Optimization of a screening lead for factor VIIa/TF

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 17, 2001, Pages 2253-2256

  Young, Wendy B ^a   Kolesnikov, Aleksandr ^a   Rai, Roopa ^a   Sprengeler, Paul A ^a   Leahy, Ellen M ^a   Shrader, William D ^a   Sangalang, Joan ^a   Burgess Henry, Jana ^a   Spencer, Jeff ^a   Elrod, Kyle ^a   Cregar, Lynne ^a  

^a Axys Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3' AMINO 5 CHLORO 2 HYDROXYBIPHENYL 3 YL) 1H BENZOIMIDAZOLE 5 CARBOXAMIDINE; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS;

AMIDINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FACTOR VIIA; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PHENYLACETATES; PROTHROMBIN TIME; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17944363800     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00420-6     Document Type: Article

References (19)