Oral administration of myelin induces antigen-specific TGF-β1 secreting T cells in patients with multiple sclerosis

Annals of the New York Academy of Sciences

Volumn 835, Issue , 1997, Pages 120-131

  Hafler, David A ^a,b   Kent, Sally C ^a   Pietrusewicz, Matthew J ^a   Khoury, Samia J ^a   Weiner, Howard L ^a   Fukaura, Hikoaki ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; MYELIN; MYLORAL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADULT; ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; CELL SECRETION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MULTIPLE SCLEROSIS; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; T LYMPHOCYTE;

ANIMALIA; BOVINAE;

EID: 0031578938     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48623.x     Document Type: Conference Paper

References (20)

1. MCFARLIN, D. E. & H. F. MCFARLAND. 1982. Multiple sclerosis. N. Engl. J. Med. 307: 1183-1188.
2. HAFLER, D. A. & H. L. WEINER. 1995. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144: 75-107.
3. ZAMVIL, S., P. NELSON, J. TROTTER, D. MITCHELL, R. KNOBLER, R. FRITZ & L. STEINMAN. 1985. T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 317: 355-358.
4. TUOHY, V. K., R. A. SOBEL & M. B. LEES. 1988. Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. J. Immunol. 140: 1868-1873.
5. LININGTON, C., T. BERGER, L. PERRY, S. WEERTH, D. HINZE-SELCH, Y. ZHANG, H. C. LU, H. LASSMANN & H. WEKERLE. 1993. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immunol. 23: 1364-1372.
6. KHOURY, S. J., W. W. HANCOCK & H. L. WEINER. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor-β, interleukin-4, and prostaglandin E expression in the brain. J. Exp. Med. 176: 1355-1364.
7. CHASE, M. W. 1946. Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc. Soc. Exp. Biol. Med. 61: 257-259.
8. MOWAT, A. M. 1987. The regulation of immune responses to dietary protein antigens. Immunol. Today 8: 93-98.
9. HIGGINS, P. J. & H. L. WEINER. 1988. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol. 140: 440-445.
10. BITAR, D. M. & C. C. WHITACRE. 1988. Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell. Immunol. 112: 364-370.
11. THOMPSON, H. S. & N. A. STAINES. 1986. Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats. Clin. Exp. Immunol. 64: 581-586.
12. NAGLER-ANDERSON, C., L. A. BOBER, M. E. ROBINSON, G. W. SISKIND & G. J. THORBECKE. 1986. Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc. Natl. Acad. Sci. USA 83: 7443-7446.
13. ZHANG, Z. J., C. S. Y. LEE, O. LIDER & H. L. WEINER. 1990. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J. Immunol. 145: 2489-2493.
14. NUSSENBLATT, R. B., R. R. CASPI, R. MAHDI, C.-C. CHAN, F. ROBERGE, O. LIDER & H. L. WEINER. 1990. Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J. Immunol. 144: 1689-1695.
15. ZHANG, Z. J., L. DAVIDSON, G. EISENBARTH & H. L. WEINER. 1991. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88: 10252-10256.
16. WEINER, H. L., G. A. MACKLIN, M. MATSUI, E. J. ORAV, S. J. KHOURY, D. M. DAWSON & D. A. HAFLER. 1993. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259: 1321-1324.
17. TRENTHAM, D. E., R. A. DYNESIUS-TRENTHAM, E. J. ORAV, D. COMBITCHI, C. LORENZO, K. L. SEWELL, D. A. HAFLER & H. L. WEINER. 1993. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 261: 1727-1730.
18. HOHOL, M. J., S. J. KHOURY, S. L. COOK, E. J. ORAV, D. A. HAFLER & H. L. WEINER. 1996. Three year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Ann. N. Y. Acad. Sci. 778: 243-250.
19. MILLER, A., O. LIDER & H. L. WEINER. 1991. Antigen-driven bystander suppression following oral administration of antigens. J. Exp. Med. 174: 791-798.
20. CHEN, Y., V. K. KUCHROO, J.-I. INOBE, D. A. HAFLER & H. L. WEINER. 1994. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science 265: 1237-1240.