Small, noncovalent serine protease inhibitors

Medicinal Research Reviews

Volumn 19, Issue 2, 1999, Pages 179-197

  Sanderson, Philip E J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Orally active; Peptidomimetic; Selective noncovalent thrombin or factor Xa inhibitors; Structure based drug design

Indexed keywords

1 (6 AMINO 2 METHYL 3 PYRIDINYLMETHYLAMINOCARBONYLMETHYL) 3 PHENETHYLAMINO 6 METHYL 2 PYRAZINONE; 1 [3 (4 AMIDINOPHENYL) 2 (1,2,3,4 TETRAHYDRO 2 METHYL 7 ISOQUINOLINYLSULFONAMIDO)PROPIONYL] 1,2,3,6 TETRAHYDRO 4 METHYLPICOLINIC ACID; [N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL] N [(7 AMIDINO 2 NAPHTHYL)METHYL]SULFAMOYL]ACETIC ACID; ARGATROBAN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; INOGATRAN; L 370518; L 371912; L 373890; MELAGATRAN; N (9 HYDROXY 9 FLUORENECARBOXY)PROLINE (4 AMINOCYCLOHEXYLMETHYL)AMIDE; N [2 [5 [AMINO(IMINO)METHYL] 2 HYDROXYPHENOXY] 3,5 DIFLUORO 6 [3 (4,5 DIHYDRO 1 METHYL 1H IMIDAZOL 2 YL)PHENOXY]PYRIDIN 4 YL] N METHYLGLYCINE; NAPSAGATRAN; SERINE PROTEINASE INHIBITOR; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; UROKINASE;

ANTICOAGULATION; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG POTENCY; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; LIPOPHILICITY; PUBLICATION; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICOAGULANTS; FACTOR XA; HUMANS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0033017497     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1128(199903)19:2<179::AID-MED4>3.0.CO;2-5     Document Type: Review

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