Neuropeptides and obesity

Nutrition

Volumn 16, Issue 10, 2000, Pages 916-923

  Beck, Bernard ^a  

^a INSERM   (France)

Author keywords

Feeding behavior; Genetic models; Hypothalamic networks; Stress

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; INSULIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN RECEPTOR; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; NEUROPEPTIDE Y; NEUROTENSIN; PROOPIOMELANOCORTIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARCUATE NUCLEUS; CALORIC INTAKE; CONFERENCE PAPER; ENERGY EXPENDITURE; FEEDBACK SYSTEM; FEEDING BEHAVIOR; FOOD INTAKE; GENE MUTATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MOUSE; NEUROTRANSMISSION; NONHUMAN; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AGOUTI; ANIMALIA;

EID: 0033782054     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(00)00410-X     Document Type: Conference Paper

References (170)

1. The spread of the obesity epidemic in the United States, 1991-1998
2. Prevalence of overweight and obesity among school children in Jena (Germany)
3. Neuropeptide regulation of appetite and weight
4. Cholecystokinin, neurotensin and corticotropin-releasing factor-3 important anorexic peptides
5. Physiology and pharmacology of corticotropin-releasing factor
6. Hypothalamic CART is a new anorectic peptide regulated by leptin
7. Neuropeptide Y in multiple hypothalamic sites controls eating behavior, endocrine, and autonomic systems for body energy balance
8. Orexins and orexin receptors; a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
9. The role of galanin in feeding behavior
10. Two important systems in energy homeostasis; melanocortins and melanin-concentrating hormone
11. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
12. The human obesity gene map; the 1998 update
13. The Zucker-fatty rat; a review
14. The obese Zucker rat; a choice for fat metabolism
15. Genetic obesity-is the defect in the sympathetic nervous system?-A review through developmental studies in the preobese Zucker rat
16. Rat obesity gene fatty (fa) maps to chromosome-5-evidence for homology with the mouse gene diabetes (db)
17. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
18. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (lepr)
19. Leptin receptor missense mutation in the fatty Zucker rat
20. Substitution at codon 269 (glutamine->proline) of the leptin receptor (OB-r) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat
21. Overview; neurobiology of OB protein (leptin)
22. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats
23. Neuropeptide Y in hypothalamic paraventricular nucleus; a center coordinating energy metabolism
24. Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behaviour of obese Zucker rats
25. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
26. Neuropeptide Y feeding receptors; are multiple subtypes involved?
27. Hypothalamic regulatory peptides in obese and lean Zucker rats
28. Hypothalamic neuropeptide Y (NPY) in obese Zucker rats; implications in feeding and sexual behaviors
29. Altered neuropeptide-Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats-possible relationship to obesity and neuroendocrine disturbances
30. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation
31. Elevated neuropeptide-Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating
32. Hypothalamic neuropeptide-Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats-potential regulation thereof by corticotropin-releasing factor
33. Developmental aspects of differences in hypothalamic preproneuropeptide Y messenger ribonucleic acid content in lean and genetically obese Zucker rats
34. Critical effects of aging and nutritional state on hypothalamic neuropeptide-Y and galanin gene expression in lean and genetically obese zucker rats
35. A molecular genetic method for genotyping fatty (fa/fa) rats
36. 2 and early detection of fa/fa genotype in rats
37. Inguinal fat pad weight plotted versus body weight as a method of genotype identification in 16-day-old Zucker rats
38. Neuropeptide Y overexpression in the preweanling Zucker (Fa/fa) rat
39. Ontogeny of hyperphagia in the Zucker (fa/fa) rat
40. Is the onset of obesity in suckling fa/fa rats linked to a potentially larger milk intake?
41. Developmental changes in the fatty (fa/fa) rat:evidence for defective thermogenesis preceding the hyperlipogenesis and hyperinsulinemia
42. Hypothalamic neuropeptide-Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats
43. Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 'feeding' receptor
44. Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats-changes in the microstructure of the feeding behavior
45. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats
46. Stimulation of feeding in lean but not in obese Zucker rats by a selective neuropeptide Y Y5 receptor agonist
47. Intraventricular neuropeptide Y injections stimulate food intake in lean, but not obese Zucker rats
48. A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats
49. Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats
50. Unexpected regulation of hypothalamic neuropeptide-Y by food deprivation and refeeding in the Zucker rat
51. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus
52. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
53. Neuropeptide Y, insuline, leptine et controle de la masse grasse
54. Central insulin administration reduces neuropeptide-Y messenger RNA expression in the arcuate nucleus of food-deprived lean (FA/FA) but not obese (fa/fa) Zucker rats
55. Hypothalamic neuropeptide expression after food restriction in Zucker rats-evidence of persistent neuropeptide-Y gene activation
56. Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats
57. Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats
58. Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites
59. Meal patterns in the genetically obese Zucker rat
60. Daily rhythms of feeding in the genetically obese and lean Zucker rats
61. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity
62. Stimulation of feeding by galanin-anatomical localization and behavioral specificity of this peptides effects in the brain
63. Regulation of galanin gene expression in the hypothalamic paraventricular nucleus of the obese Zucker rat by manipulation of dietary macronutrients
64. Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats
65. Galanin is a physiological regulator of spontaneous pulsatile secretion of growth hormone in the male rat
66. 3H]-naloxone binding and elevated dynorphin-A((1-8)) content in Zucker rat brain
67. Central somatostatin-a re-examination of its effects on feeding
68. Mechanisms of impaired growth hormone secretion in genetically obese Zucker rats-roles of growth hormone-releasing factor and somatostatin
69. Tissue and serum somatostatin-like immunoreactivity in lean and obese Zucker rats
70. Tissue somatostatin levels in three models of genetic obesity in rats
71. Somatostatin concentrations in discrete hypothalamic nuclei of genetically obese Zucker rats
72. Immunocytochemical analysis of somatostatin in the hypothalamus of obese and non-obese Zucker rats
73. Sex-related alterations in hypothalamic growth hormone-releasing hormone mRNA but not somatostatin mRNA-expressing cells in genetically obese Zucker rats
74. Somatostatin and growth hormone-releasing factor release from Zucker rat hypothalamic tissue
75. Cholecystokinin, bobesin and neurotensin in brain tissue from obese animals
76. Neurotensin in microdissected brain nuclei and in the pituitary of the lean and obese Zucker rats
77. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats
78. Early modification of neuropeptide-Y but not of neurotensin in the suprachiasmatic nucleus of the obese Zucker rat
79. Quantitative autoradiographic localization of neurotensin binding sites in lean and obese Zucker rats
80. Neurotensin decreases with fasting in the ventromedian nucleus of obese Zucker rats
81. Decreased sensitivity of obese Zucker rats to the putative satiety agent cholecystokinin
82. Devazepide increases food intake in male but not female Zucker rats
83. Effects of CCK antibodies on food intake and weight gain in Zucker rats
84. Diet composition alters the satiety effect of cholecystokinin in lean and obese Zucker rats
85. Levels of gastrin-cholecystokinin-like immunoreactivity in the brains of genetically obese and non-obese rats
86. Brain cholecystokinin and nutritional status in rats and mice
87. Changes in brain CCK concentrations with peripheral CCK injections in Zucker rats
88. Lean (Fa/Fa) but not obese (fa/fa) Zucker rats release cholecystokinin at PVN after a gavaged meal
89. Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdala
90. Direct projections from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus; possible role in stress-induced adrenocorticotropin release
91. Corticotropin-Releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide-Y
92. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide-Y
93. Effects of corticotropin releasing factor on genetically obese (fatty) rats
94. Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats
95. Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal
96. Immunoreactive corticotropin-releasing hormone levels in brain regions of genetically obese Zucker rats
97. Immunoreactive corticotropin-releasing hormone levels in the hypothalamus of female Wistar fatty rats
98. Immunoreactive corticotropin-releasing hormone levels in discrete hypothalamic nuclei of genetically obese Zucker rats
99. Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats
100. Functional activation of CRH neurons and expression of the genes encoding CRH and its receptors in food-deprived lean (Fa/?) and obese (fa/fa) Zucker rats
101. Positional cloning of the mouse obese gene and its human homologue
102. Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice
103. Increased neuropeptide-Y messenger ribonucleic acid (messenger RNA) and decreased neurotensin messenger RNA in the hypothalamus of the obese (ob/ob) mouse
104. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
105. Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation and refeeding
106. Reduced hypothalamic neurotensin concentrations in the genetically obese diabetic (ob/ob) mouse-possible relationship to obesity
107. Down-regulated NPY receptor subtype-5 mRNA expression in genetically obese mouse brain
108. Neuropeptide Y increases food intake in mice
109. Similar effects of NPY on energy metabolism and on plasma insulin in adrenalectomized ob/ob and lean mice
110. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
111. Role of the Y5 neuropeptide Y receptor in feeding and obesity
112. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the Agouti obesity syndrome
113. Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models
114. Distribution and quantification of immunoreactive orexin A in rat tissues
115. Down regulation of the prepro-orexin gene expression in genetically obese mice
116. A role for melanin-concentrating hormone in the central regulation of feeding behaviour
117. Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(Ob)/Lep(Ob) mice
118. The central melanocortin system and energy homeostasis
119. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
120. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
121. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
122. Increased beta-endorphin and dynorphin concentrations in discrete hypothalamic regions of genetically obese (ob/ob) mice
123. Hypothalamic Agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
124. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
125. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
126. Independent and additive effects of central POMC and leptin pathways on murine obesity
127. Immunoreactive neurotensin in spontaneous syndromes of obesity and diabetes in mice
128. Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice
129. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice
130. Hypothalamic neuropeptide-Y disturbances in the obese (cp/cp) JCR-LA corpulent rat
131. The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation
132. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat
133. The yellow mouse obesity syndrome and mechanisms of Agouti-induced obesity
134. Macronutrient diet intake of the lethal yellow agouti (A(Y)/a) mouse
135. Overexpression of Agr leads to obesity in transgenic mice
136. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
137. Long-term administration of MC4 receptor antagonist HS014 causes hyperphagia and obesity in rats
138. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
139. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
140. Anatomy of an endogenous antagonist; relationship between Agouti-related protein and proopiomelanocortin in brain
141. Organization of projections from the dorsomedial nucleus of the hypothalamus; a PHA-l study in the rat
142. Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice
143. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
144. Corticotropin-releasing factor (CRF) induced anorexia is not influenced by a melanocortin 4 receptor blockage
145. Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats
146. Genetic studies of the mouse mutations mahogany and mahoganoid
147. Distribution of mahogany/attractin mRNA in the rat central nervous system
148. The mahogany protein is a receptor involved in suppression of obesity
149. Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti
150. Peptides, enzymes and obesity; new insights from a 'dead' enzyme
151. Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice
152. Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice; a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing
153. Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK-identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain
154. Physiological and anatomical circuitry between Agouti-related protein and leptin signaling
155. Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus
156. Fat (fat), and Tubby (tub). Two autosomal recessive mutations causing obesity syndromes in the mouse
157. Identification and characterization of the mouse obesity gene tubby; a member of a novel gene family
158. A candidate gene for the mouse mutation tubby
159. Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation
160. Evidence of altered hypothalamic pro-piomelanocortin/neuropeptide Y mRNA expression in tubby mice
161. Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene
162. A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene
163. Disordered food intake and obesity in rats lacking cholecystokinin A receptors
164. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors
165. Spontaneous activity, sleep, and body temperature in rats lacking the CCK-A receptor
166. Downregulation of melanocortin receptors in brain areas involved in food intake and reward mechanisms in obese (OLETF) rats
167. Increased adrenocorticotropin responses to acute stress in Otsuka Long-Evans Tokushima Fatty (type 2 diabetic) rats
168. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
169. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus; evidence of a cellular basis for the adipostat