Transdermal insulin delivery using lipid enhanced electroporation

Biochimica et Biophysica Acta - Biomembranes

Volumn 1564, Issue 1, 2002, Pages 5-8

  Sen, Arindam ^a   Daly, Megan E ^a   Hui, Sek Wen ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Electroporation; Insulin; Liposome; Permeation; Porcine; Skin; Stratum corneum; Transdermal administration

Indexed keywords

1,2 DIMYRISTOYL 3 PHOSPHATIDYLSERINE; FLUORESCEIN; GLASS; INSULIN; LIPID; PHOSPHOLIPID; PLATINUM; SERINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APPARATUS; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRODE; ELECTROPORATION; EPIDERMIS; FLUORESCENCE MICROSCOPE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; ELECTROPORATION; FLUORESCEIN; INSULIN; MICROSCOPY, FLUORESCENCE; SKIN; SWINE; UNITHIOL;

SUIDAE;

EID: 0037136038     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2736(02)00453-4     Document Type: Article

References (17)

1. Electrochemical and iontophoretic studies of human skin
2. Changes in the passive electrical properties of human stratum corneum due to electroporation
3. Analysis of enhanced transdermal transport by skin electroporation
4. Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery
5. Characterization of electric pulse induced permeabilization of porcine skin using surface electrodes
6. Transdermal transport of methylene blue through full-thickness porcine skin by electroporation-electrophoresis
7. Transdermal delivery of metoprolol by electroporation
8. Transdermal delivery of fentanyl by electroporation: I. Influence of electrical factors
9. Transdermal delivery of macromolecules using skin electroporation
10. Spatially constrained skin electroporation with sodium thiosulfate and urea creates transdermal microconduits
11. Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule
12. Iontophoresis of monomeric insulin analogues in vitro: Effects of insulin charge and skin pretreatment
13. Transdermal inotophoretic delivery of bovine insulin and monomeric human insulin analogue
14. The relation of conformation and association of insulin to receptor binding; X-ray and circular dichroism studies and hystricomorph insulins
15. Molecular structure of insulin: The insulin monomer and its assembly