Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum

Molecular and Biochemical Parasitology

Volumn 85, Issue 1, 1997, Pages 25-40

  Wooden, Jason M ^a   Hartwell, Leland H ^a   Vasquez, Brandi ^a,b   Sibley, Carol Hopkins ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

antifolate; drug resistance; malaria; Plasmodium falciparum; Saccharomyces cerevisiae

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; DRUG ANALYSIS; DRUG RESISTANCE; ENZYME ACTIVITY; MOLECULAR CLONING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; GENES, PROTOZOAN; PHENANTHRENES; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 0031002773     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(96)02808-3     Document Type: Article

References (44)

1. Peters, W. (1987) Chemotherapy and Drug Resistance in Malaria, Academic Press, London.
2. White, N.J. (1992) Antimalarial drug resistance: the pace quickens. J. Antimicrob. Chemother. 30, 571-85.
3. Hyde, J.E. (1990) The dihydrofolate reductase-thymidylate synthase gene in the drug resistance of malaria parasites. Pharm. Ther. 48, 45-59.
4. Milhous, W.K., Weatherly, N.F., Bowdre, J.H. and Desjardins, R.E. (1985) In vitro activities of and mechanisms of resistance to antifol antimalarial drugs. Antimicrob. Agents Chemother. 27, 525-30.
5. Childs, G.E. and Lambros, C. (1986) Analogues of N-benzyloxydihydrotriazines: in vitro antimalarial activity against Plasmodium falciparum. Ann. Trop. Med. Parasitol. 80, 177-81.
6. Canfield, C.J., Milhous, W.K., Ager, A.L., Rossan, R.N., Sweeney, T.R., Lewis, N.J. and Jacobus, D.P. (1993) PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists. Am. J. Trop. Med. Hyg. 49, 121-6.
7. Sirawaraporn, W., Prapunwattana, P., Sirawaraporn, R., Yuthavong, Y. and Santi, D.V. (1993) The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression and anti-folate-resistant mutants. J. Biol. Chem. 268, 21637-44.
8. Huennekens, F.M. (1994) The methotrexate story: a paradigm for development of cancer chemotherapeutic agents. Adv. Enzyme-Regul. 34, 397-419.
9. Coderre, J.A., Beverley, S.M., Schimke, R.T. and Santi, D.V. (1983) Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc. Natl. Acad. Sci. USA 80, 2132-6.
10. Thaithong, S., Chan, S.W., Songsomboon, S., Wilairat, P., Seesod, N., Sueblinwong, T., Goman, M., Ridley, R. and Beale, G. (1992) Pyrimethamine resistant mutations in Plasmodium falciparum. Mol. Biochem. Parasitol. 52, 149-57.
11. Tanaka, M., Gu, H.M., Bzik, D.J., Li, W.B. and Inselburg, J. (1990) Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications. Mol. Biochem. Parasitol. 42, 83-91.
12. Zolg, J.W., Plitt, J.R., Chen, G.-X. and Palmer, S. (1989) Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol. Biochem. Parasitol. 36, 253-262.
13. 108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon. Am. J. Trop. Med. Hyg. 45, 492-7.
14. Plowe, C.V., Djimde, A., Bouare, M., Doumbo, O. and Wellems, T.E. (1995) Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am. J. Trop. Med. Hyg. 52, 565-8.
15. Peterson, D.S., Walliker, D. and Wellems, T.E. (1988) Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc. Natl. Acad. Sci. USA 85, 9114-8.
16. Cowman, A.F., Morry, M.J., Biggs, B.A., Cross, G.A. and Foote, S.J. (1988) Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 85, 9109-13.
17. Foote, S.J., Galatis, D. and Cowman, A.F. (1990) Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Proc. Natl. Acad. Sci. USA 87, 3014-7.
18. Peterson, D.S., Milhous, W.K. and Wellems, T.E. (1990) Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc. Natl. Acad. Sci. USA 87, 3018-22.
19. Garrett, C.E., Coderre, J.A., Meek, T.D., Garvey, E.P., Claman, D.M., Beverley, S.M. and Santi, D.V. (1984) A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol. Biochem. Parasitol. 11, 257-65.
20. Sirawaraporn, W., Sirawaraporn, R., Cowman, A.F., Yuthavong, Y. and Santi, D.V. (1990) Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry 29, 10779-85.
21. Hall, S.J., Sims, P.F. and Hyde, J.E. (1991) Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli. Mol. Biochem. Parasitol. 45, 317-30.
22. Lagosky, P.A., Taylor, G.R. and Haynes, R.H. (1987) Molecular characterization of the Saccharomyces cerevisiae dihydrofolate reductase gene (DFR1). Nucleic Acids Res. 15, 10355-10371.
23. Oduola, A.M., Milhous, W.K., Weatherly, N.F., Bowdre, J.H. and Desjardins, R.E. (1988) Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro. Exp. Parasitol. 67, 354-60.
24. Sikorski, R.S. and Hieter, P. (1989) A system or shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
25. Huang, T., Barclay, B.J., Kalman, T.I., VonBorstel, R.C. and Hastings, P.J. (1992) The phenotype of a dihydrofolate reductase mutant in Saccharomyces cerevisiae. Gene 121, 167-171.
26. Zolg, J.W., MacLeod, A.J., Dickson, I.H. and Scaife, J.G. (1982) Plasmodium falciparum: modifications of the in vitro culture conditions improving parasitic yields. J. Parasitol. 68, 1072-1080.
27. Sherman, F., Fink, G.R. and Lawrence, C.W., (1979) Methods in Yeast Genetics, Cold Spring Harbor Press, Cold Spring Harbor, NY.
28. Wooden, J.M., Gould, E.E., Paull, A.T. and Sibley, C.H. (1992) Plasmodium falciparum: a simple polymerase chain reaction method for differentiating strains. Exp. Parasitol. 74, 207-212.
29. Hoffman, C.S. and Winston, F. (1987) A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57, 267-72.
30. Bzik, D.J., Li, W.B., Horii, T. and Inselburg, J. (1987) Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Proc. Natl. Acad. Sci. USA 84, 8360-4.
31. Higuchi, R. (1989) Simple and rapid preparation of samples for PCR, In PCR Technology: Principles and Applications for DNA Amplification (Erlich H., ed.), pp. 31-38. Stockton Press, San Francisco.
32. Saiki, R., Scharf, S., Faloona, F., Mullis, K., Horn, G., Erlich, H. and Arnheim, N. (1985) Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230, 1350-1354.
33. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, NY.
34. Ito, H., Fukuda, Y., Murata, K. and Kimura, A. (1983) Transformation of intact yeat cells treated with alkali cations. J. Bacteriol. 153, 163-168.
35. Genther, C.S., Schoeny, R.S., Loper, J.C. and Smith, C.C. (1977) Antifolate studies. Activities of 40 potential antimalarial compounds against senstitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. J. Med. Chem. 20, 237-243.
36. Knighton, D.R., Kan, C.C., Howland, E., Janson, C.A., Hostomska, Z., Welsh, K.M. and Matthews, D.A. (1994) Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase. Nat. Struct. Biol. 1, 186-94.
37. Pillai, R., Kytle, K., Reyes, A. and Colicelli, J. (1993) Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase. Proc. Natl. Acad. Sci. USA 90, 11970-11974.
38. Nitiss, J.L. (1994) Using yeast to study resistance to topoisomerase II-targeting drugs. Cancer Chemother. Pharmacol. 34, 6-13.
39. Desjardins, R.E., Canfield, C.J., Haynes, J.H. and Chulay, J.D. (1979) Quantitative assessment of anitmalarial activity in vitro by a semiautomatedmicrodilution technique. Antimicrobial Agents and Chemotherapy 16, 710-718.
40. Brooks, D.R., Wang, P., Read, M., Watkins, W.M., Sims, P.F. and Hyde, J.E. (1994) Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur. J. Biochem. 224, 397-405.
41. Tosh, K. and Kilbey, B. (1995) The gene encoding topoisomerase I from the human malaria parasite Plasmodium falciparum. Gene 163, 151-4.
42. Gamage, S.A., Tepsiri, N., Wilairat, P., Wojcik, S.J., Figgitt, D.P., Ralph, R.K. and Denny, W.A. (1994) Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. J. Med. Chem. 37, 1486-94.
43. Edwards, M.L., Stemerick, D.M., Bitonti, A.J., Dumont, J.A., McCann, P.P., Bey, P. and Sjoerdsma, A. (1991) Antimalarial polyamine analogues. J. Med. Chem. 34, 569-74.
44. Hibasami, H., Tsukada, T., Nishiguchi, Y., Sakurai, M., Shirakawa, S. and Nakashima, K. (1994) Remarkable activation of polyamine biosynthesis in hematopoiesis and hyperplasia of spleen in mice with hemolytic anemia caused by infection with Plasmodium berghei. Int. J. Parasitol. 24, 213-7.