Endocrine function of neuropeptide Y knockout mice

Regulatory Peptides

Volumn 70, Issue 2-3, 1997, Pages 199-202

  Erickson, Jay C ^a   Ahima, Rexford S ^b   Hollopeter, Gunther ^a   Flier, Jeffrey S ^b   Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Corticosterone; Hypothalamic pituitary axis; Leptin; Starvation; Testosterone; Thyroxine

Indexed keywords

CORTICOSTERONE; LEPTIN; NEUROPEPTIDE Y; TESTOSTERONE; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENDOCRINE FUNCTION; ESTRUS CYCLE; HORMONAL REGULATION; HORMONE DEFICIENCY; HORMONE RESPONSE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MOUSE; NERVE EXCITABILITY; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; STARVATION;

ANIMALS; EATING; ENDOCRINE GLANDS; ESTRUS DETECTION; FASTING; FEMALE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPEPTIDE Y;

ANIMALIA;

EID: 0030753638     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(97)01007-0     Document Type: Article

References (23)

1. Colmers WF, Wahlestedt C. The Biology of Neuropeptide Y and Related Peptides. New Jersey: Humana Press, 1993.
2. McDonald JK, Koenig JI. Neuropeptide Y actions on reproductive and endocrine functions. In: Colmers WF, Wahlestedt, C, editors. The Biology of Neuropeptide Y and Related Peptides. New Jersey: Humana Press, 1993:419-456.
3. White JD. Neuropeptide Y: a central regulator of energy homeostasis. Regul Pept 1993;49:93-107.
4. Koenig JI. Regulation of the hypothalamic-pituitary axis by neuropeptide Y Ann New York Acad Sci 1990;611:317-28.
5. Wahlestedt C, Skagerberg G, Ekman R, Helig M, Sundler F, Hakanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res 1987;417:33-8.
6. Harfstrand A, Eneroth P, Agnati L, Fuxe K. Further studies on the effect of central administration of neuropeptide Y on neuroendocrine function in the male rat: relationship to hypothalamic catecholamines. Regul Pept 1987;17:167-79.
7. Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, Rivier JE, Sizonenko PC, Aubert ML. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 1993;132:224-34.
8. Pierroz DD, Catzeflis C, Aebi AC, Rivier JE, Aubert ML. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 1996;137:3-12.
9. McDonald JK, Lumpkin MD, Samson WK, McCann SM. Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. Proc Natl Acad Sci USA 1985;82:561-4.
10. DeQuidt ME, Emson PC. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system. II. Immunohistochemical analysis. Neuroscience 1986;18:545-618.
11. Liposits ZL, Paull WK. Neuropeptide Y and ACTH-immunoreactive innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. An immunohistochemical study at the light and electron microscopic levels. Histochemistry 1988;88:227-34.
12. Toni R, Jackson IMD, Lechan RM. Neuropeptide Y-immunoreactive innervation of thyrotropin-releasing hormone-synthesizing neurons in the rat hypothalamic paraventricular nucleus. Endocrinology 1990;126:2444-53.
13. Tsuruo Y, Kawano H, Kagotani Y, Hisano S, Daikoku S, Chihara K, Zhang T, Yanaihara N. Morphological evidence for neuronal regulation of luteinizing hormone-releasing hormone-containing neurons by neuropeptide Y in the rat septo-preoptic area. Neurosci Lett 1990;110:261-6.
14. McDonald JK, Koenig JI, Gibbs DM, Collins P, Noe BD. High concentrations of neuropeptide-Y in pituitary portal blood of rats. Neuroendocrinology 1987;46:538-41.
15. Sahu A, Kalra PS, Kalra SP. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 1988;9:83-6.
16. White JD, Kershaw M. Increased hypothalamic neuropeptide Y expression following food deprivation. Mol Cell Neurosci 1990;1:41-8.
17. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 1991;88:10931-5.
18. Gruaz NM, Pierroz DD, Rohner-Jeanrenaud F, Sizonenko PC, Aubert ML. Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology 1993;133:1891-4.
19. Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996;274:1704-7.
20. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-2.
21. Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996;381:415-8.
22. Yuan YD, Carlson RG. Structure, cyclic change, and function, vagina and vulva, rat. In: Jones TC, Mohr U, Hunt RD, editors. Genital System. Berlin:Springer-Verlag, 1987:161-168.
23. Kaiyala KJ, Woods SC, Schwartz MW. New model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr 1995;62(suppl.):1123S-34S.