Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype

Endocrinology

Volumn 140, Issue 9, 1999, Pages 4046-4055

  Raposinho, Paula D ^a,b,c   Broqua, Pierre ^a,b   Pierroz, Dominique D ^a,b   Hayward, Amanda ^b   Dumont, Yvan ^d   Quirion, Remi ^d   Junien, Jean Louis ^b   Aubert, Michel L ^a,e  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b Ferring Research Institute Ltd   (United Kingdom)

^c INSTITUTO TECNOLÓGICO E NUCLEAR   (Portugal)

^d MCGILL UNIVERSITY   (Canada)

^e Hopital des Enfants Hopitaux universitaires de Geneve   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

LUTEINIZING HORMONE; NEUROPEPTIDE Y; NEUROPEPTIDE Y5 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN HOMOGENATE; CASTRATION; CONTROLLED STUDY; HORMONAL REGULATION; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; LUTEINIZING HORMONE RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033305479     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.9.6985     Document Type: Article

References (53)

1. Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
2. Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to α-adrenoceptor blockade
3. Neuropeptide Y distribution in the rat brain
4. The anatomy of neuropeptide-Y containing neurons in rat brain
5. Y-receptors subtypes-how many more?
6. Multiple receptors for the pancreatic polypeptide (PP-fold) family: Physiological implications
7. Cloning and expression of a novel neuropeptide Y receptor
8. Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family
9. Neuropeptide Y: Localization in the central nervous system and neuroehdocrine functions
10. Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats
11. Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats
12. NPY and human pancreatic polypeptide stimulate feeding behavior in rats
13. Neuropeptide Y injected in the paraventricular nucleus: A powerful stimulant of feeding behavior
14. NPY stimulates feeding but inhibits sexual behavior in rats
15. Norepinephrine-like effects of neuropeptide Y in the rat
16. Effects of NPY on the release of anterior pituitary hormones in the rat
17. Neuropeptide Y supresses pulsatile secretion of luteinizing hormone in ovariectomized rats: Possible site of action
18. Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits
19. Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus monkeys
20. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in the intact adult female rats
21. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in adult male rats
22. Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat
23. Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats
24. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y and peptide YY
25. A receptor subtype involved in neuropeptide Y-induced food intake
26. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior
27. 32]neuropeptide Y (NPY): A competitive antagonist of NPY in rat hypothalamus
28. Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem
29. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain
30. Mandatary neuropeptide-steroid signaling for the preovulatory luteinizing-hormone-releasing hormone discharge
31. 2 radioligands
32. Evidence that neuropeptide Y could represent a neuroendocrlne inhibitor of sexual maturation in unfavorable metabolic conditions in the rat
33. Many LH peaks are needed to physiologically stimulate testosterone secretion: Modulation by fasting and NPY
34. Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP3226
35. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents
36. High-affinity neuropepide Y antagonists
37. NPY-induced feeding involves the action of a Y1-like receptor in rodents
38. Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotropic hormone release
39. The pharmacology of neuropeptide (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes
40. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligonucleotides
41. Characterization of the neuropeptide Y receptor that mediates feeding in the rat: A role for the Y5 receptor?
42. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
43. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
44. Attenuation of the obesity syndrome of ob/ob mice by the lost of neuropeptide Y
45. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
46. Role of the Y5 neuropeptide Y receptor in feeding and obesity
47. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
48. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
49. Increased hypothalamic neuropeptide Y concentrations in diabetic rats
50. Neuropeptide-Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats
51. Role of leptin in the neuroendocrine response to fasting