Reduction of both pro- and anti-inflammatory cytokines after 6 months of interferon beta-1a treatment of multiple sclerosis

Journal of Neuroimmunology

Volumn 103, Issue 2, 2000, Pages 202-210

  Khademi, Mohsen ^a   Wallström, Erik ^a,b   Andersson, Magnus ^a,b   Piehl, Fredrik ^a   Di Marco, Roberto ^a,c   Olsson, Tomas ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Cerebrospinal fluid; Interferon beta; Interferon gamma; Interleukin 10; Multiple sclerosis; Tumor necrosis factor alpha

Indexed keywords

BETA1 INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFECT; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; NEUROIMMUNOLOGY; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADULT; CELL COUNT; CELLS, CULTURED; CEREBROSPINAL FLUID; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERFERON TYPE II; INTERFERON-BETA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; RNA, MESSENGER; TUBERCULIN;

EID: 0033953738     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00184-8     Document Type: Article

References (33)

1. Andersson M., Khademi M., Wallstrom E., Olsson T. Cytokine profile in interferon-β treated multiple sclerosis patients: reduction of IL-10 mRNA-expressing cells in peripheral blood. Eur. J. Neurol. 4:1997;567-571.
2. Czerkinsky C., Andersson G., Ekre H.P., Nilsson L.A., Klareskog L., Ouchterlony O. Reverse Elispot assay for clonal analysis of cytokine production: I. Enumeration of gamma-interferon-secreting cells. J. Immunol. Methods. 110:1988;29-36.
3. Dagerlind A., Friberg K., Bean A.J., Hokfelt T. Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry. 98:1992;39-49.
4. Dayal A.S., Jensen M.A., Lledo A., Arnason B.G.W. Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta-1b. Neurology. 45:1995;2173-2177.
5. Dayal A.S., Jensen M.A., Lledo A., Arnason B.G.W. IFN-secreting cells - reply. Neurology. 47:1996;854-855.
6. Farrar M.A., Schreiber R.D. The molecular cell biology of interferon-gamma and its receptor. Annu. Rev. Immunol. 11:1993;571-611.
7. Gray P.W., Leung D.W., Pennica D., Yelverton E., Najarian R., Simonsen C.C., Derynck R., Sherwood P.J., Wallace D.M., Berger S.L., Levinson A.D., Goeddel D.V. Expression of human immune interferon cDNA in E. coli and monkey cells. Nature. 295:1982;503-508.
8. The IFNB Multiple Sclerosis Study Group Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology. 43:1993;655-661.
9. Jacobs L.D., Cookfair D.L., Rudick R.A., Herndon R.M., Richert J.R., Salazar A.M., Fischer J.S., Goodkin D.E., Granger C.V., Simon J.H., Alam J.J., Bartoszak D.M., Bourdette D.N., Braiman J., Brownscheidle C.M., Coats M.E., Cohan S.L., Dougherty D.S., Kinkel R.P., Mass M.K.et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann. Neurol. 39:1996;285-294.
10. Kabilan L., Andersson G., Lolli F., Ekre H.P., Olsson T., Troye-Blomberg M. Detection of intracellular expression and secretion of interferon-gamma at the single-cell level after activation of human T cells with tetanus toxoid in vitro. Eur. J. Immunol. 20:1990;1085-1089.
11. Kaplow I.S. Letter: substitute for benzidine in myeloperoxidase stains. Am. J. Clin. Pathol. 63:1975;451.
12. Leppert D., Waubant E., Burk M.R., Oksenberg J.R., Hauser S.L. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells - a possible mechanism for treatment efficacy in multiple sclerosis. Ann. Neurol. 40:1996;846-852.
13. Link J., Soderstrom M., Ljungdahl A., Hojeberg B., Olsson T., Xu Z., Fredrikson S., Wang Z.Y., Link H. Organ-specific autoantigens induce interferon-gamma and interleukin-4 mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Neurology. 44:1994;728-734.
14. Lu H.T., Riley J.L., Babcock G.T., Huston M., Stark G.R., Boss J.M., Ransohoff R.M. Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kDa DNA-binding protein, ISGF3-gamma. J. Exp. Med. 182:1995;1517-1525.
15. Matusevicius D., Kivisakk P., Navikas V., Tian W.Z., Soderstrom M., Fredrikson S., Link H. Influence of IFN-beta-1b (betaferon) on cytokine mRNA profiles in blood mononuclear cells and plasma levels of soluble VCAM-1 in multiple sclerosis. Eur. J. Neurol. 5:1998;265-275.
16. Noronha A., Toscas A., Jensen M.A. Interferon beta decreases T cell activation and interferon-gamma production in multiple sclerosis. J. Neuroimmunol. 46:1993;145-153.
17. Olsson T. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:1995;245-268.
18. Olsson T. Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurology. 45:1995;S11-S15.
19. Olsson T., Zhi W.W., Hojeberg B., Kostulas V., Jiang Y.P., Anderson G., Ekre H.P., Link H. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. J. Clin. Invest. 86:1990;981-985.
20. Ossege L.M., Sindern E., Patzold T., Malin J.P. Immunomodulatory effects of interferon-beta-1b in vivo: induction of the expression of transforming growth factor-beta1 and its receptor type II. J. Neuroimmunol. 91:1998;73-81.
21. Panitch H.S., Hirsch R.L., Haley A.S., Johnson K.P. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1:1987;893-895.
22. Paty, D.W., Ebers, G.C., 1998. Multiple Sclerosis. F.A. Davis, Philadelphia.
23. Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R., Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature. 312:1984;724-729.
24. PRISMS Study Group Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet. 352:1998;1498-1504.
25. Rep M.H.G., Hintzen R.Q., Polman C.H., Vanlier R.A.W. Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells. J. Neuroimmunol. 67:1996;111-118.
26. Rudick R.A., Ransohoff R.M., Peppler R., Medendorp S.V., Lehmann P., Alam J. Interferon beta induces interleukin-10 expression - relevance to multiple sclerosis. Ann. Neurol. 40:1996;618-627.
27. Rudick R.A., Ransohoff R.M., Lee J.C., Peppler R., Yu M., Mathisen P.M., Tuohy V.K. In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis. Neurology. 50:1998;1294-1300.
28. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:1996;299-302.
29. Vieira P., de Waal-Malefyt R., Dang M.N., Johnson K.E., Kastelein R., Fiorentino D.F., deVries J.E., Roncarolo M.G., Mosmann T.R., Moore K.W. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. U.S.A. 88:1991;1172-1176.
30. Weber F., Polak T., Gunther A., Kubuschok B., Janovskaja J., Bitsch A., Poser S., Rieckmann P. Synergistic immunomodulatory effects of interferon-beta1b and the phosphodiesterase inhibitor pentoxifylline in patients with relapsing-remitting multiple sclerosis. Ann. Neurol. 44:1998;27-34.
31. Weinstock-Guttman B., Ransohoff R.M., Kinkel R.P., Rudick R.A. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann. Neurol. 37:1995;7-15.
32. Williams G.J., Witt P.L. Comparative study of the pharmacodynamic and pharmacologic effects of Betaseron and Avonex. J. Interferon Cytokine Res. 18:1998;967-975.
33. Yokota T., Otsuka T., Mosmann T., Banchereau J., DeFrance T., Blanchard D., De Vries J.E., Lee F., Arai K. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc. Natl. Acad. Sci. U.S.A. 83:1986;5894-5898.