메뉴 건너뛰기




Volumn 178, Issue 4, 2003, Pages 373-383

The role of intramuscular lipid in insulin resistance

Author keywords

Acyl CoAs; Ceramide; Diacylglycerol; Dietary fat; Fatty acid tracers; In vivo insulin action; Muscle; Protein kinase C

Indexed keywords

ACYL COENZYME A; CERAMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; FATTY ACID; GLUCOSE; GLYCOGEN SYNTHASE; HEXOKINASE; HEXOSAMINE; INSULIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROTEIN KINASE C;

EID: 0042160182     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2003.01162.x     Document Type: Conference Paper
Times cited : (208)

References (121)
  • 1
    • 0037119410 scopus 로고    scopus 로고
    • Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis
    • Atkinson, L.L., Fischer, M.A. & Lopaschuk, G.D. 2002. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 277, 29424-29430.
    • (2002) J Biol Chem , vol.277 , pp. 29424-29430
    • Atkinson, L.L.1    Fischer, M.A.2    Lopaschuk, G.D.3
  • 2
    • 0035515278 scopus 로고    scopus 로고
    • Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
    • Bachmann, O.P., Dahl do, M.B., Brechtel, K. et al. 2001. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 50, 2579-2584.
    • (2001) Diabetes , vol.50 , pp. 2579-2584
    • Bachmann, O.P.1    Do Dahl, M.B.2    Brechtel, K.3
  • 5
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg, A.H., Combs, T.P., Du, X., Brownlee, M. & Scherer, P.E. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7, 947-953.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 6
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
    • Bjornholm, M., Kawano, Y., Lehtihet, M. & Zierath, J.R. 1997. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46, 524-527.
    • (1997) Diabetes , vol.46 , pp. 524-527
    • Bjornholm, M.1    Kawano, Y.2    Lehtihet, M.3    Zierath, J.R.4
  • 7
    • 0033856104 scopus 로고    scopus 로고
    • Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
    • Blaak, E.E., Wagenmakers, A.J., Glatz, J.F. et al. 2000. Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle. Am J Physiol Endocrinol Metab 279, E146-E154.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Blaak, E.E.1    Wagenmakers, A.J.2    Glatz, J.F.3
  • 8
    • 0026002683 scopus 로고
    • Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
    • Boden, G., Jadali, F., White, J. et al. 1991. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88, 960-966.
    • (1991) J Clin Invest , vol.88 , pp. 960-966
    • Boden, G.1    Jadali, F.2    White, J.3
  • 9
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden, G., Chen, X., Ruiz, J., White, J.V. & Rossetti, L. 1994. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93, 2438-2446.
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 10
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    • Boden, G., Lebed, B., Schatz, M., Homko, C. & Lemieux, S. 2001. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50, 1612-1617.
    • (2001) Diabetes , vol.50 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 11
    • 0035487315 scopus 로고    scopus 로고
    • A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
    • Cazzolli, R., Carpenter, L., Biden, T.J. & Schmitz-Peiffer, C. 2001. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes 50, 2210-2218.
    • (2001) Diabetes , vol.50 , pp. 2210-2218
    • Cazzolli, R.1    Carpenter, L.2    Biden, T.J.3    Schmitz-Peiffer, C.4
  • 12
    • 0031753812 scopus 로고    scopus 로고
    • Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
    • Chalkley, S.M., Hettiarachchi, M., Chisholm, D.J. & Kraegen, E.W. 1998. Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat. Metabolism 47, 1121-1126.
    • (1998) Metabolism , vol.47 , pp. 1121-1126
    • Chalkley, S.M.1    Hettiarachchi, M.2    Chisholm, D.J.3    Kraegen, E.W.4
  • 13
    • 0026690888 scopus 로고
    • Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme A esters in liver and skeletal muscle
    • Chen, M.T., Kaufman, L.N., Spennetta, T. & Shrago, E. 1992. Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme A esters in liver and skeletal muscle. Metabolism 41, 564-569.
    • (1992) Metabolism , vol.41 , pp. 564-569
    • Chen, M.T.1    Kaufman, L.N.2    Spennetta, T.3    Shrago, E.4
  • 14
    • 0035142288 scopus 로고    scopus 로고
    • Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats
    • Choi, C.S., Lee, F.N. & Youn, J.H. 2001. Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats. Diabetes 50, 418-424.
    • (2001) Diabetes , vol.50 , pp. 418-424
    • Choi, C.S.1    Lee, F.N.2    Youn, J.H.3
  • 15
    • 0028960787 scopus 로고
    • Skeletal muscle utilization of free fatty acids in women with visceral obesity
    • Colberg, S.R., Simoneau, J.A., Thaete, F.L. & Kelley, D.E. 1995. Skeletal muscle utilization of free fatty acids in women with visceral obesity (see comments). J Clin Invest 95, 1846-1853.
    • (1995) J Clin Invest , vol.95 , pp. 1846-1853
    • Colberg, S.R.1    Simoneau, J.A.2    Thaete, F.L.3    Kelley, D.E.4
  • 16
    • 0033960381 scopus 로고    scopus 로고
    • The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction
    • Corkey, B.E., Deeney, J.T., Yaney, G.C., Tornheim, K. & Prentki, M. 2000. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr 130, 299S-304S.
    • (2000) J Nutr , vol.130
    • Corkey, B.E.1    Deeney, J.T.2    Yaney, G.C.3    Tornheim, K.4    Prentki, M.5
  • 18
    • 0035880016 scopus 로고    scopus 로고
    • Sphingomyelin and ceramide as regulators of development and lifespan
    • Cutler, R.G. & Mattson, M.P. 2001. Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev 122, 895-908.
    • (2001) Mech Ageing Dev , vol.122 , pp. 895-908
    • Cutler, R.G.1    Mattson, M.P.2
  • 19
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo, R.A., Jacot, E., Jequier, E., Maeder, E., Wahren, J. & Felber, J.P. 1981. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 1000-1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 20
    • 0026713687 scopus 로고
    • Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme A
    • DiRusso, C.C., Heimert, T.L. & Metzger, A.K. 1992. Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme A. J Biol Chem 267, 8685-8691.
    • (1992) J Biol Chem , vol.267 , pp. 8685-8691
    • DiRusso, C.C.1    Heimert, T.L.2    Metzger, A.K.3
  • 21
    • 0035149738 scopus 로고    scopus 로고
    • Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
    • Dobbins, R.L., Szczepaniak, L.S., Bentley, B., Esser, V., Myhili, J. & McGarry, J.D. 2001. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 50, 123-130.
    • (2001) Diabetes , vol.50 , pp. 123-130
    • Dobbins, R.L.1    Szczepaniak, L.S.2    Bentley, B.3    Esser, V.4    Myhili, J.5    McGarry, J.D.6
  • 22
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner, A., Laurent, D., Marcucci, M. et al. 1999. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103, 253-259.
    • (1999) J Clin Invest , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3
  • 23
    • 0033834079 scopus 로고    scopus 로고
    • Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle
    • Ellis, B.A., Poynten, A., Lowy, A.J. et al. 2000. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol Metab 279, E554-E560.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Ellis, B.A.1    Poynten, A.2    Lowy, A.J.3
  • 24
    • 0031968221 scopus 로고    scopus 로고
    • Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man
    • Enoksson, S., Degerman, E., Hagstrom-Toft, E., Large, V. & Arner, P. 1998. Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man. Diabetologia 41, 560-568.
    • (1998) Diabetologia , vol.41 , pp. 560-568
    • Enoksson, S.1    Degerman, E.2    Hagstrom-Toft, E.3    Large, V.4    Arner, P.5
  • 25
    • 0030897513 scopus 로고    scopus 로고
    • Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling
    • Faergeman, N.J. & Knudsen, J. 1997. Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling. Biochem J 323, 1-12.
    • (1997) Biochem J , vol.323 , pp. 1-12
    • Faergeman, N.J.1    Knudsen, J.2
  • 26
    • 0023930822 scopus 로고
    • The theoretical bases of indirect calorimetry: A review
    • Ferrannini, E. 1988. The theoretical bases of indirect calorimetry: a review. Metabolism 37, 287-301.
    • (1988) Metabolism , vol.37 , pp. 287-301
    • Ferrannini, E.1
  • 27
    • 0021032715 scopus 로고
    • Effect of fatty acids on glucose production and utilization in man
    • Ferrannini, E., Barrett, E.J., Bevilacqua, S. & DeFronzo, R.A. 1983. Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72, 1737-1747.
    • (1983) J Clin Invest , vol.72 , pp. 1737-1747
    • Ferrannini, E.1    Barrett, E.J.2    Bevilacqua, S.3    DeFronzo, R.A.4
  • 28
    • 0026577332 scopus 로고
    • Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4
    • Friedman, J.E., Dohm, G.L., Leggett-Frazier, N. et al. 1992. Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4. J Clin Invest 89, 701-705.
    • (1992) J Clin Invest , vol.89 , pp. 701-705
    • Friedman, J.E.1    Dohm, G.L.2    Leggett-Frazier, N.3
  • 29
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis, J., Tsao, T.S., Javorschi, S. et al. 2001. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98, 2005-2010.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3
  • 30
    • 0033850426 scopus 로고    scopus 로고
    • Local factors modulate tissue-specific NEFA utilization: Assessment in rats using 3H-(R)-2-bromopalmitate
    • Furler, S.M., Cooney, G.J., Hegarty, B.D., Lim-Fraser, M.Y., Kraegen, E.W. & Oakes, N.D. 2000. Local factors modulate tissue-specific NEFA utilization: assessment in rats using 3H-(R)-2-bromopalmitate. Diabetes 49, 1427-1433.
    • (2000) Diabetes , vol.49 , pp. 1427-1433
    • Furler, S.M.1    Cooney, G.J.2    Hegarty, B.D.3    Lim-Fraser, M.Y.4    Kraegen, E.W.5    Oakes, N.D.6
  • 31
    • 26744465236 scopus 로고    scopus 로고
    • Selective reversal of high fat diet induced muscle gene expression by PPAR agonists: Micoarray analysis in rats
    • Furler, S.M., Lapsys, N., Denyer, G.S. et al. 2002. Selective reversal of high fat diet induced muscle gene expression by PPAR agonists: micoarray analysis in rats. Diabetologia 45 (Suppl. 2), A238.
    • (2002) Diabetologia , vol.45 , Issue.2 SUPPL.
    • Furler, S.M.1    Lapsys, N.2    Denyer, G.S.3
  • 32
    • 0036828824 scopus 로고    scopus 로고
    • Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy
    • Gan, S.K., Kraegen, E.W., Carr, A., Thompson, C.H. et al. 2002. Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy. Diabetes 451, 3163-3169.
    • (2002) Diabetes , vol.451 , pp. 3163-3169
    • Gan, S.K.1    Kraegen, E.W.2    Carr, A.3    Thompson, C.H.4
  • 33
    • 0026723385 scopus 로고
    • Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM
    • Garvey, W.T., Maianu, L., Hancock, J.A., Golichowski, A.M. & Baron, A. 1992. Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41, 465-475.
    • (1992) Diabetes , vol.41 , pp. 465-475
    • Garvey, W.T.1    Maianu, L.2    Hancock, J.A.3    Golichowski, A.M.4    Baron, A.5
  • 34
    • 0030765908 scopus 로고    scopus 로고
    • Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
    • Goodpaster, B.H., Thaete, F.L., Simoneau, J.A. & Kelley, D.E. 1997. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46, 1579-1585.
    • (1997) Diabetes , vol.46 , pp. 1579-1585
    • Goodpaster, B.H.1    Thaete, F.L.2    Simoneau, J.A.3    Kelley, D.E.4
  • 35
    • 0034107084 scopus 로고    scopus 로고
    • Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    • Goodpaster, B.H., Thaete, F.L. & Kelley, D.E. 2000. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 71, 885-892.
    • (2000) Am J Clin Nutr , vol.71 , pp. 885-892
    • Goodpaster, B.H.1    Thaete, F.L.2    Kelley, D.E.3
  • 36
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • Goodyear, L.J., Giorgino, F., Sherman, L.A., Carey, J., Smith, R.J. & Dohm, G.L. 1995. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95, 2195-2204.
    • (1995) J Clin Invest , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1    Giorgino, F.2    Sherman, L.A.3    Carey, J.4    Smith, R.J.5    Dohm, G.L.6
  • 37
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin, M.E., Marcucci, M.J., Cline, G.W. et al. 1999. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48, 1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 38
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo, M., Gervois, P., Raspe, E. et al. 2000. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275, 16638-16642.
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspe, E.3
  • 39
    • 0035133331 scopus 로고    scopus 로고
    • Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
    • Hajduch, E., Balendran, A., Batty, I.H. et al. 2001. Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia 44, 173-183.
    • (2001) Diabetologia , vol.44 , pp. 173-183
    • Hajduch, E.1    Balendran, A.2    Batty, I.H.3
  • 40
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas, J.L., Gajiwala, K.S., Maffei, M. et al. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 41
    • 0030926433 scopus 로고    scopus 로고
    • Role of the glucosamine pathway in fat-induced insulin resistance
    • Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W. & Rossetti, L. 1997. Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest 99, 2173-2182.
    • (1997) J Clin Invest , vol.99 , pp. 2173-2182
    • Hawkins, M.1    Barzilai, N.2    Liu, R.3    Hu, M.4    Chen, W.5    Rossetti, L.6
  • 42
    • 0036316341 scopus 로고    scopus 로고
    • Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats
    • Hegarty, B.D., Cooney, G.J., Kraegen, E.W. & Furler, S.M. 2002. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes 51, 1477-1484.
    • (2002) Diabetes , vol.51 , pp. 1477-1484
    • Hegarty, B.D.1    Cooney, G.J.2    Kraegen, E.W.3    Furler, S.M.4
  • 43
    • 0032473950 scopus 로고    scopus 로고
    • Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha
    • Hertz, R., Magenheim, J., Berman, I. & Bar-Tana, J. 1998. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha. Nature 392, 512-516.
    • (1998) Nature , vol.392 , pp. 512-516
    • Hertz, R.1    Magenheim, J.2    Berman, I.3    Bar-Tana, J.4
  • 44
    • 0032587240 scopus 로고    scopus 로고
    • The role of TNFalpha and TNF receptors in obesity and insulin resistance
    • Hotamisligil, G.S. 1999. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 245, 621-625.
    • (1999) J Intern Med , vol.245 , pp. 621-625
    • Hotamisligil, G.S.1
  • 45
    • 0036099857 scopus 로고    scopus 로고
    • Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
    • Hundal, R.S., Petersen, K.F., Mayerson, A.B. et al. 2002. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109, 1321-1326.
    • (2002) J Clin Invest , vol.109 , pp. 1321-1326
    • Hundal, R.S.1    Petersen, K.F.2    Mayerson, A.B.3
  • 46
    • 0036095269 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells - Inhibition by the AMP-activated protein kinase activation
    • Ido, Y., Carling, D. & Ruderman, N. 2002. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells - inhibition by the AMP-activated protein kinase activation. Diabetes 51, 159-167.
    • (2002) Diabetes , vol.51 , pp. 159-167
    • Ido, Y.1    Carling, D.2    Ruderman, N.3
  • 47
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin resistant high-fat fed rats
    • Iglesias, M.A., Ye, J.M., Frangioudakis, G. et al. 2002. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin resistant high-fat fed rats. Diabetes 451, 2886-2894.
    • (2002) Diabetes , vol.451 , pp. 2886-2894
    • Iglesias, M.A.1    Ye, J.M.2    Frangioudakis, G.3
  • 48
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IkB-alpha
    • Itani, S.I., Ruderman, N.B., Schmieder, F. & Boden, G. 2002. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IkB-alpha. Diabetes 51, 2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 49
    • 0030762382 scopus 로고    scopus 로고
    • Lipolysis: Contribution from regional fat
    • Jensen, M.D. 1997. Lipolysis: contribution from regional fat. Annu Rev Nutr 17, 127-139.
    • (1997) Annu Rev Nutr , vol.17 , pp. 127-139
    • Jensen, M.D.1
  • 50
    • 0029874429 scopus 로고    scopus 로고
    • Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1
    • Kanety, H., Hemi, R., Papa, M.Z. & Karasik, A. 1996. Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1. J Biol Chem 271, 9895-9897.
    • (1996) J Biol Chem , vol.271 , pp. 9895-9897
    • Kanety, H.1    Hemi, R.2    Papa, M.Z.3    Karasik, A.4
  • 51
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: A reexamination
    • Kelley, D.E. & Mandarino, L.J. 2000. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49, 677-683.
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.E.1    Mandarino, L.J.2
  • 52
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • Kelley, D.E., Mokan, M., Simoneau, J.A. & Mandarino, L.J. 1993. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92, 91-98.
    • (1993) J Clin Invest , vol.92 , pp. 91-98
    • Kelley, D.E.1    Mokan, M.2    Simoneau, J.A.3    Mandarino, L.J.4
  • 53
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley, D.E., Goodpaster, B., Wing, R.R. & Simoneau, J.A. 1999. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277, E1130-E1141.
    • (1999) Am J Physiol , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 54
    • 0027946529 scopus 로고
    • Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
    • Kelley, D.E. & Simoneau, J.A. 1994. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J Clin Invest 94, 2349-2356.
    • (1994) J Clin Invest , vol.94 , pp. 2349-2356
    • Kelley, D.E.1    Simoneau, J.A.2
  • 55
    • 0029962282 scopus 로고    scopus 로고
    • Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats
    • Kim, J.K., Wi, J.K. & Youn, J.H. 1996. Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats. Diabetes 45, 651-658.
    • (1996) Diabetes , vol.45 , pp. 651-658
    • Kim, J.K.1    Wi, J.K.2    Youn, J.H.3
  • 56
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim, Y.B., Nikoulina, S.E., Ciaraldi, T.P., Henry, R.R. & Kahn, B.B. 1999. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104, 733-741.
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 58
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim, J.K., Fillmore, J.J., Chen, Y. et al. 2001. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci USA 98, 7522-7527.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7522-7527
    • Kim, J.K.1    Fillmore, J.J.2    Chen, Y.3
  • 59
    • 0035133716 scopus 로고    scopus 로고
    • Myocardial fatty acid oxidation in patients with impaired glucose tolerance
    • Knuuti, J., Takala, T.O., Nagren, K. et al. 2001. Myocardial fatty acid oxidation in patients with impaired glucose tolerance. Diabetologia 44, 184-187.
    • (2001) Diabetologia , vol.44 , pp. 184-187
    • Knuuti, J.1    Takala, T.O.2    Nagren, K.3
  • 60
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya, D. & King, G.L. 1998. Protein kinase C activation and the development of diabetic complications. Diabetes 47, 859-866.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 61
    • 0030720085 scopus 로고    scopus 로고
    • Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity
    • Koyama, K., Chen, G., Lee, Y. & Unger, R.H. 1997. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol 273, E708-E713.
    • (1997) Am J Physiol , vol.273
    • Koyama, K.1    Chen, G.2    Lee, Y.3    Unger, R.H.4
  • 62
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
    • Kraegen, E.W., Clark, P.W., Jenkins, A.B., Daley, E.A., Chisholm, D.J. & Storlien, L.H. 1991. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40, 1397-1403.
    • (1991) Diabetes , vol.40 , pp. 1397-1403
    • Kraegen, E.W.1    Clark, P.W.2    Jenkins, A.B.3    Daley, E.A.4    Chisholm, D.J.5    Storlien, L.H.6
  • 63
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • published errata appeared in Diabetologia 1999; 42, 386 and 1999; 42, 1269
    • Krssak, M., Falk Petersen, K., Dresner, A. et al. 1999. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study (published errata appeared in Diabetologia 1999; 42, 386 and 1999; 42, 1269). Diabetologia 42, 113-116.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3
  • 64
    • 33745359912 scopus 로고    scopus 로고
    • Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats
    • Laybutt, D.R., Chisholm, D.J. & Kraegen, E.W. 1997. Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats. Am J Physiol 273, E1-E9.
    • (1997) Am J Physiol , vol.273
    • Laybutt, D.R.1    Chisholm, D.J.2    Kraegen, E.W.3
  • 65
    • 0033399406 scopus 로고    scopus 로고
    • Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
    • Laybutt, D.R., Schmitz-Peiffer, C., Saha, A.K., Ruderman, N.B., Biden, T.J. & Kraegen, E.W. 1999. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol 277, E1070-E1076.
    • (1999) Am J Physiol , vol.277
    • Laybutt, D.R.1    Schmitz-Peiffer, C.2    Saha, A.K.3    Ruderman, N.B.4    Biden, T.J.5    Kraegen, E.W.6
  • 66
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., Wilkison, W.O., Willson, T.M. & Kliewer, S.A. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270, 12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 67
    • 0031857333 scopus 로고    scopus 로고
    • Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid
    • Maki, M.T., Haaparanta, M., Nuutila, P. et al. 1998. Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid. J Nucl Med 39, 1320-1327.
    • (1998) J Nucl Med , vol.39 , pp. 1320-1327
    • Maki, M.T.1    Haaparanta, M.2    Nuutila, P.3
  • 68
    • 0032037738 scopus 로고    scopus 로고
    • PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes
    • Martin, G., Schoonjans, K., Staels, B. & Auwerx, J. 1998. PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes. Atherosclerosis 137 (Suppl), S75-S80.
    • (1998) Atherosclerosis , vol.137 , Issue.SUPPL.
    • Martin, G.1    Schoonjans, K.2    Staels, B.3    Auwerx, J.4
  • 69
    • 0035514950 scopus 로고    scopus 로고
    • Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    • Mensink, M., Blaak, E.E., van Baak, M.A., Wagenmakers, A.J. & Saris, W.H. 2001. Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes. Diabetes 50, 2548-2554.
    • (2001) Diabetes , vol.50 , pp. 2548-2554
    • Mensink, M.1    Blaak, E.E.2    Van Baak, M.A.3    Wagenmakers, A.J.4    Saris, W.H.5
  • 70
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi, Y., Kim, Y.B., Peroni, O.D. et al. 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415, 339-343.
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3
  • 71
    • 1842405349 scopus 로고    scopus 로고
    • Leptin directly alters lipid partitioning in skeletal muscle
    • published erratum appears in Diabetes 1997;46, 1663
    • Muoio, D.M., Dohm, G.L., Fiedorek, F.T. Jr., Tapscott, E.B., Coleman, R.A. & Dohm, G.L. 1997. Leptin directly alters lipid partitioning in skeletal muscle (published erratum appears in Diabetes 1997;46, 1663). Diabetes 46, 1360-1363.
    • (1997) Diabetes , vol.46 , pp. 1360-1363
    • Muoio, D.M.1    Dohm, G.L.2    Fiedorek F.T., Jr.3    Tapscott, E.B.4    Coleman, R.A.5    Dohm, G.L.6
  • 72
    • 0028267475 scopus 로고
    • Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: Possible implications in fatty acid oxidation defects
    • Nesher, M. & Boneh, A. 1994. Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: possible implications in fatty acid oxidation defects. Biochim Biophys Acta 1221, 66-72.
    • (1994) Biochim Biophys Acta , vol.1221 , pp. 66-72
    • Nesher, M.1    Boneh, A.2
  • 73
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • Nishizuka, Y. 1995. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9, 484-496.
    • (1995) FASEB J , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 74
    • 0028076266 scopus 로고
    • A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
    • Oakes, N.D., Kennedy, C.J., Jenkins, A.B., Laybutt, D.R., Chisholm, D.J. & Kraegen, E.W. 1994. A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 43, 1203-1210.
    • (1994) Diabetes , vol.43 , pp. 1203-1210
    • Oakes, N.D.1    Kennedy, C.J.2    Jenkins, A.B.3    Laybutt, D.R.4    Chisholm, D.J.5    Kraegen, E.W.6
  • 75
    • 0030784947 scopus 로고    scopus 로고
    • Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
    • Oakes, N.D., Bell, K.S., Furler, S.M. et al. 1997a. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 46, 2022-2028.
    • (1997) Diabetes , vol.46 , pp. 2022-2028
    • Oakes, N.D.1    Bell, K.S.2    Furler, S.M.3
  • 76
    • 0030811602 scopus 로고    scopus 로고
    • The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat
    • Oakes, N.D., Camilieri, S., Furler, S.M., Chisholm, D.J. & Kraegen, E.W. 1997b. The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat. Metabolism 46, 935-942.
    • (1997) Metabolism , vol.46 , pp. 935-942
    • Oakes, N.D.1    Camilieri, S.2    Furler, S.M.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 77
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes, N.D., Cooney, G.J., Camilieri, S., Chisholm, D.J. & Kraegen, E.W. 1997c. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46, 1768-1774.
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilieri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 78
    • 0033038994 scopus 로고    scopus 로고
    • Development and initial evaluation of a novel method for assessing tissue-specific plasma free fatty acid utilization in vivo using (R)-2-bromopalmitate tracer
    • Oakes, N.D., Kjellstedt, A., Forsberg, G.B. et al. 1999. Development and initial evaluation of a novel method for assessing tissue-specific plasma free fatty acid utilization in vivo using (R)-2-bromopalmitate tracer. J Lipid Res 40, 1155-1169.
    • (1999) J Lipid Res , vol.40 , pp. 1155-1169
    • Oakes, N.D.1    Kjellstedt, A.2    Forsberg, G.B.3
  • 79
    • 0035029876 scopus 로고    scopus 로고
    • Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability
    • Oakes, N.D., Thalen, P.G., Jacinto, S.M. & Ljung, B. 2001. Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Diabetes 50, 1158-1165.
    • (2001) Diabetes , vol.50 , pp. 1158-1165
    • Oakes, N.D.1    Thalen, P.G.2    Jacinto, S.M.3    Ljung, B.4
  • 80
    • 0025339442 scopus 로고
    • Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme
    • Orellana, A., Hidalgo, P.C., Morales, M.N., Mezzano, D. & Bronfman, M. 1990. Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme. Eur J Biochem 190, 57-61.
    • (1990) Eur J Biochem , vol.190 , pp. 57-61
    • Orellana, A.1    Hidalgo, P.C.2    Morales, M.N.3    Mezzano, D.4    Bronfman, M.5
  • 81
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • Pan, D.A., Lillioja, S., Kriketos, A.D. et al. 1997. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46, 983-988.
    • (1997) Diabetes , vol.46 , pp. 983-988
    • Pan, D.A.1    Lillioja, S.2    Kriketos, A.D.3
  • 82
    • 0031957844 scopus 로고    scopus 로고
    • Role of non-esterified fatty acids in the pathogenesis of type 2 diabetes mellitus
    • Paolisso, G. & Howard, B.V. 1998. Role of non-esterified fatty acids in the pathogenesis of type 2 diabetes mellitus (see comments). Diabet Med 15, 360-366.
    • (1998) Diabet Med , vol.15 , pp. 360-366
    • Paolisso, G.1    Howard, B.V.2
  • 83
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter, M.A., Cullen, M.J., Baker, M.B. et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 84
    • 0029933665 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
    • Peraldi, P., Hotamisligil, G.S., Buurman, W.A., White, M.F. & Spiegelman, B.M. 1996. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 271, 13018-13022.
    • (1996) J Biol Chem , vol.271 , pp. 13018-13022
    • Peraldi, P.1    Hotamisligil, G.S.2    Buurman, W.A.3    White, M.F.4    Spiegelman, B.M.5
  • 85
    • 0032764784 scopus 로고    scopus 로고
    • Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • Perseghin, G., Scifo, P., De Cobelli, F. et al. 1999. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48, 1600-1606.
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3
  • 86
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    • Phillips, D.I., Caddy, S., Ilic, V. et al. 1996. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45, 947-950.
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.1    Caddy, S.2    Ilic, V.3
  • 87
    • 0035134739 scopus 로고    scopus 로고
    • Transgenic rescue of defective CD36 ameliorates insulin resistance in spontaneously hypertensive rats
    • Pravenec, M., Landa, V., Zidek, V. et al. 2001. Transgenic rescue of defective CD36 ameliorates insulin resistance in spontaneously hypertensive rats. Nat Genet 27, 156-158.
    • (2001) Nat Genet , vol.27 , pp. 156-158
    • Pravenec, M.1    Landa, V.2    Zidek, V.3
  • 88
    • 0032813243 scopus 로고    scopus 로고
    • Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - Effects of feeding
    • Qu, X., Seale, J.P. & Donnelly, R. 1999. Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding. J Endocrinol 162, 207-214.
    • (1999) J Endocrinol , vol.162 , pp. 207-214
    • Qu, X.1    Seale, J.P.2    Donnelly, R.3
  • 89
    • 0028860254 scopus 로고
    • Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding
    • Raman, N. & DiRusso, C.C. 1995. Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding. J Biol Chem 270, 1092-1097.
    • (1995) J Biol Chem , vol.270 , pp. 1092-1097
    • Raman, N.1    DiRusso, C.C.2
  • 90
    • 50549202600 scopus 로고
    • The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle, P.J., Garland, P.B., Hales, C.N. & Newsholm, E.A. 1963. The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholm, E.A.4
  • 91
    • 0013772629 scopus 로고
    • Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles
    • Randle, P.J., Newsholme, E.A. & Garland, P.B. 1964. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J 93, 652-665.
    • (1964) Biochem J , vol.93 , pp. 652-665
    • Randle, P.J.1    Newsholme, E.A.2    Garland, P.B.3
  • 92
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus
    • Randle, P.J., Garland, P.B., Newsholme, E.A. & Hales, C.N. 1965. The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann N Y Acad Sci 131, 324-333.
    • (1965) Ann N Y Acad Sci , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 93
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven, G.M. 1988. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 94
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden, M., Price, T.B., Perseghin, G. et al. 1996. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97, 2859-2865.
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 95
    • 0033007561 scopus 로고    scopus 로고
    • Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans
    • Roden, M., Krssak, M., Stingi, H. et al. 1999. Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes 48, 358-364.
    • (1999) Diabetes , vol.48 , pp. 358-364
    • Roden, M.1    Krssak, M.2    Stingl, H.3
  • 96
    • 0034455277 scopus 로고    scopus 로고
    • Perspective: Hexosamines and nutrient sensing
    • Rossetti, L. 2000. Perspective: hexosamines and nutrient sensing. Endocrinology 141, 1922-1925.
    • (2000) Endocrinology , vol.141 , pp. 1922-1925
    • Rossetti, L.1
  • 97
    • 0036288590 scopus 로고    scopus 로고
    • Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice
    • Rottman, J.N., Bracy, D., Malabanan, C., Yue, Z., Clanton, J. & Wasserman, D.H. 2002. Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice. Am J Physiol 283, E116-E123.
    • (2002) Am J Physiol , vol.283
    • Rottman, J.N.1    Bracy, D.2    Malabanan, C.3    Yue, Z.4    Clanton, J.5    Wasserman, D.H.6
  • 98
    • 0033749620 scopus 로고    scopus 로고
    • Signalling aspects of insulin resistance in skeletal muscle. Mechanisms induced by lipid over-supply
    • Schmitz-Peiffer, C. 2000. Signalling aspects of insulin resistance in skeletal muscle. Mechanisms induced by lipid over-supply. Cell Signal 12, 583-594.
    • (2000) Cell Signal , vol.12 , pp. 583-594
    • Schmitz-Peiffer, C.1
  • 99
    • 0030914330 scopus 로고    scopus 로고
    • Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
    • Schmitz-Peiffer, C., Browne, C.L., Oakes, N.D. et al. 1997a. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46, 169-178.
    • (1997) Diabetes , vol.46 , pp. 169-178
    • Schmitz-Peiffer, C.1    Browne, C.L.2    Oakes, N.D.3
  • 100
    • 0030678164 scopus 로고    scopus 로고
    • Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653
    • Schmitz-Peiffer, C., Oakes, N.D., Browne, C.L., Kraegen, E.W. & Biden, T.J. 1997b. Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653. Am J Physiol 273, E915-E921.
    • (1997) Am J Physiol , vol.273
    • Schmitz-Peiffer, C.1    Oakes, N.D.2    Browne, C.L.3    Kraegen, E.W.4    Biden, T.J.5
  • 101
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer, C., Craig, D.L. & Biden, T.J. 1999. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 274, 24202-24210.
    • (1999) J Biol Chem , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 102
    • 0032470236 scopus 로고    scopus 로고
    • Cellular mechanism of nutritionally induced insulin resistance: The desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome
    • Shafrir, E. & Ziv, E. 1998. Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome. J Basic Clin Physiol Pharmacol 9, 347-385.
    • (1998) J Basic Clin Physiol Pharmacol , vol.9 , pp. 347-385
    • Shafrir, E.1    Ziv, E.2
  • 103
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • Shimabukuro, M., Koyama, K., Chen, G. et al. 1997. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94, 4637-4641.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 104
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S. & Goldstein, J.L. 1999. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401, 73-76.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 105
    • 0030743034 scopus 로고    scopus 로고
    • The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs)
    • Staels, B., Schoonjans, K., Fruchart, J.C. & Auwerx, J. 1997. The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs). Biochimie 79, 95-99.
    • (1997) Biochimie , vol.79 , pp. 95-99
    • Staels, B.1    Schoonjans, K.2    Fruchart, J.C.3    Auwerx, J.4
  • 106
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan, C.M., Bailey, S.T., Bhat, S. et al. 2001. The hormone resistin links obesity to diabetes. Nature 409, 307-312.
    • (2001) Nature , vol.409 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 107
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien, L.H., Jenkins, A.B., Chisholm, D.J., Pascoe, W.S., Khouri, S. & Kraegen, E.W. 1991. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40, 280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 108
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • Summers, S.A., Garza, L.A., Zhou, H. & Birnbaum, M.J. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol 18, 5457-5464.
    • (1998) Mol Cell Biol , vol.18 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 109
    • 0034820062 scopus 로고    scopus 로고
    • Long-term (5-year) effects of a reduced-fat diet intervention in individuals with glucose intolerance
    • Swinburn, B.A., Metcalf, P.A. & Ley, S.J. 2001. Long-term (5-year) effects of a reduced-fat diet intervention in individuals with glucose intolerance. Diabet Care 24, 619-624.
    • (2001) Diabet Care , vol.24 , pp. 619-624
    • Swinburn, B.A.1    Metcalf, P.A.2    Ley, S.J.3
  • 110
    • 0033007207 scopus 로고    scopus 로고
    • Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo
    • Szczepaniak, L.S., Babcock, E.E., Schick, F. et al. 1999. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276, E977-E989.
    • (1999) Am J Physiol , vol.276
    • Szczepaniak, L.S.1    Babcock, E.E.2    Schick, F.3
  • 111
    • 0033755148 scopus 로고    scopus 로고
    • Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance
    • Thompson, A.L. & Cooney, G.J. 2000. Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance. Diabetes 49, 1761-1765.
    • (2000) Diabetes , vol.49 , pp. 1761-1765
    • Thompson, A.L.1    Cooney, G.J.2
  • 112
    • 0033830528 scopus 로고    scopus 로고
    • Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro
    • Thompson, A.L., Lim-Fraser, M.Y., Kraegen, E.W. & Cooney, G.J. 2000. Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro. Am J Physiol Endocrinol Metab 279, E577-E584.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Thompson, A.L.1    Lim-Fraser, M.Y.2    Kraegen, E.W.3    Cooney, G.J.4
  • 113
    • 0025123408 scopus 로고
    • 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo
    • Turinsky, J., O'Sullivan, D.M. & Bayly, B.P. 1990. 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J Biol Chem 265, 16880-16885.
    • (1990) J Biol Chem , vol.265 , pp. 16880-16885
    • Turinsky, J.1    O'Sullivan, D.M.2    Bayly, B.P.3
  • 114
    • 0344848623 scopus 로고    scopus 로고
    • Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: Studies with PET and 14(R, S)-[18F]fluoro-6-thia-heptadecanoic acid
    • Turpeinen, A.K., Takala, T.O., Nuutila, P. et al. 1999. Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R, S)-[18F]fluoro-6-thia-heptadecanoic acid. Diabetes 48, 1245-1250.
    • (1999) Diabetes , vol.48 , pp. 1245-1250
    • Turpeinen, A.K.1    Takala, T.O.2    Nuutila, P.3
  • 115
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • Virkamaki, A., Korsheninnikova, E., Seppala-Lindroos, A. et al. 2001. Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50, 2337-2343.
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamaki, A.1    Korsheninnikova, E.2    Seppala-Lindroos, A.3
  • 118
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi, T., Kamon, J., Waki, H. et al. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7, 941-946.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 119
    • 0034457523 scopus 로고    scopus 로고
    • Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells
    • Yaney, G.C., Korchak, H.M. & Corkey, B.E. 2000. Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology 141, 1989-1998.
    • (2000) Endocrinology , vol.141 , pp. 1989-1998
    • Yaney, G.C.1    Korchak, H.M.2    Corkey, B.E.3
  • 120
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: Comparison with PPAR-gamma activation
    • Ye, J.M., Doyle, P.J., Iglesias, M.A., Watson, D.G., Cooney, G.J. & Kraegen, E.W. 2001. Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation. Diabetes 50, 411-417.
    • (2001) Diabetes , vol.50 , pp. 411-417
    • Ye, J.M.1    Doyle, P.J.2    Iglesias, M.A.3    Watson, D.G.4    Cooney, G.J.5    Kraegen, E.W.6
  • 121
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of IRS-1 associated phosphatidylinositol 3-kinase activity in muscle
    • Yu, C., Chen, Y., Cline, G.W. et al. 2002. Mechanism by which fatty acids inhibit insulin activation of IRS-1 associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277, 50230-50236.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.