Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis

Journal of Neuroimmunology

Volumn 82, Issue 1, 1998, Pages 22-30

  Bright, John J ^a   Musuro, Bola F ^a   Du, Caigan ^a   Sriram, Subramaniam ^a  

^a Multiple Sclerosis Res Laboratory   (United States)

Author keywords

CNS demyelination; Experimental allergic encephalitis; Interleukin 12; Multiple sclerosis

Indexed keywords

INTERLEUKIN 12;

ALLERGIC ENCEPHALITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; DEMYELINATION; IMMUNOPATHOGENESIS; INTERFERON PRODUCTION; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIBODIES; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION; GUINEA PIGS; INTERLEUKIN-12; LYMPHOID TISSUE; MICE; MICE, INBRED STRAINS; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0032005162     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00184-7     Document Type: Article

References (45)

1. Baker D., O'Neill J.K., Turk J.L. Cytokines in the CNS of mice during chronic experimental allergic encephalitis. Cell. Immunol. 134:1991;505-512.
2. Billiau A., Heremans H., Vandekerckhove F., Dijkmans R., Sobis H., Meulepas E., Carton H. Enhancement of EAE by antibodies to IFNγ J. Immunol. 140:1988;1506-1510.
3. Blasi E., Mathieson B.J., Varesio L., Cleveland J.L., Bochert P.A., Rapp U.R. Selective immortalization of murine macrophages from fresh bone marrow by raf/myc recombinant murine retrovirus. Nature. 318:1985;667-670.
4. Brunda M.J. Interleukin-12. J. Leukocyte. Biol. 55:1994;280-288.
5. Ferber I., Brocke S., Edwards C.T., Ridgway W., Dinisco C., Steinman L., Dalton D., Fathman C.G. Mice with the disrupted IFN-γ gene are susceptible to EAE. J. Immunol. 176:1996;5-7.
6. Flesch I.E., Hess J.H., Huang S., Aguet M., Rothe J., Bluethman H., Kaufmann S.H.E. Early IL-12 production by macrophages in response to mycobacterial infection depends upon IFN-γ and TNF-α J. Exp. Med. 181:1995;1615-1622.
7. Ford A.L., Goodsall A.L., Hickey W.F., Sedwick J.D. Normal adult ramified microglia separated from other CNS macrophges by flow cytometric sorting: phenotypic differences defined and direct ex vivo antigen presentation to MBP reactive CD4 T cell compared. J. Immunol. 154:1995;4309-4320.
8. Gazinelli R.T., Hieny S., Wynn T.A., Wolf S., Sher A. IL-12 is required for the T lymphocyte independent induction of IFN-γ by an intracellular parasite and induces resistance in T cell deficient mice. Proc. Natl. Acad. Sci. (USA). 90:1993;6115-6120.
9. Ghalib J.W., Whittle J.A., Kubin M., Hashim F.A., El-Hassan M., Grabstein K.H., Trinchieri G., Reed S.G. IL-12 enhances Th1 type responses in human Leishmania donovani infections. J. Immunol. 154:1995;4623-4629.
10. Heinzel F.P., Rerko R.M., Ahmed F., Hujer A.M. IFN-γ independent production of IL-12 during murine endotoxemia. J. Immunol. 157:1996;4521-4528.
11. Hickey W., Kimura H. Perivascular microglial cells of the CNS are bone marrow derived and present antigen in vivo. Science. 239:1988;290-293.
12. Johns L.D., Flanders K.C., Ranges G.E., Sriram S. Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta1. J. Immunol. 147:1991;1792-1803.
13. Kennedy M.K., Picha K.S., Fanslow W.C., Grabstein K.H., Alderson M.R., Clifford K.N., Chin W.A., Mohler K.M. CD40/CD40L interactions are required for T cell dependent production of IL-12 by mouse macrophages. Eur. J. Immunol. 26:1996;370-378.
14. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the CNS of mice with EAE reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
15. Krakowski M., Owens T. Interferon gamma confers resistance to EAE. Eur. J. Immunol. 26:1996;1641-1646.
16. Lehmann P.V., Sercarz E.E., Forsthuber T., Dayan C.M., Gammon G. Determinant spreading and the dynamics of the T-cell repertoire. Immunol. Today. 14:1993;203-208.
17. Leonard J.P., Waldburger K.E., Goldman S.J. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin-12. J. Exp. Med. 181:1995;381-386.
18. Linnington C., Bradl M., Lassman H., Brunner C., Vass K. Augmentation of demyelination in rat acute EAE by circulating mouse monoclonal antibody against myelin oligodendrocyte glycoprotein. Am. J. Pathol. 130:1988;443-454.
19. Lodge P.A., Sriram S. Regulation of microglial activation by TGF-β, IL-10 and CSF-1. J. Leukocyte Biol. 60:1996;502-508.
20. Ma X., Chow J.M., Grui G., Carra G., Cerosa F., Wolf S.F., Dzialo R., Trinchieri G. The IL-12 p40 gene is primed by IFN-γ in monocytic cells. J. Exp. Med. 183:1996;147-155.
21. Mannie M.D., Dinarello C.A., Paterson P.Y. Interleukin-1 and myelin basic protein synergistically augement adoptive transfer activity of lymphocytes mediating experimental autoimmune encephalomyelitis in Lewis rats. J. Immunol. 138:1987;4229-4235.
22. Martin R., McFarland H.F., McFarlin D.E. Immunology of demyelinating disease. Ann. Rev. Immunol. 10:1992;153-169.
23. Maruo S., Toyo-oka K., Oh-hora M., Tai X.-G., Iwata H., Takenaka H., Yamada S., Ono S., Hamaoka S., Kobayashi M., Wysocka M., Trinchieri G., Fujiwara H. IL-12 produced by antigen presenting cells induces IL-2 independant proliferation of T helper clones. J. Immunol. 156:1996;1748-1755.
24. Mcfarlin D.E., Mcfarland H.F. Multiple Sclerosis. N. Eng. J. Med. 307:1982;1183-1188.
25. McKnight A.J., Zimmer G.J., Fogelman I., Wolf S.F., Abbas A.K. Effects of IL-12 on helper T cell dependent immune responses in vivo. J. Immunol. 152:1994;2172-2178.
26. Merrill J., Kono D.H., Clayton J., Ando D., Hinton D.R., Hofman F.M. Inflammatory cytokines in the peptide induced disease of EAE. Proc. Natl. Acad. Sci. (USA). 89:1992;574-579.
27. Neurath M.F., Fuss I., Kellsall B.L., Stuber E., Strober W. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1995;1281-1291.
28. Owens T., Sriram S. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis. Neurol. Clin. 13:1995;51-73.
29. Pearlman E.F., Heinzel P., Hazlett F.E., Kazura J.W. IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi. J. Immunol. 154:1995;4658-4664.
30. Racke M., Sriram S., Carlino J., Cannella B., Raine C., McFarlin D. Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2. J. Neuroimmunol. 46:1993;175-184.
31. Raine C.S. Analysis of autoimmune demyelination: its impact on MS. Lab. Invest. 50:1984;608-635.
32. Scolding N.J., Zajicek J.P., Compston D.A.S. The pathogenesis of demyelinating disease. Prog. Neurobiol. 43:1994;143-173.
33. Seder R.A., Gazzinelli R., Sher A., Paul W. IL-12 acts directly on CD4 T cells to enhance priming for gamma interferon production and diminishes IL-4 inhibition of such priming. Proc. Natl. Acad. Sci. (USA). 90:1993;10188-10193.
34. Selmaj K., Raine C.S., Cross A.H. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 30:1991;694-700.
35. Selmaj K.W., Raine C.S. Tumor necrosis factor mediates myelin and oligodendrocyte injury in vitro. Ann. Neurol. 23:1989;339-345.
36. Shu U., Kiniwa M., Maliszewski C., Vezzio N., Hakimi J., Gately M., Delespesse G. Activated T cell induce IL-12 production by monocytes via CD40-CD40L ligand interaction. Eur. J. Immunol. 25:1995;1125-1128.
37. Skeene M.J., Miller M.A., T M.S., Ziegler H.K. Regulation of murine macrophage IL-12 production: Activation of macrophages in vivo, restimulation in vitro and modulation by other cytokines. J. Immunol. 156:1996;1196-1206.
38. Tremblau S., Penn G., Posi E., Mortara A., Gately M.K., Adorini L. IL-12 administration induces T helper type-I T cells and accellerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:1995;817-826.
39. Trinchieri G. IL-12 and its role in the generation of Th1 cells. Immunol. Today. 14:1993;335-339.
40. Trinchieri G. IL-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann. Rev. Immunol. 13:1995;251-276.
41. Trotter J.L., Clark H.B., Collins K.G., Wegeschiede C.L., Scarpellini J.D. Myelin proteolipid protein induces demyelinating disease in mice. J. Neurol. Sci. 79:1987;173-178.
42. Windhagen A., Newcombe J., Dangond F., Strand C., Woodroofe M., Cuzner M.L., Hafler D.A. Expression of co-stimulatory molecules B7-1 (CD80) B7-2(CD86) and IL-12 in MS lesions. J. Exp. Med. 182:1995;1985-1996.
43. Wynn T.A., Jankovic D., Hieny S., Cheever A.W., Sher A. IL-12 enhances vaccine induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production and tissue eosinophilia. J. Immunol. 154:1995;4701-4708.
44. Zamvil S.S., Steinman L.S. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:1990;579-621.
45. Zamvil S.S., Nelson P., Trotter J., Mitchell D., Knoblev R., Fritz R., Steinman L. T cell clones specific for myelin basic protein induce chronic relapsing EAE and demyelination. Nature. 317:1985;355-358.