-
1
-
-
0002369226
-
Recent advances in polymer assisted solution-phase chemical library synthesis and purification
-
Flynn DL, Devraj RV, Parlow JJ: Recent advances in polymer assisted solution-phase chemical library synthesis and purification. Curr Opin Drug Discov Dev 1998, 1:41-50. This review reports the comprehensive use of polymer-assisted solution-phase chemical library synthesis techniques through to early 1998.
-
(1998)
Curr Opin Drug Discov Dev
, vol.1
, pp. 41-50
-
-
Flynn, D.L.1
Devraj, R.V.2
Parlow, J.J.3
-
2
-
-
0031741510
-
Polymer-assisted solution phase (PASP) chemical library synthesis
-
Flynn DL, Devraj RV, Naing W, Parlow JJ, Weidner JJ, Yang S: Polymer-assisted solution phase (PASP) chemical library synthesis. Med Chem Res 1998, 8:219-243. This review summarizes the various purification techniques included in polymer-assisted solution-phase synthesis utilizing the fundamental properties of complementary molecular reactivity and molecular recognition.
-
(1998)
Med Chem Res
, vol.8
, pp. 219-243
-
-
Flynn, D.L.1
Devraj, R.V.2
Naing, W.3
Parlow, J.J.4
Weidner, J.J.5
Yang, S.6
-
3
-
-
0032948663
-
Solid-supported reagent strategies for rapid purification of combinatorial synthesis products
-
Booth RJ, Hodges JC: Solid-supported reagent strategies for rapid purification of combinatorial synthesis products. Accounts Chem Res 1999, 32:18-26. This review provides an overview of various strategies for the use of solid-supported reagents in the rapid purification of library synthesis products from 1997 through to early 1998.
-
(1999)
Accounts Chem Res
, vol.32
, pp. 18-26
-
-
Booth, R.J.1
Hodges, J.C.2
-
4
-
-
0032082589
-
Solution phase combinatorial chemistry
-
Merritt AT: Solution phase combinatorial chemistry. Comb Chem High Throughput Screening 1998, 1:57-72. This review provides an overview of all solution-phase strategies for the preparation and purification of chemical library synthesis products from 1994 through to 1997.
-
(1998)
Comb Chem High Throughput Screening
, vol.1
, pp. 57-72
-
-
Merritt, A.T.1
-
5
-
-
0032029989
-
Solution-phase library generation: Methods and applications in drug discovery
-
Gayo LM: Solution-phase library generation: Methods and applications in drug discovery. Biotechnol Bioeng 1998, 61:95-106. This review provides highlights from all solution-phase strategies for the preparation and purification of chemical library synthesis products from 1996 through to early 1998.
-
(1998)
Biotechnol Bioeng
, vol.61
, pp. 95-106
-
-
Gayo, L.M.1
-
6
-
-
0031817880
-
High throughput purification methods in combinatorial solution phase synthesis
-
Ferritto R, Seneci P: High throughput purification methods in combinatorial solution phase synthesis. Drugs Future 1998, 23:643-654. This review provides an overview of purification strategies for solution-phase combinatorial synthesis from 1996 through 1997.
-
(1998)
Drugs Future
, vol.23
, pp. 643-654
-
-
Ferritto, R.1
Seneci, P.2
-
8
-
-
0031152048
-
Combinatorial chemistry using polymer supported reagents
-
Kaldor SW, Siegel MG: Combinatorial chemistry using polymer supported reagents. Curr Opin Chem Biol 1997, 1:101-106. This is one of the first reviews that highlights the advances in the use of polymer-supported quench reagents and polymer-supported reagents/catalysts through to early 1997.
-
(1997)
Curr Opin Chem Biol
, vol.1
, pp. 101-106
-
-
Kaldor, S.W.1
Siegel, M.G.2
-
9
-
-
0032543080
-
Strategy-level separations in organic synthesis: From planning to practice
-
Curran DP: Strategy-level separations in organic synthesis: From planning to practice. Angew Chem Int Ed Engl 1998, 37:1175-1196. This review highlights the concept of 'phase-switching' such that the product is purified by subjecting the reaction mixture to one or more simple phase-separation techniques.
-
(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 1175-1196
-
-
Curran, D.P.1
-
10
-
-
0031029886
-
Fluorous synthesis: A fluorous-phase strategy for improving separation efficiency in organic synthesis
-
Studer A, Hadida S, Ferritto R, Kim SY, Jeger P, Wipf P, Curran DP: Fluorous synthesis: A fluorous-phase strategy for improving separation efficiency in organic synthesis. Science 1997, 275:823-826.
-
(1997)
Science
, vol.275
, pp. 823-826
-
-
Studer, A.1
Hadida, S.2
Ferritto, R.3
Kim, S.Y.4
Jeger, P.5
Wipf, P.6
Curran, D.P.7
-
11
-
-
0029926720
-
Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
-
Cheng S, Comer DD, Williams JP, Myers PL, Boger DL: Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules. J Am Chem Soc 1996, 118:2567-2573.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 2567-2573
-
-
Cheng, S.1
Comer, D.D.2
Williams, J.P.3
Myers, P.L.4
Boger, D.L.5
-
12
-
-
0030607141
-
Use of solid-supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries
-
Kaldor SW, Siegel MG, Fritz JE, Dressman BA, Hahn PJ: Use of solid-supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries. Tetrahedron Lett 1996, 37:7193-7196.
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 7193-7196
-
-
Kaldor, S.W.1
Siegel, M.G.2
Fritz, J.E.3
Dressman, B.A.4
Hahn, P.J.5
-
13
-
-
0030952762
-
Chemical library purification strategies based on principles of complementary molecular reactivity and recognition
-
Flynn DL, Crich JZ, Devraj RV, Hockerman SL, Parlow JJ, South MS, Woodard SS: Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition. J Am Chem Soc 1997, 119:4874-4881. This paper describes complementary molecular reactivity and molecular recognition purification concepts for solution-phase synthesis, including reactant sequestering resins, by-product sequestering resins, 'tagged-reagent' sequestering resins, and reaction-quenching resins.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 4874-4881
-
-
Flynn, D.L.1
Crich, J.Z.2
Devraj, R.V.3
Hockerman, S.L.4
Parlow, J.J.5
South, M.S.6
Woodard, S.S.7
-
14
-
-
0030987922
-
Polymer-supported quenching reagents for parallel purification
-
Booth RJ, Hodges JC: Polymer-supported quenching reagents for parallel purification. J Am Chem Soc 1997, 119:4882-4886. This paper describes the use of functionalized resins to remove excess reactants from solution-phase chemical library product mixtures, and highlights the use of the method in a multistep pyrazole synthesis.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 4882-4886
-
-
Booth, R.J.1
Hodges, J.C.2
-
15
-
-
0000965816
-
Combinatorial synthesis of 2-thioxo-4-dihydropyrimidinones
-
Sim MM, Lee CL, Ganesan A: Combinatorial synthesis of 2-thioxo-4-dihydropyrimidinones. J Org Chem 1997, 62:9358-9360.
-
(1997)
J Org Chem
, vol.62
, pp. 9358-9360
-
-
Sim, M.M.1
Lee, C.L.2
Ganesan, A.3
-
16
-
-
0001768317
-
Utility of complementary molecular reactivity and molecular recognition (CMR/R) technology and polymer-supported reagents in the solution-phase synthesis of heterocyclic carbonaxamide
-
Parlow JJ, Mischke DA, Woodard SS: Utility of complementary molecular reactivity and molecular recognition (CMR/R) technology and polymer-supported reagents in the solution-phase synthesis of heterocyclic carboxamides. J Org Chem 1997, 62:5908-5919. This paper describes the use of complementary molecular reactivity and molecular recognition purification methodology combined with polymer-supported reagents for the high-speed parallel solution-phase synthesis of analogues in a herbicidal lead-development program.
-
(1997)
J Org Chem
, vol.62
, pp. 5908-5919
-
-
Parlow, J.J.1
Mischke, D.A.2
Woodard, S.S.3
-
17
-
-
0032537038
-
Solution-phase parallel synthesis of a benzoxazinone library using complementary molecular reactivity and molecular recognition (CMR/R) purification technology
-
Parlow JJ, Flynn DL: Solution-phase parallel synthesis of a benzoxazinone library using complementary molecular reactivity and molecular recognition (CMR/R) purification technology. Tetrahedron 1998, 54:4013-4031. This paper highlights a multistep solution-phase library synthesis of benzoxazinones using combinations of complementary molecular reactivity and molecular recognition purification concepts and polymeric reagents as the sole method of purification.
-
(1998)
Tetrahedron
, vol.54
, pp. 4013-4031
-
-
Parlow, J.J.1
Flynn, D.L.2
-
18
-
-
0032575201
-
Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation
-
Blackburn C, Guan B, Fleming P, Shiosaki K, Tsai S: Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation. Tetrahedron Lett 1998, 39:3635-3638.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 3635-3638
-
-
Blackburn, C.1
Guan, B.2
Fleming, P.3
Shiosaki, K.4
Tsai, S.5
-
19
-
-
0032171671
-
Solution phase library of perhydrooxazin-4-ones
-
Panunzio M, Villa M, Missio A, Rossi T, Seneci P: Solution phase library of perhydrooxazin-4-ones. Tetrahedron Lett 1998, 39:6585-6588.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 6585-6588
-
-
Panunzio, M.1
Villa, M.2
Missio, A.3
Rossi, T.4
Seneci, P.5
-
20
-
-
0032403246
-
Generation of a library of 4-thiazolidinones utilizing polymer supported quench (PSQ) reagent methodology
-
Ault-Justus SE, Hodges JC, Wilson MW: Generation of a library of 4-thiazolidinones utilizing polymer supported quench (PSQ) reagent methodology. Biotechnol Bioeng 1998, 61:17-22.
-
(1998)
Biotechnol Bioeng
, vol.61
, pp. 17-22
-
-
Ault-Justus, S.E.1
Hodges, J.C.2
Wilson, M.W.3
-
21
-
-
0032537040
-
Combinatorial synthesis of dihydropyridone libraries and their derivatives
-
Creswell MW, Bolton GL, Hodges JC, Meppen M: Combinatorial synthesis of dihydropyridone libraries and their derivatives. Tetrahedron 1998, 54:3983-3998. This paper highlights a multistep solution-phase library synthesis of 4-aminopiperidines using a combination of polymer-supported quenching techniques and liquid-phase extractions as the sole method of purification.
-
(1998)
Tetrahedron
, vol.54
, pp. 3983-3998
-
-
Creswell, M.W.1
Bolton, G.L.2
Hodges, J.C.3
Meppen, M.4
-
22
-
-
0000684017
-
Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening
-
Gennari C, Ceccarelli S, Piarulli U, Montalbetti CAGN, Jackson RFW: Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening. J Org Chem 1998, 63:5312-5313.
-
(1998)
J Org Chem
, vol.63
, pp. 5312-5313
-
-
Gennari, C.1
Ceccarelli, S.2
Piarulli, U.3
Montalbetti, C.A.G.N.4
Jackson, R.F.W.5
-
23
-
-
0032080369
-
Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles
-
Xu W, Mohan R, Morrissey MM: Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles. Bioorg Med Chem Lett 1998, 8:1089-1092. This paper reports a one-pot multistep solution-phase reaction sequence demonstrating the use of a combination of polymer-supported bases achieving regioselective alkylations/acylations.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 1089-1092
-
-
Xu, W.1
Mohan, R.2
Morrissey, M.M.3
-
24
-
-
0032497394
-
Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array
-
Warmus JS, Ryder TR, Hodges JC, Kennedy RM, Brady KD: Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array. Bioorg Med Chem Lett 1998, 8:2309-2314.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2309-2314
-
-
Warmus, J.S.1
Ryder, T.R.2
Hodges, J.C.3
Kennedy, R.M.4
Brady, K.D.5
-
25
-
-
33748718537
-
Use of polymer supported reagents for clean multi-step organic synthesis: Preparation of amines and amine derivatives from alcohols for use in compound library generation
-
Ley SV, Bolli MH, Hinzen B, Gervois AG, Hall BJ: Use of polymer supported reagents for clean multi-step organic synthesis: Preparation of amines and amine derivatives from alcohols for use in compound library generation. J Chem Soc Perkin Trans 1998, 15:2239-2242.
-
(1998)
J Chem Soc Perkin Trans
, vol.15
, pp. 2239-2242
-
-
Ley, S.V.1
Bolli, M.H.2
Hinzen, B.3
Gervois, A.G.4
Hall, B.J.5
-
26
-
-
0030767571
-
Polymer-supported bases in combinatorial chemistry: Synthesis of aryl ethers from phenols and alkyl halides and aryl halides
-
Xu W, Mohan R, Morrissey MM: Polymer-supported bases in combinatorial chemistry: Synthesis of aryl ethers from phenols and alkyl halides and aryl halides. Tetrahedron Lett 1997, 38:7337-7340.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 7337-7340
-
-
Xu, W.1
Mohan, R.2
Morrissey, M.M.3
-
27
-
-
0032504083
-
Solid-phase synthesis of substituted tetramic acids
-
Matthews J, Rivero RA: Solid-phase synthesis of substituted tetramic acids. J Org Chem 1998, 63:4808-4810.
-
(1998)
J Org Chem
, vol.63
, pp. 4808-4810
-
-
Matthews, J.1
Rivero, R.A.2
-
28
-
-
0032212587
-
Solution-phase combinatorial synthesis of ureas using nitrophenylcarbamates
-
Raju B, Kassir JM, Kogan TP: Solution-phase combinatorial synthesis of ureas using nitrophenylcarbamates. Bioorg Med Chem Lett 1998, 8:3043-3048.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 3043-3048
-
-
Raju, B.1
Kassir, J.M.2
Kogan, T.P.3
-
29
-
-
0032568333
-
Solution-phase synthesis of 2,6,9-trisubstituted purines
-
Fiorini MT, Abell C: Solution-phase synthesis of 2,6,9-trisubstituted purines. Tetrahedron Lett 1998, 39:1827-1830.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 1827-1830
-
-
Fiorini, M.T.1
Abell, C.2
-
30
-
-
0032487973
-
A new scavenger resin for amines
-
Coppola GM: A new scavenger resin for amines. Tetrahedron Lett 1998, 39:8233-8236. This paper reports the preparation and application of a novel polymer-bound isatoic anhydride used as an electrophile for the sequestration of primary and secondary amines.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 8233-8236
-
-
Coppola, G.M.1
-
31
-
-
0032575179
-
Solid phase synthesis of urea libraries using a diversifiable thiophenoxy carbonyl linker
-
Dressman BA, Singh U, Kaldor SW: Solid phase synthesis of urea libraries using a diversifiable thiophenoxy carbonyl linker. Tetrahedron Lett 1998, 39:3631-3634. This paper reports a novel thiophenoxy p-nitrophenylcarbonate-linked resin used to generate isocyanates in solution phase through the intermediacy of a resin-bound carbamate. The reactive isocyanate is reacted with amines to form substituted ureas.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 3631-3634
-
-
Dressman, B.A.1
Singh, U.2
Kaldor, S.W.3
-
32
-
-
0032537031
-
Solution-phase parallel synthesis using ion-exchange resins
-
Suto MJ, Gayo-Fung LM, Palanki MSS, Sullivan R: Solution-phase parallel synthesis using ion-exchange resins. Tetrahedron 1998, 54:4141-4150. This paper reports the use of ion-exchange resins for the purification of solution-phase chemical libraries and post-cleavage product mixtures from solution-phase parallel synthesis synthesis.
-
(1998)
Tetrahedron
, vol.54
, pp. 4141-4150
-
-
Suto, M.J.1
Gayo-Fung, L.M.2
Palanki, M.S.S.3
Sullivan, R.4
-
33
-
-
0031021840
-
Ion-exchange resins for solution phase parallel synthesis of chemical libraries
-
Gayo LM, Suto MJ: Ion-exchange resins for solution phase parallel synthesis of chemical libraries. Tetrahedron Lett 1997, 38:513-516.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 513-516
-
-
Gayo, L.M.1
Suto, M.J.2
-
34
-
-
0032567966
-
Arylsulfonate esters in solid phase organic synthesis. I. Cleavage with amines, thiolate, and imidazole
-
Rueter JK, Nortey SO, Baxter EW, Leo GC, Reitz AB: Arylsulfonate esters in solid phase organic synthesis. I. Cleavage with amines, thiolate, and imidazole. Tetrahedron Lett 1998, 39:975-978.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 975-978
-
-
Rueter, J.K.1
Nortey, S.O.2
Baxter, E.W.3
Leo, G.C.4
Reitz, A.B.5
-
35
-
-
0000631409
-
Phosgenated p-nitrophenyl(polystyrene)ketoxime or phoxime resin. A new resin for the solid-phase synthesis of ureas via thermolytic cleavage of oxime-carbamates
-
Scialdone MA, Shuey SW, Soper P, Hamuro Y, Burns DM: Phosgenated p-nitrophenyl(polystyrene)ketoxime or phoxime resin. A new resin for the solid-phase synthesis of ureas via thermolytic cleavage of oxime-carbamates. J Org Chem 1998, 63:4802-4807.
-
(1998)
J Org Chem
, vol.63
, pp. 4802-4807
-
-
Scialdone, M.A.1
Shuey, S.W.2
Soper, P.3
Hamuro, Y.4
Burns, D.M.5
-
36
-
-
0032514499
-
A convenient method for the preparation of acylsulfonamide libraries
-
Sturino, CF, Labelle M: A convenient method for the preparation of acylsulfonamide libraries. Tetrahedron Lett 1998, 39:5891-5894.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 5891-5894
-
-
Sturino, C.F.1
Labelle, M.2
-
37
-
-
0032508083
-
Solid-phase synthesis of tetramic acids
-
Kulkarni BA, Ganesan A: Solid-phase synthesis of tetramic acids. Tetrahedron Lett 1998, 39:4369-4372.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 4369-4372
-
-
Kulkarni, B.A.1
Ganesan, A.2
-
38
-
-
0032497346
-
A mixed resin bed for the quenching and purification of tetrabutylammonium flouride mediated desilylating reactions
-
Parlow JJ, Vazquez ML, Flynn DL: A mixed resin bed for the quenching and purification of tetrabutylammonium fluoride mediated desilylating reactions. Bioorg Med Chem Lett 1998, 8:2391-2394.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2391-2394
-
-
Parlow, J.J.1
Vazquez, M.L.2
Flynn, D.L.3
-
39
-
-
0030873736
-
Non-acidic cleavage of Wang-derived ethers from solid support: Utilization of a mixed-bed scavenger for DDQ
-
Deegan TL, Gooding OW, Baudart S, Porco JA Jr: Non-acidic cleavage of Wang-derived ethers from solid support: Utilization of a mixed-bed scavenger for DDQ. Tetrahedron Lett 1997, 38:4973-4976. This paper describes the use of a mixed resin bed containing polymer-bound ascorbate and a polymer-bound bicarbonate to quench excess DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) and sequester the DDQ by-product after DDQ-mediated release of alcohols from Wang resin.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 4973-4976
-
-
Deegan, T.L.1
Gooding, O.W.2
Baudart, S.3
Porco J.A., Jr.4
-
40
-
-
0032494719
-
Impurity annihilation; a strategy for solution phase combinatorial chemistry with minimal purification
-
Barrett AGM, Smith ML, Zecri FJ: Impurity annihilation; a strategy for solution phase combinatorial chemistry with minimal purification. Chem Commun 1998, 21:2317-2318. This paper reports the novel use of in situ polymerization using 1,4-phenylene diisocyanate and pentaethylenehexamine for the use of sequestering either nucleophiles or electrophiles by the order of addition.
-
(1998)
Chem Commun
, vol.21
, pp. 2317-2318
-
-
Barrett, A.G.M.1
Smith, M.L.2
Zecri, F.J.3
-
41
-
-
0033534495
-
Polymer-assisted solution phase synthesis: A general method for sequestration of by-products formed from activated acyl-transfer reactants
-
Weidner JJ, Parlow JJ, Flynn DL: Polymer-assisted solution phase synthesis: A general method for sequestration of by-products formed from activated acyl-transfer reactants. Tetrahedron Lett 1999, 40:239-242.
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 239-242
-
-
Weidner, J.J.1
Parlow, J.J.2
Flynn, D.L.3
-
42
-
-
0032497423
-
Novel inhibitors of α4β1 integrin receptor interactions through library synthesis and screening
-
Souers AJ, Virgilio AA, Schurer SS, Ellman JA, Kogan TP, West HE, Ankener W, Vanderslice P: Novel inhibitors of α4β1 integrin receptor interactions through library synthesis and screening. Bioorg Med Chem Lett 1998, 8:2297-2302.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2297-2302
-
-
Souers, A.J.1
Virgilio, A.A.2
Schurer, S.S.3
Ellman, J.A.4
Kogan, T.P.5
West, H.E.6
Ankener, W.7
Vanderslice, P.8
-
43
-
-
0000140378
-
A novel cleavage technique to generate small molecule compounds and libraries via a two-resin system
-
Ouyang X, Armstrong RW, Murphy MM: A novel cleavage technique to generate small molecule compounds and libraries via a two-resin system. J Org Chem 1998, 63:1027-1032.
-
(1998)
J Org Chem
, vol.63
, pp. 1027-1032
-
-
Ouyang, X.1
Armstrong, R.W.2
Murphy, M.M.3
-
44
-
-
0032541679
-
Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin activation/capture approach/REACAP
-
Chen C, Munoz B: Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin activation/capture approach/REACAP. Tetrahedron Lett 1998, 39:6781-6784.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 6781-6784
-
-
Chen, C.1
Munoz, B.2
-
45
-
-
0030813190
-
In situ chemical tagging: Tetrafluorophthalic anhydride as a 'sequestration enabling reagent' (SER) in the purification of solution-phase combinatorial libraries
-
Parlow JJ, Naing W, South MS, Flynn DL: In situ chemical tagging: Tetrafluorophthalic anhydride as a 'sequestration enabling reagent' (SER) in the purification of solution-phase combinatorial libraries. Tetrahedron Lett 1997, 38:7959-7962. This paper highlights the use of tetrafluorophthalic anhydride as a sequestration-enabling reagent used to derivatize nucleophiles affording carboxy-tagged derivatives sequesterable by base-functionalized resins.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 7959-7962
-
-
Parlow, J.J.1
Naing, W.2
South, M.S.3
Flynn, D.L.4
-
46
-
-
0032029575
-
Solution-phase simultaneous addition of functionalities (SPSAF) and chemical transformation to prepare N,N′-disubstituted piperazine libraries
-
Kung PP, Cook PD: Solution-phase simultaneous addition of functionalities (SPSAF) and chemical transformation to prepare N,N′-disubstituted piperazine libraries. Biotechnol Bioeng 1998, 61:119-125.
-
(1998)
Biotechnol Bioeng
, vol.61
, pp. 119-125
-
-
Kung, P.P.1
Cook, P.D.2
-
47
-
-
0030964314
-
Solution-phase synthesis of a combinatorial thiohydantoin library
-
Sim MM, Ganesan A: Solution-phase synthesis of a combinatorial thiohydantoin library. J Org Chem 1997, 62:3230-3235.
-
(1997)
J Org Chem
, vol.62
, pp. 3230-3235
-
-
Sim, M.M.1
Ganesan, A.2
-
48
-
-
0032485516
-
Novel quenchers for solution phase parallel synthesis
-
Nikam SS, Kornberg BE, Ault-Justus SE, Rafferty MF: Novel quenchers for solution phase parallel synthesis. Tetrahedron Lett 1998, 39:1121-1124.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 1121-1124
-
-
Nikam, S.S.1
Kornberg, B.E.2
Ault-Justus, S.E.3
Rafferty, M.F.4
-
49
-
-
0030998777
-
Rapid purification of small molecule libraries by ion exchange chromatography
-
Siegel MG, Hahn PJ, Dressman BA, Fritz JE, Grunwell JR, Kaldor SW: Rapid purification of small molecule libraries by ion exchange chromatography. Tetrahedron Lett 1997, 38:3357-3360. This paper highlights the use of resin capture using ion-exchange resins. In addition, sequestration-enabling reagents were utilized to derivatize nonionizable species, permitting their sequestration and yielding pure products.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 3357-3360
-
-
Siegel, M.G.1
Hahn, P.J.2
Dressman, B.A.3
Fritz, J.E.4
Grunwell, J.R.5
Kaldor, S.W.6
-
50
-
-
0032497352
-
Chemically tagged Mitsunobu reagents for use in solution-phase chemical library synthesis
-
Starkey GW, Parlow JJ, Flynn DL: Chemically tagged Mitsunobu reagents for use in solution-phase chemical library synthesis. Bioorg Med Chem Lett 1998, 8:2385-2390. This paper highlights the use of chemically tagged Mitsunobu reagents allowing post-reaction sequestration of the tagged reagents and tagged reagent by-products via polymer-bound carbonate resin.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2385-2390
-
-
Starkey, G.W.1
Parlow, J.J.2
Flynn, D.L.3
-
51
-
-
0029963887
-
Postcondensation modifications of Ugi four-component condensation products: 1-isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture
-
Keating TA, Armstrong RW: Postcondensation modifications of Ugi four-component condensation products: 1-isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture. J Am Chem Soc 1996, 118:2574-2583.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 2574-2583
-
-
Keating, T.A.1
Armstrong, R.W.2
-
52
-
-
0030062225
-
Synthesis of tetrasubstituted ethylenes on solid support via resin capture
-
Brown SD, Armstrong RW: Synthesis of tetrasubstituted ethylenes on solid support via resin capture. J Am Chem Soc 1996, 118:6331-6332.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 6331-6332
-
-
Brown, S.D.1
Armstrong, R.W.2
-
53
-
-
0030973401
-
Automated synthesis and purification of amides. Exploitation of automated solid phase extraction in organic synthesis
-
Lawrence RM, Biller SA, Fryszman OM, Poss MA: Automated synthesis and purification of amides. Exploitation of automated solid phase extraction in organic synthesis. Synthesis 1997, 5:553-558.
-
(1997)
Synthesis
, vol.5
, pp. 553-558
-
-
Lawrence, R.M.1
Biller, S.A.2
Fryszman, O.M.3
Poss, M.A.4
-
54
-
-
0032554975
-
Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry
-
Miller MW, Vice SF, McCombie SW: Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry. Tetrahedron Lett 1998, 39:3429-3432.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 3429-3432
-
-
Miller, M.W.1
Vice, S.F.2
McCombie, S.W.3
-
55
-
-
0000375897
-
Simultaneous deprotection and purification of Boc-amines based on ionic resin capture
-
Liu YS, Zhao C, Bergbreiter DE, Romo D: Simultaneous deprotection and purification of Boc-amines based on ionic resin capture. J Org Chem 1998, 63:3471-3473.
-
(1998)
J Org Chem
, vol.63
, pp. 3471-3473
-
-
Liu, Y.S.1
Zhao, C.2
Bergbreiter, D.E.3
Romo, D.4
-
56
-
-
0030831922
-
Parallel synthesis of tamoxifen and derivatives on solid support via resin capture
-
Brown SD, Armstrong RW: Parallel synthesis of tamoxifen and derivatives on solid support via resin capture. J Org Chem 1997, 62:7076-7077. This paper demonstrates the concept of a covalent resin capture/release strategy to synthesize tetra-substituted olefins related to Tamoxifen.
-
(1997)
J Org Chem
, vol.62
, pp. 7076-7077
-
-
Brown, S.D.1
Armstrong, R.W.2
-
57
-
-
0002574674
-
Use ring-opening cross-metathesis to construct molecular motifs
-
Cuny GD, Hauske JR: Use ring-opening cross-metathesis to construct molecular motifs. Chemtech 1998, 28:25-31.
-
(1998)
Chemtech
, vol.28
, pp. 25-31
-
-
Cuny, G.D.1
Hauske, J.R.2
-
58
-
-
0030839735
-
The application of high-throughput synthesis and purification to the preparation of ethanolamines
-
Shuker AJ, Siegel MG, Matthews DP, Weigel LO: The application of high-throughput synthesis and purification to the preparation of ethanolamines. Tetrahedron Lett 1997, 38:6149-6152.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 6149-6152
-
-
Shuker, A.J.1
Siegel, M.G.2
Matthews, D.P.3
Weigel, L.O.4
-
59
-
-
0031996291
-
The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents
-
Siegel MG, Shuker AJ, Droste CA, Hahn PJ, Jesudason CD, McDonald JH III, Matthews DP, Rito CJ, Thorpe AJ: The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents. Mol Divers 1998, 3:113-116.
-
(1998)
Mol Divers
, vol.3
, pp. 113-116
-
-
Siegel, M.G.1
Shuker, A.J.2
Droste, C.A.3
Hahn, P.J.4
Jesudason, C.D.5
McDonald J.H. III6
Matthews, D.P.7
Rito, C.J.8
Thorpe, A.J.9
-
60
-
-
0031452355
-
Ion-exchange resins for combinatorial synthesis: 2,4-pyrrolidinediones by Dieckmann condensation
-
Kulkarni BA, Ganesan A: Ion-exchange resins for combinatorial synthesis: 2,4-pyrrolidinediones by Dieckmann condensation. Angew Chem Int Ed Engl 1997, 36:2454-2455. This paper highlights the use of A-26 hydroxide resin to promote cyclization of N-acyl amino acid esters to afford ionically trapped resin-bound pyrrolidinediones. Washing away nontrapped impurities and subsequent release with acid affords pure products.
-
(1997)
Angew Chem Int Ed Engl
, vol.36
, pp. 2454-2455
-
-
Kulkarni, B.A.1
Ganesan, A.2
-
61
-
-
20344397295
-
Solution-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones
-
Kulkarni B, Ganesan A: Solution-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones. Chem Commun 1998, 7:785-786.
-
(1998)
Chem Commun
, vol.7
, pp. 785-786
-
-
Kulkarni, B.1
Ganesan, A.2
-
62
-
-
0032548129
-
Use of tetrabenzo[a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of ciprofloxacin
-
Hay AM, Hobbs-Dewitt S, MacDonald AA, Ramage R: Use of tetrabenzo[a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of ciprofloxacin. Tetrahedron Lett 1998, 39:8721-8724.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 8721-8724
-
-
Hay, A.M.1
Hobbs-Dewitt, S.2
MacDonald, A.A.3
Ramage, R.4
-
63
-
-
0032168143
-
Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-D-galactopyranoside library
-
Nilsson UJ, Fournier EJL, Hindsgaul Ole: Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-D-galactopyranoside library. Bioorg Med Chem 1998, 6:1563-1575.
-
(1998)
Bioorg Med Chem
, vol.6
, pp. 1563-1575
-
-
Nilsson, U.J.1
Fournier, E.J.L.2
Hindsgaul, Ole.3
-
64
-
-
33749113659
-
Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents
-
Habermann J, Ley SV, Scott JS: Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents. J Chem Soc Perkin Trans 1 1998, 19:3127-3130. This paper highlights a six-step solution-phase library syntheis of piperidino-thiomorpholics using combinations of polymer-supported reagents and solid-sequestering agents without any chromotographic purification steps.
-
(1998)
J Chem Soc Perkin Trans 1
, vol.19
, pp. 3127-3130
-
-
Habermann, J.1
Ley, S.V.2
Scott, J.S.3
-
65
-
-
0033612114
-
High-throughput purification of solution-phase periodinane mediated oxidation reactions utilizing a novel thiosulfate resin
-
in press
-
Parlow JJ, Case BL, South MS: High-throughput purification of solution-phase periodinane mediated oxidation reactions utilizing a novel thiosulfate resin. Tetrahedron 1999, in press. This paper illustrates a high-throughput purification protocol of periodinane mediated oxidation reactions utilzing a mixed resin bed containing A-26 thiosulfate resin, used to reduce the hypervalent iodine oxidants to their corresponding II species, which are sequestered by a base-functionalized resin.
-
(1999)
Tetrahedron
-
-
Parlow, J.J.1
Case, B.L.2
South, M.S.3
|