Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+

Biochemistry

Volumn 38, Issue 14, 1999, Pages 4303-4312

  Cody, Vivian ^a   Galitsky, Nikolai ^a   Rak, Dawn ^a   Luft, Joseph R ^a   Pangborn, Walter ^a   Queener, Sherry F ^b  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHENYLALANINE; PYROPHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ALPHA HELIX; ARTICLE; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR MODEL; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; NADP; PNEUMOCYSTIS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PNEUMOCYSTIS CARINII; PROTOZOA;

EID: 0033528719     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982728m     Document Type: Article

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