The role of IFN-γ in the production of Th2 subpopulations: Implications for variable Th2-mediated pathologies in autoimmunity

Journal of Immunology

Volumn 167, Issue 6, 2001, Pages 3074-3081

  Wensky, A ^a   Marcondes, M C G ^a   Lafaille, J J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CYTOKINE PRODUCTION; EFFECTOR CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

EID: 0035884845     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.6.3074     Document Type: Article

References (43)

1. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
2. Functional diversity of helper T lymphocytes
3. Cytokines induce the development of functionally heterogeneous T helper cell subsets
4. + T cell responses: The alternative approaches
5. Differential regulation of murine T lymphocyte subsets
6. The role of helper T cell subsets in autoimmune diseases
7. + T cells
8. Lymphokine production by human T cells in disease states
9. + T-cell phenotype development
10. Th1 and Th2 subsets: Paradigms lost?
11. The relationship of IL-4- and IFN-γ-producing T cells studied by lineage ablation of IL-4-producing cells
12. Disruption of the murine IL-4 gene blocks Th2 cytokine responses
13. Susceptibility to Leishmania major infection in interleukin-4-deficient mice
14. Induction of airway mucus production By T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
15. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
16. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
17. Differential regulation of interleukin 4 and interleukin 5 gene expression: A comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines
18. Dissociation of production of interleukin-4 and interleukin-5
19. How is expression of the interleukin-5 gene regulated?
20. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
21. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
22. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
23. Multiple defects of immune cell function in mice with disrupted interferon-γ genes
24. 4 integrin by CD4 T cells is required for their entry into brain parenchyma
25. Quantitative polymerase chain reaction analysis reveals marked overexpression of 1β interleukin-1 and interferon-γ mRNA in the lymph nodes of lupus-prone mice
26. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4
27. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
28. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
29. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
30. Anti-proliferative effect of IFN-γ in immune regulation. IV. Murine CTL clones produce IL-3 and GM-CSF, the activity of which is masked by the inhibitory action of secreted IFN-γ
31. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation
32. Helper T cell differentiation is controlled by the cell cycle
33. IL- 12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ
34. Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells
35. Th2-induced airway mucus production is dependent on IL-4Rα, but not on eosinophils
36. Lack of interferon-γ receptor β chain and the prevention of interferon-γ signaling in Th1 cells
37. Ligand-induced autoregulation of IFN-γ receptor/β chain expression in T helper cell subsets
38. Stat6-independent GATA-3 autoactivation directs IL4-independent Th2 development and commitment
39. GATA-3-dependent enhancer activity in IL-4 gene regulation
40. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
41. IFN-γ shapes immune invasion of the central nervous system via regulation of chemokines
42. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
43. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense