E.W. The antidotal action of sodium nitrite and sodium thiolsulfate against cyanide poisoning. J. Clin. Pharmacol. 32:1992;368-375.
23. Mueller M., Borland C. Delayed cyanide poisoning following acetonitrile ingestion. Postgrad. Med. J. 73:1997;299-300.
24. van Rijswijk R.E., Hoekman K., Burger C.W., Verheijen R.H., Vermorken J.B. Experience with intraperitoneal cisplatin and etoposide and i.v. sodium thiosulfate protection in ovarian cancer patients with either pathologically complete response or minimal residual disease. Ann. Oncol. 8:1997;1235-1241.
25. Dahlborg S.A., Petrillo A., Crossen J.R., Roman-Goldstein S., Doolittle N.D., Fuller K.H., Neuwelt E.A. The potential for complete and durable responses in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery. Cancer J. Sci. Am. 4:1998;110-124.
26. Prausnitz M.R., Seddick D.S., Kon A.A., Bose V.G., Frankenburg S., Klaus S.N., Langer R., Weaver J.C. Methods for in vivo tissue electroporation using surface electrodes. Drug Delivery. 1:1993;125-131.
27. Prausnitz M.R., Pliquett U., Langer R., Weaver J.C. Rapid temporal control of transdermal drug delivery by electroporation. Pharm. Res. 11:1994;1834-1837.
28. Vanbever R., Lecouturier N., Preat V. Transdermal delivery of metoprolol by electroporation. Pharm. Res. 11:1994;1657-1662.
29. Riviere J.E., Monteiro-Riviere N.A., Rogers R.A., Bommannan D., Tamada J.A., Potts R.O. Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology. J. Controlled Release. 36:1995;229-233.
30. Pliquett U., Weaver J.C. Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties. Bioelectrochem. Bioenerget. 39:1996;1-12.
31. Pliquett U., Weaver J.C. Transport of a charged molecule across the human epidermis due to electroporation. J. Controlled Release. 38:1996;1-10.
32. Prausnitz M.R., Lee C.S., Liu C.H., Pang J.C., Singh T.-P., Langer R., Weaver J.C. Transdermal transport efficiency during skin electroporation and iontophoresis. J. Controlled Release. 38:1996;205-217.
33. Gallo S.A., Oseroff A.R., Johnson P.G., Hui S.W. Characterization of electric-pulse-induced permeabilization of porcine skin using surface electrodes. Biophysical Journal. 72:1997;2805-2811.
34. Vanbever R., Fouchard D., Jadoul A., De Morre N., Preat V., Marty J.-P. In vivo noninvasive evaluation of hairless rat skin after high-voltage pulse exposure. Skin Pharmacol. Appl. Skin Physiol. 11:1998;23-34.
35. Vanbever R., Langers G., Montmayeur S., Preat V. Transdermal delivery of fentanyl: rapid onset of analgesia using skin electroporation. J. Controlled Release. 50:1998;225-235.
36. Johnson P.G., Gallo S.A., Hui S.W., Oseroff A.R. A pulsed electric filed enhances cutaneous delivery of methylene blue in excised full-thickness porcine skin. J. Invest. Dermatol. 88:1998;457-463.
37. Chen T., Segall E.M., Langer R., Weaver J.C. Skin electroporation: rapid measurements of the transdermal voltage and flux of four fluorescent molecules show a transition to large fluxes near 50 V for 1 ms pulses. J. Pharm. Sci. 87:1998;1368-1374.
38. R. Vanbever, U.F. Pliquett, V. Preat, J.C. Weaver. Comparison of the effects of short, high-voltage and long, medium-voltage pulses on skin electrical and transport properties, 1999 (in press).
39. Chen T., Langer R., Weaver J.C. Charged microbeads are not transported across human stratum corneum in Vitro by short high-voltage pulses. Bioelectrochem. Bioenerget. 48:1999;181-192.
40. Weaver J.C., Vaughan T.E., Chizmadzhev Y. Theory of electrical creation of aqueous pathways across skin transport barriers. Advanced Drug Delivery Reviews. 35:1999;21-39.
41. Pliquett U., Langer R., Weaver J.C. Changes in the passive electrical properties of human stratum corneum due to electroporation. Biochim. Biophys. Acta. 1239:1995;111-121.
42. Merino V., Kalia Y.N., Guy R.H. Transdermal therapy and diagnosis by iontophoresis. Trends in Biotechnology. 15:1997;288-290.
43. Renkin E.M. Filtration, diffusion and molecular sieving through porous cellulose membranes. J. Gen. Physiol. 38:1954;225-243.
44. Chizmadzhev Yu.A., Zarnytsin V., Weaver J.C., Potts R.O. Mechanism of electroinduced ionic species transport through a multilamellar lipid system. Biophysical J. 68:1995;749-765.
45. Weaver J.C., Vaughan T.E., Chizmadzhev Y. Theory of skin electroporation: implications of straight-through aqueous pathway segments that connect adjacent corneocytes. J. Invest. Dermatol. Symp. Proc. 3:1998;143-147.
46. Liu C.-C., Jin Z. Applications of microfabrication and micromachining techniques to biotechnology. Trends in Biotechnology. 15:1997;213-216.
47. Domenge C., Orlowski S., Luboinski B., De Baere T., Schwaab G., Belehradek J., Mir L.M. Antitumor electrochemotherapy: new advances in the clinical protocol. Cancer. 77:1996;956-963.
48. Heller R., Jaroszeski M., Glass L.F., Messina J.L., Rapport D.P., DeConti R.C., Fenske N.A., Gilbert R.A., Mir L.M., Reintgen D.S. Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer. 77:1996;964-971.
49. Parsegian V.A. Energy of an ion crossing a low dielectric membrane: Solutions to four relevant electrostatic problems. Nature. 221:1969;844-846.
50. Larroche C., Besson I., Dussap C.-G., Bourrust F., Gros J.-B. Characterization of water distribution in cell pellets using nonlabeled sodium thiosulfate as an interstitial space marker. Biotechnol. Prog. 9:1993;214-217.
51. Weaver J.C., Vanbever R., Vaughan T.E., Prausnitz M.R. Heparin alters transdermal transport associated with electroporation. Biochem. Biophy. Res. Commun. 234:1997;637-640.
52. Menton D.N. A minimum-surface mechanism to account for the organization of cells into columns in the mammalian epidermis. Am. J. Anat. 145:1976;1-22.
53. Bergstresser P.R., Chapman S.L. Maturation of normal human epidermis without an ordered structure. Br. J. Dermatol. 102:1980;641-648.