Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist

Journal of Biological Chemistry

Volumn 272, Issue 12, 1997, Pages 7699-7706

  Grouzmann, Eric ^a   Buclin, Thierry ^a   Martire, Maria ^c   Cannizzaro, Clara ^c   Dörner, Barbara ^b   Razaname, Alain ^b   Mutter, Manfred ^b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYCLIC AMP; NEUROPEPTIDE Y; NEUROPEPTIDE Y2 RECEPTOR; NORADRENALIN; RECEPTOR SUBTYPE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; DOSE RESPONSE; HUMAN; HUMAN CELL; NEUROTRANSMITTER RELEASE; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING;

BINDING, COMPETITIVE; CALCIUM; CYCLIC AMP; HUMANS; NEUROPEPTIDE Y; NOREPINEPHRINE; PEPTIDES, CYCLIC; RECEPTORS, NEUROPEPTIDE Y; TUMOR CELLS, CULTURED;

EID: 0030909709     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.12.7699     Document Type: Article

References (22)

1. Tatemoto, K., Carlquist, M., and Mutt, V. (1982) Nature 296, 659-660
2. Tatemoto, K. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 5485-5489
3. Ekblad, E., Edvinsson, L., Uddman, R., Wahlestedt, C., and Hakanson, R. (1984) Regul. Pept. 8, 225-235
4. Wahlestedt, C., and Reis, D, J. (1993) Annu. Rev. Pharmacol. Toxicol. 32, 309-352
5. Michel, M. C. (1991) Trends Pharmacol. Sci. 12, 389-394
6. Herzog, H., Hort, Y. J., Ball, H. J., Hayes, G., Shine, J., and Selbie, L. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 5794-5798
7. Larhammar, D., Blomqvist, A. G., Yee, F., Jazin, E., Yoo, H., and Wahlestedt, C. (1992) J. Biol. Chem. 267, 10935-10938
8. Rose, P. M., Prabhavathi, F., Lynch, J. S., Frazier, S. T., Fisher, S. M., Kodukula, K., Kienzle, B., and Seethala, R. (1995) J. Biol. Chem. 270, 22661-22664
9. Gerald, C., Walker, M. W., Vaysse, P. J.-J., He, C., Branchek, T. A., and Weinshank, R. L. (1995) J. Biol. Chem. 270, 26758-26761
10. Lundell, I., Blomqvist, A. G., Berglund, M. M., Schober, D. A., Johnson, D., Statnick, M. A., Gadski, R. A., Gehlert, D. R., and Larhammar, D. (1995) J. Biol. Chem. 270, 29123-29128
11. Walker, P., Grouzmann, E., Burnier, M., and Waeber, B. (1991) Trends Pharmacol. Sci. 12, 111-115
12. Martire, M., Pistritto, G., Mores, N., Agnati, L. F., and Fuxe, K. (1993) Eur. J. Pharmacol. 230, 231-234
13. Greber, S., Schwarzer, C., and Sperk, G. (1994) Br. J. Pharmacol. 113, 737-740
14. Blasquez, C., Jégou, S., Tranchand Bunel, D., Fournier, A., and Vaudry, H. (1992) Brain Res. 596, 163-168
15. Barker-Gibb, M. L., Scott, C. J., Boublik, J. H., and Clarke, I. J. (1995) J. Endocrinol. 147, 565-579
16. Wang, J., Clofi, P., and Crowley, W. R. (1996) Endocrinology 137, 587-94
17. Larsen, P. J., Jukes, K. E., Chowdrey, H. S., Lightman, S. L., and Jessop, D. S. (1994) Endocrinology 134, 1635-1639
18. Schwartz, T. W., Fuhlendorff, J., Kjems, L. L., Kristensen, M. S., Vervelde, M., O'Hare, M., Krstenansky, J. L., and Bjornholm, B. (1990) Ann. N. Y. Acad. Sci. 611, 35-47
19. Wahlestedt, C., Yanaihara, N., and Hakanson, R. (1986) Regul. Pept. 13, 307-318
20. Beck-Sickinger, A. G., Wieland, H. A., Wittneben, H., Willim, K. D., Rudolf, K., and Jung, G. (1994) Eur. J. Biochem. 225, 947-958
21. Rudolf, K., Eberlein, W., Engel, W., Wieland, H. A., Willim, K. D., Entzeroth, M., Wienen, W., Beck-Sickinger, A. G., and Doods, H. N. (1994) Eur. J. Pharmacol. 271, R11-R13
22. Serradeil-Le Gai., C., Valette, G., Rouby, P. E., Pellet, A., Oury-Donat, F., Brossard, G., Lespy, L., Marty, E., Neliat, G., de Cointet, P., Maffrand, J. P., and Le Fur, G. (1995) FEBS Lett. 362, 192-196