-
1
-
-
0023339504
-
Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
-
Cahilly-Snyder L, Yang-Feng T, Francke U, George DL. (1987) Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat. Cell Mol. Gen. 13:235-244.
-
(1987)
Somat. Cell Mol. Gen.
, vol.13
, pp. 235-244
-
-
Cahilly-Snyder, L.1
Yang-Feng, T.2
Francke, U.3
George, D.L.4
-
2
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
-
Fakharzadeh SS, Trusko SP, George DL. (1991) Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10:1565-1569.
-
(1991)
EMBO J.
, vol.10
, pp. 1565-1569
-
-
Fakharzadeh, S.S.1
Trusko, S.P.2
George, D.L.3
-
3
-
-
0027498314
-
The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
-
Finlay CA. (1993) The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol. 13: 301-306.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 301-306
-
-
Finlay, C.A.1
-
4
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83.
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
5
-
-
0027368879
-
The human MDM-2 oncogene is overexpressed in leukemias
-
Bueso-Ramos CE, Yang Y, deLeon E, McCown P, Stass SA, Albitar M. (1993) The human MDM-2 oncogene is overexpressed in leukemias. Blood 82:2617-2623.
-
(1993)
Blood
, vol.82
, pp. 2617-2623
-
-
Bueso-Ramos, C.E.1
Yang, Y.2
DeLeon, E.3
McCown, P.4
Stass, S.A.5
Albitar, M.6
-
6
-
-
0027508958
-
MDM2 gene amplification in metastatic osteosarcoma
-
Ladanyi M, Cha C, Lewis R, Jhanwar SC, Huvos AG, Healey JH. (1993) MDM2 gene amplification in metastatic osteosarcoma. Cancer Res. 53:16-18.
-
(1993)
Cancer Res.
, vol.53
, pp. 16-18
-
-
Ladanyi, M.1
Cha, C.2
Lewis, R.3
Jhanwar, S.C.4
Huvos, A.G.5
Healey, J.H.6
-
7
-
-
0027232042
-
p53 mutation and MDM2 amplification in human soft tissue sarcomas
-
Leach FS, Tokino T, Meltzer P, et al. (1993) p53 mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res. 53:2231-2234.
-
(1993)
Cancer Res.
, vol.53
, pp. 2231-2234
-
-
Leach, F.S.1
Tokino, T.2
Meltzer, P.3
-
8
-
-
0027196974
-
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
-
Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. (1993) Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53:2736-2739.
-
(1993)
Cancer Res.
, vol.53
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
Schmidt, E.E.4
Collins, V.P.5
-
9
-
-
0027302563
-
The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma
-
Sheikh MS, Shao Z-M, Hussain A, Fontana JA. (1993) The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma. Cancer Res. 53:3226-3228.
-
(1993)
Cancer Res.
, vol.53
, pp. 3226-3228
-
-
Sheikh, M.S.1
Shao, Z.-M.2
Hussain, A.3
Fontana, J.A.4
-
10
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo C, Latres E, Drobnjak M, et al. (1994) Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res. 54:794-799.
-
(1994)
Cancer Res.
, vol.54
, pp. 794-799
-
-
Cordon-Cardo, C.1
Latres, E.2
Drobnjak, M.3
-
11
-
-
0029882622
-
p53 and MDM2 expression in oral squamous cell carcinoma
-
Matsumura T, Yoshihama Y, Kimura T, Shintani S, Alcalde RE. (1996) p53 and MDM2 expression in oral squamous cell carcinoma. Oncology 53:308-312.
-
(1996)
Oncology
, vol.53
, pp. 308-312
-
-
Matsumura, T.1
Yoshihama, Y.2
Kimura, T.3
Shintani, S.4
Alcalde, R.E.5
-
12
-
-
0028081261
-
The MDM2 oncogens overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
-
Watanabe T, Hotta T, Ichikawa A, et al. (1994) The MDM2 oncogens overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood 84: 3158-3165.
-
(1994)
Blood
, vol.84
, pp. 3158-3165
-
-
Watanabe, T.1
Hotta, T.2
Ichikawa, A.3
-
13
-
-
0027956208
-
Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
-
Landers JE, Haines DS, Strauss JF, George DL. (1994) Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 9:2745-2750.
-
(1994)
Oncogene
, vol.9
, pp. 2745-2750
-
-
Landers, J.E.1
Haines, D.S.2
Strauss, J.F.3
George, D.L.4
-
14
-
-
0030036517
-
The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target
-
Picksley SM, Spicer JF, Barnes DM, Lane DP. (1996) The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target. Acta Oncologica 35: 429-434.
-
(1996)
Acta Oncologica
, vol.35
, pp. 429-434
-
-
Picksley, S.M.1
Spicer, J.F.2
Barnes, D.M.3
Lane, D.P.4
-
15
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J, Zambetti GP, Olson, DC, George D, Levine AJ. (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
16
-
-
0029171789
-
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
-
Chen J, Lin J, Levine AJ. (1995) Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med. 1:142-152.
-
(1995)
Mol. Med.
, vol.1
, pp. 142-152
-
-
Chen, J.1
Lin, J.2
Levine, A.J.3
-
17
-
-
0029913730
-
1 arrest and apoptosis functions of the p53 tumor suppressor protein
-
1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16:2445-2452.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2445-2452
-
-
Chen, J.1
Wu, X.2
Lin, J.3
Levine, A.J.4
-
18
-
-
0029972806
-
p53: Puzzle and paradigm
-
Ko LJ, Prives C. (1996) p53: Puzzle and paradigm. Genes Dev. 10:1054-1072.
-
(1996)
Genes Dev.
, vol.10
, pp. 1054-1072
-
-
Ko, L.J.1
Prives, C.2
-
19
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R, Wagner DS, Lozano G. (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378:203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
20
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones SN, Roe AE, Donehower LA, Bradley A. (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378:206-208.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
22
-
-
0027143217
-
The mdm-2 gene is induced in response to UV light in a p53-dependent manner
-
Perry ME, Piette J, Zawadzki JA, Harvey D, Levine AJ. (1993) The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 90:11623-11627.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 11623-11627
-
-
Perry, M.E.1
Piette, J.2
Zawadzki, J.A.3
Harvey, D.4
Levine, A.J.5
-
23
-
-
0027222956
-
Mapping of the p53 and mdm-2 interaction domains
-
Chen J, Marechal V, Levine AJ. (1993) Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol. 13:4107-4114.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4107-4114
-
-
Chen, J.1
Marechal, V.2
Levine, A.J.3
-
24
-
-
0030941037
-
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis
-
Marechal V, Elenbaas B, Taneyhill L, et al. (1997) Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis. Oncogene 14:1427-1433.
-
(1997)
Oncogene
, vol.14
, pp. 1427-1433
-
-
Marechal, V.1
Elenbaas, B.2
Taneyhill, L.3
-
25
-
-
0027999512
-
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
-
Marechal V, Elenbaas B, Piette J, Nicolas J-C, Levine AJ. (1994) The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol. Cell. Biol. 14:7414-7420.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7414-7420
-
-
Marechal, V.1
Elenbaas, B.2
Piette, J.3
Nicolas, J.-C.4
Levine, A.J.5
-
26
-
-
0028277934
-
The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger
-
Boddy MN, Freemont PS, Borden KLB. (1994) The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger. Trends Biochem. Sci. 19:198-199.
-
(1994)
Trends Biochem. Sci.
, vol.19
, pp. 198-199
-
-
Boddy, M.N.1
Freemont, P.S.2
Borden, K.L.B.3
-
27
-
-
0029760621
-
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
-
Elenbaas B, Dobbelstein M, Roth J, Shenk T, Levine AJ. (1996) The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med. 2:439-451.
-
(1996)
Mol. Med.
, vol.2
, pp. 439-451
-
-
Elenbaas, B.1
Dobbelstein, M.2
Roth, J.3
Shenk, T.4
Levine, A.J.5
-
28
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao Z-X, Chen J, Levine AJ, et al. (1995) Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375:694-698.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.-X.1
Chen, J.2
Levine, A.J.3
-
29
-
-
0029028353
-
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
-
Martin K, Trouche D, Hagemeier C, Sorensen TS, La Thangue NB, Kouzarides T. (1995) Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375:691-694.
-
(1995)
Nature
, vol.375
, pp. 691-694
-
-
Martin, K.1
Trouche, D.2
Hagemeier, C.3
Sorensen, T.S.4
La Thangue, N.B.5
Kouzarides, T.6
-
30
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie PH, Gorina S, Marechal V, et al. (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274:948-953.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
-
31
-
-
0027437850
-
Cdil, a human G1- and S-phase protein phosphatase that associates with Cdk2
-
Gyuris J, Golemis E, Chertkov H, Brent R. (1993) Cdil, a human G1- and S-phase protein phosphatase that associates with Cdk2. Cell 75:791-803.
-
(1993)
Cell
, vol.75
, pp. 791-803
-
-
Gyuris, J.1
Golemis, E.2
Chertkov, H.3
Brent, R.4
-
32
-
-
0024669291
-
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
-
Sikorski RS, Hieter P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
-
(1989)
Genetics
, vol.122
, pp. 19-27
-
-
Sikorski, R.S.1
Hieter, P.2
-
34
-
-
0028303752
-
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
-
Lin J, Chen J, Elenbaas B, Levine AJ. (1994) Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8:1235-1246.
-
(1994)
Genes Dev.
, vol.8
, pp. 1235-1246
-
-
Lin, J.1
Chen, J.2
Elenbaas, B.3
Levine, A.J.4
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