Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: Prospective cohort study

British Medical Journal

Volumn 320, Issue 7251, 2000, Pages 1706-1707

  Salonen, Jukka T ^a   Tuomainen, Tomi Pekka ^a   Kontula, Kimmo ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUCOSE; TYROSINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; GENE MUTATION; GLUCOSE BLOOD LEVEL; HEMOCHROMATOSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 0034709699     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.320.7251.1706     Document Type: Article

References (5)

1. 1 Yaouanq JM. Diabetes and haemochromatosis: current concepts, management and prevention. Diabetes Metab 1995;21:319-29.
2. 2 Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet 1996;13:399-408.
3. 3 Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJ. Global prevalence of putative haemochromatosis mutations. J Med Genet 1997;34:275-8.
4. 4 Salonen JT, Nyssönen K, Tuomainen T-P, Mäenpää PH; Korpela H, Kaplan GA, et al. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ 1995;311:1124-7.
5. 5. Tuomainen T-P, Kontula K, Nyyssönen K, Lakka TA, Heliö T, Salonen JT. Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation: a prospective cohort study in men in eastern Finland. Circulation 1999;100:1274-9.