X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

Journal of Biological Chemistry

Volumn 271, Issue 47, 1996, Pages 29988-29992

  Brandstetter, Hans ^a,c   Kühne, Anja ^a   Bode, Wolfram ^a   Huber, Robert ^a   Von der Saal, Wolfgang ^b   Wirthensohn, Klaus ^b   Engh, Richard A ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A;

ARTICLE; BLOOD CLOTTING; COMPETITIVE INHIBITION; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HEMOSTASIS; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THROMBOCYTE ACTIVATION; X RAY ANALYSIS;

ANTICOAGULANTS; BINDING SITES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR XA; HUMANS; NAPHTHALENES; PROPIONIC ACIDS; SUBSTRATE SPECIFICITY;

EID: 0029923976     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.47.29988     Document Type: Article

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