Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: Comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 3, 2003, Pages 1115-1121

  Suleymanov, Osman D ^a   Szalony, James A ^a   Salyers, Anita K ^a   Lachance, Rhonda M ^a   Parlow, John J ^a   South, Michael S ^a   Wood, Rhonda S ^a   Nicholson, Nancy S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 5 [1 [2 [[4 [AMINO(IMINO)METHYL]BENZYL]AMINO] 2 OXOETHYL] 3 CHLORO 4 (ISOPROPYLAMINO) 6 OXO 1,6 DIHYDROPYRAZIN 2 YL]BENZOIC ACID; ANTITHROMBOCYTIC AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; BLOOD CLOTTING FACTOR 8 INHIBITOR; SMALL MOLECULE TRANSPORT AGENT; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLEEDING TIME; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMORAL ARTERY FLOW; HEMOSTASIS; LEG BLOOD FLOW; NONHUMAN; PRIMATE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOGENESIS; THROMBOSIS; THROMBUS;

AMINOBENZOIC ACIDS; ANIMALS; BLEEDING TIME; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR VIIA; FACTOR XA; FIBRINOLYTIC AGENTS; FOREARM; HEMODYNAMIC PROCESSES; MACACA FASCICULARIS; MALE; PROTHROMBIN TIME; PYRAZINES; SODIUM CHLORIDE; THROMBIN; THROMBOPLASTIN; THROMBOSIS;

EID: 0041932150     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.052779     Document Type: Article

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