-
1
-
-
0030805616
-
Tissue factor in the pathogenesis of Atherosclerosis
-
Taubman M.B., Fallon J.T., Schecter A.D., Giesen P., Medlowitz M., Fyfe B.S., Marmur J.D., Nemerson Y. Tissue factor in the pathogenesis of Atherosclerosis. Thromb Haemostasis. 78:1997;200-204.
-
(1997)
Thromb Haemostasis
, vol.78
, pp. 200-204
-
-
Taubman, M.B.1
Fallon, J.T.2
Schecter, A.D.3
Giesen, P.4
Medlowitz, M.5
Fyfe, B.S.6
Marmur, J.D.7
Nemerson, Y.8
-
2
-
-
0029890757
-
Manifestation of cryptic fibroblast tissue factor occurs at detergent concentrations which dissolve the plasma membrane
-
Carson S.D. Manifestation of cryptic fibroblast tissue factor occurs at detergent concentrations which dissolve the plasma membrane. Blood Coagl Fibrinolysis. 7:1996;303-313.
-
(1996)
Blood Coagl Fibrinolysis
, vol.7
, pp. 303-313
-
-
Carson, S.D.1
-
3
-
-
13044304178
-
Blood-borne tissue factor: Another view of thrombosis
-
Initial report that challenges the paradigm of TF being involved only in the initiation of coagulation. Experimental evidence that supports a role for blood borne-TF in the propagation of a thrombus is presented.
-
Giesen P.L., Rauch U., Bohrmann B., Kling D., Roque M., Fallon J.T., Badimon J.J., Himber J., Riederer M.A., Nemerson Y. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci USA. 96:1999;2311-2315. Initial report that challenges the paradigm of TF being involved only in the initiation of coagulation. Experimental evidence that supports a role for blood borne-TF in the propagation of a thrombus is presented.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2311-2315
-
-
Giesen, P.L.1
Rauch, U.2
Bohrmann, B.3
Kling, D.4
Roque, M.5
Fallon, J.T.6
Badimon, J.J.7
Himber, J.8
Riederer, M.A.9
Nemerson, Y.10
-
4
-
-
0034234462
-
Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor
-
Rauch U., Bonderman D., Bohrmann B., Badimon J.J., Himber J., Riederer M.A., Nemerson Y. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood. 96:2000;170-175.
-
(2000)
Blood
, vol.96
, pp. 170-175
-
-
Rauch, U.1
Bonderman, D.2
Bohrmann, B.3
Badimon, J.J.4
Himber, J.5
Riederer, M.A.6
Nemerson, Y.7
-
5
-
-
0033535978
-
Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina
-
This study evaluated the plasma levels of TF in patients with unstable angina and found them to be elevated.
-
Soejima H., Ogawa H., Yasue H., Kaikita K., Nishiyama K., Misumi K., Takazoe K., Miyao Y., Yoshimura M., Kugiyama K., et al. Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina. Circulation. 99:1999;2908-2913. This study evaluated the plasma levels of TF in patients with unstable angina and found them to be elevated.
-
(1999)
Circulation
, vol.99
, pp. 2908-2913
-
-
Soejima, H.1
Ogawa, H.2
Yasue, H.3
Kaikita, K.4
Nishiyama, K.5
Misumi, K.6
Takazoe, K.7
Miyao, Y.8
Yoshimura, M.9
Kugiyama, K.10
-
6
-
-
0034063089
-
Measurement of tissue factor activity in whole blood
-
Santucci R.A., Erlich J., Labriola J., Wilson M., Kao K.J., Kickler T.S., Spillert C., Mackman N. Measurement of tissue factor activity in whole blood. Thromb Haemost. 83:2000;445-454.
-
(2000)
Thromb Haemost
, vol.83
, pp. 445-454
-
-
Santucci, R.A.1
Erlich, J.2
Labriola, J.3
Wilson, M.4
Kao, K.J.5
Kickler, T.S.6
Spillert, C.7
MacKman, N.8
-
7
-
-
0034698095
-
Release of active tissue factor by human arterial smooth muscle cells
-
Schecter A.D., Spirn B., Rossikhina M., Giesen P.L., Bogdanov V., Fallon J.T., Fischer E.A., Schnapp L.M., Nemerson Y., Taubman M.B. Release of active tissue factor by human arterial smooth muscle cells. Circ Res. 87:2000;126-132.
-
(2000)
Circ Res
, vol.87
, pp. 126-132
-
-
Schecter, A.D.1
Spirn, B.2
Rossikhina, M.3
Giesen, P.L.4
Bogdanov, V.5
Fallon, J.T.6
Fischer, E.A.7
Schnapp, L.M.8
Nemerson, Y.9
Taubman, M.B.10
-
8
-
-
0025992702
-
Coronary thrombosis: Pathogenesis and clinical manifestations
-
Falk E. Coronary thrombosis: pathogenesis and clinical manifestations. Am J Cardiol. 68:1991;28B-35B.
-
(1991)
Am J Cardiol
, vol.68
-
-
Falk, E.1
-
9
-
-
0034015006
-
The role of plaque rupture and thrombosis in coronary artery disease
-
A recent review that looks at the mechanisms underlying the development of atherosclerotic plaques, factors leading to plaque rupture and subsequent thromboses and their clinical consequences.
-
Zaman A.G., Helft G., Worthley S.G., Badimon J.J. The role of plaque rupture and thrombosis in coronary artery disease. Atherosclerosis. 149:2000;251-266. A recent review that looks at the mechanisms underlying the development of atherosclerotic plaques, factors leading to plaque rupture and subsequent thromboses and their clinical consequences.
-
(2000)
Atherosclerosis
, vol.149
, pp. 251-266
-
-
Zaman, A.G.1
Helft, G.2
Worthley, S.G.3
Badimon, J.J.4
-
10
-
-
0033551191
-
Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques: Effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions
-
Badimon J.J., Lettino M., Toschi V., Fuster V., Berrozpe M., Chesebro J.H., Badimon L. Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques: effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions. Circulation. 99:1999;1780-1787.
-
(1999)
Circulation
, vol.99
, pp. 1780-1787
-
-
Badimon, J.J.1
Lettino, M.2
Toschi, V.3
Fuster, V.4
Berrozpe, M.5
Chesebro, J.H.6
Badimon, L.7
-
11
-
-
0033014459
-
Co-localization of tissue factor and tissue factor pathway inhibitor in coronary
-
Kaikita K., Takeya M., Ogawa H., Suefuji H., Yasue H., Takahashi K. Co-localization of tissue factor and tissue factor pathway inhibitor in coronary. Atherosclerosis J Pathol. 188:1999;180-188.
-
(1999)
Atherosclerosis J Pathol
, vol.188
, pp. 180-188
-
-
Kaikita, K.1
Takeya, M.2
Ogawa, H.3
Suefuji, H.4
Yasue, H.5
Takahashi, K.6
-
12
-
-
0022485106
-
Haemostatic function and ischaemic heart disease: Principal result of the Northwick Park Heart Study
-
Meade T.W., Mellows S., Brozovic M., Miller G.J., Chakrabarti R.R., North W.R., Haines A.P., Stirling Y., Imeson J.D., Thompson S.G. Haemostatic function and ischaemic heart disease: principal result of the Northwick Park Heart Study. Lancet. 2:1986;533-537.
-
(1986)
Lancet
, vol.2
, pp. 533-537
-
-
Meade, T.W.1
Mellows, S.2
Brozovic, M.3
Miller, G.J.4
Chakrabarti, R.R.5
North, W.R.6
Haines, A.P.7
Stirling, Y.8
Imeson, J.D.9
Thompson, S.G.10
-
13
-
-
0034648734
-
Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease
-
Girelli D., Russo C., Ferraresi P., Olivieri O., Pinotti M., Friso S., Manzato F., Mazzucco A., Bernardi F., Corrocher R. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. New Engl J Med. 343:2000;774-780.
-
(2000)
New Engl J Med
, vol.343
, pp. 774-780
-
-
Girelli, D.1
Russo, C.2
Ferraresi, P.3
Olivieri, O.4
Pinotti, M.5
Friso, S.6
Manzato, F.7
Mazzucco, A.8
Bernardi, F.9
Corrocher, R.10
-
14
-
-
0029984412
-
Antithrombotic and antilesion benefits without hemorrhagic risks by inhibiting tissue factor pathway
-
Harker L.A., Hanson S.R., Wilcox J.N., Kelly A.B. Antithrombotic and antilesion benefits without hemorrhagic risks by inhibiting tissue factor pathway. Haemost (suppl). 26:(1):1996;76-82.
-
(1996)
Haemost (Suppl)
, vol.26
, Issue.1
, pp. 76-82
-
-
Harker, L.A.1
Hanson, S.R.2
Wilcox, J.N.3
Kelly, A.B.4
-
15
-
-
0031932604
-
Antithrombotic effects of recombinant human, active site-blocked factor VIIa in a rabbit model of recurrent arterial thrombosis
-
Golino P., Ragni M., Cirillo P., D'Andrea D., Scognamiglio A., Ravera A., Buono C., Ezban M., Corcione N., Vigorito F., et al. Antithrombotic effects of recombinant human, active site-blocked factor VIIa in a rabbit model of recurrent arterial thrombosis. Circulation Res. 82:1998;39-46.
-
(1998)
Circulation Res
, vol.82
, pp. 39-46
-
-
Golino, P.1
Ragni, M.2
Cirillo, P.3
D'Andrea, D.4
Scognamiglio, A.5
Ravera, A.6
Buono, C.7
Ezban, M.8
Corcione, N.9
Vigorito, F.10
-
16
-
-
0030824413
-
Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function
-
Himber J., Kirchhofer D., Riederer M., Tschopp T.B., Steiner B., Roux S.P. Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function. Thromb Haemost. 78:1997;1142-1149.
-
(1997)
Thromb Haemost
, vol.78
, pp. 1142-1149
-
-
Himber, J.1
Kirchhofer, D.2
Riederer, M.3
Tschopp, T.B.4
Steiner, B.5
Roux, S.P.6
-
17
-
-
0030917536
-
A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent
-
Kelley R.F., Refino C.J., O'Connell M.P., Modi N., Sehl P., Lowe D., Pater C., Bunting S. A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent. Blood. 89:1997;3219-3227.
-
(1997)
Blood
, vol.89
, pp. 3219-3227
-
-
Kelley, R.F.1
Refino, C.J.2
O'Connell, M.P.3
Modi, N.4
Sehl, P.5
Lowe, D.6
Pater, C.7
Bunting, S.8
-
18
-
-
84858627425
-
Inhibiting factor VIIa-TF activity effectively prevents thrombosis without bleeding side effects [abstract]
-
Murphy M.K., LaChance R.M., Stillwell L.I., Torr-Brown S.R., Girard T.J. Inhibiting factor VIIa-TF activity effectively prevents thrombosis without bleeding side effects [abstract]. Blood. 90:1997;294a.
-
(1997)
Blood
, vol.90
-
-
Murphy, M.K.1
Lachance, R.M.2
Stillwell, L.I.3
Torr-Brown, S.R.4
Girard, T.J.5
-
19
-
-
0001246901
-
Tissue factor pathway inhibitor
-
A.A. Sasahara, & J. Loscalo. New York: Marcel Dekker
-
Girard T.J. Tissue factor pathway inhibitor. Sasahara A.A., Loscalo J. New Therapeutic Agents in Thrombosis and Thrombolysis. 1997;225-260 Marcel Dekker, New York.
-
(1997)
New Therapeutic Agents in Thrombosis and Thrombolysis
, pp. 225-260
-
-
Girard, T.J.1
-
20
-
-
0025904459
-
Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody
-
Taylor F.B. Jr, Chang A., Ruf W., Morrissey J.H., Hinshaw L., Catlett R., Blick K., Edgingtion T.S. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circulation Shock. 33:1991;127-134.
-
(1991)
Circulation Shock
, vol.33
, pp. 127-134
-
-
Taylor F.B., Jr.1
Chang, A.2
Ruf, W.3
Morrissey, J.H.4
Hinshaw, L.5
Catlett, R.6
Blick, K.7
Edgingtion, T.S.8
-
21
-
-
0033603552
-
Adenovirus-mediated local expression of human tissue factor pathway inhibitor eliminates shear stress-induced recurrent thrombosis in the injured carotid artery of the rabbit
-
Nishida T., Ueno H., Atsuchi N., Kawano R., Asada Y., Nakahara Y., Kamikubo Y., Takeshita A., Yasui H. Adenovirus-mediated local expression of human tissue factor pathway inhibitor eliminates shear stress-induced recurrent thrombosis in the injured carotid artery of the rabbit. Circ Res. 84:1999;1446-1452.
-
(1999)
Circ Res
, vol.84
, pp. 1446-1452
-
-
Nishida, T.1
Ueno, H.2
Atsuchi, N.3
Kawano, R.4
Asada, Y.5
Nakahara, Y.6
Kamikubo, Y.7
Takeshita, A.8
Yasui, H.9
-
22
-
-
0034711777
-
Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor
-
Zoldhelyi P., McNatt J., Shelat H.S., Yamamoto Y., Chen Z.Q., Willerson J.T. Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor. Circulation. 101:2000;289-295.
-
(2000)
Circulation
, vol.101
, pp. 289-295
-
-
Zoldhelyi, P.1
McNatt, J.2
Shelat, H.S.3
Yamamoto, Y.4
Chen, Z.Q.5
Willerson, J.T.6
-
24
-
-
0028839499
-
Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral artery injury model
-
Jang Y., Guzman L.A., Lincoff A.M., Gottsauner-Wolf M., Forudi F., Hart C.E., Coutman D.W., Ezban M., Ellis S.G., Topol E.J. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral artery injury model. Circulation. 92:1995;3041-3050.
-
(1995)
Circulation
, vol.92
, pp. 3041-3050
-
-
Jang, Y.1
Guzman, L.A.2
Lincoff, A.M.3
Gottsauner-Wolf, M.4
Forudi, F.5
Hart, C.E.6
Coutman, D.W.7
Ezban, M.8
Ellis, S.G.9
Topol, E.J.10
-
25
-
-
0032879138
-
Structural requirements for TFPI-mediated inhibition of neointimal thickening after balloon injury in the rat
-
Han X., Girard T.J., Baum P., Abendschein D.R., Broze G.J. Jr. Structural requirements for TFPI-mediated inhibition of neointimal thickening after balloon injury in the rat. Arterioscler Thromb Vasc Biol. 10:1999;2563-2567.
-
(1999)
Arterioscler Thromb Vasc Biol
, vol.10
, pp. 2563-2567
-
-
Han, X.1
Girard, T.J.2
Baum, P.3
Abendschein, D.R.4
Broze G.J., Jr.5
-
26
-
-
0032543282
-
Sequential injury of the rabbit abdominal aorta induces intramural coagulation and luminal narrowing independent of intimal mass: Extrinsic pathway inhibition eliminates luminal narrowing
-
Courtman D.W., Schwartz S.M., Hart C.E. Sequential injury of the rabbit abdominal aorta induces intramural coagulation and luminal narrowing independent of intimal mass: extrinsic pathway inhibition eliminates luminal narrowing. Circ Res. 82:1998;996-1006.
-
(1998)
Circ Res
, vol.82
, pp. 996-1006
-
-
Courtman, D.W.1
Schwartz, S.M.2
Hart, C.E.3
-
27
-
-
0034042062
-
Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits
-
Recombinant FVIIai resulted in a significant reduction in both infarct size and no-reflow area in a rabbit model.
-
Golino P., Ragni M., Cirillo P., Scognamiglio A., Ravera A., Buono C., Guarino A., Piro O., Lambiase C., Botticella F., et al. Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits. Am J Physiol Heart Circulation Physiol. 278:2000;H1507-H1516. Recombinant FVIIai resulted in a significant reduction in both infarct size and no-reflow area in a rabbit model.
-
(2000)
Am J Physiol Heart Circulation Physiol
, vol.278
-
-
Golino, P.1
Ragni, M.2
Cirillo, P.3
Scognamiglio, A.4
Ravera, A.5
Buono, C.6
Guarino, A.7
Piro, O.8
Lambiase, C.9
Botticella, F.10
-
28
-
-
0034070660
-
Intimal tissue factor activity is released from the arterial wall after injury
-
Giesen P.L.A., Fyfe B.S., Fallon J.T., Roque M., Mendlowitz M., Rossikhina M., Guha A., Badimon J.J., Nemerson Y., Taubman M.B. Intimal tissue factor activity is released from the arterial wall after injury. Thromb Haemostasis. 83:2000;622-628.
-
(2000)
Thromb Haemostasis
, vol.83
, pp. 622-628
-
-
Giesen, P.L.A.1
Fyfe, B.S.2
Fallon, J.T.3
Roque, M.4
Mendlowitz, M.5
Rossikhina, M.6
Guha, A.7
Badimon, J.J.8
Nemerson, Y.9
Taubman, M.B.10
-
29
-
-
0001173470
-
Mechanistic and pharmacological evaluation of NAPc2, a novel small protein inhibitor of the factor VIIa/tissue factor complex [abstract]
-
Vlasuk G.P., Bergum P.W., Rote W.E., Ruf W. Mechanistic and pharmacological evaluation of NAPc2, a novel small protein inhibitor of the factor VIIa/tissue factor complex [abstract]. Thrombosis and Haemostasis (Suppl). 77:1997;688.
-
(1997)
Thrombosis and Haemostasis (Suppl)
, vol.77
, pp. 688
-
-
Vlasuk, G.P.1
Bergum, P.W.2
Rote, W.E.3
Ruf, W.4
-
30
-
-
0001627096
-
Early clinical evaluation of rNAPc2, a novel inhibitor of blood coagulation factor VIIa/tissue factor (FVIIa/TF) [abstract]
-
Vlasuk G., Bradbury A., Bergum P., Rote W. Early clinical evaluation of rNAPc2, a novel inhibitor of blood coagulation factor VIIa/tissue factor (FVIIa/TF) [abstract]. J Am Coll Cardiol. 33:1999;255a-256a.
-
(1999)
J Am Coll Cardiol
, vol.33
-
-
Vlasuk, G.1
Bradbury, A.2
Bergum, P.3
Rote, W.4
-
31
-
-
0000103203
-
A dose-response study of the factor VIIa/tissue factor inhibitor rNAPc in the prevention of postoperative venous thrombosis in patients undergoing total knee arthroplasty [abstract]
-
Lee A., Agnelli G., Buller H., Ginsberg J., Heit J., Rote W., Vlasuk G., Gent M. A dose-response study of the factor VIIa/tissue factor inhibitor rNAPc in the prevention of postoperative venous thrombosis in patients undergoing total knee arthroplasty [abstract]. Blood. 95:2000;491a.
-
(2000)
Blood
, vol.95
-
-
Lee, A.1
Agnelli, G.2
Buller, H.3
Ginsberg, J.4
Heit, J.5
Rote, W.6
Vlasuk, G.7
Gent, M.8
-
34
-
-
0000684302
-
First clinical investigation of a tissue-factor inhibitor administered during percutaneous coronary revascularization: A randomized, double-blinded dose-escalation trial-assessing safety and efficacy of FFR-FVIIa in percutaneous transluminal coronary angioplasty (ASIS) trial
-
The preliminary report of results from a clinical trial in which patients were treated with FVIIai following PTCA. The results supported a trend for efficacy with some increase in minor bleeds. Various levels of heparin were needed and given with the FVIIai.
-
Lincoff A.M. First clinical investigation of a tissue-factor inhibitor administered during percutaneous coronary revascularization: A randomized, double-blinded dose-escalation trial-assessing safety and efficacy of FFR-FVIIa in percutaneous transluminal coronary angioplasty (ASIS) trial. J Am Coll Cardiol. 36:2000;312-313. The preliminary report of results from a clinical trial in which patients were treated with FVIIai following PTCA. The results supported a trend for efficacy with some increase in minor bleeds. Various levels of heparin were needed and given with the FVIIai.
-
(2000)
J Am Coll Cardiol
, vol.36
, pp. 312-313
-
-
Lincoff, A.M.1
-
35
-
-
18844480902
-
Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia
-
De Jong E., Dekkers P.E.P., Creasey A.A., Hack C.E., Paulson S.K., Karim A., Kesecioglu J., Levi M., van Deventer S.J.H., van der Poll T. Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia. Blood. 95:2000;1124-1129.
-
(2000)
Blood
, vol.95
, pp. 1124-1129
-
-
De Jong, E.1
Dekkers, P.E.P.2
Creasey, A.A.3
Hack, C.E.4
Paulson, S.K.5
Karim, A.6
Kesecioglu, J.7
Levi, M.8
Van Deventer, S.J.H.9
Van Der Poll, T.10
-
36
-
-
0033495803
-
New potential therapeutic modalities: Tissue factor pathway inhibitor
-
Creasey A.A. New potential therapeutic modalities: tissue factor pathway inhibitor. Sepsis. 3:1999;173-182.
-
(1999)
Sepsis
, vol.3
, pp. 173-182
-
-
Creasey, A.A.1
-
37
-
-
0034732235
-
Peptide exosite inhibitors of factor VIIa as anticoagulants
-
This article reports on the identification of a novel mechanism for the inhibition of TF/FVIIa activity. An 'exosite' inhibitor peptide that binds near to, but in an area distinct from, the FVIIa active site and disrupts activity is presented.
-
Dennis M.S., Elgenbrot C., Skeleton N.J., Ultsch M.H., Santell L., Dwyer M.A., O'Connell M.P., Lazarus R.A. Peptide exosite inhibitors of factor VIIa as anticoagulants. Nature. 404:2000;465-470. This article reports on the identification of a novel mechanism for the inhibition of TF/FVIIa activity. An 'exosite' inhibitor peptide that binds near to, but in an area distinct from, the FVIIa active site and disrupts activity is presented.
-
(2000)
Nature
, vol.404
, pp. 465-470
-
-
Dennis, M.S.1
Elgenbrot, C.2
Skeleton, N.J.3
Ultsch, M.H.4
Santell, L.5
Dwyer, M.A.6
O'Connell, M.P.7
Lazarus, R.A.8
-
40
-
-
0038934482
-
Preparation of amidinophenylcarbamoylbiphenyl derivatives and heterocyclic analogue thereof as inhibitors of blood coagulation factor VIIa [abstract 184864n]
-
Senokuchi K., Ogawa K. Preparation of amidinophenylcarbamoylbiphenyl derivatives and heterocyclic analogue thereof as inhibitors of blood coagulation factor VIIa [abstract 184864n]. Chem Abst. 131:1999;709.
-
(1999)
Chem Abst
, vol.131
, pp. 709
-
-
Senokuchi, K.1
Ogawa, K.2
|