Experimental autoimmune encephalomyelitis in IL-4-deficient mice

International Immunology

Volumn 9, Issue 5, 1997, Pages 799-803

  Liblau, Roland ^a,b   Steinman, Lawrence ^a,c   Brocke, Stefan ^a,d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Autoimmunity; Central nervous system; Cytokines; T(h)2 T cells

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 4;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE COURSE; DISEASE SEVERITY; HELPER CELL; IMMUNOREGULATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RELAPSE; REMISSION;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERLEUKIN-4; MICE; MICE, MUTANT STRAINS; RECURRENCE; REMISSION, SPONTANEOUS; TH2 CELLS;

EID: 0031011146     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.5.799     Document Type: Article

References (36)

1. Paul, W. E. and Seder, R. A. 1994. Lymphocyte response and cytokines, Cell 76:241.
2. Mustafa, M., Vingsbo, C., Olsson, T., Issazadeh, S., Ljungdahl, A. and Holmdahl, R. 1994. Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles. J. Immunol. 153:3337.
3. Scott, B., Liblau, R., Degerman, S., Marconi, A. L., Caton, A. J., McDevitt, H. O. and Lo, D. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1:73.
4. + T cells. J. Exp. Med. 182:1591.
5. h2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
6. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
7. Kühn, R., Rajewsky, K. and Müller W. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707.
8. h2 cytokine responses. Nature 362:245.
9. h2 cells in systemic autoimmunity. Immunol. Today 12:223.
10. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34.
11. Kennedy, M. K., Torrance, D. S., Picha, K. S. and Mohler, K. M. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.
12. Baron, J. L., Madri, J. A., Ruddle, N. H., Hashim, G. and Janeway, C. A., Jr. 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57.
13. h2 cells with related peptide specificity: relative roles of interleukin (IL)-4 and IL-10. J. Neuroimmunol. 48:213.
14. Khoury, S. J., Hancock, W. W. and Weiner H. L. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with down-regulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4 and prostaglandin E expression in brain. J. Exp. Med. 176:1355.
15. h2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. J. Immunol. 155:4052.
16. + suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur. J. Immunol. 22:1757.
17. Billiau, A., Heremans, H., vandekerckhove, P., Dijkmans, R., Sobis, H., Meulepas, E. and Carton, H. 1988. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ. J. Immunol. 140:1506.
18. Ruddle, N. H., Bergman, C. M., McGrath, K. M., Lingenheld, E. G., Grunnet, M. L., Padula, S. J. and Clark, R. B. 1990. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172:1193.
19. Leonard, J. P., Waldburger, K. E. and Goldman, S. J. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:381.
20. Karin, N., Mitchell, D. J., Brocke, S. and Steinman, L. 1994. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon-γ and tumor necrosis factor α production. J. Exp. Med. 180:2227.
21. Racke, M. K., Bonomo, A., Scott, D. E., Cannella, B., Levine, A., Raine, C. S., Shevach, E. M. and Röcken, M. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961.
22. Rott, O., Fleischer, B. and Cash, E. 1994. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24:1434.
23. Cash, E., Minty, A., Ferrara, P., Caput, D., Fradelizi, D. and Rott, O. 1994. Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats. J. Immunol. 152:4258.
24. Chen, Y., Kuchroo, V. K., Inobe, J. I., Hafler, D. A. and Weiner, H. L. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
25. Nicholson, L. B., Greer, J. M., Sobel, R. A., Lees, M. B. and Kuchroo, V. K. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
26. Brocke, S., Gijbels, K., Allegretta, M., Ferbert, I., Piercy, C., Blankenstein, T., Martin, R., Utz, U., Karin, N., Mitchell, D., Veromaa, T., Waisman, A., Gaur, A., Conlon, P., Ling, N., Fairchild, P. J., Wraith, D. C., O'Garra, A., Fathman, C. G. and Steinman, L. 1996. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379:343.
27. Saoudi, A., Simmonds, S., Huitinga, I. and Mason, D. 1995. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells. J. Exp. Med. 182:335.
28. Garside, P., Steel, M., Worthey, E. A., Satostar, A., Alexander, J., Bluethmann, H., Liew, F. Y. and Mowat, A. M. 1995. T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. J. Immunol. 154:5649.
29. Vajdy, M., Kosco-Vilbois, M. H., Kopf, M., Köhler, G. and Lycke, N. 1995. Impaired mucosal immune responses in interleukin-4-targeted mice. J. Exp. Med. 181:41.
30. Lawrence, R. A., Allen, J. E., Gregory, W. J., Kopf, M. and Maizels, R. M. 1995. Infection of IL-4 deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response. J. Immunol. 154:5995.
31. Noben-Trauth, N., Kropf, P. and Müller, I. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987.
32. Pearlman, E., Lass, J. H., Bardenstein, D. S., Kopf, M., Hazlet, F. E., Jr, Diaconu, E. and Kazura, J. W. 1995. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). J. Exp. Med. 182:931.
33. Baker, D., Rosenwasser, O. A., O'Neill, J. K. and Turk, J. L. 1995. Genetic analysis of experimental allergic encephalomyelitis in mice. J. Immunol. 155:4046.
34. -/- mice. Science 256:1210.
35. Kuruvilla, A. P., Shah, R., Hochwald, G. M., Liggitt, H. D., Palladino, M. A. and Thorbecke, G. J. 1991. Protective effect of transforming growth factor β1 on experimental autoimmune diseases in mice. Proc. Natl Acad. Sci. USA 88:2918.
36. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:909.