Efficacious, orally bioavailable thrombin inhibitors based on 3- aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4466-4474

  Sanderson, Philip E J ^a   Lyle, Terry A ^a   Cutrona, Kellie J ^a   Dyer, Dona L ^a   Dorsey, Bruce D ^a   McDonough, Colleen M ^a   Naylor Olsen, Adel M ^a   Chen, I Wu ^a   Chen, Zhongguo ^a   Cook, Jacquelynn J ^a   Cooper, Carolyn M ^a   Gardell, Stephen J ^a   Hare, Timothy R ^a   Krueger, Julie A ^a   Lewis, S Dale ^a   Lin, Jiunn H ^a   Lucas Jr , Bobby J ^a   Lyle, Elizabeth A ^a   Lynch Jr , Joseph J ^a   Stranieri, Maria T ^a   Vastag, Kari ^a   Yan, Youwei ^a   Shafer, Jules A ^a   Vacca, Joseph P ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 AMINO 6 METHYL 5 PYRIDINYLMETHYLAMINOCARBONYLMETHYL) 3 BENZYLSULFONAMIDO 6 METHYL 2 PYRIDINONE; 1 (6 AMINO 2 METHYL 3 PYRIDINYLMETHYLAMINOCARBONYLMETHYL) 3 PHENETHYLAMINO 6 METHYL 2 PYRAZINONE; 3 (1 PHENYL 2 PROPYLAMINO) 6 METHYL 1 (2 AMINO 6 METHYL 5 METHYLCARBOXAMIDOMETHYLPYRIDINYL)PYRAZINONE; 3 (2 PHENETHYLAMINO) 6 METHYL 1 (2 AMINO 6 METHYL 5 METHYLENECARBOXAMIDOMETHYLPYRIDINYL)PYRAZINONE; 3 BENZYLSULFONYLAMINO 6 METHYL 1 (2 AMINO 6 METHYL 5 METHYLENECARBOXAMIDOMETHYLPYRIDINYL) 2 PYRIDINONE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; THROMBOSIS; THROMBOSIS PREVENTION;

EID: 15144357944     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980368v     Document Type: Article

References (21)

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19. i data quoted in this report are for the human enzymes.
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