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Volumn 7, Issue 4, 1996, Pages 386-391

Initiation of blood coagulation: The tissue factor/factor VIIa complex

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7A; CYTOKINE RECEPTOR; GLYCOPROTEIN; THROMBOPLASTIN;

EID: 0030221068     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(96)80112-1     Document Type: Article
Times cited : (62)

References (46)
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    • 2+ release from internal stores. Even though the VIIa concentration used was very high (200 nM) the number of responding cells (stimulated endothelial cells and J82 cells) was rather low. These results support a true receptor function for TF.
    • 2+ release from internal stores. Even though the VIIa concentration used was very high (200 nM) the number of responding cells (stimulated endothelial cells and J82 cells) was rather low. These results support a true receptor function for TF.
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    • of special interest. This paper describes a metastasis model using melanoma cells expressing mutated forms of TF that either lack the cytoplasmic domain or have no clotting activity due to mutations in the extracellular domain. The results indicate that melanoma cell metastasis is dependent on the presence of the cytoplasmic domain of TF and a role of TF in tumor metastasis that is distinct from TF-initiated coagulation is proposed.
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