Polymer-assisted solution-phase library synthesis and crystal structure of α-ketothiazoles as tissue factor VIIa inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 19, 2003, Pages 4043-4049

  Parlow, John J ^a   Dice, Thomas A ^a   Lachance, Rhonda M ^a   Girard, Thomas J ^a   Stevens, Anna M ^a   Stegeman, Roderick A ^a   Stallings, William C ^a   Kurumbail, Ravi G ^a   South, Michael S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KETOTHIAZOLE DERIVATIVE; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; POLYMER; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; REACTION ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FACTOR VIIA; HUMANS; INHIBITORY CONCENTRATION 50; KETONES; MODELS, MOLECULAR; POLYMERS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THROMBIN; THROMBOPLASTIN;

EID: 0141790759     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030130t     Document Type: Article

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