Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 14, 2003, Pages 2319-2325

  South, Michael S ^a   Case, Brenda L ^a   Wood, Rhonda S ^a   Jones, Darin E ^a   Hayes, Michael J ^a   Girard, Thomas J ^a   Lachance, Rhonda M ^a   Nicholson, Nancy S ^a   Clare, Michael ^a   Stevens, Anna M ^a   Stegeman, Roderick A ^a   Stallings, William C ^a   Kurumbail, Ravi G ^a   Parlow, John J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; PYRAZINE DERIVATIVE; THIAZOLE DERIVATIVE; THROMBIN;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

PRIMATES;

EID: 12444325189     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00410-4     Document Type: Article

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