cDNA cloning and chromosome mapping of the human Fe65 gene: Interaction of the conserved cytoplasmic domains of the human β-amyloid precursor protein and its homologues with the mouse Fe65 protein

Human Molecular Genetics

Volumn 5, Issue 10, 1996, Pages 1589-1598

  Bressler, Steven L ^a   Gray, Matthew D ^a   Sopher, Bryce L ^a   Hu, Qubai ^a   Hearn, Mark G ^a   Pham, Dao G ^a   Dinulos, Mary Beth ^a   Fukuchi, Ken Ichiro ^b   Sisodia, Sangram S ^c   Miller, Margaret A ^a   Disteche, Christine M ^a   Martin, George M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA; HYBRID PROTEIN; PHOSPHOTYROSINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BRAIN; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 11P; CHROMOSOME MAP; CONTROLLED STUDY; DNA LIBRARY; EMBRYO; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MAPPING; HUMAN; HUMAN TISSUE; METAPHASE CHROMOSOME; MOLECULAR CLONING; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; RNA ANALYSIS;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CHROMOSOME BANDING; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA, COMPLEMENTARY; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RATS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 10144251747     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Goate, A.M., Chartier-Harlin, M.C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Rogers, P., Talbot, C., Perica, K., Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M. and Hardy, J. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706.
2. Mullan, M., Crawford, F., Houlden, H., Axelman, K., Lilius, L., Winblad, B. and Lannfelt, L. (1992) A pathogenic mutation for probably Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet. 1, 345-347.
3. Carter, D.A., Desmarais, E., Bellis, M., Campion, D., Clerget-Darpoux, F., Brice, A., Agid, Y., Jaillard-Serradt, A. and Mallet, J. (1992) More missence in amyloid gene. (Letter) Nature Genet. 2, 255-256.
4. Haass, C. and Selkoe, D.J. (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75, 1039-104.
5. Cai, X.-D., Golde, T.E. and Younkin, S.G. (1993) Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259, 514-516.
6. Zhao, B., Sisodia, S.S. and Kusiak, J.W. (1995) Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells. J. Neurosci. Res. 40, 261-268.
7. Gravina, S.A., Ho, L., Eckman, C.B., Long, K.E., Otvos, L., Jr., Younkin, L.H., Suzuki, N. and Younkin, S.G. (1995) Amyloid β protein in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ 40 or Aβ 42(43). J. Biol. Chem. 270, 7013-7016.
8. Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., Kanazawa, I. and Mori, H. (1994) APP717 missense mutation affects the ratio of amyloid β protein species (Aβ1-42/43 and Aβ1-40) in familial Alzheimer's disease brain. J. Biol. Chem. 269, 32721-32724.
9. Levy-Lahad, E., Wasco, W., Poorkay, P., Romano, D.M., Oshima, J., Pettingell, W.H., Yu, C.-E., Jondro, P.D., Schmidt, S.D., Wang, K., Crowley, A.C., Fu, Y.-H., Guenette, S.Y., Gales, D., Nemens, E.M., Wijsman, E.M., Bird, T.D., Schellenberg, G.D. and Tanzi, R.E. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
10. Rogaev, E.I., Sherrington, R., Rogaeva, E.A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C. Holman, K. Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, I., Cohen., D., Lannfelt, L., Fraser, P.E., Rommens, J.H. and St.-George-Hyslop, P.H. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 75-78.
11. Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.-F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Da Silva, H.A.R., Haines, J.L., Pericak-Vance, M.A., Tanzi, R.E., Roses, A.D. Fraser, P.E., Rommens, J.M., St. George-Hyslop, P.H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
12. Querfurth, H.W., Wijsman, E.M., St. George-Hyslop, P.H. and Selkoe, D.J. (1995) Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Res. Mol. Brain Res. 28, 319-337.
13. Lampe, T.H., Bird, T.D., Nochlin, D., Nemens, E., Risse, S.C., Sumi, S.M., Koerker, R., Leaird, B., Wier, M. and Raskind, M.A. (1994) Phenotype of chromosome 14-linked familial Alzheimer's disease in a large kindred. Ann. Neurol. 36, 368-378.
14. Kang, J. Lemaire, H.G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.H., Multhaup, G., Beyreuther, K. and Muller-Hill, B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
15. Tanzi, R.E., Gusella, J.F., Watkins, P.C., Brunz, G.A.P., St.-George-Hyslop, P.H., Van Keuren, M.L., Patterson, D., Pagan, S., Kurnit, D.M., and Neve, R.L. (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880-884.
16. Goldgaber, D., Lerman, M.I., McBride, O.W., Saffiotti, U. and Gajdusek, D.C. (1987) Characterization and chromosomal localization of cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
17. Allsop, D. and Williams, C.H. (1994) Amyloidosis in Alzheimer's disease. Biochem. Neurodegen. Dis. 22, 171-175.
18. Fukuchi, K.-I., Kamino, K., Deeb, S.S., Smith, A.C., Dang, T. and Martin, G.M. (1992) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Res. Comm. 182, 165-173.
19. Duilio, A., Zambano, M., Mogavero, A.R., Ammendola, R., Cimino, F. and Russo, T. (1991) A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases. Nucleic Acids Res. 19, 5269-5274.
20. Bork P. and Margolis, B. (1995) A phosphotyrosine interaction domain. Cell 80, 693-694.
21. Bork, P. and Sudol, M. (1994) The WW domain: a signalling site in dystrophin? Trends Biochem. Sci. 19, 531-533.
22. Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A. and Russo, T. (1995) The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270, 30853-30856.
23. Blaikie, P., Immanuel, D., Wu, J., Li, N., Yajnik, V. and Margolis, B. (1994) A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J. Biol. Chem. 269, 32031-32034.
24. Batzer, A.G., Blaikie, P., Nelson, K., Schlessinger, J. and Margolis, B. (1995) The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor. Mol. Cell. Biol. 15, 4403-4409.
25. Chen, W.-J., Goldstein, J.L. and Brown, M.S. (1990) NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265, 3116-3123.
26. Koo, E.H. and Squazzo, S.L. (1994) Evidence that production and release of amyloid β-protein involves the endocytic pathway. J.Biol. Chem. 269, 17386-17389.
27. Lai, A., Sisodia, S.S. and Trowbridge, I.S. (1995) Characterization of sorting signals in the β-amyloid precursor protein cytoplasmic domain. J. Biol. Chem. 270, 5363-3573.
28. Wasco, W., Bupp, K., Magendantz, M., Gusella, J.F., Tanzi, R.E. and Solomon, F. (1992) Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid β protein precursor. Proc. Natl. Acad. Sci. USA 89, 10758-10762.
29. Slunt, H.H., Thinakaran, G., von Koch, C., Lo, A.C.Y., Tanzi, R.E. and Sisodia, S.S. (1994) Expression of a ubiquitous, cross-reactive homologue of the mouse β-amyloid precursor protein (APP). J. Biol. Chem. 269, 2637-2644.
30. Faraonio, R. Minopoli, G., Porcellini, A., Costanzo, F., Cimino, F. and Russo, T. (1994) The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription. Nucleic Acids Res. 22, 4876-4883.
31. Simeone, A., Duilio, A., Fiore, F., Acampora, D., Felise, C.D., Faraonio, R., Palocci, F., Cimino, F. and Russo, T. (1994) Expression of the neuron specific Fe65 gene marks the development of embryo ganglionic derivatives. Dev. Neurosci. 16, 53-60.
32. Price, J.L., Davis, P.B., Morris, J.C. and White, D.L. (1991) The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol. Aging 12, 295-312.
33. Giannakopoulos, P., Hof, P.R., Vallet, P.G., Giannakopoulos, A.-S., Charnay, Y. and Bouras, C. (1995) Quantitative analysis of neuropathologic changes in the cerebral cortex of centenarians. Prog. Neuro-Psychopharmacol. & Biol. Psychiatry 19, 577-592.
34. Guenette, S.Y., Chen, J., Jondro, P.D. and Tanzi, R.E. (1996) Association of a novel human Fe65-like protein with the cytoplasmic domain of the β-amyloid precursor protein. Proc. Natl Acad. Sci. USA, In press.
35. Chen, H.I. and Sudol, M. (1995) The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Proc. Natl Acad. Sci. USA 92, 7819-7823.
36. Haass, C., Koo, E., Mellon, E., Hung, A.Y. and Selkoe, D.J. (1992) Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
37. Nordstedt, C., Caporaso, G., Thyberg, J., Gandy, S. and Greengard, P. (1993) Identification of the Alzheimer b/A4 amyloid precursor protein in clathrin coated vesicles purified from PC12 cells. J. Biol.Chem. 268, 608-612.
38. Schindler, C. and Darnell, J.E. (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64, 621-651.
39. Ihle, J.N. (1996) STATs: signal transducers and activators of transcription. Cell 84, 331-334.
40. Chien, C.T., Bartel, P.L., Sternglanz, R. and Fields, S. (1995) The two hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA 88, 9578-9582.
41. Vojtek, A.B., Hollenberg, S.M. and Cooper, J.A. (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205-214.
42. Breeden, L. and Nasmyth K. (1985) Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol. 50, 643-650.
43. Saiki, R.K., Scharf, S., Faloona, F., Mullis, K.B., Horn, G.T., Erlich, H.A. and Arnheim, N. (1985) Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230, 1350-1354
44. Sanger, F., Nicklen, S. and Coulson, A.R. (1977) DNA sequencing with chain terminating inhibitors. Proc. Natl Acad. Sci. USA 74, 5463-5467.
45. Smith, B. and Johnson, K.S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67, 31-40.
46. Schagger, H. and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166, 368-379.
47. Church, G. and Gilbert, W. (1984) Genomic sequencing. Proc. Natl Acad. Sci. USA 81, 1991-1995.
48. Miller, M.A., Kolb, P.E. and Raskind, M.A. (1993) A method for simultaneous detection of multiple mRNAs using digoxigenin and radioisotopic cRNA probes. J. Histochem. Cytochem. 41, 1741-1750.
49. Villacres, E.C., Kia, Z., Bookbinder, L.H., Edelhoff, S., Disteche, C.M. and Storm, D.R. (1993) Cloning, chromosomal mapping and expression of human fetal brain Type I adenylyl cyclase. Genomics 16, 473-478.
50. Edelhoff, S., Ayer, D.E., Zervos, A.S., Steingrimsson, E., Jenkins, N.A., Copeland, N.G., Eisenman, R.N., Brent, R. and Disteche, C.M. (1994) Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI to human chromosome 10 and mouse chromosome 19. Oncogene 9, 665-668.