An amino acid substitution in the Babesia bovis dihydrofolate reductase-thymidylate synthase gene is correlated to cross-resistance against pyrimethamine and WR99210

Molecular and Biochemical Parasitology

Volumn 133, Issue 2, 2004, Pages 209-219

  Gaffar, Fasila R ^a   Wilschut, Karlijn ^a   Franssen, Frits F J ^a   De Vries, Erik ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Apicomplexa; Babesia bovis; DHFR TS; Drug resistance; Pyrimethamine; WR99210

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; PYRIMETHAMINE; THYMIDYLATE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; BABESIA BOVIS; CELL CYCLE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG BINDING SITE; ENZYME ACTIVE SITE; ENZYME BINDING; ERYTHROCYTE; EXON; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC CODE; GENETIC CONSERVATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE CULTIVATION; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTOZOAL GENETICS; SEQUENCE HOMOLOGY; SPECIES COMPARISON; STRAIN DIFFERENCE; SYNTENY; THEILERIA PARVA;

APICOMPLEXA; BABESIA; BABESIA BOVIS; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; THEILERIA; THEILERIA PARVA;

EID: 0346157319     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2003.08.013     Document Type: Article

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