Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage

FASEB Journal

Volumn 17, Issue 12, 2003, Pages 1622-1630

  Joseph, Troy W ^a   Zaika, Alex ^a   Moll, Ute M ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Cytoplasm; Degradation; Nucleus; p53 HDM2; Proteasomes; Ubiquitination

Indexed keywords

CAMPTOTHECIN; CISPLATIN; DNA; LEPTOMYCIN B; PROTEASOME; PROTEIN; PROTEIN MDM2; PROTEIN P53; REX PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CYTOPLASM; DNA DAMAGE; DOWN REGULATION; GAMMA IRRADIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ULTRAVIOLET IRRADIATION;

CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; DNA DAMAGE; DOWN-REGULATION; HUMANS; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

HTLV1;

EID: 0042415612     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.02-0931com     Document Type: Article

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