Neuropeptide Y: The universal soldier

Cellular and Molecular Life Sciences

Volumn 60, Issue 2, 2003, Pages 350-377

  Pedrazzini, T ^a   Pralong, F ^a   Grouzmann, E ^a  

^a University of Lausanne Medical Center   (Switzerland)

Author keywords

Heart failure; Hypertension; Leptin; Metabolic disorders; Obesity; Receptor

Indexed keywords

NEUROPEPTIDE FF; NEUROPEPTIDE FF RECEPTOR; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y3 RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; NEUROPEPTIDE Y6 RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RESPONSE; CATECHOLAMINE RELEASE; CHROMAFFIN CELL; ENERGY BALANCE; FOOD INTAKE; HEART FAILURE; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; HYPOTHALAMUS; METABOLIC DISORDER; NEUROENDOCRINE SYSTEM; NONHUMAN; OBESITY; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; APPETITE STIMULANTS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; FORECASTING; HUMANS; HYPOTHALAMUS; MODELS, BIOLOGICAL; NEUROPEPTIDE Y; NEUROSECRETORY SYSTEMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NEUROPEPTIDE Y; SIGNAL TRANSDUCTION;

EID: 0345268794     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180300029     Document Type: Review

References (362)

1. Groop L. (2000) Genetics of the metabolic syndrome. Br. J. Nutr. 83 Suppl. 1: S39-S48
2. Good D. J. (2000) How tight are your genes? Transcriptional and posttranscriptional regulation of the leptin receptor, NPY and POMC genes. Horm.Behav. 37: 284-298
3. Bjorntorp P. and Rosmond R. (2000) Neuroendocrine abnormalities in visceral obesity. Int. J. Obes. Relat. Metab. Disord. 24 Suppl. 2: S80-S85
4. Tatemoto K., Carlquist M. and Mutt V. (1982) Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296: 659-660
5. Ekblad E., Edvinsson L., Wahlestedt C., Uddman R., Hakanson R., and Sundler F. (1984) Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regul. Pept. 8: 225-235
6. Tatemoto K. (1982) Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA 79: 2514-2518
7. Larhammar D. (1996) Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 62: 1-11
8. Schwartz T. W., Fuhlendorff J., Kjems L. L., Kristensen M. S., Vervelde M., O'Hare M. et al. (1990) Signal epitopes in the three-dimensional structure of neuropeptide Y. Interaction with Y1, Y2, and pancreatic polypeptide receptors. Ann. N.Y. Acad. Sci. 611: 35-47
9. Minth C. D., Bloom S. R., Polak J. M. and Dixon J. E. (1984) Cloning, characterization and DNA sequence of a human cDNA encoding neuropeptide tyrosine. Proc. Natl. Acad. Sci. USA 81: 4577-4581
10. Higuchi H., Yang H. Y. and Sabol S. L. (1988) Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution and regulation by glucocorticoids, cyclic AMP and phorbol ester. J. Biol. Chem. 263: 6288-6295
11. Brakch N., Rist B., Beck-Sickinger A. G., Goenaga J., Wittek R., Burger E. et al. (1997). Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations. Biochem 36: 16309-16320
12. Hopsu-Havu V. K. and Glenner G. G. (1966) A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide. Histochemie 7: 197-201
13. Grandt D., Dahms P., Schimiczek M., Eysselein V. E., Reeve J. R. Jr and Mentlein R. (1993) [Proteolytic processing by dipeptidyl aminopeptidase IV generates receptor selectivity for peptide YY (PYY)]. Med. Klin. 88: 143-145
14. Stange T., Kettmann U. and Holzhausen H. J. (1996) Immunoelectron microscopic single and double labelling of aminopeptidase N (CD 13) and dipeptidyl peptidase IV (CD 26). Acta Histochem. 98: 323-331
15. Shibuya-Saruta H., Kasahara Y. and Hashimoto Y. (1996) Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties. J. Clin. Lab Anal. 10: 435-440
16. Yaron A. and Mlynar D. (1968) Aminopeptidase-P. Biochem. Biophys. Res. Commun. 32: 658-663
17. Medeiros M. D. and Turner A. J. (1994) Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P and endopeptidase-24.11. Endocrinology 134: 2088-2094
18. Ryan J. W., Denslow N. D., Greenwald J. A. and Rogoff M. A. (1994) Immunoaffinity purifications of aminopeptidase P from guinea pig lungs, kidney and serum. Biochem. Biophys. Res. Commun. 205: 1796-1802
19. Mentlein R., von Kolszynski M., Sprang R. and Lucius R. (1990) Proline-specific proteases in cultivated neuronal and glial cells. Brain Res. 527: 159-162
20. Medeiros M. S. and Turner A. J. (1996) Metabolism and functions of neuropeptide Y. Neurochem. Res. 21: 1125-1132
21. Allen J. M., Yeats J. C., Adrian T. E. and Bloom S. R. (1984) Radioimmunoassay of neuropeptide Y. Regul. Pept. 8: 61-70
22. Corder R. and Lowry P. J. (1985). An immunoradiometric assay for the measurement of neuropeptide Y in plasma. Peptides 6: 1195-1200
23. Lundberg J. M., Martinsson A., Hemsen A., Theodorsson-Norheim E., Svedenhag J., Ekblom B. et al. (1985) Co-release of neuropeptide Y and catecholamines during physical exercise in man. Biochem. Biophys. Res. Commun. 133: 30-36
24. Theodorsson-Norheim E., Hemsen A. and Lundberg J. M. (1985) Radioimmunoassay for neuropeptide Y (NPY): chromatographic characterization of immunoreactivity in plasma and tissue extracts. Scand. J. Clin. Lab. Invest. 45: 355-365
25. Grouzmann E., Comoy E. and Bohuon C. (1989) Plasma neuropeptide Y concentrations in patients with neuroendocrine rumors. J. Clin. Endocrinol. Metab. 68: 808-813
26. Grouzmann E., Aubert J. F., Waeber B. and Brunner H. R. (1992) A sensitive and specific two-site, sandwich-amplified enzyme immunoassay for neuropeptide Y. Peptides 13: 1049-1054
27. Wahlestedt C., Grundemar L., Hakanson R., Heilig M., Shen G. H., Zukowska-Grojec Z. et al. (1990) Neuropeptide Y receptor subtypes, Y1 and Y2. Ann. N.Y. Acad. Sci. 611: 7-26
28. Wahlestedt C., Yanaihara N. and Hakanson R. (1986) Evience for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13: 307-318
29. Fuhlendorff J., Gether U., Aakerlund L., Langeland-Johansen N., Thogersen H., Melberg S. G. et al. (1990) [Leu31,Pro34] Neuropeptide Y: a specific Y1 receptor agonist. Proc. Natl. Acad. Sci. USA 87: 182-186
30. Blomqvist A. and Herzog H. (1997) Y-receptor subtypes - how many more? Trends Neurosci. 20: 294-298
31. Gehlert D. R. (1998) Multiple receptors for the pancreatic polypeptide (PP-fold) family: physiological implications. Proc. Soc. Exp. Biol. Med. 218: 7-22
32. Larhammar D., Wraith A., Berglund M. M., Holmberg S. K. and Lundell I. (2001) Origins of the many NPY-family receptors in mammals. Peptides 22: 295-307
33. Wraith A., Tornsten A., Chardon P., Harbitz I., Chowdhary B. P., Andersson L. et al. (2000) Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome Res. 10: 302-310
34. Eva C., Keinänen K., Monyer H., Seeburg P. and Sprengel R. (1992) Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Lett 271: 81-84
35. Eva C., Oberto A., Sprengel R. and Genazzani E. (1992) The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett. 314: 285-288
36. Ball H. J., Shine J. and Herzog H. (1995) Multiple promoters regulate tissue-specific expression of the human NPY-Y1 receptor gene. J. Biol. Chem. 270: 27272-27276
37. Aakerlund L., Gether U., Fuhlendorff J., Schwartz T. W. and Thastrup O. (1990) Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase. FEBS Lett. 260: 73-78
38. Motulsky H. J. and Michel M. C. (1988) Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells. Am. J. Physiol. 255: E880-E885
39. Krause J., Eva C., Seeburg P. and Sprengel R. (1992) Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol. Pharmacol. 41: 817-821
40. Mullins D., Kirby D., Hwa J., Guzzi M., Rivier J. and Parker E. (2001) Identification of potent and selective neuropeptide YY(1) receptor agonists with orexigenic activity in vivo. Mol. Pharmacol. 60: 534-540
41. Soll R. M., Dinger M. C., Lundell I., Larhammer D. and Beck-Sickinger A. G. (2001) Novel analogues of neuropeptide Y with a preference for the Y1-receptor. Eur. J. Biochem. 268: 2828-2837
42. Lundberg J. M. and Tatemoto K. (1982) Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to alpha-adrenoceptor blockade. Acta Physiol. Scand. 116: 393-402
43. Rudolf K., Eberlein W., Engel W., Wieland H. A., Willim K. D., Entzeroth M., Wienen W. et al. (1994) The first highly potent and selective non-peptide neuropeptide YY1 receptor antagonist: BIBP3226. Eur. J. Pharmacol. 271: R11-R13
44. Cervin A., Lindberg S., Mercke U. and Uddman R. (1992) Neuropeptide Y in the rabbit maxillary sinus modulates cholinergic acceleration of mucociliary activity. Acta Otolaryngol. 112: 872-881
45. Lundberg J. M. and Modin A. (1995) Inhibition of sympathetic vasoconstriction in pigs in vivo by the neuropeptide Y-Y1 receptor antagonist BIBP 3226. Br. J. Pharmacol. 116: 2971-2982
46. Zukowska-Grojec Z., Dayao E. K., Karwatowska-Prokopczuk E., Hauser G. J. and Doods H. N. (1996) Stress-induced mesenteric vasoconstriction in rats is mediated by neuropeptide YY1 receptors. Am. J. Physiol. 270: H796-H800
47. Mezzano V., Donoso V., Capurro D. and Huidobro-Toro J. P. (1998) Increased neuropeptide Y pressor activity in Goldblatt hypertensive rats: in vivo studies with BIBP 3226. Peptides 19: 1227-1232
48. Wieland H. A., Engel W., Eberlein W., Rudolf K. and Doods H. N. (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br. J. Pharmacol. 125: 549-555
49. Leban J. J., Heyer D., Landavazo A., Matthews J., Aulabaugh A. and Daniels A. J. (1995) Novel modified carboxy terminal fragments of neuropeptide Y with high affinity for Y2-type receptors and potent functional antagonism at a Y1-type receptor. J. Med. Chem. 38: 1150-1157
50. Gehlert D. R., Schober D. A., Beavers L., Gadski R., Hoffman J. A., Smiley D. L. et al. (1996) Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor. Mol. Pharmacol. 50: 112-118
51. Serradeil-Le Gal C., Valette G., Rouby P. E., Pellet A., Oury-Donat F., Brossard G. et al. (1995) SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist. FEBS Lett. 362: 192-196
52. Kanatani A., Hata M., Mashiko S., Ishihara A., Okamoto O., Haga Y. et al. (2001) A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol. Pharmacol. 59: 501-505
53. Gerald C., Walker M. W., Vaysse P. J., He C., Branchek T. A. and Weinshank R. L. (1995) Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem. 270: 26758-26761
54. Lutz C. M., Frankel W. N., Richards J. E. and Thompson D. A. (1997) Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8. Genomics 41: 498-500
55. Gehlert D. R., Beavers L. S., Johnson D., Gackenheimer S. L., Schober D. A. and Gadski R. A. (1996) Expression cloning of a human brain neuropeptide YY2 receptor. Mol. Pharmacol. 49: 224-228
56. Zhang X., Shi T., Holmberg K., Landry M., Huang W., Xiao H. et al. (1997) Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. Proc. Natl. Acad. Sci. USA 94: 729-734
57. Wieland H. A., Willim K. and Doods H. N. (1995) Receptor binding profiles of NPY analogues and fragments in different tissues and cell lines. Peptides 16: 1389-1394
58. Beck-Sickinger A. G., Grouzmann E., Hoffmann E., Gaida W., van Mei E. G., Waeber B. et al. (1992) A novel cyclic analog of neuropeptide Y specific for the Y2 receptor. Eur. J. Biochem. 206: 957-964
59. Goumain M., Voisin T., Lorinet A. M., Ducroc R., Tsocas A., Roze C. et al. (2001) The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. Mol. Pharmacol. 60: 124-134
60. Lacroix J. S., Ulman L. G. and Potter E. K. (1994) Modulation by neuropeptide Y of parasympathetic nerve-evoked nasal vasodilatation via Y2 prejunctional receptor. Br. J. Pharmacol. 113: 479-484
61. Mahns D. A., Lacroix J. S. and Potter E. K. (1998) Inhibition of vagal vasodilatation by a selective neuropeptide Y Y2 receptor agonist in the bronchial circulation of anaesthetised dogs. J.Auton. Nerv. Syst. 73: 80-85
62. Grouzmann E., Buclin T., Martire M., Cannizzaro C., Dorner B., Razaname A. et al. (1997) Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist. J. Biol. Chem. 272: 7699-7706
63. Dumont Y., Cadieux A., Doods H., Pheng L. H., Abounader R., Hamel E. et al. (2000) BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. Br. J. Pharmacol. 129: 1075-1088
64. Voisin T., Goumain M., Lorinet A. M., Maoret J. J. and Laburthe M. (2000) Functional and molecular properties of the human recombinant Y4 receptor: resistance to agonist-promoted desensitization. J. Pharmacol. Exp. Ther. 292: 638-646
65. Bard J. A., Walker M. W., Branchek T. A. and Weinshank R. L. (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem. 270: 26762-26765
66. Lundell I., Statnick M. A., Johnson D., Schober D. A., Starback P., Gehlert D. R. et al. (1996) The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Proc. Natl. Acad. Sci. USA 93: 5111-5115
67. Gerald C., Walker M. W., Criscione L., Gustafson E. L., Batzl-Hartmann C., Smith K. E. et al. (1996) A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382: 168-171
68. Inui A. (1999). Neuropeptide Y feeding receptors: are multiple subtypes involved? Trends Pharmacol. Sci. 20: 43-46
69. Bischoff A. and Michel M. C. (1999) Emerging functions for neuropeptide Y5 receptors. Trends Pharmacol. Sci. 20: 104-106
70. Naveilhan P., Neveu I., Arenas E. and Ernfors P. (1998) Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system. Neurosci. 87: 289-302
71. Dumont Y., Fournier A. and Quirion R. (1998) Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J. Neurosci. 18: 5565-5574
72. Dumont Y., Jacques D., Bouchard P. and Quirion R. (1998) Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4 and Y5 receptors in rodents, guinea pig and primate brains. J. Comp. Neurol. 402: 372-384
73. Balasubramaniam A., Sheriff S., Johnson M. E., Prabhakaran M., Huang Y., Fischer J. E. et al. (1994) [D-TRP32]neuropeptide Y: a competitive antagonist of NPY in rat hypothalamus. J. Med. Chem. 37: 811-815
74. Hwa J. J., Witten M. B., Williams P., Ghibaudi L., Gao J., Salisbury B. G. et al. (1999) Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Am. J. Physiol. 277: R1428-R1434
75. Haynes A. C., Arch J. R., Wilson S., McClue S. and Buckingham R. E. (1998) Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor? Regul. Pept. 75-76: 355-361
76. Cabrele C., Langer M., Bader R., Wieland H. A., Doods H. N., Zerbe O. et al. (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J. Biol. Chem. 275: 36043-36048
77. Criscione L., Rigollier P., Batzl-Hartmann C., Rueger H., Stricker-Krongrad A., Wyss P. et al. (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest. 102: 2136-2145
78. Della Zuana O., Sadlo M., Germain M., Feletou M., Chamorro S., Tisserand F. et al. (2001) Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade. Int. J. Obes. Relat. Metab. Disord. 25: 84-94
79. Kanatani A., Ishihara A., Iwaasa H., Nakamura K., Okamoto O., Hidaka M. et al. (2000) L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys. Res. Commun. 272: 169-173
80. Gregor P., Feng Y., DeCarr L. B., Cornfield L. J. and McCaleb M. L. (1996) Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. J. Biol. Chem. 271: 27776-27781
81. Weinberg D. H., Sirinathsinghji D. J., Tan C. P., Shiao L. L., Morin N., Rigby M. R. et al. (1996) Cloning and expression of a novel neuropeptide Y receptor. J. Biol. Chem. 271: 16435-16438
82. Matsumoto M., Nomura T., Momose K., Ikeda Y., Kondou Y., Akiho H. et al. (1996) Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J. Biol. Chem. 271: 27217-27220
83. Starback P., Wraith A., Eriksson H. and Larhammar D. (2000) Neuropeptide Y receptor gene y6: multiple deaths or resurrections? Biochem. Biophys. Res. Commun. 277: 264-269
84. Lee C. C. and Miller R. J. (1998) Is there really an NPY Y3 receptor? Regul. Pept. 75-76: 71-78
85. Wahlestedt C., Regunathan S. and Reis D. J. (1992) Identification of cultured cells selectively expressing Y1-, Y2- or Y3-type receptors for neuropeptide Y/peptide YY. Life Sci. 50: L7-12
86. Higuchi H., Costa E. and Yang H. Y. (1988) Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells. J. Pharmacol. Exp. Ther. 244: 468-474
87. Norenberg W., Bek M., Limberger N., Takeda K. and Illes P. (1995) Inhibition of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells by Y3-type neuropeptide Y receptors via the adenylate cyclase/protein kinase A system. Naunyn Schmiedebergs Arch. Pharmacol. 351: 337-347
88. Foucart S., Bleakman D., Bindokas V. P. and Miller R. J. (1993) Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia. J. Pharmacol. Exp. Ther. 265: 903-909
89. Grundemar L., Wahlestedt C. and Reis D. J. (1991) Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem J. Pharmacol. Exp. Ther. 258: 633-638
90. Balasubramaniam A., Sheriff S., Rigel D. F. and Fischer J. E. (1990) Characterization of neuropeptide Y binding sites in rat cardiac ventricular membranes. Peptides 11: 545-550
91. Dumont Y., Satoh H., Cadieux A., Taoudi-Benchekroun M., Pheng L. H., St Pierre S. et al. (1993) Evaluation of truncated neuropeptide Y analogues with modifications of the tyrosine residue in position 1 on Y1, Y2 and Y3 receptor sub-types. Eur. J. Pharmacol. 238: 37-45
92. Jacques D., Cadieux A., Dumont Y. and Quirion R. (1995) Apparent affinity and potency of BIBP3226, a non-peptide neuropeptide Y receptor antagonist, on purported neuropeptide Y Y1, Y2 and Y3 receptors. Eur. J. Pharmacol. 278: R3-R5
93. McCullough L. A. and Westfall T. C. (1996) Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases. J. Neurochem. 67: 1090-1099
94. Cavadas C., Silva A. P., Mosimann F., Cotrim M. D., Ribeiro C. A., Brunner H. R. et al. (2001) NPY regulates catecholamine secretion from human adrenal chromaffin cells. J. Clin. Endocrinol. Metab. 86: 5956-5963
95. Bonini J. A., Jones K. A., Adham N., Forray C., Artymyshyn R., Durkin M. et al. (2000) Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J. Biol. Chem. 275: 39324-39331
96. Mollereau C., Gouarderes C., Dumont Y., Kotani M., Detheux M., Doods H. et al. (2001) Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br. J. Pharmacol. 133: 1-4
97. Kassis S., Olasmaa M., Terenius L. and Fishman P. H. (1987) Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein. J. Biol. Chem. 262: 3429-3431
98. Westlind-Danielsson A., Unden A., Abens J., Andell S. and Bartfai T. (1987) Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex. Neurosci. Lett. 74: 237-242
99. Reynolds E. E. and Yokota S. (1988) Neuropeptide Y receptor-effector coupling mechanisms in cultured vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 151: 919-925
100. Shigeri Y., Nakajima S. and Fujimoto M. (1995) Neuropeptide Y Y1 receptors-mediated increase in intracellular Ca2+ concentration via phospholipase C-dependent pathway in porcine aortic smooth muscle cells. J. Biochem. 118: 515-520
101. Lobaugh L. A. and Blackshear P. J. (1990) Neuropeptide Y stimulation of myosin light chain phosphorylation in cultured aortic smooth muscle cells. J. Biol. Chem. 265: 18393-18399
102. Herzog H., Hort Y. J., Ball H. J., Hayes G., Shine J. and Selbie L. A. (1992) Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. USA 89: 5794-5798
103. Nie M. and Selbie L. A. (1998) Neuropeptide Y Y1 and Y2 receptor-mediated stimulation of mitogen-activated protein kinase activity. Regul. Pept. 75-76: 207-213
104. Mannon P. J. and Mele J. M. (2000) Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptor. Biochem. J. 350 Pt 3: 655-661
105. Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H. et al. (1995) Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure and functional expression of the receptors. J. Biol. Chem. 270: 30102-30110
106. Keffel S., Schmidt M., Bischoff A. and Michel M. C. (1999) Neuropeptide-Y stimulation of extracellular signal-regulated kinases in human erythroleukemia cells. J. Pharmacol. Exp. Ther. 291: 1172-1178
107. Bleakman D., Colmers W. F., Fournier A. and Miller R. J. (1991) Neuropeptide Y inhibits Ca2+ influx into cultured dorsal root ganglion neurones of the rat via a Y2 receptor. Br. J. Pharmacol. 103: 1781-1789
108. Lynch J. W., Lemos V. S., Bucher B., Stoclet J. C. and Takeda K. (1994) A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line. J. Biol. Chem. 269: 8226-8233
109. Freitag C., Svendsen A. B., Feldthus N., Lossl K. and Sheikh S. P. (1995) Coupling of the human Y2 receptor for neuropeptide Y and peptide YY to guanine nucleotide inhibitory proteins in permeabilized SMS-KAN cells. J. Neurochem. 64: 643-650
110. Shigeri Y. and Fujimoto M. (1994) Y2 receptors for neuropeptide Y are coupled to three intracellular signal transduction pathways in a human neuroblastoma cell line. J. Biol. Chem. 269: 8842-8848
111. Nakamura M., Aoki Y, and Hirano D. (1996) Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim. Biophys. Acta 1284: 134-137
112. Grouzmann E., Meyer C., Burki E. and Brunner H. (2001) Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319. Peptides 22: 379-386
113. Wong L. B., Park C. L. and Yeates D. B. (1998) Neuropeptide Y inhibits ciliary beat frequency in human ciliated cells via nPKC, independently of PKA. Am. J. Physiol. 275: C440-C448
114. Walker M. W., Smith K. E., Bard J., Vaysse P. J., Gerald C., Daouti S. et al. (1997) A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide. Peptides 18: 609-612
115. Sun L. and Miller R. J. (1999) Multiple neuropeptide Y receptors regulate K+ and Ca2+ channels in acutely isolated neurons from the rat arcuate nucleus. J. Neurophysiol. 81: 1391-1403
116. Sun L., Philipson L. H. and Miller R. J. (1998) Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors. J. Pharmacol. Exp. Ther. 284: 625-632
117. Bischoff A., Puttmann K., Kotting A., Moser C., Buschauer A. and Michel M. C. (2001) Limited signal transduction repertoire of human Y(5) neuropeptide Y receptors expressed in HEC-1B cells. Peptides 22: 387-394
118. Pellieux C., Sauthier T., Domenighetti A., Marsh D. J., Palmiter R. D., Brunner H. R. et al. (2000) Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors. Proc. Natl. Acad. Sci. USA 97: 1595-1600
119. Haynes J. M., Selbie L. A. and Hill S. J. (1999) Gi-Protein alpha-subunit mRNA antisense oligonucleotide inhibition of Gi-coupled receptor contractile activity in the epididymis of the guinea-pig. Br. J. Pharmacol. 127: 85-90
120. Selbie L. A., King N. V., Dickenson J. M. and Hill S. J. (1997) Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors. Biochem. J. 328 (Pt 1): 153-158
121. Selbie L. A. and Hill S. J. (1998). G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol. Sci. 19: 87-93
122. Selbie L. A., Darby K., Schmitz-Peiffer C., Browne C. L., Herzog H., Shine J. et al. (1995) Synergistic interaction of Y1-neuropeptide Y and alpha 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C, and arachidonic acid production. J. Biol. Chem. 270: 11789-11796
123. Morris M. J., Russell A. E., Kapoor V., Cain M. D., Elliott J. M., West M. J. et al. (1986) Increases in plasma neuropeptide Y concentrations during sympathetic activation in man. J. Auton. Nerv. Syst. 17: 143-149
124. Morris M. J., Elliott J. M., Cain M. D., Kapoor V., West M. J. and Chalmers J. P. (1986) Plasma neuropeptide y levels rise in patients undergoing exercise tests for the investigation of chest pain. Clin. Exp. Pharmacol. Physiol. 13: 437-440
125. Russell A. E., Cain M. D., Kapoor V., Morris M. J. and Chalmers J. P. (1989) Neuropeptide Y-like immunoreactivity of plasma during hypoglycaemia in man. J. Auton. Nerv. Syst. 26: 85-88
126. Kaijser L., Pernow J., Berglund B. and Lundberg J. M. (1990) Neuropeptide Y is released together with noradrenaline from the human heart during exercise and hypoxia. Clin. Physiol. 10: 179-188
127. Solt V. B., Brown M. R., Kennedy B., Kolterman O. G. and Ziegler M. G. (1990) Elevated insulin, norepinephrine and neuropeptide Y in hypertension. Am. J. Hypertens. 3: 823-828
128. Chalmers J., Morris M., Kapoor V., Cain M., Elliott J., Russell A. et al. (1989) Neuropeptide Y in the sympathetic control of blood pressure in hypertensive subjects. Clin. Exp. Hypertens. A 11 Suppl. 1: 59-66
129. Ullman B., Hulting J. and Lundberg J. M. (1994) Prognostic value of plasma neuropeptide-Y in coronary care unit patients with and without acute myocardial infarction. Eur. Heart J. 15: 454-461
130. Ullman B., Lindvall K., Lundberg J. M., Sigurdsson A. and Swedberg K. (1994) Response of plasma neuropeptide Y and noradrenaline to dynamic exercise and ramipril treatment in patients with congestive heart failure. Clin. Physiol. 14: 123-134
131. Hulting J., Sollevi A., Ullman B., Franco-Cereceda A. and Lundberg J. M. (1990) Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure. Cardiovasc. Res. 24: 102-108
132. Madsen B. K., Husum D., Videbaek R., Stokholm K. H., Saelsen L. and Christensen N. J. (1993) Plasma immunoreactive neuropeptide Y in congestive heart failure at rest and during exercise. Scand. J. Clin. Lab Invest 53: 569-576
133. Anderson F. L., Port J. D., Reid B. B., Hanson G., Kralios A. C., Hershberger R. E. et al. (1992) Effect of therapeutic dopamine administration on myocardial catecholamine and neuropeptide Y concentrations in the failing ventricles of patients with idiopathic dilated cardiomyopathy. J. Cardiovasc. Pharmacol. 20: 800-806
134. Missouris C. G., Grouzmann E., Buckley M. G., Barron J., MacGregor G. A. and Singer D. R. (1998) How does treatment influence endocrine mechanisms in acute severe heart failure? Effects on cardiac natriuretic peptides, the renin system, neuropeptide Y and catecholamines. Clin. Sci. 94: 591-599
135. Dubois-Rande J. L., Como E., Merlet P., Benvenuti C., Carville C., Hittinger L. et al. (1992) Relationship among neuropeptide Y, catecholamines and haemodynamics in congestive heart failure. Eur. Heart J. 13: 1233-1238
136. Karvonen M. K., Pesonen U., Koulu M., Niskanen L., Laakso M., Rissanen A. et al. (1998) Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat. Med. 4: 1434-1437
137. Karvonen M. K., Koulu M., Pesonen U., Uusitupa M. I., Tammi A., Viikari J. et al. (2000) Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children. J. Clin. Endocrinol. Metab. 85: 1455-1460
138. Niskanen L., Voutilainen-Kaunisto R., Terasvirta M., Karvonen M. K., Valve R., Pesonen U. et al. (2000) Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes. Exp. Clin. Endocrinol. Diabetes 108: 235-236
139. Makino K., Kataoka Y., Hirakawa Y., Ikeda A., Yamauchi A. and Oishi A. R. (2001) A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population. J. Clin. Pharm. Ther. 26: 201-203
140. Kallio J., Pesonen U., Kaipio K., Karvonen M. K., Jaakkola U., Heinonen O. J. et al. (2001) Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans. FASEB J. 15: 1242-1244
141. Walker P., Grouzmann E., Burnier M. and Waeber B. (1991) The role of neuropeptide Y in cardiovascular regulation. Trends Pharmacol. Sci. 12: 111-115
142. Wahlestedt C., Edvinsson L., Ekblad E. and Hakanson R. (1985) Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action. J. Pharmacol. Exp. Ther. 234: 735-741
143. Edvinsson L., Hakanson R., Steen S., Sundler F., Uddman R. and Wahlestedt C. (1985) Innervation of human omental arteries and veins and vasomotor response to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. Regul. Pept. 12: 67-79
144. Edvinsson L., Ekblad E., Hakanson R. and Wahlestedt C. (1984) Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br. J. Pharmacol. 83: 519-525
145. Han C. and Abel P. W. (1987) Neuropeptide Y potentiates contraction and inhibits relaxation of rabbit coronary arteries. J. Cardiovasc. Pharmacol. 9: 675-681
146. Schuerch L. V., Linder L. M., Grouzmann E. and Haefeli W. E. (1998) Human neuropeptide Y potentiates alpha1-adrenergic blood pressure responses in vivo. Am. J. Physiol. 275: H760-H766
147. Pedrazzini T., Seydoux J., Kustner P., Aubert J.-F., Grouzmann E., Beermann F. et al. (1998) Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat. Med. 4: 722-726
148. Malmstrom R. E. and Lundberg J. M. (1995) Endogenous NPY acting on the Y1 receptor accounts for the long-lasting part of the sympathetic contraction in guinea-pig vena cava: evidence using SR 120107A. Acta Physiol. Scand. 155: 329-330
149. Malmstrom R. E. and Lundberg J. M. (1995) Neuropeptide Y accounts for sympathetic vasoconstriction in guinea-pig vena cava: evidence using BIBP 3226 and 3435. Eur. J. Pharmacol. 294: 661-668
150. Han S., Chen X., Cox B., Yang C. L., Wu Y. M., Naes L. et al. (1998) Role of neuropeptide Y in cold stress-induced hypertension. Peptides 19: 351-358
151. Watson J. D., Sury M. R., Corder R., Carson R., Bouloux P. M., Lowry P. J. et al. (1988) Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations. J. Endocrinol. 116: 421-426
152. Arnalich F., Sanchez J. F., Martinez M., Jimenez M., Lopez J., Vazquez J. J. et al. (1995) Changes in plasma concentrations of vasoactive neuropeptides in patients with sepsis and septic shock. Life Sci. 56: 75-81
153. Hauser G. J., Myers A. K., Dayao E. K. and Zukowska-Grojec Z. (1993) Neuropeptide Y infusion improves hemodynamics and survival in rat endotoxic shock. Am. J. Physiol. 265: H1416-H1423.
154. Qureshi N. U., Dayao E. K., Shirali S., Zukowska-Grojec Z. and Hauser G. J. (1998) Endogenous neuropeptide Y mediates vasoconstriction during endotoxic and hemorrhagic shock. Regul. Pept. 75-76: 215-220
155. McMahon C. D., Buxton D. F., Elsasser T. H., Gunter D. R., Sanders L. G., Steele B. P. et al. (1999) Neuropeptide Y restores appetite and alters concentrations of GH after central administration to endotoxic sheep. J. Endocrinol. 161: 333-339
156. Gayle D., Ilyin S. E. and Plata-Salaman C. R. (1999) Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus. Am. J. Physiol. 277: R1188-R1195
157. Sergeyev V., Broberger C. and Hokfelt T. (2001) Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus. Brain Res. Mol. Brain Res. 90: 93-100
158. Lundberg J. M., Pernow J., Tatemoto K. and Dahlof C. (1985) Pre- and postjunctional effects of NPY on sympathetic control of rat femoral artery. Acta Physiol. Scand. 123: 511-513
159. Pernow J., Lundberg J. M., Kaijser L., Hjemdahl P., Theodorsson-Norheim E., Martinsson A. et al. (1986) Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man. Clin. Physiol. 6: 561-578
160. Lundberg J. M. and Stjarne L. (1984) Neuropeptide Y (NPY) depresses the secretion of 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens. Acta Physiol. Scand. 120: 477-479
161. Stjernquist M., Emson P., Owman C., Sjoberg N. O., Sundler F. and Tatemoto K. (1983) Neuropeptide Y in the female reproductive tract of the
162. Grundemar L., Grundstrom N., Johansson I. G., Andersson R. G. and Hakanson R. (1990) Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways. Br. J. Pharmacol. 99: 473-476
163. Wahlestedt C. and Hakanson R. (1986) Effects of neuropeptide Y (NPY) at the sympathetic neuroeffector junction. Can pre- and postjunctional receptors be distinguished? Med. Biol. 64: 85-88
164. Westfall T. C., Han S. P., Chen X. L., del Valle K., Curfman M., Ciarleglio A. et al. (1990) Presynaptic peptide receptors and hypertension. Ann. N.Y. Acad. Sci. 604: 372-388
165. Potter E. K. (1985) Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: Neuro-modulation by neuropeptide Y? Neurosci. Lett. 54: 117-121
166. Potter E. K., Barden J. A., McCloskey M. J., Selbie L. A., Tseng A., Herzog H. et al. (1994) A novel neuropeptide Y analog, N-acetyl [Leu28,Leu31]neuropeptide Y-(24- 36), with functional specificity for the presynaptic (Y2) receptor. Eur. J. Pharmacol. 267: 253-262
167. Smith-White M. A., Herzog H. and Potter E. K. (2002) Role of neuropeptide Y Y(2) receptors in modulation of cardiac parasympathetic neurotransmission. Regul. Pept. 103: 105-111
168. Mahns D. A., Revington M. L., Runcie M. J., McCloskey D. I. and Potter E. K. (1998) Inhibition of sympathetic cholinergic vasodilatation by a selective NPY Y2 receptor agonist in the gracilis muscle of anaesthetised dogs. J. Auton. Nerv. Syst. 68: 14-20
169. Smith-White M. A., Hardy T. A., Brock J. A. and Potter E.K. (2001) Effects of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246, on Y2 receptors at peripheral neuroeffector junctions. Br. J. Pharmacol. 132: 861-868
170. Ellis J. L. and Burnstock G. (1990) Neuropeptide Y neuro-modulation of sympathetic co-transmission in the guinea-pig vas deferens. Br. J. Pharmacol. 100: 457-462
171. Cheung D. W. and Dukkipati R. (1991) An electrophysiological study on the effect of neuropeptide Y on sympathetic neurotransmission in guinea pig vas deferens. J. Pharmacol. Exp. Ther. 257: 979-983
172. Grundemar L., Widmark E., Waldeck B. and Hakanson R. (1988) Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea. Regul. Pept. 23: 309-313
173. Grundemar L. (1998) Suppression of sensory C fiber-mediated contractions by neuropeptide Y Y1 receptors in the guinea pig bronchi. Regul. Pept. 75-76: 181-184
174. Takahashi T., Ichinose M., Yamauchi H., Miura M., Nakajima N., Ishikawa J. et al. (1993) Neuropeptide Y inhibits neurogenic inflammation in guinea pig airways. J. Appl. Physiol. 75: 103-107
175. Lacroix J. S., Ricchetti A. P., Morel P., Mossimann B., Waeber B. and Grouzmann E. (1996) Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects. Br. J. Pharmacol. 118: 2079-2084
176. Baraniuk J. N., Silver P. B., Kaliner M. A. and Barnes P. J. (1992) Neuropeptide Y is a vasoconstrictor in human nasal mucosa. J. Appl. Physiol. 73: 1867-1872
177. Lacroix J. S. and Mosimann B. L. (1996) Attenuation of allergen-evoked nasal responses by local pretreatment with exogenous neuropeptide Y in atopic patients. J. Allergy Clin. Immunol. 98: 611-616
178. Renshaw D., Thomson L. M., Carroll M., Kapas S. and Hinson J. P. (2000) Actions of neuropeptide Y on the rat adrenal cortex. Endocrinology 141: 169-173
179. Takiyyuddin M. A., Brown M. R., Dinh T. Q., Cervenka J. H., Braun S. D., Parmer R. J. et al. (1994) Sympatho-adrenal secretion in humans: factors governing catecholamine and storage vesicle peptide co-release. J. Auton. Pharmacol. 14: 187-200
180. Majane E. A., Alho H., Kataoka Y., Lee C. H. and Yang T. (1986) Neuropeptide Y in bovine adrenal glands and characterization. Endocrinology 117: 1162-1168
181. de Quidt M. E. and Emson P. C. (1986) Neuropeptide Y in the adrenal gland: characterization, distribution and drug effects. Neurosci. 19: 1011-1022
182. Damase-Michel C., Tavernier G., Giraud P., Montastruc J. L., Montastruc P. and Tran M. A. (1993) Effects of clonidine, dihydralazine and splanchnic nerve stimulation on the release of neuropeptide Y, MET-enkephalin and catecholamines from dog adrenal medulla. Naunyn Schmiedebergs Arch. Pharmacol. 348: 379-384
183. Wikstrom L. M., Meister B., Franck J. and Fried G. (1996) Changes in enkephalin and neuropeptide Y-like immunoreactivity in rabbit chromaffin tissues during perinatal development. Regul. Pept. 61: 37-44
184. Allen J. M., Adrian T. E., Polak J. M. and Bloom S. R. (1983) Neuropeptide Y (NPY) in the adrenal gland. J. Auton. Nerv. Syst. 9: 559-563
185. Lundberg J. M., Fried G., Pernow J. and Theodorsson-Norheim E. (1986) Co-release of neuropeptide Y and catecholamines upon adrenal activation in the cat. Acta Physiol. Scand. 126: 231-238
186. Gulbenkian S., Wharton J., Hacker G. W., Varndell I. M., Bloom S. R. and Polak J. M. (1985) JM Co-localization of neuropeptide tyrosine (NPY) and its C-terminal flanking peptide (C-PON). Peptides 6: 1237-1243
187. Hexum T. D. and Russett L. R. (1989) Stimulation of cholinergic receptor mediated secretion from the bovine adrenal medulla by neuropeptide Y. Neuropeptides 13: 35-41
188. Shimoda K, Shen G. H., Pfeiffer R. F., McComb R. D. and Yang H. Y. (1993) Antiserum against neuropeptide Y enhances the nicotine-mediated release of catecholamines from cultured rat adrenal chromaffin cells. Neurochem. Int. 23: 71-77
189. DiMaggio D. A., Farah J. M. Jr and Westfall T. C. (1994) Effects of differentiation on neuropeptide-Y receptors and responses in rat pheochromocytoma cells. Endocrinology 134: 719-727
190. McCullough L. A., Egan T. M. and Westfall T C. (1998) Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells. Am. J. Physiol. 274: C1290-C1297
191. Shigeri Y. and Fujimoto M. (1993) Neuropeptide Y stimulates DNA synthesis in vascular smooth muscle cells. Neurosci. Lett. 149: 19-22
192. Zukowska-Grojec Z., Pruszczyk P., Colton C., Yao J., Shen G. H., Myers A. K. et al. (1993) Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. Peptides 14: 263-268
193. Erlinge D., Yoo H., Edvinsson L., Reis D. J. and Wahlestedt C. (1993) Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters. Am. J. Physiol. 265: H1089-H1097
194. Erlinge D., Brunkwall J. and Edvinsson L. (1994) Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP. Regul. Pept. 50: 259-265
195. Zukowska-Grojec Z., Karwatowska-Prokopczuk E., Fisher T. A. and Ji H. (1998) Mechanisms of vascular growth-promoting effects of neuropeptide Y: role of its inducible receptors. Regul. Pept. 75-76: 231-238
196. Zukowska-Grojec Z., Karwatowska-Prokopczuk E., Rose W., Rone J., Movafagh S., Ji H. et al. (1998) Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circ. Res. 83: 187-195
197. Millar B. C., Schluter K. D., Zhou X. J., McDermott B. J. and Piper H. M. (1994) Neuropeptide Y stimulates hypertrophy of adult ventricular cardiomyocytes. Am. J. Physiol. 266: C1271-C1277
198. Goldberg Y., Taimor G., Piper H. M. and Schluter K. D. (1998) Intracellular signaling leads to the hypertrophic effect of neuropeptide Y. Am. J. Physiol. 275: C1207-C1215
199. Kanevskij M., Taimor G., Schafer M., Piper H. M. and Schluter K. D. (2002) Neuropeptide Y modifies the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine. Cardiovasc. Res. 53: 879-887
200. Grouzmann E., Alvarez-Bolado G., Meyer C., Osterheld M. C., Burnier M., Brunner H. R. et al. (1994) Localization of neuropeptide Y and its C-terminal flanking peptide in human renal tissue. Peptides 15: 1377-1382
201. Echtenkamp S. F. and Dandridge P. F. (1989) Influence of renal sympathetic nerve stimulation on renal function in the primate. Am. J. Physiol. 257: F204-F209
202. Echtenkamp S. F. and Dandridge P. F. (1989) Renal actions of neuropeptide Y in the primate. Am. J. Physiol. 256: F524-F531
203. Bischoff A. and Michel M. C. (1998) Renal effects of neuropeptide Y. Pflugers Arch. 435: 443-453
204. Malmstrom R. E. and Lundberg J. M. (1997) Time-dependent effects of ischaemia on neuropeptide Y mechanisms in pig renal vascular control in vivo. Acta Physiol Scand. 161: 327-338.
205. Malmstrom, R.E. (1997). Neuropeptide Y Y1 receptor mechanisms in sympathetic vascular control. Acta Physiol. Scand. Suppl. 636: 1-55
206. Januszewicz A., Symonides B., Lapinski M., Lewandowski J., Januszewicz M., Rowinski O. et al. (1995) Endothelin-1 and neuropeptide Y plasma concentrations in renal venous blood of hypertensive patients with unilateral renal artery stenosis. J. Hum. Hypertens. 9: 815-820
207. Shin L. H., Dovgan P. S., Nypaver T. J., Carretero O. A. and Beierwaltes W. H. (2000) Role of neuropeptide Y in the development of two-kidney, one-clip renovascular hypertension in the rat. J. Vasc. Surg. 32: 1015-1021
208. Waeber B., Evequoz D., Aubert J. F., Fluckiger J. P., Juillerat L., Nussberger J. et al. (1990) Prevention of renal hypertension in the rat by neuropeptide Y. J. Hypertens. 8: 21-25
209. Bray G. A. and York D. A. (1998) The MONA LISA hypothesis in the time of leptin. Recent Prog. Horm. Res. 53: 95-117
210. Bray G. A. (1991) Obesity, a disorder of nutrient partitioning: the MONA LISA hypothesis. J. Nutr. 121: 1146-1162
211. Edholm O. G. (1977) Energy balance in man studies carried out by the Division of Human Physiology, National Institute for Medical Research. J. Hum. Nutr. 31: 413-431
212. Schwartz M.W., Woods S. C., Porte D. Jr, Seeley R. J. and Baskin D. G. (2000) Central nervous system control of food intake. Nature 404: 661-671
213. Mystkowski P. and Schwartz M. W. (2000) Gonadal steroids and energy homeostasis in the leptin era. Nutrition 16: 937-946
214. Elmquist J. K., Maratos-Flier E., Saper C. B. and Flier J. S. (1998) Unraveling the central nervous system pathways underlying responses to leptin. Nat. Neurosci. 1: 445-450
215. Barsh G. S., Farooqi I. S. and O'Rahilly S. (2000) Genetics of body-weight regulation. Nature 404: 644-651
216. Stanley B. G., Daniel D. R., Chin A. S. and Leibowitz S. F. (1985) Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6: 1205-1211
217. Welch C. C., Grace M. K., Billington C. J. and Levine A. S. (1994) Preference and diet type affect macronutrient selection after morphine, NPY, norepinephrine and deprivation. Am. J. Physiol. 266: R426-R433
218. Rohner-Jeanrenaud F. (1999) Neuroendocrine regulation of nutrient partitioning. Ann. N.Y. Acad. Sci. 892: 261-271
219. Kalra S. P. (1997) Appetite and body weight regulation: is it all in the brain? Neuron 19: 227-230
220. Vettor R., Zarjevski N., Cusin I., Rohner-Jeanrenaud F. and Jeanrenaud B. (1994) Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia 37: 1202-1208
221. Zarjevski N., Cusin I., Vettor R., Rohner-Jeanrenaud F. and Jeanrenaud B. (1993) Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133: 1753-1758
222. Kalra S. P., Dube M. G., Sahu A., Phelps C. P. and Kalra P. S. (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA 88: 10931-10935
223. Williams G., Steel J. H., Cardoso H., Ghatei M. A., Lee Y. C., Gill J. S. et al. (1988) Increased hypothalamic neuropeptide Y concentrations in diabetic rat. Diabetes 37: 763-772
224. Beck B., Burlet A., Bazin R., Nicolas J. P. and Burlet C. (1993) Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating. J. Nutr. 123: 1168-1172
225. McKibbin P. E., Cotton S. J., McMillan S., Holloway B., Mayers R., McCarthy H. D. et al. (1991) Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances. Diabetes 40: 1423-1429
226. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L. and Friedman J. M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
227. Schwartz M. W., Baskin D. G., Bukowski T. R., Kuijper J. L., Foster D., Lasser G. et al. (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535
228. White J. D., Olchovsky D., Kershaw M. and Berelowitz M. (1990) Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology 126: 765-772
229. Beck B. (2000) Neuropeptides and obesity. Nutrition 16: 916-923
230. Schwartz M. W., Seeley R. J., Campfield L. A., Burn P. and Baskin D. G. (1996) Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98: 1101-1106
231. McKibbin P. E., McCarthy H. D., Shaw P. and Williams G. (1992) Insulin deficiency is a specific stimulus to hypothalamic neuropeptide Y: a comparison of the effects of insulin replacement and food restriction in streptozocin-diabetic rats. Peptides 13: 721-727
232. Erickson J. C., Hollopeter G. and Palmiter R. D. (1996) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274: 1704-1707
233. Erickson J. C., Clegg K. E. and Palmiter R. D. (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381: 415-421
234. Sahu A., Dube M. G., Phelps C. P., Sninsky C. A., Kalra P. S. and Kalra S. P. (1995) Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis. Endocrinology 136: 5718-5724
235. Sipols A. J., Baskin D. G. and Schwartz M. W. (1995) Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44: 147-151
236. Vettor R., Pagano C., Granzotto M., Englaro P., Angeli P., Blum W.F. et al. (1998) Effects of intravenous neuropeptide Y on insulin secretion and insulin sensitivity in skeletal muscle in normal rats. Diabetologia 41: 1361-1367
237. Sainsbury A., Rohner-Jeanrenaud F., Cusin I., Zakrzewska K. E., Halban P. A., Gaillard R. C. et al. (1997) Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyper-insulinaemia. Diabetologia 40: 1269-1277
238. Zakrzewska K. E., Sainsbury A., Cusin I., Rouru J., Jeanrenaud B. and Rohner-Jeanrenaud F. (1999) Selective dependence of intracerebroventricular neuropeptide Y-elicited effects on central glucocorticoids. Endocrinology 140: 3183-3187
239. Adeghate E., Ponery A. S., Pallot D. J. and Singh J. (2001) Distribution of vasoactive intestinal polypeptide, neuropeptide-Y and substance P and their effects on insulin secretion from the in vitro pancreas of normal and diabetic rats. Peptides 22: 99-107
240. Labelle M., Boulanger Y., Fournier A., St Pierre S. and Savard R. (1997) Tissue-specific regulation of fat cell lipolysis by NPY in 6-OHDA-treated rats. Peptides 18: 801-808
241. Dyer C. J., Simmons J. M., Matteri R. L. and Keisler D. H. (1997) Effects of an intravenous injection of NPY on leptin and NPY-Y1 receptor mRNA expression in ovine adipose tissue. Domest. Anim Endocrinol. 14: 325-333
242. Ollmann M. M., Wilson B. D., Yang Y. K., Kerns J. A., Chen Y., Gantz I. et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278: 135-138
243. Broberger C., Johansen J., Johansson C., Schalling M. and Hokfelt T. (1998) The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA 95: 15043-15048.
244. Mizuno T. M., Kleopoulos S. P., Bergen H. T., Roberts J. L., Priest C. A. and Mobbs C. V. (1998) Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47: 294-297
245. Kristensen P., Judge M. E., Thim L., Ribel U., Christjansen K. N., Wulff B. S. et al. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393: 72-76
246. Spanswick D., Smith M. A., Groppi V. E., Logan S. D. and Ashford M. L. (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390: 521-525
247. Loftus T. M., Jaworsky D. E., Frehywot G. L., Townsend C. A., Ronnett G. V., Lane M. D. et al. (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288: 2379-2381
248. Kumar M. V., Shimokawa T., Nagy T. R. and Lane M. D. (2002) Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc. Natl. Acad. Sci. USA 99: 1921-1925
249. Shimokawa T., Kumar M. V. and Lane M. D. (2002) Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc. Natl. Acad. Sci. USA 99: 66-71
250. Elias C. F., Lee C., Kelly J., Aschkenasi C., Ahima R. S., Couceyro P. R. et al. (1998) Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neur 21: 1375-1385
251. Jhanwar-Uniyal M., Beck B., Jhanwar Y. S., Burlet C. and Leibowitz S. F. (1993) Neuropeptide Y projection from arcuate nucleus to parvocellular division of paraventricular nucleus: specific relation to the ingestion of carbohydrate. Brain Res. 631: 97-106
252. Richard D., Huang Q. and Timofeeva E. (2000) The corticotropin-releasing hormone system in the regulation of energy balance in obesity. Int. J. Obes. Relat. Metab. Disord. 24 Suppl. 2: S36-S39
253. Bernardis L. L. and Bellinger L. L. (1993) The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neurosci. Biobehav. Rev. 17: 141-193
254. Broberger C., De Lecea L., Sutcliffe J. G. and Hokfelt T. (1998) Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 402: 460-474
255. De Matteis R. and Cinti S. (1998) Ultrastructural immunolocalization of leptin receptor in mouse brain. Neuroendocrinology 68: 412-419
256. Wellman P. J. (2000) Norepinephrine and the control of food intake. Nutrition 16: 837-842
257. Iyengar S., Li D. L. and Simmons R. M. (1999) Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding? J. Pharmacol. Exp. Ther. 289: 1031-1040
258. Parker R. M. and Herzog H. (1999) Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur. J. Neurosci. 11: 1431-1448
259. Stanley B. G., Magdalin W., Seirafi A., Nguyen M. M. and Leibowitz S. F. (1992) Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 13: 581-587
260. Leibowitz S. F. and Alexander J. T. (1991) Analysis of neuropeptide Y-induced feeding: dissociation of Y1 and Y2 receptor effects on natural meal patterns. Peptides 12: 1251-1260
261. Kask A., Rago L. and Harro J. (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br. J. Pharmacol. 124: 1507-1515
262. Kanatani A., Ishihara A., Asahi S., Tanaka T., Ozaki S. and Ihara M. (1996) Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology 137: 3177-3182
263. Yokosuka M., Dube M. G., Kalra P. S. and Kalra S. P. (2001) The mPVN mediates blockade of NPY-induced feeding by a Y5 receptor antagonist: a c-FOS analysis. Peptides 22: 507-514
264. Roche C., Boutin P., Dina C., Gyapay G., Basdevant A., Hager J. et al. (1997) Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity. Diabetologia 40: 671-675
265. Rosenkranz K., Hinney A., Ziegler A., von Prittwitz S., Barth N., Roth H. et al. (1998) Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes. Int. J. Obes. Relat Metab Disord. 22: 157-163
266. Jenkinson C. P., Cray K., Walder K., Herzog H., Hanson and Ravussin E. (2000) Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians. Int. J. Obes. Relat. Metab. Disord. 24: 580-584
267. Flynn M. C., Turrin N. P., Plata-Salaman C. R. and French-Mullen J. M. (1999) Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothio-oligodeoxynucleotide. Physiol. Behav. 66: 881-884
268. Schaffhauser A. O., Stricker-Krongrad A., Brunner L., Cumin F., Gerald C., Whitebread S. et al. (1997) Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes 46: 1792-1798
269. Lopez-Valpuesta F. J., Nyce J. W., Griffin-Biggs T. A., Ice J. C. and Myers R. D. (1996) Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats. Proc. R. Soc. Lond. B Biol. Sci. 263: 881-886
270. Lopez-Valpuesta F. J., Nyce J. W. and Myers R. D. (1996) NPY-Y1 receptor antisense injected centrally in rats causes hyperthermia and feeding. Neuroreport 7: 2781-2784
271. Schaffhauser A. O., Whitebread S., Haener R., Hofbauer K. G. and Stricker-Krongrad A. (1998) Neuropeptide Y Y1 receptor antisense oligodeoxynucleotides enhance food intake in energy-deprived rats. Regul. Pept. 75-76: 417-423
272. Marsh D. J., Hollopeter G., Kafer K. E. and Palmiter R. D. (1998) Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat. Med. 4: 718-721
273. Kanatani A., Mashiko S., Murai N., Sugimoto N., Ito J., Fukuroda T. et al. (2000) Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology 141: 1011-1016
274. Naveilhan P., Hassani H., Canals J. M., Ekstrand A. J., Larefalk A., Chhajlani V. et al. (1999) Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat. Med. 5: 1188-1193
275. Sainsbury A., Schwarzer C., Couzens M., Fetissov S., Furtinger S., Jenkins A. et al. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. USA 99: 8938-8943
276. Edwardson J. A. and Hough C. A. (1975) The pituitary-adrenal system of the genetically obese (ob/ob) mouse. J. Endocrinol. 65: 99-107
277. Cunningham J. J., Calles-Escandon J., Garrido F., Carr D. B. and Bode H. H. (1986) Hypercorticosteronuria and diminished pituitary responsiveness to corticotropin-releasing factor in obese Zucker rats. Endocrinology 118: 98-101
278. Guillaume-Gentil C., Rohner-Jeanrenaud F., Abramo F., Bestetti G. E., Rossi G. L. and Jeanrenaud B. (1990) Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat. Endocrinology 126: 1873-1879
279. Considine R. V., Sinha M. K., Heiman M. L., Kriauciunas A., Stephens T. W., Nyce M. R. et al. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334: 292-295
280. Heiman M. L., Ahima R. S., Craft L. S., Schoner B., Stephens T. W. and Flier J. S. (1997) Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 138: 3859-3863
281. Ahima R. S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E. et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252
282. Wahlestedt C., Skagerberg G., Ekman R., Heilig M., Sundler F. and Hakanson R. (1987) Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res. 417: 33-38
283. Haas D. A. and George S. R. (1987) Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: lack of effect in other rat brain regions. Life Sci. 41: 2725-2731
284. Harfstrand A., Eneroth P., Agnati L. and Fuxe K. (1987) Further studies on the effects of central administration of neuropeptide Y on neuroendocrine function in the male rat: relationship to hypothalamic catecholamines. Regul. Pept. 17: 167-179
285. Small C. J., Morgan D. G., Meeran K., Heath M. M., Gunn I., Edwards C. M. et al. (1997) Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. Proc. Natl. Acad. Sci. USA 94: 11686-11691
286. Erickson J. C., Ahima R. S., Hollopeter G., Flier J. S. and Palmiter R. D. (1997) Endocrine function of neuropeptide Y knockout mice. Regul. Pept. 70: 199-202
287. Steiner H. J., Schmid K. W., Fischer-Colbrie R., Sperk G. and Winkler H. (1989) Co-localization of chromogranin A and B, secretogranin II and neuropeptide Y in chromaffin granules of rat adrenal medulla studied by electron microscopic immunocytochemistry. Histochemistry 91: 473-477
288. Mazzocchi G. and Nussdorfer G. G. (1987) Neuropeptide-Y acutely stimulates rat zona glomerulosa in vivo. Neuropeptides 9: 257-262
289. Bernet F., Bernard J., Laborie C., Montel V., Maubert E. and Dupouy J. P. (1994) Neuropeptide Y (NPY)- and vasoactive intestinal peptide (VIP)-induced aldosterone secretion by rat capsule/glomerular zone could be mediated by catecholamines via beta 1 adrenergic receptors. Neurosci. Lett. 166: 109-112
290. Barnea A., Cho G., Hajibeigi A., Aguila M. C. and Magni P. (1991) Dexamethasone-induced accumulation of neuropeptide-Y by aggregating fetal brain cells in culture: a process dependent on the developmental age of the aggregates. Endocrinology 129: 931-938
291. Tempel D. L. and Leibowitz S. F. (1993) Glucocorticoid receptors in PVN: interactions with NE, NPY, and Gal in relation to feeding. Am. J. Physiol. 265: E794-E800
292. White B. D., Dean R. G. and Martin R. J. (1990) Adrenalectomy decreases neuropeptide Y mRNA levels in the arcuate nucleus. Brain Res. Bull. 25: 711-715
293. Akabayashi A., Watanabe Y., Wahlestedt C., McEwen B. S., Paez X. and Leibowitz S. F. (1994) Hypothalamic neuropeptide Y, its gene expression and receptor activity: relation to circulating corticosterone in adrenalectomized rats. Brain Res. 665: 201-212
294. Dean R. G. and White B. D. (1990) Neuropeptide Y expression in rat brain: effects of adrenalectomy. Neurosci. Lett. 114: 339-344
295. Larsen P. J., Jessop D. S., Chowdrey H. S., Lightman S. L. and Mikkelsen J. D. (1994) Chronic administration of glucocorticoids directly upregulates prepro- neuropeptide Y and Y1-receptor mRNA levels in the arcuate nucleus of the rat. J. Neuroendocrinol. 6: 153-159
296. Solano J. M. and Jacobson L. (1999) Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA. Am. J. Physiol. 277: E708-E716
297. Wisialowski T., Parker R., Preston E., Sainsbury A., Kraegen E., Herzog H. et al. (2000) Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus. J. Clin. Invest. 105: 1253-1259
298. Cone R. D. (2000) The corticotropin-releasing hormone system and feeding behavior - a complex web begins to unravel. Endocrinology 141: 2713-2714
299. Jeanrenaud B. and Rohner-Jeanrenaud F. (2000) CNS-periphery relationships and body weight homeostasis: influence of the glucocorticoid status. Int. J. Obes. Relat. Metab. Disord. 24 Suppl. 2: S74-S76
300. Marshall J. C. and Kelch R. P. (1979) Low dose pulsatile gonadotropin-releasing hormone in anorexia nervosa: a model of human pubertal development. J. Clin. Endocrinol. Metab. 49: 712-718
301. Pierroz D. D., Gruaz N. M., d'Alieves V. and Aubert M. L. (1995) Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat. Neuroendocrinologyy 61: 293-300
302. Pierroz D. D., Catzeflis C., Aebi A. C., Rivier J. E. and Aubert M. L. (1996) Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 137: 3-12
303. Catzeflis C., Pierroz D. D., Rohner-Jeanrenaud F., Rivier J. E., Sizonenko P. C. and Aubert M. L. (1993) Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 132: 224-234
304. Gruaz N. M., Pierroz D. D., Rohner-Jeanrenaud F., Sizonenko P. C. and Aubert M. L. (1993) Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology 133: 1891-1894
305. McDonald J. K., Lumpkin M. D., Samson W. K. and McCann S. M. (1985) Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. Proc. Natl. Acad. Sci. USA 82: 561-564
306. Pierroz D. D., Aebi A. C., Huhtaniemi I. T. and Aubert M. L. (1999) Many LH peaks are needed to physiologically stimulate testosterone secretion: modulation by fasting and NPY. Am. J. Physiol. 276: E603-E610
307. Bergonzelli G. E., Pralong F. P., Glauser M., Cavadas C., Grouzmann E. and Gaillard R. C. (2001) Interplay between galanin and leptin in the hypothalamic control of feeding via corticotropin-releasing hormone and neuropeptide Y. Diabetes 50: 2666-2672
308. Stephens T. W., Basinski M., Bristow P. K., Bue-Valleskey J. M., Burgett S. G., Craft L. et al. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532
309. Chehab F. F., Mounzih K., Lu R. and Lim M. E. (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275: 88-90
310. Ahima R. S., Dushay J., Flier S. N., Prabakaran D. and Flier J. S. (1997) Leptin accelerates the onset of puberty in normal female mice. J. Clin. Invest. 99: 391-395
311. Pralong F. P., Voirol M., Giacomini M., Gaillard R. C. and Grouzmann E. (2000) Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors. Regul. Pept. 95: 47-52
312. Pralong F. P., Gonzales C., Voirol M. J., Palmiter R. D., Brunner H. R., Gaillard R. C. et al. (2002) The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J. 16: 712-714
313. Kiess W., Muller G., Galler A., Reich A., Deutscher J., Klammt J. et al. (2000) Body fat mass, leptin and puberty. J. Pediatr. Endocrinol. Metab. 13 Suppl. 1: 717-722
314. Cunningham M. J., Clifton D. K. and Steiner R. A. (1999) Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol. Reprod. 60: 216-222
315. Hileman S. M., Pierroz D. D. and Flier J. S. (2000) Leptin, nutrition, and reproduction: timing is everything. J. Clin. Endocrinol. Metab. 85: 804-807
316. McDonald J. K., Lumpkin M. D. and DePaolo L. V. (1989) Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action. Endocrinology 125: 186-191
317. Khorram O., Pau K. Y. and Spies H. G. (1988) Release of hypothalamic neuropeptide Y and effects of exogenous NPY on the release of hypothalamic GnRH and pituitary gonadotropins in intact and ovariectomized does in vitro. Peptides 9: 411-417
318. Kalra S. P. and Crowley W. R. (1984) Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats. Neuroendocrinology 38: 511-513
319. Kalra S. P., Fuentes M., Fournier A., Parker S. L. and Crowley W. R. (1992) Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats. Endocrinology 130: 3323-3330
320. Raposinho P. D., Broqua P., Pierroz D. D., Hayward A., Dumont Y., Quirion R. et al. (1999) Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. Endocrinology 140: 4046-4055
321. Kalra S. P. and Crowley W. R. (1984) Norepinephrine-like effects of neuropeptide Y on LH release in the rat. Life Sci. 35: 1173-1176
322. Bauer-Dantoin A. C., McDonald J. K. and Levine J. E. (1991) Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-stimulated LH surges in pentobarbital-blocked proestrous rats. Endocrinology 129: 402-408
323. Kalra S. P. and Crowley W. R. (1992) Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone. Front Neuroendocrinol. 13: 1-46
324. Minami S., Frautschy S. A., Plotsky P. M., Sutton S. W. and Sarkar D. K. (1990) Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing-hormone-releasing hormone. Neuroendocrinology 52: 112-115
325. Leupen S. M., Besecke L. M. and Levine J. E. (1997) Neuropeptide Y Y1-receptor stimulation is required for physiological amplification of preovulatory luteinizing hormone surges. Endocrinology 138: 2735-2739
326. Raposinho P. D., Broqua P., Hayward A., Akinsanya K., Galyean R., Schteingart C. et al. (2000) Stimulation of the gonadotropic axis by the neuropeptide Y receptor Y1 antagonist/Y4 agonist 1229U91 in the male rat. Neuroendocrinology 71: 2-7
327. Jain M. R., Pu S., Kalra P. S. and Kalra S. P. (1999) Evidence that stimulation of two modalities of pituitary luteinizing hormone release in
328. Sainsbury A., Schwarzer C., Couzens M., Jenkins A., Oakes S. R., Ormandy C. J. et al. (2002) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev. 16: 1077-1088
329. Lebrethon M. C., Vandersmissen E., Gerard A., Parent A. S., Junien J. L. and Bourguignon J. P. (2000) In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 141: 1464-1469
330. Fekete C., Kelly J., Mihaly E., Sarkar S., Rand W. M., Legradi G. et al. (2001) Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis. Endocrinology 142: 2606-2613
331. Seoane L. M., Carro E., Tovar S., Casanueva F. F. and Dieguez C. (2000) Regulation of in vivo TSH secretion by leptin. Regul. Pept. 92: 25-29
332. Nillni E. A., Vaslet C., Harris M., Hollenberg A., Bjorbak C. and Flier J. S. (2000) Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J. Biol. Chem. 275: 36124-36133
333. Chan Y. Y., Clifton D. K. and Steiner R. A. (1996) Role of NPY neurones in GH-dependent feedback signalling to the brain. Horm. Res. 45 Suppl. 1: 12-14
334. Rettori V., Milenkovic L., Aguila M. C. and McCann S. M. (1990) Physiologically significant effect of neuropeptide Y to suppress growth hormone release by stimulating somatostatin discharge. Endocrinology 126: 2296-2301
335. Vuagnat B. A., Pierroz D. D., Lalaoui M., Englaro P., Pralong F. P., Blum W. F. et al. (1998) Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology 67: 291-300
336. Heilig M. and Widerlov E. (1995) Neurobiology and clinical aspects of neuropeptide Y. Crit. Rev. Neurobiol. 9: 115-136
337. Heilig M. and Thorsell A. (2002) Brain neuropeptide Y (NPY) in stress and alcohol dependence. Rev. Neurosci. 13: 85-94.
338. Vezzani A., Sperk G. and Colmers W. F. (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22: 25-30
339. Baraban S. C. (1998) Neuropeptide Y and limbic seizures. Rev. Neurosci. 9: 117-128
340. Tecott L. H. and Heberlein U. (1998) Y do we drink? Cell 95: 733-735
341. Kosten T. R., Markou A. and Koob G. F. (1998) Depression and stimulant dependence: neurobiology and pharmacotherapy. J. Nerv. Ment. Dis. 186: 737-745
342. Markou A., Kosten T. R. and Koob G. F. (1998) Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 18: 135-174
343. Li T. K. (2000) Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J. Stud. Alcohol 61: 5-12
344. Wahlestedt C., Merlo Pich E., Koob G. F., Yee F. and Heilig M. (1993) Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259: 528-531
345. Widerlov E., Lindstrom L. H., Wahlestedt C. and Ekman R. (1988) Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively. J. Psychiatr. Res. 22: 69-79
346. Traskman-Bendz L., Ekman R., Regnell G. and Ohman R. (1992) HPA-related CSF neuropeptides in suicide attempters. Eur. Neuropsychopharmacol. 2: 99-106
347. Roy A. (1993) Neuropeptides in relation to suicidal behavior in depression. Neuropsychobiology 28: 184-186
348. Obuchowicz E. (1996) Long-term treatment with chlorpromazine and haloperidol but not with sulpiride and clozapine markedly elevates neuropeptide Y-like immunoreactivity in the rat hypothalamus. Neuropeptides 30: 471-478
349. Redrobe J. P., Dumont Y., Fournier A. and Quirion R. (2002) The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 26: 615-624
350. St Pierre J. A., Nouel D., Dumont Y., Beaudet A. and Quirion R. (2000) Sub-population of cultured hippocampal astrocytes expresses neuropeptide Y Y(1) receptors. Glia 30: 82-91
351. St Pierre J. A., Dumont Y., Nouel D., Herzog H., Hamel E. and Quirion R. (1998) Preferential expression of the neuropeptide Y Y1 over the Y2 receptor subtype in cultured hippocampal neurons and cloning of the rat Y2 receptor. Br. J. Pharmacol. 123: 183-194
352. Redrobe J. P., Dumont Y., St Pierre J. A. and Quirion R. (1999) Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition. Brain Res. 848: 153-166
353. Palmiter R. D., Erickson J. C., Hollopeter G., Baraban S. C. and Schwartz M. W. (1998) Life without neuropeptide Y. Recent Prog. Horm. Res. 53: 163-199
354. Marsh D. J., Baraban S. C., Hollopeter G. and Palmiter R. D. (1999) Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc. Natl. Acad. Sci. USA 96: 13518-13523
355. Thiele T. E., Marsh D. J., Ste M. L., Bernstein I. L. and Palmiter R. D. (1998) Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396: 366-369
356. Thiele T. E., Miura G. I., Marsh D. J., Bernstein I. L. and Palmiter R. D. (2000) Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor. Pharmacol. Biochem. Behav. 67: 683-691
357. Thiele T. E., Koh M. T. and Pedrazzini T. (2002) Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor. J. Neurosci. 22: RC208
358. Badia-Elder N. E., Stewart R. B., Powrozek T. A., Roy K. F., Murphy J. M. and Li T. K. (2001) Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcohol Clin. Exp. Res. 25: 386-390
359. Kelley S. P., Nannini M. A., Bratt A. M. and Hodge C. W. (2001) Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration. Peptides 22: 515-522
360. Kauhanen J., Karvonen M. K., Pesonen U., Koulu M., Tuomainen T. P., Uusitupa M. I. et al. (2000) Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am. J. Med. Genet. 93: 117-121
361. Ilveskoski E., Kajander O. A., Lehtimaki T., Kunnas T., Karhunen P. J., Heinala P. et al. (2001) Association of neuropeptide y polymorphism with the occurrence of type 1 and type 2 alcoholism. Alcohol Clin. Exp. Res. 25: 1420-1422
362. Okubo T. and Harada S. (2001) Polymorphism of the neuropeptide Y gene: an association study with alcohol withdrawal. Alcohol Clin. Exp. Res. 25: 59S-62S