Transfection of the human malaria parasite Plasmodium falciparum

International Journal for Parasitology

Volumn 29, Issue 6, 1999, Pages 945-955

  Waterkeyn, J G ^a   Crabb, B S ^b   Cowman, A F ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Gene knock outs; Genome modification; Integration; Plasmodium; Stable transformation; Transfection; Transient transformation

Indexed keywords

ANTIMALARIAL AGENT; CHLORAMPHENICOL ACETYLTRANSFERASE; METHOTREXATE; PLASMID DNA; PLASMID VECTOR; PYRIMETHAMINE; SULFADOXINE;

CONFERENCE PAPER; DNA TRANSFECTION; DRUG RESISTANCE; EPISOME; GENE FUNCTION; GENETIC TRANSFORMATION; HUMAN; KNOCKOUT GENE; MUTATION; NONHUMAN; PLASMODIUM FALCIPARUM; PROMOTER REGION; REGULATOR GENE;

ANIMALS; HUMANS; PLASMIDS; PLASMODIUM FALCIPARUM; TRANSFECTION;

PLASMODIUM FALCIPARUM;

EID: 0032809774     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(99)00047-8     Document Type: Conference Paper

References (34)

1. Wu Y., Sifri C.D., Lei H.H., Su X.Z., Wellems T.E. Transfection of Plasmodium falciparum within human red blood cells. Proc Natl Acad Sci USA. 92:1995;973-977.
2. Wu Y., Kirkman L.A., Wellems T.E. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci USA. 93:1996;1130-1134.
3. Crabb B.S., Cowman A.F. Stable transfection of Plasmodium falciparum blood stages by homologous and non-homologous recombination. Proc Natl Acad Sci USA. 93:1996;7289-7294.
4. van der Wel A.M., Tomás A.M., Kocken C.H.M., Malhotra P., Janse C.J., Waters A.P., Thomas A.W. Transfection of the primate malaria parasite Plasmodium knowlesi using entirely heterologous constructs. J Exp Med. 185:1997;1499-1503.
5. Crabb B.S., Triglia T., Waterkeyn J.G., Cowman A.F. Stable transgene expression in Plasmodium falciparum. Mol Biochem Parasitol. 90:1997;131-144.
6. Wellems T.E., Howard R.J. Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum. Proc Natl Acad Sci USA. 83:1986;6065-6069.
7. Rojas M.O., Wasserman M. Stage-specific expression of the calmodulin gene in Plasmodium falciparum. J Biochem. 118:1995;1118-1123.
8. Horrocks P., Kilbey B.J. Physical and functional mapping of the transcriptional start site of Plasmodium falciparum proliferating cell nuclear antigen. Mol Biochem Parasitol. 82:1996;207-215.
9. Sullivan D.J. Jr., Ayala Y.M., Goldberg D.E. An unexpected 5′ untranslated intron in the P.falciparum genes for histidine-rich proteins II and III. Mol Biochem Parasitol. 83:1996;247-251.
10. Horrocks P, Lanzer M. Mutational analysis identifies a five base pair cis-acting sequence essential for GBP130 promoter activity in Plasmodium falciparum. Mol Biochem Parasitol 1998 (in press).
11. Fidock D.A., Wellems T.E. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci USA. 94:1997;10931-10936.
12. Crabb B.S., Cooke B.M., Reeder J.C.et al. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell. 89:1997;287-296.
13. vandijk M.R., Vinkenoog R., Ramesar J., Vervenne R.A.W., Waters A.P., Janse C.J. Replication, expression and segregation of plasmid-borne DNA in genetically transformed malaria parasites. Mol Biochem Parasitol. 86:1997;155-162.
14. Waters A.P., vandijk M.R., Ramesar J., Janse C.J. Stable transfection of the blood stages of malarial parasites. Ann Trop Med Parasitol. 91:1997;S63-S67.
15. Black M.W., Boothroyd J.C. Development of a stable episomal shuttle vector for Toxoplasma gondii. J Biol Chem. 273:1998;3972-3979.
16. Triglia T., Wang P., Sims P.F.G., Hyde J.E., Cowman A.F. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J. 17:1998;3807-3815.
17. Donald R.G.K., Roos D.S. Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii. Mol Biochem Parasitol. 63:1994;243-253.
18. Vanwye J.D., Haldar K. Expression of green fluorescent protein in Plasmodium falciparum. Mol Biochem Parasitol. 87:1997;225-229.
19. vandijk M.R., Waters A.P., Janse C.J. Stable transfection of malaria parasite blood stages. Science. 268:1995;1358-1362.
20. Thaithong S., Chan S.W., Songsomboon S.et al. Pyrimethamine resistant mutations in Plasmodium falciparum. Mol Biochem Parasitol. 52:1992;149-158.
21. Gardner M.J., Tettelin H., Carucci D.J.et al. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science. 282:1998;1126-1132.
22. Donald R.G.K., Roos D.S. Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria. Proc Natl Acad Sci USA. 90:1993;11703-11707.
23. Huennekens F.M. The methotrexate story: a paradigm for development of cancer. Adv Enzyme Regul. 34:1994;397-419.
24. Cowman A.F., Morry M.J., Biggs B.A., Cross G.A.M., Foote S.J. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA. 85:1988;9109-9113.
25. Peterson D.S., Walliker D., Wellems T.E. Evidence that a point mutation in dyhydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA. 85:1988;9114-9118.
26. Childs G., Lambros C. Analogues of N-benzyloxydihydrotriazines: in vitro antimalarial activity against Plasmodium falciparum. Ann Trop Med Parasitol. 80:1986;177-181.
27. Donald R.G.K., Roos D.S. Insertional mutagenesis and marker rescue in a protozoan parasite: cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii. Proc Natl Acad Sci USA. 92:1995;5749-5753.
28. Donald R.G.K., Carter D., Ullman B., Roos D.S. Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase gene. J Biol Chem. 271:1996;14010-14019.
29. Goonewardene R., Daily J., Kaslow D.et al. Transfection of the malaria parasite and expression of firefly luciferase. Proc Natl Acad Sci USA. 90:1993;5234-5236.
30. Chalfie M., Tu Y., Euskirchen G., Ward W.W., Prasher D.C. Green fluorescent protein as a marker for gene expression. Science. 263:1994;802-805.
31. Hamann L., Buss H., Tannich E. Tetracycline-controlled gene expression in Entamoeba histolytica. Mol Biochem Parasitol. 84:1997;83-91.
32. Ramakrishnan G., Vines R.R., Mann B.J., Petri W.A. Jr. A tetracycline-inducible gene expression system in Entamoeba histolytica. Mol Biochem Parasitol. 84:1997;93-100.
33. Gueiros-Filho F.J., Beverley S.J. Trans-kingdom transposition of the Drosophila element mariner within the protozoan Leishmania. Science. 276:1997;1716-1719.
34. Plasterk R.H. The Tcl/marcher transposon family. Curr Top Microbiol Immunol. 204:1996;125-143.