Expedient synthesis of 5-unsubstituted 3,4-dihydro pyrimidin-2(1H)-ones

Tetrahedron Letters

Volumn 39, Issue 51, 1998, Pages 9315-9318

  Steele, Thomas G ^a   Coburn, Craig A ^a   Patane, Michael A ^a   Bock, Mark G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Biginelli reaction; Decarboxylation; Pyrimidinones

Indexed keywords

PYRIMIDINONE DERIVATIVE;

ARTICLE; DECARBOXYLATION; HYDROLYSIS; REACTION ANALYSIS; SYNTHESIS;

EID: 0032542189     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02155-8     Document Type: Article

References (10)

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3. 2. For a recent review, see Kappe, C. O. Tetrahedron 1993,49, 6937.
4. 3. Hu, E. H.; Sidler, D. R.; Dolling, U-H. J. Org. Chem. 1998, 63, 3454.
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6. 5. Zigeuner, G.; Knopp, C.; Blaschke, H. Monatsh. Chem. 1976, 107, 587.
7. 6. (a) Ireland, R. E.; Norbeck, D. W.; Mandel, G. S.; Mandel, N. S. J. Am. Chem. Soc. 1985, 107, 3285.
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9. 7. No attempt was made to rigorously exclude moisture.
10. 8. It is advisable that reaction products 6 and 7 not be stored at room temperature for a prolonged period of time. In some instances, decomposition has been observed.