Gonadal steroids and energy homeostasis in the leptin era

Nutrition

Volumn 16, Issue 10, 2000, Pages 937-946

  Mystkowski, Paul ^a   Schwartz, Michael W ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Androgens; Body composition; Energy homeostasis; Estrogens; Food intake; Gonadal steroids; Hypothalamus; Leptin

Indexed keywords

AGOUTI RELATED PROTEIN; ANDROGEN; AROMATASE; ESTROGEN; ESTROGEN RECEPTOR; LEPTIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; SEX HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANOREXIA; BODY COMPOSITION; BODY WEIGHT; CONFERENCE PAPER; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; HOMEOSTASIS; HUMAN; LIPID STORAGE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BODY WEIGHT; EATING; ENERGY METABOLISM; GONADS; HOMEOSTASIS; HUMAN; LEPTIN; SEX HORMONES; STEROIDS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033775888     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(00)00458-5     Document Type: Conference Paper

References (153)

1. Central nervous system control of food intake
2. Genetics of body-weight regulation
3. Mice lacking melanin-concentrating hormone are hypophagic and lean
4. Obesity, diabetes and the central nervous system
5. What's in a name? In search of leptin's physiological role
6. Aromatization of androgens by muscle and adipose tissue in vivo
7. Low serum testosterone and sex-hormone-binding-globulin in massively obese men
8. Testosterone decrease and oestrogen increase in male patients with obesity
9. Increased estrogen production in obese men
10. Relationship of plasma sex hormones to different parameters of obesity in male subjects
11. Obese men have elevated plasma levels of estrone sulfate
12. Plasma oestrone-fatty acid ester levels are correlated with body fat mass in humans
13. The effect of weight loss on reproductive hormones in obese men
14. Obese young men have elevated plasma estrogen levels but obese premenopausal women do not
15. Obesity, serum cholesterol, and estrogens in premenopausal women
16. Food-restricted, prepubertal, female rats; rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone
17. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men
18. Plasma free and non-sex-hormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity
19. Depressed plasma testosterone and fractional binding of testosterone in obese males
20. Pathogenesis of the decreased androgen levels in obese men
21. Signals that regulate food intake and energy homeostasis
22. The role of leptin in human obesity and disease; a review of current evidence
23. Variations in regulation of energy exchange associated with estrus, diestrus, and pseudopregnancy in rats
24. Ovarian influences on the meal patterns of female rats
25. Some effects of ovarian hormones on food intake and body weight in female rats
26. Sex differences in body-weight changes following gonadectomy of rats
27. Effects of stereoisomers of estradiol on food intake, body weight and hoarding behavior in female rats
28. The rat LTW(m) Leydig cell tumor; cancer anorexia due to estrogen
29. Estrogens and the Leydig LTW(m) tumor syndrome; anorexia and diet aversions attenuated by area postrema lesions
30. Some characteristics of feeding during streptoxotocin-induced diabetes in the rat
31. Androgenic control of food intake and body weight in male rats
32. Dose-dependent effects of testosterone on feeding and body weight in male rats
33. Use of orchiectomy and testosterone replacement to explore meal number-to-meal size relationship in male rats
34. Effects of testosterone on body weight and adipose tissue; role of aromatization
35. New insights into sympathetic regulation of glucose and fat metabolism (in process citation)
36. Role of food intake in estradiol-induced body weight changes in female rats
37. Hypothalamic melanin concentrating hormone is a target for the anorexic effect of estrogen
38. Energy balance in ovariectomized rats with and without estrogen replacement
39. Effects of ovarian steroids on energy balance in rats fed a highly palatable diet
40. Effects of estrogen on food intake, body weight, and temperature of male and female obese mice
41. Oxygen consumption of oestradiol-treated rats
42. Effects of ovarian hormones on energy balance and brown adipose tissue thermogenesis
43. Energy balance and brown fat activity in adrenalectomized male, female, and castrated male rats
44. Effects of oral testosterone undecanoate on growth, body composition, strength and energy expenditure of adolescent boys
45. Induction of uncoupling protein expression in brown and white adipose tissue by leptin
46. Direct effects of leptin on brown and white adipose tissue
47. Analysis of ovariectomy and estrogen effects on body composition in rats by X-ray and magnetic resonance imaging techniques
48. Food intake, body weight, and adiposity in female rats; actions and interactions of progestins and antiestrogens
49. The effects of gonadectomy on the sex differences in dietary self-selection patterns and carcass compositions of rats
50. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause
51. Effects of hormone replacement therapy on weight, body composition, fat distribution, and food intake in early postmenopausal women; a prospective study
52. Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women
53. Effect of postmenopausal hormone therapy on body weight and waist and hip girths. Postmenopausal Estrogen-Progestin Interventions Study Investigators
54. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
55. Generation and reproductive phenotypes of mice lacking estrogen receptor β
56. Estrogen receptor null mice; what have we learned and where will they lead us?
57. The distribution of estrogen receptor β mRNA in forebrain regions of the estrogen receptor α knockout mouse
58. Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility
59. Sex differences in androgen-regulated expression of cytochrome P450 aromatase in the rat brain
60. Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men
61. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
62. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency
63. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats
64. Effect of sustained estradiol release in the intact male rat; correlation of estradiol serum levels with actions on body weight, serum testosterone, and peripheral androgen-dependent tissues
65. Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals
66. Effects of testosterone and estrogens on deltoid and trochanter adipocytes in two cases of transsexualism
67. A re-evaluation of the anabolic effect of testosterone in rats; interactions with gonadectomy, adrenalectomy and hypophysectomy
68. Effects of castration and testosterone substitution on body composition and muscle metabolism in rats
69. The effects of castration on body composition, adipose tissue cellularity and lipid and carbohydrate metabolism in adult male rats
70. Effects of androgens on dietary self-selection and carcass composition in male rats
71. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism
72. Testosterone deficiency in young men; marked alterations in whole body protein kinetics, strength, and adiposity
73. Physiological levels of estradiol stimulate plasma high density lipoprotein2 cholesterol levels in normal men
74. Effect of testosterone on the appetite, body weight and composition of the normal rat
75. The effect of anabolic steroids on lean body mass; the dose response curve
76. Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped
77. Nandrolone decanoate treatment of post-menopausal osteoporosis for 2 years and effects of withdrawal
78. Changes in soft tissue body composition and plasma lipid metabolism during nandrolone decanoate therapy in postmenopausal osteoporotic women
79. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
80. Clinical review 85; emerging issues in androgen replacement therapy
81. Role of leptin in the neuroendocrine response to fasting
82. Role of leptin in hypothalamic-pituitary function
83. Leptin is a metabolic signal to the reproduction system
84. Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women
85. Novel B219/OB receptor isoforms; possible role of leptin in hematopoiesis and reproduction
86. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat
87. The adipose obese gene product, leptin; evidence of a direct inhibitory role in ovarian function
88. Leptin directly stimulates aromatase activity in human luteinized granulosa cells
89. Does estradiol mediate leptin's effects on adiposity and body weight?
90. Expression of functional leptin receptors in rodent Leydig cells
91. Leptin inhibits testosterone secretion from adult rat testis in vitro
92. Leptin and androgens in male obesity; evidence for leptin contribution to reduced androgen levels
93. Inverse correlation between serum testosterone and leptin in men
94. Strong association between serum levels of leptin and testosterone in men
95. Sexual dimorphism in plasma leptin concentration
96. Effects of gender, body composition, and menopause on plasma concentrations of leptin
97. Dihydrotestosterone, stanozolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro; lack of effect of testosterone
98. Regulation of leptin by steroid hormones in rat adipose tissue
99. Depot- and sex-specific differences in human leptin mRNA expression; implications for the control of regional fat distribution
100. Identification of oestrogen receptors and oestrogen receptor mRNA in human adipose tissue
101. In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes; evidence for a regional specific regulation by sex steroid hormones
102. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men
103. Rats with hypothalamic obesity are insensitive to central leptin injections
104. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats; evidence for loss of its satiety effect in VMH-lesioned rats
105. The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin
106. Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors
107. Effects of ovariectomy and estradiol injections on food intake and body weight in rats with ventromedial hypothalamic lesions
108. Sex differences in hyperphagia and body weight following hypothalamic damage
109. The effects of estrogens on food intake and body weight following ventromedial hypothalamic lesions
110. The effects of estradiol on body weight and food intake in normal weight VMH-lesioned rats
111. Effects of gonadectomy on hypothalamic obesity in male and female rats
112. Effects of ovariectomy and estradiol on body weight and food intake in gold thioglucose-treated mice
113. Effects of PVN lesions on the responsiveness of female rats to estradiol
114. Lesions of hypothalamic paraventricular nuclei do not prevent the effect of estradiol on energy and fat balance
115. Influence of ovarian hormones on the recovery period following lateral hypothalamic lesions
116. The effects of lateral hypothalamic lesions and castration upon the body weight and composition of male rats
117. Veptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus
118. Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation
119. Localization of neuropeptide-Y immunoreactivity in estradiol-concentrating cells in the hypothalamus
120. Withdrawal of (corrected) estrogen increases hypothalamic neuropeptide Y (NPY) mRNA expression in ovariectomized obese rat
121. Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat
122. Increased neuropeptide Y concentrations in specific hypothalamic regions of lactating rats; possible relationship to hyperphagia and adaptive changes in energy blanace
123. Anorectic effects of estrogen may be mediated by decreased neuropeptide-Y release in the hypothalamic paraventricular nucleus
124. Effects of ovarian hormones on the concentrations of immunoreactive neuropeptide Y in discrete brain regions of the female rat; correlation with serum luteinizing hormone (LH) and median eminence LH-releasing hormone
125. Estradiol inhibits the increase of hypothalamic neuropeptide Y mRNA expression induced by weight loss in ovariectomized rats
126. Neuropeptide Y gene expression in the arcuate nucleus; sexual dimorphism and modulation by testosterone
127. Testosterone raises neuropeptide-Y concentration in selected hypothalamic sites and in vitro release from the medial basal hypothalamus of castrated male rats
128. Steroidal regulation of hypothalamic neuropeptide Y release and gene expression
129. Age-related decrease in neuropeptide-Y gene expression in the arcuate nucleus of the male rat brain is independent of testicular feedback
130. Effects of orchidectomy on levels of the mRNAs encoding gonadotropin-releasing hormone and other hypothalamic peptides in the adult male rhesus monkey (Macaca mulatta)
131. Agouti related peptide (Agrp) stimulates the hypothalamo pituitary gonadal axis in vivo and in vitro in male rats
132. Two important systems in energy homeostasis; melanocortins and melanin-concentrating hormone
133. Identification of targets of leptin action in rat hypothalamus
134. Melanin-concentrating hormone, melanocortin receptors and regulation of luteinizing hormone release
135. Stimulatory effect of melanin-concentrating hormone on luteinising hormone release
136. The influence of gonadal steroids on pre-pro melanin-concentrating hormone mRNA in female rats
137. 17beta-estradiol regulation of melanin-concentrating hormone and neuropeptide-E-I contents in cynomolgus monkeys; a preliminary study
138. The effect and possible mode of action of alpha-melanocyte-stimulating hormone on gonadotropin release in the ovariectomized rat; an in vivo and in vitro analysis
139. Regulation of proopiomelanocortin messenger ribonucleic acid content by sex steroids in the arcuate nucleus of the female rat brain
140. Estrogen decreases rat hypothalamic proopiomelanocortin messenger ribonucleic acid levels
141. Testosterone regulation of pro-opiomelanocortin messenger ribonucleic acid (mRNA) in the arcuate nucleus of the male rat
142. Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus
143. The role of corticotropin-releasing factor and urocortin in the modulation of ingestive behavior
144. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
145. Effects of adrenocortical and gonadal steroids on the secretion in vitro of corticotrophin and its hypothalamic releasing factor
146. Effects of corticotropin-releasing factor on energy balance in rats are sex dependent
147. Gonadal regulation of corticotropin-releasing factor immunoreactivity in hypothalamus
148. Corticotropin releasing hormone mRNA is elevated on the afternoon of proestrus in the parvocellular paraventricular nuclei of the female rat
149. The modulatory role of estrogens on corticotropin-releasing factor gene expression in the hypothalamic paraventricular nucleus of ovariectomized rats; role of the adrenal gland
150. Treatment with alpha-helical-CRF(9-41) prevents the anorectic effect of 17-beta estradiol
151. Androgen inhibits the increases in hypothalamic corticotropin-releasing hormone (CRH) and CRH-immunoreactivity following gonadectomy
152. Independent and overlapping effects of corticosterone and testosterone on corticotropin-releasing hormone and arginine vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus and stress-induced adrenocorticotropic hormone release