Mutagenesis of dihydrofolate reductase from Plasmodium falciparum: Analysis in Saccharomyces cerevisiae of triple mutant alleles resistant to pyrimethamine or WR99210

Molecular and Biochemical Parasitology

Volumn 113, Issue 1, 2001, Pages 139-150

  Ferlan, Jill T ^a   Mookherjee, Somnath ^a   Okezie, Ihuoma Nicole ^a   Fulgence, Lucy ^a   Sibley, Carol Hopkins ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

DHFR; Drug resistance; Malaria

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; FUNGAL PROTEIN; MUTANT PROTEIN; PROTOZOAL PROTEIN; PYRIMETHAMINE;

ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DNA SEQUENCE; DOSE CALCULATION; GENETIC RESISTANCE; IC 50; INFECTION CONTROL; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE;

ALLELES; ANIMALS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; GENETIC COMPLEMENTATION TEST; INHIBITORY CONCENTRATION 50; MUTAGENESIS; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; SACCHAROMYCES CEREVISIAE; TETRAHYDROFOLATE DEHYDROGENASE; TRANSFECTION;

PLASMODIUM FALCIPARUM; SACCHAROMYCES CEREVISIAE;

EID: 0035089646     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(01)00207-9     Document Type: Article

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