Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

Science

Volumn 295, Issue 5557, 2002, Pages 1086-1089

  Gadek, T R ^a   Burdick, D J ^a   McDowell, R S ^a   Stanley, M S ^a   Marsters, Jr ^a   Paris, K J ^a   Oare, D A ^a   Reynolds, M E ^a   Ladner, C ^a   Zioncheck, K A ^a   Lee, W P ^a   Gribling, P ^a   Dennis, M S ^a   Skelton, N J ^a   Tumas, D B ^a   Clark, K R ^a   Keating, S M ^a   Beresini, M H ^a   Tilley, J W ^a   Presta, L G ^a   Bodary, S C ^a   more..

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGENS; IMMUNOLOGY; PHARMACOKINETICS;

IMMUNE SYSTEM FUNCTIONS;

PROTEINS;

EPITOPE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

IMMUNE SYSTEM; PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; EXTRAVASATION; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MIXED LYMPHOCYTE CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-ALANINE; CYCLOSPORINE; DERMATITIS, IRRITANT; DINITROFLUOROBENZENE; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOSUPPRESSIVE AGENTS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, INBRED BALB C; MOLECULAR MIMICRY; MUTAGENESIS; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 18244370299     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.295.5557.1086     Document Type: Article

References (30)