-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
3
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
R.S. Ahima, D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, and J.S. Flier Role of leptin in the neuroendocrine response to fasting Nature (London) 382 1996 250 252
-
(1996)
Nature (London)
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
Qu, D.4
Lowell, B.5
Maratos-Flier, E.6
Flier, J.S.7
-
4
-
-
0029665017
-
Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro
-
J.W. Kolaczynski, M.R. Nyce, R.V. Considine, G. Boden, J.J. Nolan, R. Henry, S.R. Mudaliar, J. Olefsky, and J.F. Caro Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro Diabetes 45 1996 699 701
-
(1996)
Diabetes
, vol.45
, pp. 699-701
-
-
Kolaczynski, J.W.1
Nyce, M.R.2
Considine, R.V.3
Boden, G.4
Nolan, J.J.5
Henry, R.6
Mudaliar, S.R.7
Olefsky, J.8
Caro, J.F.9
-
5
-
-
0030883332
-
Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects
-
G. Boden, X. Chen, J.W. Kolaczynski, and M. Polansky Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects J. Clin. Invest. 100 1997 1107 1113
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 1107-1113
-
-
Boden, G.1
Chen, X.2
Kolaczynski, J.W.3
Polansky, M.4
-
6
-
-
0030013679
-
Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men
-
K.R. Segal, M. Landt, and S. Klein Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men Diabetes 45 1996 988 991
-
(1996)
Diabetes
, vol.45
, pp. 988-991
-
-
Segal, K.R.1
Landt, M.2
Klein, S.3
-
7
-
-
0030903264
-
Glucocorticoids as counterregulatory hormones of leptin: Toward an understanding of leptin resistance
-
K.E. Zakrzewska, I. Cusin, A. Sainsbury, F. Rohner-Jeanrenaud, and B. Jeanrenaud Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance Diabetes 46 1997 717 719
-
(1997)
Diabetes
, vol.46
, pp. 717-719
-
-
Zakrzewska, K.E.1
Cusin, I.2
Sainsbury, A.3
Rohner-Jeanrenaud, F.4
Jeanrenaud, B.5
-
8
-
-
0029021599
-
Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
-
P. De Vos, R. Saladin, J. Auwerx, and B. Staels Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake J. Bio. Chem. 270 1995 15958 15961
-
(1995)
J. Bio. Chem.
, vol.270
, pp. 15958-15961
-
-
De Vos, P.1
Saladin, R.2
Auwerx, J.3
Staels, B.4
-
9
-
-
0032435159
-
Variations in glucocorticoid levels within the physiological range affect plasma leptin levels
-
A. Elimam, U. Knutsson, M. Bronegard, P. Stierna, K. Albertsson-Wikland, and C. Marcus Variations in glucocorticoid levels within the physiological range affect plasma leptin levels Eur. J. Endocrinol. 139 1998 615 620
-
(1998)
Eur. J. Endocrinol.
, vol.139
, pp. 615-620
-
-
Elimam, A.1
Knutsson, U.2
Bronegard, M.3
Stierna, P.4
Albertsson-Wikland, K.5
Marcus, C.6
-
10
-
-
0031939531
-
IL-1 beta mediates leptin induction during inflammation
-
R. Faggioni, G. Fantuzzi, J. Fuller, C.A. Dinarello, K.R. Feingold, and C. Grunfeld IL-1 beta mediates leptin induction during inflammation J. Am. J. Physiol. 274 1998 R204 R208
-
(1998)
J. Am. J. Physiol.
, vol.274
-
-
Faggioni, R.1
Fantuzzi, G.2
Fuller, J.3
Dinarello, C.A.4
Feingold, K.R.5
Grunfeld, C.6
-
11
-
-
17344384196
-
Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
-
P. Sarraf, R.C. Frederich, E.M. Turner, G. Ma, N.T. Jaskowiak, D.J. Rivet 3rd, J.S. Flier, B.B. Lowell, D.L. Fraker, and H.R. Alexander Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia J. Exp. Med. 185 1997 171 175
-
(1997)
J. Exp. Med.
, vol.185
, pp. 171-175
-
-
Sarraf, P.1
Frederich, R.C.2
Turner, E.M.3
Ma, G.4
Jaskowiak, N.T.5
Rivet III, D.J.6
Flier, J.S.7
Lowell, B.B.8
Fraker, D.L.9
Alexander, H.R.10
-
12
-
-
0034613023
-
Elevated serum leptin concentrations induced by experimental acute inflammation
-
O. Gualillo, S. Eiras, F. Lago, C. Dieguez, and F.F. Casanueva Elevated serum leptin concentrations induced by experimental acute inflammation Life Sci. 67 20 2000 2433 2441
-
(2000)
Life Sci.
, vol.67
, Issue.20
, pp. 2433-2441
-
-
Gualillo, O.1
Eiras, S.2
Lago, F.3
Dieguez, C.4
Casanueva, F.F.5
-
13
-
-
0030884125
-
Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans
-
C.S. Mantzoros, S. Moschos, I. Avramopoulos, V. Kaklamani, A. Liolios, D.E. Doulgerakis, I. Griveas, N. Katsilambros, and J.S. Flier Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans J. Clin. Endocrinol. Metab. 82 1997 3408 3413
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 3408-3413
-
-
Mantzoros, C.S.1
Moschos, S.2
Avramopoulos, I.3
Kaklamani, V.4
Liolios, A.5
Doulgerakis, D.E.6
Griveas, I.7
Katsilambros, N.8
Flier, J.S.9
-
14
-
-
9844227914
-
Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone
-
W.F. Blum, P. Englaro, S. Hatsch, A. Juul, N.T. Hertel, J. Muller, N.E. Skakkebaek, M.L. Heiman, M. Birkett, A.M. Attanasio, W. Kiess, and W. Rascher Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone Clin. Endocrinol. Metab. 82 1997 2904 2910
-
(1997)
Clin. Endocrinol. Metab.
, vol.82
, pp. 2904-2910
-
-
Blum, W.F.1
Englaro, P.2
Hatsch, S.3
Juul, A.4
Hertel, N.T.5
Muller, J.6
Skakkebaek, N.E.7
Heiman, M.L.8
Birkett, M.9
Attanasio, A.M.10
Kiess, W.11
Rascher, W.12
-
15
-
-
0031666525
-
Serum leptin concentration in women: Effect of age, obesity, and estrogen administration
-
V.D. Castracane, R.R. Kraemer, M.A. Franken, G.R. Kraemer, and T. Gimpel Serum leptin concentration in women: effect of age, obesity, and estrogen administration Fertil. Steril. 70 1998 472 477
-
(1998)
Fertil. Steril.
, vol.70
, pp. 472-477
-
-
Castracane, V.D.1
Kraemer, R.R.2
Franken, M.A.3
Kraemer, G.R.4
Gimpel, T.5
-
16
-
-
0033514956
-
Regulation of fatty acid homeostasis in cells: Novel role of leptin
-
R.H. Unger, Y.T. Zhou, and L. Orci Regulation of fatty acid homeostasis in cells: novel role of leptin Proc. Natl. Acad. Sci. USA 96 1999 2327 2332
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2327-2332
-
-
Unger, R.H.1
Zhou, Y.T.2
Orci, L.3
-
17
-
-
0032572722
-
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
-
G.M. Lord, G. Matarese, J.K. Howard, R.J. Baker, S.R. Bloom, and R.I. Lechler Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression Nature 394 1998 897 901
-
(1998)
Nature
, vol.394
, pp. 897-901
-
-
Lord, G.M.1
Matarese, G.2
Howard, J.K.3
Baker, R.J.4
Bloom, S.R.5
Lechler, R.I.6
-
18
-
-
0029952911
-
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
-
T. Gainsford, T.A. Willson, D. Metcalf, E. Handman, C. McFarlane, A. Ng, N.A. Nicola, W.S. Alexander, and D.J. Hilton Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells Proc. Natl. Acad. Sci. USA 93 1996 14564 14568
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14564-14568
-
-
Gainsford, T.1
Willson, T.A.2
Metcalf, D.3
Handman, E.4
McFarlane, C.5
Ng, A.6
Nicola, N.A.7
Alexander, W.S.8
Hilton, D.J.9
-
19
-
-
0030847881
-
Sympathetic and cardiorenal actions of leptin
-
W.G. Haynes, W.J. Sivitz, D.A. Morgan, S.A. Walsh, and A.L. Mark Sympathetic and cardiorenal actions of leptin Hypertension 30 1997 619 623
-
(1997)
Hypertension
, vol.30
, pp. 619-623
-
-
Haynes, W.G.1
Sivitz, W.J.2
Morgan, D.A.3
Walsh, S.A.4
Mark, A.L.5
-
20
-
-
0031019763
-
Role of leptin in hypothalamic-pituitary function
-
W.H. Yu, M. Kimura, A. Walczewska, S. Karanth, and S.M. McCann Role of leptin in hypothalamic-pituitary function Proc. Natl. Acad. Sci. USA 94 1997 1023 1028
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1023-1028
-
-
Yu, W.H.1
Kimura, M.2
Walczewska, A.3
Karanth, S.4
McCann, S.M.5
-
21
-
-
0030919919
-
Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
-
S.R. Bornstein, K. Uhlmann, A. Haidan, M. Ehrhart-Bornstein, and W.A. Scherbaum Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly Diabetes 46 1997 1235 1238
-
(1997)
Diabetes
, vol.46
, pp. 1235-1238
-
-
Bornstein, S.R.1
Uhlmann, K.2
Haidan, A.3
Ehrhart-Bornstein, M.4
Scherbaum, W.A.5
-
22
-
-
0030855190
-
Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
-
M.L. Heiman, R.S. Ahima, L.S. Craft, B. Schoner, T.W. Stephens, and J.S. Flier Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress Endocrinology 138 1997 3859 3863
-
(1997)
Endocrinology
, vol.138
, pp. 3859-3863
-
-
Heiman, M.L.1
Ahima, R.S.2
Craft, L.S.3
Schoner, B.4
Stephens, T.W.5
Flier, J.S.6
-
23
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
A. Strobel, T. Issad, L. Camoin, M. Ozata, and A.D. Strosberg A leptin missense mutation associated with hypogonadism and morbid obesity Nat. Genet 18 1998 213
-
(1998)
Nat. Genet
, vol.18
, pp. 213
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
24
-
-
0030010388
-
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
-
F.F. Chehab, M.E. Lim, and R. Lu Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin Nat. Genet. 12 1996 318 320
-
(1996)
Nat. Genet.
, vol.12
, pp. 318-320
-
-
Chehab, F.F.1
Lim, M.E.2
Lu, R.3
-
25
-
-
0029953957
-
Leptin is a metabolic signal to the reproductive system
-
I.A. Barash, C.C. Cheung, D.S. Weigle, H. Ren, E.B. Kabigting, J.L. Kuijper, D.K. Clifton, and R.A. Steiner Leptin is a metabolic signal to the reproductive system Endocrinology 137 1997 3144 3147
-
(1997)
Endocrinology
, vol.137
, pp. 3144-3147
-
-
Barash, I.A.1
Cheung, C.C.2
Weigle, D.S.3
Ren, H.4
Kabigting, E.B.5
Kuijper, J.L.6
Clifton, D.K.7
Steiner, R.A.8
-
26
-
-
0030868077
-
Leptin accelerates the onset of puberty in normal female mice
-
R.S. Ahima, J. Dushay, S.N. Flier, D. Prabakaran, and J.S. Flier Leptin accelerates the onset of puberty in normal female mice J. Clin. Invest. 99 1997 391 395
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 391-395
-
-
Ahima, R.S.1
Dushay, J.2
Flier, S.N.3
Prabakaran, D.4
Flier, J.S.5
-
27
-
-
0030250892
-
A role for leptin and its cognate receptor in hematopoiesis
-
B.D. Bennet, G.P. Solar, J.O. Yuan, J. Mathias, G.R. Thomas, and W. Matthews A role for leptin and its cognate receptor in hematopoiesis Curr. Biol. 9 1996 1170 1180
-
(1996)
Curr. Biol.
, vol.9
, pp. 1170-1180
-
-
Bennet, B.D.1
Solar, G.P.2
Yuan, J.O.3
Mathias, J.4
Thomas, G.R.5
Matthews, W.6
-
28
-
-
0030736770
-
Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells
-
Y. Umemoto, K. Tsuji, F. Yang, Y. Ebihara, A. Kaneko, S. Furukawa, and T. Nakahata Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells Blood 90 1997 3438 3443
-
(1997)
Blood
, vol.90
, pp. 3438-3443
-
-
Umemoto, Y.1
Tsuji, K.2
Yang, F.3
Ebihara, Y.4
Kaneko, A.5
Furukawa, S.6
Nakahata, T.7
-
29
-
-
0032508682
-
Biological action of leptin as an angiogenic factor
-
M.R. Sierra-Honigmann, A.K. Nath, C. Murakami, G. Garcia-Cardena, A. Papapetropoulos, W.C. Sessa, L.A. Madge, J.S. Schechner, M.B. Schwabb, P.J. Polverini, and J.R. Flores-Riveros Biological action of leptin as an angiogenic factor Science 281 1998 1683 1686
-
(1998)
Science
, vol.281
, pp. 1683-1686
-
-
Sierra-Honigmann, M.R.1
Nath, A.K.2
Murakami, C.3
Garcia-Cardena, G.4
Papapetropoulos, A.5
Sessa, W.C.6
Madge, L.A.7
Schechner, J.S.8
Schwabb, M.B.9
Polverini, P.J.10
Flores-Riveros, J.R.11
-
30
-
-
0032538875
-
Leptin, the product of Ob gene, promotes angiogenesis
-
A. Bouloumie, H.C. Drexler, M. Lafontan, and R. Busse Leptin, the product of Ob gene, promotes angiogenesis Circ. Res. 83 1998 1059 1066
-
(1998)
Circ. Res.
, vol.83
, pp. 1059-1066
-
-
Bouloumie, A.1
Drexler, H.C.2
Lafontan, M.3
Busse, R.4
-
32
-
-
0030929962
-
Leptin concentration in cord blood correlates with intrauterine growth
-
H.A. Koistinen, V.A. Koivisto, S. Andersson, S.L. Karonen, K. Kontula, L. Oksanen, and K.A. Teramo Leptin concentration in cord blood correlates with intrauterine growth J. Clin. Endocrinol. Metab. 82 1997 3328 3330
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 3328-3330
-
-
Koistinen, H.A.1
Koivisto, V.A.2
Andersson, S.3
Karonen, S.L.4
Kontula, K.5
Oksanen, L.6
Teramo, K.A.7
-
33
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
L.A. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G.J. Richards, L.A. Campfield, F.T. Clark, J. Deeds, J.S. Smutko, G.G. Mays, E.A. Wolf, C.A. Monroe, and R.I. Tepper Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263 1271
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
Richards, G.J.7
Campfield, L.A.8
Clark, F.T.9
Deeds, J.10
Smutko, J.S.11
Mays, G.G.12
Wolf, E.A.13
Monroe, C.A.14
Tepper, R.I.15
-
34
-
-
0030942844
-
The leptin receptor
-
L.A. Tartaglia The leptin receptor J. Biol. Chem. 272 1997 6093 6096
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
35
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
G.H. Lee, R. Proenca, J.M. Montez, K.M. Caroll, J.G. Darvishzadeh, J.I. Lee, and J.M. Friedman Abnormal splicing of the leptin receptor in diabetic mice Nature 379 1996 632 635
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Caroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
Friedman, J.M.7
-
36
-
-
0031010408
-
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
-
H. Fei, H.J. Okano, C. Li, G.H. Lee, C. Zhao, R. Darnell, and J.M. Friedman Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues Proc. Natl. Acad. Sci. USA 94 1997 7001 7005
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 7001-7005
-
-
Fei, H.1
Okano, H.J.2
Li, C.3
Lee, G.H.4
Zhao, C.5
Darnell, R.6
Friedman, J.M.7
-
37
-
-
0028117163
-
Cytokine signal transduction
-
T. Kishimoto, T. Taga, and S. Akira Cytokine signal transduction Cell 76 1994 253 262
-
(1994)
Cell
, vol.76
, pp. 253-262
-
-
Kishimoto, T.1
Taga, T.2
Akira, S.3
-
38
-
-
0028838012
-
Dimerization of cell surface receptors in signal transduction
-
C.H. Heldin Dimerization of cell surface receptors in signal transduction Cell 80 1995 213 223
-
(1995)
Cell
, vol.80
, pp. 213-223
-
-
Heldin, C.H.1
-
39
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
J.K. Elmquist, C. Bjorbaek, R.S. Ahima, J.S. Flier, and C.B. Saper Distributions of leptin receptor mRNA isoforms in the rat brain J. Comp. Neurol. 395 1998 535 547
-
(1998)
J. Comp. Neurol.
, vol.395
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
40
-
-
0031761385
-
Expression of leptin receptor isoforms in rat brain microvessels
-
C. Bjorbaek, J.K. Elmquist, P. Michl, R.S. Ahima, A. van Bueren, A.L. McCall, and J.S. Flier Expression of leptin receptor isoforms in rat brain microvessels Endocrinology 139 1997 3485 3491
-
(1997)
Endocrinology
, vol.139
, pp. 3485-3491
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Michl, P.3
Ahima, R.S.4
Van Bueren, A.5
McCall, A.L.6
Flier, J.S.7
-
41
-
-
0030015417
-
Defective STAT signaling by the leptin receptor in diabetic mice
-
N. Ghilardi, S. Ziegler, A. Wiestner, R. Stoffel, M.K. Heim, and R.C. Skoda Defective STAT signaling by the leptin receptor in diabetic mice Proc. Natl. Acad. Sci. USA 93 1996 6231 6235
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
Stoffel, R.4
Heim, M.K.5
Skoda, R.C.6
-
42
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
C. Bjorbaek, S. Uotani, B. da Silva, and J.S. Flier Divergent signaling capacities of the long and short isoforms of the leptin receptor J. Biol. Chem. 273 1997 32686 32695
-
(1997)
J. Biol. Chem.
, vol.273
, pp. 32686-32695
-
-
Bjorbaek, C.1
Uotani, S.2
Da Silva, B.3
Flier, J.S.4
-
43
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
-
C. Vaisse, J.L. Halaas, C.M. Horvath, J.E. Darnell Jr., M. Stoffel, and J.M. Friedman Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice Nat. Genet. 14 1996 95 97
-
(1996)
Nat. Genet.
, vol.14
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
Darnell Jr., J.E.4
Stoffel, M.5
Friedman, J.M.6
-
44
-
-
0032424694
-
Transcription factor STAT3 in leptin target neurons of the rat hypothalamus
-
M.L. Hakansson, and B. Meister Transcription factor STAT3 in leptin target neurons of the rat hypothalamus Neuroendocrinology 68 1998 420 427
-
(1998)
Neuroendocrinology
, vol.68
, pp. 420-427
-
-
Hakansson, M.L.1
Meister, B.2
-
45
-
-
0031040793
-
Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
-
D.W. White, K.K. Kuropatwinski, R. Devos, H. Baumann, and L.A. Tartaglia Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization J. Biol. Chem. 272 1997 4065 4071
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4065-4071
-
-
White, D.W.1
Kuropatwinski, K.K.2
Devos, R.3
Baumann, H.4
Tartaglia, L.A.5
-
46
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
C. Bjorbaek, R.M. Buchholz, S.M. Davis, S.H. Bates, D.D. Pierroz, H. Gu, B.G. Neel, M.G. Myers Jr., and J.S. Flier Divergent roles of SHP-2 in ERK activation by leptin receptors J. Biol. Chem. 276 2001 4747 4755
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4747-4755
-
-
Bjorbaek, C.1
Buchholz, R.M.2
Davis, S.M.3
Bates, S.H.4
Pierroz, D.D.5
Gu, H.6
Neel, B.G.7
Myers Jr., M.G.8
Flier, J.S.9
-
47
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
C. Bjorbaek, H.J. Lavery, S.H. Bates, R.K. Olson, S.M. Davis, J.S. Flier, and M.G. Myers Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985 J. Biol. Chem. 275 2000 40649 40657
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
-
-
Bjorbaek, C.1
Lavery, H.J.2
Bates, S.H.3
Olson, R.K.4
Davis, S.M.5
Flier, J.S.6
Myers Jr., M.G.7
-
48
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
A.S. Banks, S.M. Davis, S.H. Bates, and M.G. Myers Jr. Activation of downstream signals by the long form of the leptin receptor J. Biol. Chem. 275 2000 14563 14572
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
49
-
-
0034452029
-
Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase
-
G.R. van den Brink, T. O'Toole, J.C. Hardwick, D.E. van den Boogaardt, H.H. Versteeg, S.J. van Deventer, and M.P. Peppelenbosch Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase Mol. Cell. Biol. Res. Commum. 4 2000 144 150
-
(2000)
Mol. Cell. Biol. Res. Commum.
, vol.4
, pp. 144-150
-
-
Van Den Brink, G.R.1
O'Toole, T.2
Hardwick, J.C.3
Van Den Boogaardt, D.E.4
Versteeg, H.H.5
Van Deventer, S.J.6
Peppelenbosch, M.P.7
-
50
-
-
0037171447
-
Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2
-
O. Gualillo, S. Eiras, D.W. White, C. Dieguez, and F.F. Casanueva Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2 Mol. Cell. Endocrinol. 190 2002 83 89
-
(2002)
Mol. Cell. Endocrinol.
, vol.190
, pp. 83-89
-
-
Gualillo, O.1
Eiras, S.2
White, D.W.3
Dieguez, C.4
Casanueva, F.F.5
-
51
-
-
0034657231
-
Identification and expression analysis of leptin-regulated immediate early response and late target genes
-
W. Waelput, A. Verhee, D. Broekaert, S. Eickerman, J. Vandekerckhove, and J.H. Beattie Identification and expression analysis of leptin-regulated immediate early response and late target genes Biochem. J. 348 1-2 2000 55 61
-
(2000)
Biochem. J.
, vol.348
, Issue.12
, pp. 55-61
-
-
Waelput, W.1
Verhee, A.2
Broekaert, D.3
Eickerman, S.4
Vandekerckhove, J.5
Beattie, J.H.6
-
52
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
S.H. Bates, W.H. Stearns, T.A. Dundon, M. Schubert, A.W. Tso, Y. Wang, A.S. Banks, H.J. Lavery, A.K. Haq, E. Maratos-Flier, B.G. Neel, M.W. Schwartz, and M.G. Myers Jr. STAT3 signalling is required for leptin regulation of energy balance but not reproduction Nature 421 6925 2003 856 859
-
(2003)
Nature
, vol.421
, Issue.6925
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.5
Wang, Y.6
Banks, A.S.7
Lavery, H.J.8
Haq, A.K.9
Maratos-Flier, E.10
Neel, B.G.11
Schwartz, M.W.12
Myers Jr., M.G.13
-
53
-
-
0035195887
-
Leptin regulation of the immune response and the immunodeficiency of malnutrition
-
R. Faggioni, K.R. Feingold, and C. Grunfeld Leptin regulation of the immune response and the immunodeficiency of malnutrition FASEB J. 14 2001 2565 2571
-
(2001)
FASEB J.
, vol.14
, pp. 2565-2571
-
-
Faggioni, R.1
Feingold, K.R.2
Grunfeld, C.3
-
54
-
-
4143146273
-
Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
-
P. Mancuso, C. Canetti, A. Gottschalk, P.K. Tithof, and M. Peters-Golden Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression Am. J. Physiol. Lung Cell. Mol. Physiol. 287 2004 L497 L502
-
(2004)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.287
-
-
Mancuso, P.1
Canetti, C.2
Gottschalk, A.3
Tithof, P.K.4
Peters-Golden, M.5
-
55
-
-
0035887941
-
High-dose leptin activates human leukocytes via receptor expression on monocytes
-
H. Zarkesh-Esfahani, G. Pockley, R.A. Metcalfe, M. Bidlingmaier, Z. Wu, A. Ajami, A.P. Weetman, C.J. Strasburger, and R.J. Ross High-dose leptin activates human leukocytes via receptor expression on monocytes J. Immunol. 167 2001 4593 4599
-
(2001)
J. Immunol.
, vol.167
, pp. 4593-4599
-
-
Zarkesh-Esfahani, H.1
Pockley, G.2
Metcalfe, R.A.3
Bidlingmaier, M.4
Wu, Z.5
Ajami, A.6
Weetman, A.P.7
Strasburger, C.J.8
Ross, R.J.9
-
56
-
-
0036854487
-
Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
-
G.M. Raso, M. Pacilio, E. Esposito, A. Coppola, R. Di Carlo, and R. Meli Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1 Br. J. Pharmacol. 137 2002 799 804
-
(2002)
Br. J. Pharmacol.
, vol.137
, pp. 799-804
-
-
Raso, G.M.1
Pacilio, M.2
Esposito, E.3
Coppola, A.4
Di Carlo, R.5
Meli, R.6
-
57
-
-
0035109175
-
Leptin: A potential regulator of polymorphonuclear neutrophil bactericidal action?
-
F. Caldefie-Chezet, A. Poulin, A. Tridon, B. Sion, and M.P. Vasson Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J. Leukoc. Biol. 69 3 2001 414 418
-
(2001)
J. Leukoc. Biol.
, vol.69
, Issue.3
, pp. 414-418
-
-
Caldefie-Chezet, F.1
Poulin, A.2
Tridon, A.3
Sion, B.4
Vasson, M.P.5
-
58
-
-
0043198155
-
Leptin regulates functional capacities of polymorphonuclear neutrophils
-
F. Caldefie-Chezet, A. Poulin, and M.P. Vasson Leptin regulates functional capacities of polymorphonuclear neutrophils Free Radic. Res. 37 8 2003 809 814
-
(2003)
Free Radic. Res.
, vol.37
, Issue.8
, pp. 809-814
-
-
Caldefie-Chezet, F.1
Poulin, A.2
Vasson, M.P.3
-
59
-
-
0037427522
-
Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines
-
Y. Zhao, R. Sun, L. You, C. Gao, and Z. Tian Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines Biochem. Biophys. Res. Commun. 300 2 2003 247 252
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.300
, Issue.2
, pp. 247-252
-
-
Zhao, Y.1
Sun, R.2
You, L.3
Gao, C.4
Tian, Z.5
-
60
-
-
0036431034
-
Impaired natural killer (NK) cell activity in leptin receptor deficient mice: Leptin as a critical regulator in NK cell development and activation
-
Z. Tian, R. Sun, H. Wei, and B. Gao Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation Biochem. Biophys. Res. Commun. 298 3 2002 297 302
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.298
, Issue.3
, pp. 297-302
-
-
Tian, Z.1
Sun, R.2
Wei, H.3
Gao, B.4
-
61
-
-
0345688661
-
Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism
-
V.D. Dixit, M. Mielenz, D.D. Tabú, and N. Parvizi Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism Endocrinology 144 2003 5595 5603
-
(2003)
Endocrinology
, vol.144
, pp. 5595-5603
-
-
Dixit, V.D.1
Mielenz, M.2
Tabú, D.D.3
Parvizi, N.4
-
62
-
-
2442618838
-
The weight of leptin in immunity
-
A. La Cava, and G. Matarese The weight of leptin in immunity Nat. Rev. Immunol. 4 12 2004 371 379
-
(2004)
Nat. Rev. Immunol.
, vol.4
, Issue.12
, pp. 371-379
-
-
La Cava, A.1
Matarese, G.2
-
63
-
-
0032741972
-
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
-
J.K. Howard, G.M. Lord, G. Matarese, S. Vendetti, M.A. Ghatei, M.A. Ritter, R.I. Lechler, and S.R. Bloom Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice J. Clin. Invest. 104 8 1999 1051 1059
-
(1999)
J. Clin. Invest.
, vol.104
, Issue.8
, pp. 1051-1059
-
-
Howard, J.K.1
Lord, G.M.2
Matarese, G.3
Vendetti, S.4
Ghatei, M.A.5
Ritter, M.A.6
Lechler, R.I.7
Bloom, S.R.8
-
64
-
-
0031768795
-
Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats
-
M. Barbier, C. Cherbut, A.C. Aube, H.M. Blottiere, and J.P. Galmiche Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats Gut 43 1998 783 790
-
(1998)
Gut
, vol.43
, pp. 783-790
-
-
Barbier, M.1
Cherbut, C.2
Aube, A.C.3
Blottiere, H.M.4
Galmiche, J.P.5
-
65
-
-
2342564361
-
Leptin levels in the acute stage of ulcerative colitis
-
A. Tuzun, A. Uygun, Z. Yesilova, A.M. Ozel, A. Erdil, H. Yaman, S. Bagci, M. Gulsen, N. Karaeren, and K. Dagalp Leptin levels in the acute stage of ulcerative colitis J. Gastroenterol. Hepatol. 19 2004 429 432
-
(2004)
J. Gastroenterol. Hepatol.
, vol.19
, pp. 429-432
-
-
Tuzun, A.1
Uygun, A.2
Yesilova, Z.3
Ozel, A.M.4
Erdil, A.5
Yaman, H.6
Bagci, S.7
Gulsen, M.8
Karaeren, N.9
Dagalp, K.10
-
66
-
-
3042704740
-
Colonic leptin: Source of a novel proinflammatory cytokine involved in IBD
-
S. Sitaraman, X. Liu, L. Charrier, L.H. Gu, T.R. Ziegler, A. Gewirtz, and D. Merlin Colonic leptin: source of a novel proinflammatory cytokine involved in IBD FASEB J. 18 2004 696 698
-
(2004)
FASEB J.
, vol.18
, pp. 696-698
-
-
Sitaraman, S.1
Liu, X.2
Charrier, L.3
Gu, L.H.4
Ziegler, T.R.5
Gewirtz, A.6
Merlin, D.7
-
67
-
-
3042661014
-
Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice
-
B. Siegmund, J.A. Sennello, J. Jones-Carson, F. Gamboni-Robertson, H.A. Lehr, A. Batra, I. Fedke, M. Zeitz, and G. Fantuzzi Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice Gut. 53 2004 965 972
-
(2004)
Gut.
, vol.53
, pp. 965-972
-
-
Siegmund, B.1
Sennello, J.A.2
Jones-Carson, J.3
Gamboni-Robertson, F.4
Lehr, H.A.5
Batra, A.6
Fedke, I.7
Zeitz, M.8
Fantuzzi, G.9
-
68
-
-
0037241113
-
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
-
V. Sanna, A. Di Giacomo, A. La Cava, R.I. Lechler, S. Fontana, S. Zappacosta, and G. Matarese Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses J. Clin. Invest. 111 7 2003 241 250
-
(2003)
J. Clin. Invest.
, vol.111
, Issue.7
, pp. 241-250
-
-
Sanna, V.1
Di Giacomo, A.2
La Cava, A.3
Lechler, R.I.4
Fontana, S.5
Zappacosta, S.6
Matarese, G.7
-
69
-
-
0034998907
-
Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males
-
G. Matarese, V. Sanna, A. Di Giacomo, G.M. Lord, J.K. Howard, S.R. Bloom, R.I. Lechler, S. Fontana, and S. Zappacosta Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males Eur. J. Immunol. 31 2001 1324 1332
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 1324-1332
-
-
Matarese, G.1
Sanna, V.2
Di Giacomo, A.3
Lord, G.M.4
Howard, J.K.5
Bloom, S.R.6
Lechler, R.I.7
Fontana, S.8
Zappacosta, S.9
-
70
-
-
0036312494
-
Leptin accelerates autoimmune diabetes in female NOD mice
-
G. Matarese, V. Sanna, R.I. Lechler, N. Sarvetnick, S. Fontana, S. Zappacosta, and A. La Cava Leptin accelerates autoimmune diabetes in female NOD mice Diabetes 51 2002 1356 1361
-
(2002)
Diabetes
, vol.51
, pp. 1356-1361
-
-
Matarese, G.1
Sanna, V.2
Lechler, R.I.3
Sarvetnick, N.4
Fontana, S.5
Zappacosta, S.6
La Cava, A.7
-
71
-
-
0037080196
-
Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
-
N. Busso, So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer, and C. Gabay Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis J. Immunol. 168 2002 875 882
-
(2002)
J. Immunol.
, vol.168
, pp. 875-882
-
-
Busso, N.1
So2
Chobaz-Peclat, V.3
Morard, C.4
Martinez-Soria, E.5
Talabot-Ayer, D.6
Gabay, C.7
-
72
-
-
0032880663
-
+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation
-
+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation Clin. Rheumatol. 18 1999 394 401
-
(1999)
Clin. Rheumatol.
, vol.18
, pp. 394-401
-
-
Fraser, D.A.1
Thoen, J.2
Reseland, J.E.3
Forre, O.4
Kjeldsen-Kragh, J.5
-
73
-
-
0141762514
-
Leptin consumption in the inflamed joints of patients with rheumatoid arthritis
-
M. Bokarewa, D. Bokarew, O. Hultgren, and A. Tarkowski Leptin consumption in the inflamed joints of patients with rheumatoid arthritis Ann. Rheum. Dis. 62 2003 952 956
-
(2003)
Ann. Rheum. Dis.
, vol.62
, pp. 952-956
-
-
Bokarewa, M.1
Bokarew, D.2
Hultgren, O.3
Tarkowski, A.4
-
74
-
-
0141650600
-
A role for leptin in rheumatic diseases?
-
G. Palmer, and C. Gabay A role for leptin in rheumatic diseases? Ann. Rheum. Dis. 62 10 2003 913 915
-
(2003)
Ann. Rheum. Dis.
, vol.62
, Issue.10
, pp. 913-915
-
-
Palmer, G.1
Gabay, C.2
-
75
-
-
0035860185
-
Human articular chondrocytes express functional leptin receptors
-
Y. Figenschau, G. Knutsen, S. Shahazeydi, O. Johansen, and B. Sveinbjornsson Human articular chondrocytes express functional leptin receptors Biochem. Biophys. Res. Commun. 287 1 2001 190 197
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.287
, Issue.1
, pp. 190-197
-
-
Figenschau, Y.1
Knutsen, G.2
Shahazeydi, S.3
Johansen, O.4
Sveinbjornsson, B.5
-
76
-
-
0242552925
-
Evidence for a key role of leptin in osteoarthritis
-
H. Dumond, N. Presle, B. Terlain, D. Mainard, D. Loeuille, P. Netter, and P. Pottie Evidence for a key role of leptin in osteoarthritis Arthritis Rheum. 48 11 2003 3118 3129
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.11
, pp. 3118-3129
-
-
Dumond, H.1
Presle, N.2
Terlain, B.3
Mainard, D.4
Loeuille, D.5
Netter, P.6
Pottie, P.7
-
77
-
-
0037332229
-
Synergistic induction of nitric oxide synthase type II: In vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells
-
M. Otero, J.J. Gomez Reino, and O. Gualillo Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells Arthritis Rheum. 48 2 2003 404 409
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.2
, pp. 404-409
-
-
Otero, M.1
Gomez Reino, J.J.2
Gualillo, O.3
-
78
-
-
0037059796
-
ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status
-
S.J. Kim, J.W. Ju, C.D. Oh, Y.M. Yoon, W.K. Song, J.H. Kim, Y.J. Yoo, O.S. Bang, S.S. Kang, and J.S. Chun ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status J. Biol. Chem. 277 2 2002 1332 1339
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.2
, pp. 1332-1339
-
-
Kim, S.J.1
Ju, J.W.2
Oh, C.D.3
Yoon, Y.M.4
Song, W.K.5
Kim, J.H.6
Yoo, Y.J.7
Bang, O.S.8
Kang, S.S.9
Chun, J.S.10
-
79
-
-
0242662281
-
Systemic and local regulation of articular cartilage metabolism: Where does leptin fit in the puzzle?
-
R.F. Loeser Systemic and local regulation of articular cartilage metabolism: where does leptin fit in the puzzle? Arthritis Rheum. 48 11 2003 3009 3012
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.11
, pp. 3009-3012
-
-
Loeser, R.F.1
-
80
-
-
11844266754
-
Leptin synergizes interleukin-1 in inducing nitric oxide synthase in chondrocytes
-
M. Otero, J.J. Gomez-Reino, and O. Gualillo Leptin synergizes interleukin-1 in inducing nitric oxide synthase in chondrocytes Arthritis Rheum. 48 9 (Suppl. S) 2003 654
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.9
, pp. 654
-
-
Otero, M.1
Gomez-Reino, J.J.2
Gualillo, O.3
-
81
-
-
4644358139
-
Mapping of the leptin binding sites and design of a leptin antagonist
-
F. Peelman, K. Van Beneden, L. Zabeau, H. Iserentant, P. Ulrichts, D. Defeau, A. Verhee, D. Catteeuw, D. Elewaut, and J. Tavernier Mapping of the leptin binding sites and design of a leptin antagonist J. Biol. Chem. 279 39 2004 41038 41046
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.39
, pp. 41038-41046
-
-
Peelman, F.1
Van Beneden, K.2
Zabeau, L.3
Iserentant, H.4
Ulrichts, P.5
Defeau, D.6
Verhee, A.7
Catteeuw, D.8
Elewaut, D.9
Tavernier, J.10
|