Plasmodium falciparum: Kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase

Experimental Parasitology

Volumn 87, Issue 3, 1997, Pages 222-228

  Hekmat Nejad, Mohammad ^a   Rathod, Pradipsinh K ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

PLASMODIUM FALCIPARUM;

EID: 0031282343     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1997.4228     Document Type: Article

References (28)

1. Ackermann, W. W., and Potter, V R. 1949. Enzyme inhibition in relation to chemotherapy. Proceedings of the Society for Experimental Biology and Medicine 72, 1-9.
2. Baird, J. K., and Hoffman, S. L. 1996. Progress in prevention and treatment of malaria. Current Opinion in Infectious Diseases 9, 319-329.
3. Canfield, C. J., Milhous, W. K., Ager, A. L., Rossan, R. N., Sweeney, T. R., Lewis, N. J., and Jacobus, D. P. 1993. PS-15: A potent, orally active antimalarial from a new class of folic acid antagonists. American Journal of Tropical Medicine and Hygiene 49, 121-126.
4. Cha, S. 1975. Tight-binding inhibitors. I. Kinetic behaviour. Biochemical Pharmacology 24, 2177-2185.
5. Cha, S., Agarwal, R. P., and Parks, R. E., Jr. 1975. Tight-binding inhibitors. I. Non-steady-state nature of inhibition of milk xanthine oxidase bu allopurinol and alloxanthine and of human erythrocytic adenosine deaminase by coformycin. Biochemical Pharmacology 24, 2187-2197.
6. Chen, G-X., Mueller, C., Wendlinger, M., and Zolg, W. 1987. Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human parasite Plasmodium falciparum. Molecular Pharmacology 31, 430-437.
7. Cowman, A. F., Morry, M. J., Biggs, B. A., Cross, G. A. M., and Foote, S. J. 1988. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proceedings of the National Academy of Science USA 85, 9109-9113.
8. Crab, B. S., and Cowman, A. F. 1996. Characterization of promoters and stable transfection by homologous and non-homologous recombination in Plasmodium falciparum. Proceedings of the National Academy of Science USA 93, 7289-7294.
9. Donald, R. G. K., and Roos, D. S. 1993. Stable molecular transformation of Toxoplasma gondii: A selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistant mutations in malaria. Proceedings of National Academy of Science USA 90, 11703-11707.
10. Ferone, R., Burchall, J. J., and Hitchings, G. H. 1969. Plasmodium bergei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates. Molecular Pharmacology 5, 49-59.
11. Hekmat-Nejad, M., Lee, P., and Rathod, P. K. 1997. Plasmodium falciparum: Direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains. Experimental Parasitology 85, 303-305.
12. Hekmat-Nejad, M., and Rathod, P. K. 1996. Kinetics of Plasmodium falciparum thymidylate synthase: Interactions with high-affinity metabolites of 5-fluoroorotate and D 1694. Antimicrobial Agents and Chemotherapy 40, 1628-1632.
13. Hillcoat, B. L., and Blakely, R. L. 1966) Dihydrofolate reductase of Streptococcus faecalis. Journal of Biological Chemistry 241, 2995-3001.
14. Hitchings, G. H. 1960. Pyrimethamine: The use of an antimetabolite in the chemotherapy of malaria and other infections. Clin Pharmacology and Therapeutics 1, 570-589.
15. McCutchan, T. F., Welsh, J. A., Dame, J. B., Quakyi, I. A., Graves, P. M., Drake, J. C., and Allegra, C. J. 1984. Mechanism of pyrimethamine resistance in recent isolates of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 26, 656-659.
16. Milhous, W. K., Weatherly, N. F., Bowdre, J. H., and Desjardins, R. E. 1985. In vitro activities of and mechanisms of resistance to antifol antimalarial drugs. Antimicrobial Agents and Chemotherapy 27, 525-530.
17. Peterson, D. S., Walliker, D., and Wellems, T. E. 1988. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proceedings of the National Academy of Science USA 85, 9114-9118.
18. Peterson, D. S., Milhous, W. K., and Wellems, T. E. 1990. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proceedings of the National Academy of Science USA 87, 3018-3022.
19. Rathod, P. K., McErlean, T., and Lee, P. 1997. Variations in frequencies of drug resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 94, 9389-9393.
20. Sano, G., Morimatsu, K., and Horii, T. 1994. Purification and characterization of dihydrofolate reductase of Plasmodium falciparum expressed by a synthetic gene in Escherichia coli. Molecular and Biochemical Parasitology 63, 265-273.
21. Sirawaraporn, W., Prapunwattana, P., Sirawaraporn, R., Yuthavong, Y., and Santi, D. V. 1993. The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Journal of Biological Chemistry 268, 21637-21644.
22. Sirawaraporn, W., Sathitkul, T., Sirawaraporn, R., Yuthavong, Y., and Santi, D. V. 1997. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proceedings of National Academy of Science USA 94, 1124-1129.
23. Walter, R. D. 1986. Altered dihydrofolate reductase in pyrimethamine-resistant Plasmodium falciparum. Molecular and Biochemical Parasitology 19, 61-66.
24. Wang, P., Read, M., Sims, P. F. G., and Hyde, J. E. 1997. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Molecular Microbiology 23, 979-986.
25. Watkins, W. M., Sixsmith, D. G., Chulay, J. D., and Spencer, H. C. 1985. Antagonism of sulfadoxine and pyrimethamine antimalarial activities in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid. Molecular and Biochemical Parasitology 14, 55-61.
26. White, N. J. 1992. Antimicrobial drug resistance: The pace quickens. Journal of Antimicrobial Chemotherapy 30, 571-585.
27. Wooden, J. M., Hartwell, L. H., Vasquez, B., and Sibley, C. H. 1997. Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Molecular and Biochemical Parasitology 85, 25-40.
28. Wu, Y., Kirkman, L. A., and Wellems, T. E. 1996. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proceedings of the National Academy of Science USA 93, 1130-1134.