Inhibition of the tissue factor/factor VIIa complex - Lead optimisation using combinatorial chemistry

Tetrahedron

Volumn 55, Issue 19, 1999, Pages 6219-6230

  Roussel, Patrick ^a   Bradley, Mark ^b   Kane, Peter ^c   Bailey, Christine ^c   Arnold, Ruth ^c   Cross, Andrew ^c  

^a Pharmacia & Upjohn AB   (Sweden)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c Research Centre   (United Kingdom)

Author keywords

Amidines; Combinatorial; Library; Solid phase

Indexed keywords

AMIDINE; AMIDINONAPHTHOL; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; CONCENTRATION RESPONSE; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0033531977     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(99)00266-5     Document Type: Article

References (20)

1. Rapaport SI, Rao LVM, Arterioscler. Thromb. 1992;12;1111-1121.
2. Butenas S, Mann KG, Biochemistry 1996;35;1904-1910.
3. Neuenschwander PF, Fiore MM, Morrissey JH, J. Biol. Chem. 1993;268;21489-21492, Bom VJJ, Bertina RM, Biochem J. 1990;265;327-336.
4. Neuenschwander PF, Fiore MM, Morrissey JH, J. Biol. Chem. 1993;268;21489-21492, Bom VJJ, Bertina RM, Biochem J. 1990;265;327-336.
5. Harker LA, Hanson SR, Kelly AB, Thromb. Haemost. 1995;74;464-472.
6. Wagner G, Voight B, Pharmazie 1978;33;568-572.
7. Aoyama T, Okutome T, Nakayama T, Yaegashi T, Matsuis R, Nunomura S, Kurumi M, Sakurai Y, Fujii S, Chem. Pharm. Bull. 1985;33;1458-1471.
8. Nagahara T, Ypkoyama Y, Inamura K, Katakura S, Yamaguchi H, Hara T, Iwamoto M. J. Med. Chem. 1994;37;1200-1207.
9. Marsh, IR, Bradley, M Tetrahedron 1997;17317-17334, Marsh IR, Bradley M, Eur. J. Biochemistry, 1997;243;690-694, Marsh IR, Smith HK, Leblanc C, Bradley M, Mol. Div. 1996;2;165-170, Marsh IR, Smith H, Bradley M, Chem. Commun. 1996;941-942.
10. Marsh, IR, Bradley, M Tetrahedron 1997;17317-17334, Marsh IR, Bradley M, Eur. J. Biochemistry, 1997;243;690-694, Marsh IR, Smith HK, Leblanc C, Bradley M, Mol. Div. 1996;2;165-170, Marsh IR, Smith H, Bradley M, Chem. Commun. 1996;941-942.
11. Marsh, IR, Bradley, M Tetrahedron 1997;17317-17334, Marsh IR, Bradley M, Eur. J. Biochemistry, 1997;243;690-694, Marsh IR, Smith HK, Leblanc C, Bradley M, Mol. Div. 1996;2;165-170, Marsh IR, Smith H, Bradley M, Chem. Commun. 1996;941-942.
12. Marsh, IR, Bradley, M Tetrahedron 1997;17317-17334, Marsh IR, Bradley M, Eur. J. Biochemistry, 1997;243;690-694, Marsh IR, Smith HK, Leblanc C, Bradley M, Mol. Div. 1996;2;165-170, Marsh IR, Smith H, Bradley M, Chem. Commun. 1996;941-942.
13. Roussel P, Mathews I, Kane P, Bradley M, Tetrahedron Lett. 1997;34;4861-4864.
14. Dressman BA, Spangle LA, Kaldor SW, Tetrahedron Lett. 1996;37;937-940.
15. Kates S A, Daniels SB, Albericio F. Anal. Biochem. 1993;212:303-310, Kunz H, Unverzagt C. Angew. Chem. Int. Ed. Engl. 1994;23:436-437.
16. Kates S A, Daniels SB, Albericio F. Anal. Biochem. 1993;212:303-310, Kunz H, Unverzagt C. Angew. Chem. Int. Ed. Engl. 1994;23:436-437.
17. Rano TA, Chapman KT, Tetrahedron Lett. 1995;36;3789-3792, Krchnak V, Flegelova Z, Weichsel AS, Lebl M, Tetrahedron Lett. 1995;36;6193-6196.
18. Rano TA, Chapman KT, Tetrahedron Lett. 1995;36;3789-3792, Krchnak V, Flegelova Z, Weichsel AS, Lebl M, Tetrahedron Lett. 1995;36;6193-6196.
19. Nikam SS, Kornberg BE, Rafferty MF, J. Org. Chem. 1997;62;3754-3757.
20. Sarin VK, Kent SBH, Tam JP, Merrifield RB, Anal. Biochem. 1981;117;147-157.