Neuropeptide Y and limbic seizures

Reviews in the Neurosciences

Volumn 9, Issue 2, 1998, Pages 117-128

  Baraban, Scott C ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Epilepsy; Hippocampus; Interneuron; Knockout mice; Seizure disorders; Synaptic function; Trisynaptic circuit

Indexed keywords

ANTICONVULSIVE AGENT; BRAIN PEPTIDE; BRAIN RECEPTOR; KAINIC ACID; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; PANCREAS POLYPEPTIDE; PEPTIDE YY; PICROTOXIN; SOMATOSTATIN;

ADRENERGIC SYSTEM; ANXIETY; BRAIN CORTEX; BRAIN STEM; CARDIOVASCULAR FUNCTION; CIRCADIAN RHYTHM; COMPLEX PARTIAL SEIZURE; CORPUS STRIATUM; EPILEPTIC DISCHARGE; FEEDING; HIPPOCAMPUS; HYPOTHALAMUS; HYPOTHESIS; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LIMBIC SYSTEM; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; REVIEW; SYNAPTIC TRANSMISSION;

EID: 0031811184     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.1998.9.2.117     Document Type: Review

References (94)

1. Albers HE, Ferris CF. Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci Lett 1984; 7: 163-168.
2. Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, Polak JM. Neuropeptide Y distribution in the rat brain. Science 1983; 221: 877-879.
3. Allen JM, Adrian TE, Tatemoto K, Polak JM, Hughes J, Bloom SR. Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens. Neuropeptides 1982; 3: 71-77.
4. Andersen P, Bliss TW, Lomo T, Olsen LI, Skrede KK. Lamellar organization of hippocampal excitatory pathways. Acta Physiol Scand 1969; 76: 4A-5A.
5. Baraban SC, Hollopeter G, Erickson JC, Schwartzkroin PA, Palmiter RD. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci 1997; 17: 8927-8936.
6. Bard JA, Walker MW, Branchek TA, Weinshank RL. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y and peptide YY. J Biol Chem 1995; 270: 26762-26765.
7. Bendotti C, Vezzani A, Serafini R, Servadio A, Rivolta R, Samanin R. Increased preproneuropeptide Y mRNA in the rat hippocampus during the development of hippocampal kindling: comparison with the expression of preprosomatostatin mRNA. Neurosci Lett 1991; 132: 175-178.
8. Bijak M. Inhibitory effect of neuropeptide Y on epileptiform activity in the frontal cortex and hippocampus in vitro. Pol J Pharmacol 1995; 47: 461-463.
9. Bleakman D, Harrison NL, Colmers WF, Miller RJ. Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat. Br J Pharmacol 1992; 107: 334-340.
10. Bleakman D, Miller PJ, Colmers WF. Actions of neuropeptide Y on the electrophysiological properties of nerve cells. In: Colmers WF, Wahlestedt C, eds. The Biology of Neuropeptide Y and Related Peptides. New Jersey: Humana Press, 1993; 241-272.
11. Brene S, Lindefors N, Ballarin M, Persson H. Kainic acid-mediated increase of preprotachykinin-A messenger RNA expression in the rat hippocampus and a region-selective attenuation by dexamethasone. Neuroscience 1992; 50: 611-618.
12. Brooks PA, Kelly JS, Allen JM, Smith DAS, Stone TW. Direct excitatory effects of neuropeptide Y (NPY) on rat hippocampal neurones in vitro. Brain Res 1987; 408: 295-298.
13. Brown TH, Zador AM. Hippocampus. In: Shepherd GM, ed. The Synaptic Organization of the Brain. New York: Oxford University Press, 1990.
14. Busch-Sorensen M, Sheikh SP, O'Hare M, Tortora O, Schwartz TW, Gammeltoft S. Regional distribution of neuropeptide Y and its receptor in the porcine central nervous system. J Neurochem 1989; 52: 1545-1552.
15. Caberlotto L, Fuxe K, Sedvall G, Hurd YL. Localization of neuropeptide Y Y1 mRNA in the human brain: abundant expression in cerebral cortex and striatum. Eur J Neurosci 1997; 9: 1212-1225.
16. Chafetz RS, Nahm WK, Noebels JL. Aberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization. Mol Brain Res 1995; 31: 111-121.
17. Chan-Palay V. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by imnmnogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. J Comp Neurol 1987; 260: 201-223.
18. Chan-Palay V, Kohler C, Haesler U, Lang W, Yasargil G. Distribution of neurons and axons immunoreactive with antisera against neuropeptide Y in the normal human hippocampus. J Comp Neurol 1986; 248: 360-375.
19. Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats. Endocrinology 1984; 115: 427-429.
20. Colmers WF, Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. TINS 1994; 17: 373-379.
21. 2 receptor. Br J Pharmacol 1991; 102: 41-44.
22. Colmers WF, Lukowiak K, Pittman QJ. Neuropeptide Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism. Brain Res 1985; 346: 404-408.
23. Colmers WF, Lukowiak K, Pittman QJ. Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice. J Physiol 1987; 383: 285-299.
24. Colmers WF, Lukowiak K, Pittman QJ. Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition. J Neurosci 1988; 8: 3827-3837.
25. Dellar T, Leranth C. Synaptic connections of neuropeptide Y (NPY) immunoreactive neurons in the hilar area of the rat hippocampus. J Comp Neurol 1990; 300: 433-447.
26. de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res 1989; 495: 387-395.
27. de Quidt ME, Emson PC. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system - II. Immunohistochemical analysis. Neuroscience 1986; 18: 545-618.
28. Dumont Y, Fournier A, St-Pierre S, Schwartz TW, Quirion R. Differential distribution of neuropeptide Y1 and Y2 receptors in the rat brain. Eur J Pharmacol 1990; 191: 501-503.
29. Dumont Y, Martel JC, Fournier A, St-Pierre S, Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog Neurobiol 1992; 38: 126-167.
30. Dumont Y, Martel JC, Fournier A, St-Pierre S, Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in rat brain. J Neurosci 1993; 13: 73-86.
31. 2 receptor radioligands. Synapse 1996; 22: 139-158.
32. Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996; 381: 415-418.
33. Flood JF, Hernandez EN, Morley JE. Modulation of memory processing by neuropeptide Y. J Neurosci 1993; 13: 73-86.
34. Gall C, Lauterborn J, Isackson P, White J. Seizures, neuropeptide regulation, and mRNA expression in the hippocampus. Prog Brain Res 1990; 83: 371-390.
35. Gehlert DR, Gackenheimer SL. Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains. Neuroscience 1997; 76: 215-224.
36. 125I-labeled peptide YY binding sites in the rat brain. Neurochem Int 1992; 21: 45-67.
37. Gerald C, Walker MW, Vaysse PJJ, He C, Branchek TA, Weinshank RL. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J Biol Chem 1995; 45: 26758-26761.
38. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hargmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 1996; 382: 168-171.
39. Gruber B, Greber S, Rupp E, Sperk G. Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection. Hippocampus 1994; 4: 474-482.
40. Gustafson EL, Smith KE, Durkin MM, Walker MW, Gerald C, Weinshank R, Branchek TA. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Mol Brain Res 1997; 46: 223-235.
41. Hashimoto T, Obata K. Induction of somatostatin by kainic acid in pyramidal and granule cells of the rat hippocampus. Neurosci Lett 1991; 12: 514-527.
42. Heilig M, McLeod S, Koob GK, Britton KT. Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test. Regul Pept 1992; 41: 61-69.
43. Heilig M, Soderpalm B, Engel JA, Widerlov E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology 1989; 98: 524-529.
44. Heilig M, Widerlov E. Neurobiology and clinical aspects of neuropeptide Y. Crit Rev Neurobiol 1995; 9: 115-136.
45. Hendry SHC. Organization of neuropeptide Y neurons in the mammalian central nervous system. In: Colmers WF, Wahlestedt C, eds. The Biology of Neuropeptide Y and Related Peptides. New Jersey: Humana Press, 1993; 65-156.
46. Holm IE, Geneser FA, Zimmer J. Somatostatin- and neuropeptide Y-like immunoreactivity in the dentate area, hippocampus, and subiculum of the domestic pig. J Comp Neurol 1992; 322: 390-408.
47. Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem 1996; 271: 26315-26319.
48. Jacques D, Tong Y, Dumont Y, Shen SH, Quirion R. Expression of the neuropeptide Y Y1 receptor mRNA in the human brain: an in situ hybridization study. NeuroReport 1996; 7: 1053-1056.
49. Klapstein GJ, Colmers WF. On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro. Hippocampus 1993; 3: 103-112.
50. Klapstein GJ, Colmers WF. Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J Neurophysiol 1997; 78: 1651-1661.
51. Kohler C, Eriksson L, Davies S, Chan-Palay V. Neuropeptide Y innervation of the hippocampal region in the rat and monkey brain. J Comp Neurol 1986; 244: 384-400.
52. Kohler C, Eriksson LG, Davies S, Chan-Palay V. Colocalization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region. Neurosci Lett 1987; 78: 1-6.
53. Kohler C, Schultzberg M, Radesater A-C. Distribution of neuropeptide Y receptors in the rat hippocampal region. Neurosci Lett 1987; 75: 141-146.
54. Kragh J, Tonder N, Finsen BR, Zimmer J, Bolwig TG. Repeated electroconvulsive shocks cause transient changes in rat hippocampal somatostatin and neuropeptide Y immunoreactivity and mRNA in situ hybridization signals. Exp Brain Res 1994; 98: 305-313.
55. 1 mRNA in forebrain areas of the rat central nervous system. Eur J Neurosci 1993; 5: 1622-1637.
56. Levine AS, Morley JE. Neuropeptide Y: a potent inducer of consummatory behaviour in rats. Peptides 1984; 5: 1025-1029.
57. Lotstra F, Schiffmann SN, Vanderhaeghen J-J. Neuropeptide Y-containing neurons in the human infant hippocampus. Brain Res 1989; 478: 211-226.
58. 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens. Acta Physiol Scand 1984; 120: 477-479.
59. Mahata SK, Gruber B, Mahata M, Roder C, Fischer-Colbrie R, Sperk G. Kainic acid seizures in the rat: differential expression of chromogranin A, carboxy-peptidase H and peptidylglycine alpha-amidating monooxygenase in subfields of the hippocampal formation. Acta Neuropathol (Berl) 1993; 86: 590-595.
60. Mahata SK, Marksteiner J, Sperk G, Mahata M, Gruber B, Fischer-Colbrie R, Winkler H. Temporal lobe epilepsy of the rat: differential expression of mRNAs of chromogranin B, secretogranin II, synaptin/synaptophysin and p65 in subfield of the hippocampus. Mol Brain Res 1992; 16: 1-12.
61. Marksteiner J, Ortler M, Bellman R, Sperk G. Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat. Neurosci Lett 1990; 112: 143-148.
62. Marksteiner J, Wahler R, Bellman R, Ortler M, Krause JE, Sperk G. Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat. Neuroscience 1992; 49: 383-395.
63. Martel JC, St-Pierre S, Quirion R. Neuropeptide Y receptors in rat brain: autoradiographic localization. Peptides 1986; 7: 55-60.
64. Marty S, Berninger B, Carroll P, Thoenen H. GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor. Neuron 1996; 16: 565-570.
65. Mathern GW, Babb TL, Pretorius JK, Leite JP. Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J Neurosci 1995; 15: 3990-4004.
66. McQuiston AR, Colmers WF. Neuropeptide Y does not alter NMDA conductances in CA3 pyramidal neurons: a slice-patch study. Neurosci Lett 1992; 138: 261-264.
67. 1 receptors inhibit N-type calcium currents and reduce transient calcium increases in rat dentate granule cells. J Neurosci 1996; 16: 1422-1429.
68. Mikkelsen JD, Woldbye D, Kragh J, Larsen PJ, Bolwig TG. Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus. Mol Brain Res 1994; 23: 317-322.
69. Milner TA, Veznedaroglu E. Ultrastructural localization of neuropeptide Y-like immunoreactivity in the rat hippocampal formation. Hippocampus 1992; 2: 107-126.
70. Mitchell J, Cook I, Hervey V. Effect of seizures on hippocampal peptidergic neurons. Neuropathol Appl Neurobiol 1997; 23: 299-306.
71. Morris BJ. Neuronal localisation of neuropeptide Y gene expression in rat brain. J Comp Neurol 1989; 290: 358-368.
72. Ohhashi T, Jacobowitz DM. The effects of pancreatic polypeptides and neuropeptide Y on the rat vas deferens. Peptides 1983; 4: 381-386.
73. Ohkubo T, Niwa M, Yamashita K, Kataoka Y, Shigematsu K. Neuropeptide Y (NPY) and peptide YY (PYY) receptors in rat brain. Cell Mol Neurobiol 1990; 10: 539-552.
74. Pickel VM, Chan J, Veznedaroglu E, Milner TA. Neuropeptide Y and dynorphin-immunoreactive large dense-core vesicles are strategically localized for presynaptic modulation in the hippocampal formation and substantia nigra. Synapse 1995; 19: 160-169.
75. Pitkanen A, Beal MF, Sirvio J, Swartz KJ, Mannisto PT, Riekkinen PJ. Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazole-kindled rats. Neuropeptides 1989; 14: 197-207.
76. 2+ entry. J Neurosci 1997; 17: 8169-8177.
77. Rizzi M, Monno A, Samanin R, Sperk G, Vezzani A. Electrical kindling of the hippocampus is associated with functional activation of neuropeptide Y-containing neurons. Eur J Neurosci 1993; 5: 1534-1538.
78. Roder C, Schwarzer C, Vezzani A, Gobbi M, Mennini T, Sperk G. Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures. Neuroscience 1996; 70: 47-55.
79. Sadamatusu M, Kanai H, Masui A, Serikawa T, Yamada J, Sasa M, Kato N. Altered brain contents of neuropeptides in spontaneously epileptic rats (SER) and tremor rats with absence seizures. Life Sci 1995; 57: 523-531.
80. Schwarzer C, Williamson JM, Lothman EW, Vezzani A, Sperk G. Somatostatin, neuropeptide Y, neurokinin B and cholecystokinin immunoreactivity in two chronic models of temporal lobe epilepsy. Neuroscience 1995; 69: 831-845.
81. Sloviter RS, Lowenstein DH. Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation-induced neuronal stress. J Neurosci 1992; 12: 3004-3009.
82. Smialowska M, Bijak M, Sopala M, Tokarski K. Inhibitory effect of NPY on the picrotoxin-induced activity in the hippocampus: a behavioural and electrophysiological study. Neuropeptides 1996; 30: 7-12.
83. Sperk G, Marksteiner J, Gruber B, Bellman R, Mahata M, Ortler M. Functional changes in neuropeptide Y-and somatostatin-containing. neurons induced by limbic seizures in the rat. Neuroscience 1992; 4: 831-846.
84. Stenfors C, Srinivasan GR, Theodorsson E, Mathe AA. Electroconvulsive stimuli and brain peptides: effect of modification of seizure duration on neuropeptide Y, neurokinin A, substance P and neurotensin. Brain Res 1992; 596: 251-258.
85. Takahashi Y, Sadamatsu M, Kanai H, Masui A, Amano S, Ihara N, Kato N. Changes of immunoreactive neuropeptide Y, somatostatin and corticotropin-releasing factor (CRF) in the brain of a novel epileptic mutant rat, Ihara's genetically epileptic rat. Brain Res 1997; 776: 255-260.
86. Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y: a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 1982; 296: 659-660.
87. Tonder N, Kragh J, Finsen BR, Bolwing TG, Zimmer J. Kindling induces transient changes in neuronal expression of somatostatin, neuropeptide Y, and calbindin in adult rat hippocampus and fascia dentata. Epilepsia 1994; 35: 1299-1308.
88. Vezzani A, Civenni G, Rizzi M, Monno A, Messali S, Samanin R. Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kanic acid treated rats. Brain Res 1994; 660: 138-143.
89. Wahlestedt C, Reis DJ. Neuropeptide Y-related peptides and receptors - are the receptors potential therapeutic drug targets? Rev Pharmacol Toxicol 1993; 32: 309-352.
90. 2 receptor subtypes in human and rat brain. Brain Res 1993; 631: 27-38.
91. Woldbye DPD, Larsen PJ, Mikkelsen JD, Klemp K, Madsen TM, Bolwig TG. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nature Med 1997; 3: 761-764.
92. Woldbye DPD, Madsen TM, Larsen PJ, Mikkelsen JD, Bolwig TG. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res 1996; 737: 162-168.
93. Yu, MC, Luo CB, Long L, Yew DT. An immunohistochemical study of neuropeptide Y positive sites in the developing human hippocampal formation. Dev Brain Res 1993; 72: 277-281.
94. Zachrisson O, Mathe AA, Stenfors C, Lindefors N. Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain. Mol Brain Res 1995; 31: 71-85.