Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

Journal of Medicinal Chemistry

Volumn 46, Issue 19, 2003, Pages 4050-4062

  Parlow, John J ^a   Case, Brenda L ^a   Dice, Thomas A ^a   Fenton, Ricky L ^a   Hayes, Michael J ^a   Jones, Darin E ^a   Neumann, William L ^a   Wood, Rhonda S ^a   Lachance, Rhonda M ^a   Girard, Thomas J ^a   Nicholson, Nancy S ^a   Clare, Michael ^a   Stegeman, Roderick A ^a   Stevens, Anna M ^a   Stallings, William C ^a   Kurumbail, Ravi G ^a   South, Michael S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 5 [1 [2 [[4 [AMINO(IMINO)METHYL]BENZYL]AMINO] 2 OXOETHYL] 3 CHLORO 5 (ISOPROPYLAMINO) 6 OXO 1,6 DIHYDROPYRAZIN 2 YL]BENZOIC ACID; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; PYRAZINONE DERIVATIVE; THROMBIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; IC 50; INHIBITION KINETICS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTITHROMBIN III; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR VIIA; FIBRINOLYTIC AGENTS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PYRAZINES; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THROMBIN; THROMBOPLASTIN;

EID: 0043211876     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030131l     Document Type: Article

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