Multi-component reactions and evolutionary chemistry

Drug Discovery Today

Volumn 7, Issue 2, 2002, Pages 143-147

  Weber, Lutz ^a  

^a Morphochem AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR; RUPINTRIVIR; NATURAL PRODUCT;

BIODIVERSITY; COMBINATORIAL CHEMISTRY; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR EVOLUTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION OPTIMIZATION; REVIEW; ALGORITHM; CHEMICAL REACTION KINETICS; COMBINATORIAL LIBRARY; DRUG RESEARCH; DRUG SCREENING; PHYSICAL CHEMISTRY; REACTION ANALYSIS; STOCHASTIC MODEL; CHEMICAL MODEL; COMPUTER SIMULATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; MODELS, CHEMICAL;

EID: 0037079610     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)02090-6     Document Type: Review

References (27)

1. Discovery of new multi component reactions with combinatorial methods
2. Multicomponent reactions in organic chemistry
3. Domino reactions in organic synthesis
4. High-diversity combinatorial libraries
5. Target-oriented and diversity-oriented organic synthesis in drug discovery
6. Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis
7. Palladium catalysed cascade cyclisation-anion capture, relay switches and molecular queues
8. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries
9. Cyclization as the key step in the synthesis of pentasubstituted arenes: An efficient access to highly active inhibitors of cholesteryl ester transfer protein (CETP)
10. Proline-catalyzed asymmetric aldol reactions between ketones and unsubstituted aldehydes
11. A novel three component butenolide synthesis
12. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays
13. Diversity in very large libraries
14. Molecular diversity anaylysis and combinatorial library design
15. The NEWLEAD program: A new method for the design of candidate structures from pharmacophoric hypotheses
16. De novo design of enzyme inhibitors by Monte Carlo ligand generation
17. Multiple copy simultaneous search and constructions of ligands in binding sites: Application to inhibitors of HIV-1 aspartic protease
18. The computer program LUDI: A new method for the de novo design of enzyme inhibitors
19. Computer design of bioactive molecules: A method for receptor-based de novo ligand design
20. Combinatorial docking and combinatorial chemistry: Design of potent non-peptide thrombin inhibitors
21. Simulated molecular evolution in a full combinatorial library
22. A genetic algorithm for the automated generation of molecules within constraints
23. Evolutionary design of molecules with desired properties using the genetic algorithm