Many LH peaks are needed to physiologically stimulate testosterone secretion: Modulation by fasting and NPY

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 4 39-4, 1999, Pages

  Pierroz, Dominique D ^a   Aebi, Audrey C ^a   Huhtaniemi, Ilpo T ^b   Aubert, Michel L ^a,c  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF TURKU   (Finland)

^c Hopital des Enfants Hopitaux universitaires de Geneve   (Switzerland)

Author keywords

Luteinizing hormone; Pulsatile secretion

Indexed keywords

LUTEINIZING HORMONE; NEUROPEPTIDE Y; TESTOSTERONE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEEDING; HORMONAL REGULATION; LUTEINIZING HORMONE RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; RAT; TESTOSTERONE RELEASE;

EID: 0032899005     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.4.e603     Document Type: Article

References (32)

1. Ahima, R. S., D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, and J. S. Flier. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252, 1996.
2. Bartke, A., R. E. Steele, N. Musto, and B. V. Caldwell. Fluctuation in plasma T levels in adult male rats and mice. Endocrinology 92: 1223-1228, 1973.
3. Bergendahl, M., A. Perheentupa, and I. Huhtaniemi. Effect of short-term starvation on reproductive hormone gene expression, secretion and receptor levels in male rats. J. Endocrinol. 121: 409-417, 1989.
4. Bergendahl, M., A. Perheentupa, and I. Huhtaniemi. Starvation-induced suppression of pituitary-testicular function in rats is reversed by pulsatile gonadotropin-releasing hormone substitution. Biol. Reprod. 44: 413-419, 1991.
5. Boublik, J. H., N. A. Scott, M. R. Brown, and J. E. Rivier. Synthesis and hypertensive activity of neuropeptide Y fragments and analogs with modified N-or C-termini or D-substitutions. J. Med. Chem. 32: 587-601, 1989.
6. Bronson, F. H. Food-restricted, prepubertal female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone. Endocrinology 118: 2483-2487, 1986.
7. Catt, K. J., J. P. Harwood, R. N. Clayton, T. F. Davies, V. Chan, M. Katikineni, K. Nozu, and M. L. Dufau. Regulation of peptide hormone receptors and gonadal steroidogenesis. Recent Prog. Horm. Res. 36: 557-622, 1980.
8. Catzeflis, C., D. D. Pierroz, F. Rohner-Jeanrenaud, J. E. Rivier, P. C. Sizonenko, and M. L. Aubert. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and somatotropic axis in intact adult female rats. Endocrinology 132: 224-234, 1993.
9. Chehab, F., M. Lim, and R. Lu. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12:318-320, 1996.
10. Clark, R. G., G. Chambers, J. Lewin, and I. C. A. F. Robinson. Automated repetitive microsampling of blood: growth hormone profiles in conscious male rats. J. Endocrinol. 111: 27-35, 1986.
11. Desjardins, C. Endocrine signaling and male reproduction. Biol. Reprod. 24: 1-21, 1981.
12. Dong, Q., M. Bergendahl, I. Huhtaniemi, and D. J. Handelsman. Effect of undernutrition on pulsatile luteinizing hormone (LH) secretion in castrate and intact male rats using an ultrasensitive immunofluorometric LH assay. Endocrinology 135: 745-750, 1994.
13. Ellis, G. B., and C. Desjardins. Male rats secrete luteinizing hormone and T episodically. Endocrinology 110: 1618-1627, 1982.
14. Ellis, G. B., and C. Desjardins. Mapping episodic fluctuations in plasma LH in orchidectomized rats. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E130-E135, 1984.
15. Gruaz, N. M., Y. Arsenijevic, W. B. Wehrenberg, P. C. Sizonenko, and M. L. Aubert. Growth hormone (GH) deprivation induced by passive immunization against rat GH-releasing factor does not disturb the course of sexual maturation and fertility in the female rat. Endocrinology 135: 509-519, 1994.
16. Gruaz, N. M., D. D. Pierroz, F. Rohner-Jeanrenaud, P. C. Sizonenko, and M. L. Aubert. Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology 133: 1891-1895, 1993.
17. Haavisto, A. M., K. Pettersson, M. Bergendahl, A. Perheentupa, J. F. Roser, and I. Huhtaniemi. A supersensitive immunofluorometric assay for rat luteinizing hormone. Endocrinology 132: 1687-1691, 1993.
18. Huhtaniemi, I. T., R. N. Clayton, and K. J. Catt. Gonadotropin binding and Leydig cell activation in the rat testis in vivo. Endocrinology 111: 982-987, 1982.
19. Huhtaniemi, I. T., H. Nikula, and S. Rannikko. Treatment of prostatic cancer with a gonadotropin-releasing hormone agonist analog: acute and long-term effects on endocrine function of testis tissue. J. Clin. Endocrinol. Metab. 61: 698-704, 1985.
20. Kalra, S. P., M. G. Dube, A. Sahu, C. P. Phelps, and P. S. Kalra. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA 88: 10931-10935, 1991.
21. Klinefelter, G., and W. R. Kelce. Leydig cell responsiveness to hormonal and nonhormonal factors in vivo and in vitro. In: The Leydig Cell, edited by A. H. Payne, M. P. Hardy, and L. D. Russell. Cache River Press, 1996, vol. 1, p. 535-553.
22. Merriam, G. R., and K. W. Wachter. Algorithms for the study of episodic hormone secretion. Am. J. Physiol. 243 (Endocrinol. Metab. 6): E310-E318, 1982.
23. Pierroz, D. D., C. Catzeflis, A. C.Aebi, J. E. Rivier, and M. L. Aubert. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor-I secretion in intact adult male rats. Endocrinology 137: 3-12, 1996.
24. Pierroz, D. D., N. M. Gruaz, V. D'Allèves, and M. L. Aubert. Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat. Neuroendocrinology 61: 293-300, 1995.
25. Schwartz, M. W., R. J. Seeley, L. A. Campfield, P. Burn, and D. G. Baskin. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98: 1101-1106, 1996.
26. Södersten, P., P. Eneroch, and A. Q. Pettersson. Episodic secretion of luteinizing hormone and androgen in male rats. J. Endocrinol. 97: 145-153, 1983.
27. Spratt, D. I., L. S. L. O'Dea, D. Schoenfeld, J. Butler, P. N. Rao, and W. F. Crowley, Jr. Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E658-E666, 1988.
28. Steiner, R. A., W. J. Bremner, and D. K. Clifton. Regulation of luteinizing hormone pulse frequency and amplitude by T in the adult male rat. Endocrinology 111: 2055-2061, 1982.
29. Stephens, T. W., M. Basinski, P. K. Bristow, J. M. Bue-Valleskey, S. G. Burgett, L. Craft, J. Hale, J. Hofmann, H. M. Hsiung, A. Kriauciunas, W. MacKellar, P. J. Rsteck, Jr., B. Schoner, D. Smith, F. C. Tinsley, X. Y. Zhang, and M. Heiman. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532, 1995.
30. Thissen, J. P., J. M. Ketelslegers, and L. E. Underwood. Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 15: 80-101, 1994.
31. Turner, T. T., and C. P. Rhoades. Testicular capillary permeability: the movement of luteinizing hormone from the vascular to the interstitial compartment. J. Androl. 16: 417-423, 1995.
32. Urban, R. J., W. S. Evans, A. D. Rogol, D. L. Kaiser, M. L. Johnson, and J. D. Veldhuis. Contemporary aspects of discrete peak-detection algorythm. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr. Rev. 9: 3-36, 1987.